Cav2.1

1

Berecki G et al. Mechanism of direct Cav2.2 channel block by the κ-opioid receptor agonist U50488H.
Neuropharmacology, 2016 May 28 , 109 (49-58).

2

Nanou E et al. Altered short-term synaptic plasticity and reduced muscle strength in mice with impaired regulation of presynaptic CaV2.1 Ca2+ channels.
Proc. Natl. Acad. Sci. U.S.A., 2016 Jan 26 , 113 (1068-73).

3

Nanou E et al. Calcium sensor regulation of the CaV2.1 Ca2+ channel contributes to short-term synaptic plasticity in hippocampal neurons.
Proc. Natl. Acad. Sci. U.S.A., 2016 Jan 26 , 113 (1062-7).

4

Bomben VC et al. Isolated P/Q Calcium Channel Deletion in Layer VI Corticothalamic Neurons Generates Absence Epilepsy.
J. Neurosci., 2016 Jan 13 , 36 (405-18).

5

Tomlinson SE et al. In vivo impact of presynaptic calcium channel dysfunction on motor axons in episodic ataxia type 2.
Brain, 2016 Feb , 139 (380-91).

6

Byers HM et al. Dramatic Response After Lamotrigine in a Patient With Epileptic Encephalopathy and a De NovoCACNA1A Variant.
Pediatr. Neurol., 2016 Apr 1 , ().

7

Kim TY et al. Absence-like seizures and their pharmacological profile in tottering-6j mice.
Biochem. Biophys. Res. Commun., 2015 Jul 17-24 , 463 (148-53).

8

Chang CY et al. Apigenin, a natural flavonoid, inhibits glutamate release in the rat hippocampus.
Eur. J. Pharmacol., 2015 Sep 5 , 762 (72-81).

9

Coll M et al. Genetic investigation of sudden unexpected death in epilepsy cohort by panel target resequencing.
Int. J. Legal Med., 2015 Sep 30 , ().

10

Kaja S et al. Differential cerebellar GABAA receptor expression in mice with mutations in CaV2.1 (P/Q-type) calcium channels.
Neuroscience, 2015 Sep 24 , 304 (198-208).

11

Yin N et al. Silver nanoparticle exposure induces rat motor dysfunction through decrease in expression of calcium channel protein in cerebellum.
Toxicol. Lett., 2015 Sep 2 , 237 (112-20).

12

Takada Y et al. Rab3 interacting molecule 3 mutations associated with autism alter regulation of voltage-dependent Ca²⁺ channels.
Cell Calcium, 2015 Sep , 58 (296-306).

13

López Soto EJ et al. Constitutive and ghrelin-dependent GHSR1a activation impairs CaV2.1 and CaV2.2 currents in hypothalamic neurons.
J. Gen. Physiol., 2015 Sep , 146 (205-19).

14

Kumar D et al. Cacna1c (Cav1.2) Modulates Electroencephalographic Rhythm and Rapid Eye Movement Sleep Recovery.
Sleep, 2015 Sep , 38 (1371-80).

15

Rousset M et al. Regulation of neuronal high-voltage activated Ca(V)2 Ca(2+) channels by the small GTPase RhoA.
Neuropharmacology, 2015 Oct , 97 (201-9).

16

Jacobi H et al. Long-term disease progression in spinocerebellar ataxia types 1, 2, 3, and 6: a longitudinal cohort study.
Lancet Neurol, 2015 Nov , 14 (1101-8).

17

Damaj L et al. CACNA1A haploinsufficiency causes cognitive impairment, autism and epileptic encephalopathy with mild cerebellar symptoms.
Eur. J. Hum. Genet., 2015 Nov , 23 (1505-12).

18

Murakami M et al. Modified autonomic regulation in mice mutated in the β4 subunit of the lh/lh calcium channel.
Biochem. Biophys. Res. Commun., 2015 May 29 , 461 (200-5).

19

Blumkin L et al. Paroxysmal tonic upward gaze as a presentation of de-novo mutations in CACNA1A.
Eur. J. Paediatr. Neurol., 2015 May , 19 (292-7).

20

Chang Y et al. Myricetin inhibits the release of glutamate in rat cerebrocortical nerve terminals.
J Med Food, 2015 May , 18 (516-23).

21

Hansen PB New Role of P/Q-type Voltage-gated Calcium Channels: From Transmitter Release to Contraction of Renal Vasculature.
J. Cardiovasc. Pharmacol., 2015 May , 65 (406-11).

22

Bechi G et al. Rescuable folding defective NaV1.1 (SCN1A) mutants in epilepsy: properties, occurrence, and novel rescuing strategy with peptides targeted to the endoplasmic reticulum.
Neurobiol. Dis., 2015 Mar , 75 (100-14).

23

Cens T et al. Molecular characterization and functional expression of the Apis mellifera voltage-dependent Ca2+ channels.
Insect Biochem. Mol. Biol., 2015 Mar , 58 (12-27).

24

Tian X et al. A voltage-gated calcium channel regulates lysosomal fusion with endosomes and autophagosomes and is required for neuronal homeostasis.
PLoS Biol., 2015 Mar , 13 (e1002103).

25

Zhou FJ et al. Two New Classes of T-Type Calcium Channel Inhibitors with New Chemical Scaffolds from Ganoderma cochlear.
Org. Lett., 2015 Jun 19 , 17 (3082-5).

26

Mark MD et al. Spinocerebellar ataxia type 6 protein aggregates cause deficits in motor learning and cerebellar plasticity.
J. Neurosci., 2015 Jun 10 , 35 (8882-95).

27

Hino-Fukuyo N et al. Genomic analysis identifies candidate pathogenic variants in 9 of 18 patients with unexplained West syndrome.
Hum. Genet., 2015 Jun , 134 (649-58).

28

Kros L et al. Cerebellar output controls generalized spike-and-wave discharge occurrence.
Ann. Neurol., 2015 Jun , 77 (1027-49).

29

Carreira RJ et al. Large-scale mass spectrometry imaging investigation of consequences of cortical spreading depression in a transgenic mouse model of migraine.
J. Am. Soc. Mass Spectrom., 2015 Jun , 26 (853-61).

30

Langlhofer G et al. Length of the TM3-4 loop of the glycine receptor modulates receptor desensitization.
Neurosci. Lett., 2015 Jul 23 , 600 (176-81).

31

Nakamura Y et al. Nanoscale distribution of presynaptic Ca(2+) channels and its impact on vesicular release during development.
Neuron, 2015 Jan 7 , 85 (145-58).

32

Xu X et al. Solution NMR and calorimetric analysis of Rem2 binding to the Ca2+ channel β4 subunit: A low affinity interaction is required for inhibition of Cav2.1 Ca2+ currents.
FASEB J., 2015 Jan 6 , ().

33

Inchauspe CG et al. Familial hemiplegic migraine type-1 mutated cav2.1 calcium channels alter inhibitory and excitatory synaptic transmission in the lateral superior olive of mice.
Hear. Res., 2015 Jan , 319 (56-68).

34

Kinder S et al. Novel frameshift mutation in the CACNA1A gene causing a mixed phenotype of episodic ataxia and familiar hemiplegic migraine.
Eur. J. Paediatr. Neurol., 2015 Jan , 19 (72-4).

35

Rahman MS et al. Genetic testing for spinocerebellar ataxias in patients diagnosed as Parkinson's disease in Bangladesh.
Mymensingh Med J, 2015 Jan , 24 (44-51).

36

Marinelli S et al. Effects of age-related loss of P/Q-type calcium channels in a mice model of peripheral nerve injury.
Neurobiol. Aging, 2015 Jan , 36 (352-64).

37

Baur D et al. Developmental tightening of cerebellar cortical synaptic influx-release coupling.
J. Neurosci., 2015 Feb 4 , 35 (1858-71).

38

Naranjo D et al. Zebrafish CaV2.1 calcium channels are tailored for fast synchronous neuromuscular transmission.
Biophys. J., 2015 Feb 3 , 108 (578-84).

39

Dileköz E et al. Migraine mutations impair hippocampal learning despite enhanced long-term potentiation.
J. Neurosci., 2015 Feb 25 , 35 (3397-402).

40

Spillane J et al. Lambert-Eaton syndrome IgG inhibits transmitter release via P/Q Ca2+ channels.
Neurology, 2015 Feb 10 , 84 (575-9).

41

Scamps F et al. Nerve injury induces a Gem-GTPase-dependent downregulation of P/Q-type Ca2+ channels contributing to neurite plasticity in dorsal root ganglion neurons.
Pflugers Arch., 2015 Feb , 467 (351-66).

42

Molina-Campos E et al. Age-dependent contribution of P/Q- and R-type Ca2+ channels to neuromuscular transmission in lethargic mice.
J. Pharmacol. Exp. Ther., 2015 Feb , 352 (395-404).

43

Zhou MH et al. Molecular Basis of Regulating High Voltage-Activated Calcium Channels by S-Nitrosylation.
J. Biol. Chem., 2015 Dec 18 , 290 (30616-23).

44

Tsou WL et al. DnaJ-1 and karyopherin α3 suppress degeneration in a new Drosophila model of Spinocerebellar Ataxia Type 6.
Hum. Mol. Genet., 2015 Aug 1 , 24 (4385-96).

45

Choi JH et al. Exercise-induced downbeat nystagmus in a Korean family with a nonsense mutation in CACNA1A.
Neurol. Sci., 2015 Aug , 36 (1393-6).

46

Eikermann-Haerter K et al. Abnormal synaptic Ca(2+) homeostasis and morphology in cortical neurons of familial hemiplegic migraine type 1 mutant mice.
Ann. Neurol., 2015 Aug , 78 (193-210).

47

Lv N et al. Association study between polymorphisms in the CACNA1A, CACNA1C, and CACNA1H genes and drug-resistant epilepsy in the Chinese Han population.
Seizure, 2015 Aug , 30 (64-9).

48

Cramer SW et al. Abnormal excitability and episodic low-frequency oscillations in the cerebral cortex of the tottering mouse.
J. Neurosci., 2015 Apr 8 , 35 (5664-79).

49

Charlesworth G et al. Mutations in HPCA cause autosomal-recessive primary isolated dystonia.
Am. J. Hum. Genet., 2015 Apr 2 , 96 (657-65).

50

Nakao A et al. Compromised maturation of GABAergic inhibition underlies abnormal network activity in the hippocampus of epileptic Ca2+ channel mutant mice, tottering.
Pflugers Arch., 2015 Apr , 467 (737-52).

51

Aung T et al. A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome.
Nat. Genet., 2015 Apr , 47 (387-92).

52

Serikawa T et al. Advances on genetic rat models of epilepsy.
Exp. Anim., 2015 , 64 (1-7).

53

Wang CY et al. Meta-Analysis of Public Microarray Datasets Reveals Voltage-Gated Calcium Gene Signatures in Clinical Cancer Patients.
PLoS ONE, 2015 , 10 (e0125766).

54

Bahamonde MI et al. A Single Amino Acid Deletion (ΔF1502) in the S6 Segment of CaV2.1 Domain III Associated with Congenital Ataxia Increases Channel Activity and Promotes Ca2+ Influx.
PLoS ONE, 2015 , 10 (e0146035).

55

Subramanian M et al. Idiopathic generalized epilepsy and hypokalemic periodic paralysis in a family of South Indian descent.
Case Rep Neurol Med, 2015 , 2015 (906049).

56

Lian LY et al. Demonstration of binding of neuronal calcium sensor-1 to the cav2.1 p/q-type calcium channel.
Biochemistry, 2014 Sep 30 , 53 (6052-62).

57

Fernández-Morales JC et al. Hypoxia-elicited catecholamine release is controlled by L-type as well as N/PQ types of calcium channels in rat embryo chromaffin cells.
Am. J. Physiol., Cell Physiol., 2014 Sep 1 , 307 (C455-65).

58

Vecchia D et al. Mechanism underlying unaltered cortical inhibitory synaptic transmission in contrast with enhanced excitatory transmission in CaV2.1 knockin migraine mice.
Neurobiol. Dis., 2014 Sep , 69 (225-34).

59

Kim TY et al. Age-dependent kainate sensitivity in heterozygous rolling Nagoya Cav2.1 channel mutant mice.
Pharmacol. Biochem. Behav., 2014 Sep , 124 (250-9).

60

van Gaalen J et al. Language impairment in cerebellar ataxia.
Mov. Disord., 2014 Sep , 29 (1307-12).

61

Ford KJ et al. Archaerhodopsin voltage imaging: synaptic calcium and BK channels stabilize action potential repolarization at the Drosophila neuromuscular junction.
J. Neurosci., 2014 Oct 29 , 34 (14517-25).

62

Lin TY et al. Cyclooxygenase 2 inhibitor celecoxib inhibits glutamate release by attenuating the PGE2/EP2 pathway in rat cerebral cortex endings.
J. Pharmacol. Exp. Ther., 2014 Oct , 351 (134-45).

63

Barros J et al. Familial hemiplegic migraine due to L263V SCN1A mutation: discordance for epilepsy between two kindreds from Douro Valley.
Cephalalgia, 2014 Oct , 34 (1015-20).

64

García-Baró-Huarte M et al. Phenotypic variability in a four generation family with a p.Thr666Met CACNA1A gene mutation.
Pediatr. Neurol., 2014 Oct , 51 (557-9).

65

Stahl JS et al. Flocculus Purkinje cell signals in mouse Cacna1a calcium channel mutants of escalating severity: an investigation of the role of firing irregularity in ataxia.
J. Neurophysiol., 2014 Nov 15 , 112 (2647-63).

66

Carattino MD et al. Prostasin interacts with the epithelial Na+ channel and facilitates cleavage of the γ-subunit by a second protease.
Am. J. Physiol. Renal Physiol., 2014 Nov 1 , 307 (F1080-7).

67

Rose SJ et al. The first knockin mouse model of episodic ataxia type 2.
Exp. Neurol., 2014 Nov , 261 (553-62).

68

Yan J et al. Modulation of CaV2.1 channels by neuronal calcium sensor-1 induces short-term synaptic facilitation.
Mol. Cell. Neurosci., 2014 Nov , 63 (124-31).

69

Di Guilmi MN et al. Synaptic gain-of-function effects of mutant Cav2.1 channels in a mouse model of familial hemiplegic migraine are due to increased basal [Ca2+]i.
J. Neurosci., 2014 May 21 , 34 (7047-58).

70

Kunz HH et al. Plastidial transporters KEA1, -2, and -3 are essential for chloroplast osmoregulation, integrity, and pH regulation in Arabidopsis.
Proc. Natl. Acad. Sci. U.S.A., 2014 May 20 , 111 (7480-5).

71

Haerteis S et al. Proteolytic Activation of the Human Epithelial Sodium Channel by Trypsin IV and Trypsin I Involves Distinct Cleavage Sites.
J. Biol. Chem., 2014 May 19 , ().

72

Barros J et al. The prevalence of familial hemiplegic migraine with cerebellar ataxia and spinocerebellar ataxia type 6 in Portugal.
Headache, 2014 May , 54 (911-5).

73

Perissinotti PP et al. Down-regulation of endogenous KLHL1 decreases voltage-gated calcium current density.
Cell Calcium, 2014 May , 55 (269-80).

74

Nachbauer W et al. Episodic ataxia type 2: phenotype characteristics of a novel CACNA1A mutation and review of the literature.
J. Neurol., 2014 May , 261 (983-91).

75

Vila-Pueyo M et al. A loss-of-function CACNA1A mutation causing benign paroxysmal torticollis of infancy.
Eur. J. Paediatr. Neurol., 2014 May , 18 (430-3).

76

Alvarez-Laviada A et al. The inhibition of functional expression of calcium channels by prion protein demonstrates competition with α2δ for GPI-anchoring pathways.
Biochem. J., 2014 Mar 1 , 458 (365-74).

77

de Vries B et al. RNA expression profiling in brains of familial hemiplegic migraine type 1 knock-in mice.
Cephalalgia, 2014 Mar , 34 (174-82).

78

Kuryshev YA et al. Evaluating state dependence and subtype selectivity of calcium channel modulators in automated electrophysiology assays.
Assay Drug Dev Technol, 2014 Mar , 12 (110-9).

79

Ricoy UM et al. Distinct roles for Cav2.1-2.3 in activity-dependent synaptic dynamics.
J. Neurophysiol., 2014 Jun 15 , 111 (2404-13).

80

Duan JH et al. N-type calcium current, Cav2.2, is enhanced in small-diameter sensory neurons isolated from Nf1+/- mice.
Neuroscience, 2014 Jun 13 , 270 (192-202).

81

Wang CC et al. Dimebon, an antihistamine drug, inhibits glutamate release in rat cerebrocortical nerve terminals.
Eur. J. Pharmacol., 2014 Jul 5 , 734 (67-76).

82

García Segarra N et al. Congenital ataxia and hemiplegic migraine with cerebral edema associated with a novel gain of function mutation in the calcium channel CACNA1A.
J. Neurol. Sci., 2014 Jul 15 , 342 (69-78).

83

Inagaki A et al. Pharmacological Correction of Gating Defects in the Voltage-Gated Cav2.1 Ca(2+) Channel due to a Familial Hemiplegic Migraine Mutation.
Neuron, 2014 Jan 8 , 81 (91-102).

84

Kline CF et al. Ankyrin-B regulates Cav2.1 and Cav2.2 Expression and Targeting.
J. Biol. Chem., 2014 Jan 6 , ().

85

Satake S et al. Cav2.1 channels control multivesicular release by relying on their distance from exocytotic Ca2+ sensors at rat cerebellar granule cells.
J. Neurosci., 2014 Jan 22 , 34 (1462-74).

86

Etemad S et al. Differential neuronal targeting of a new and two known calcium channel β4 subunit splice variants correlates with their regulation of gene expression.
J. Neurosci., 2014 Jan 22 , 34 (1446-61).

87

Bashir A et al. Association of single nucleotide polymorphisms of CACNA1A gene in migraine.
Indian J Hum Genet, 2014 Jan , 20 (59-63).

88

Niimi K et al. Blockade of Cav2.1-mediated NMDA receptor signaling disrupts conditioned fear extinction.
Behav. Brain Res., 2014 Feb 1 , 259 (45-9).

89

Rochester L et al. Gait impairment precedes clinical symptoms in spinocerebellar ataxia type 6.
Mov. Disord., 2014 Feb , 29 (252-5).

90

Cox DH Modeling a Ca(2+) channel/BKCa channel complex at the single-complex level.
Biophys. J., 2014 Dec 16 , 107 (2797-814).

91

Schubert M et al. Paraneoplastic CDR2 and CDR2L antibodies affect Purkinje cell calcium homeostasis.
Acta Neuropathol., 2014 Dec , 128 (835-52).

92

Wang T et al. Endostatin is a trans-synaptic signal for homeostatic synaptic plasticity.
Neuron, 2014 Aug 6 , 83 (616-29).

93

Salvi J et al. RNAi silencing of P/Q-type calcium channels in Purkinje neurons of adult mouse leads to episodic ataxia type 2.
Neurobiol. Dis., 2014 Aug , 68 (47-56).

94

Yoshimoto T et al. Rolling Nagoya mouse strain (PROD-rol/rol) with classic piebald mutation.
J. Vet. Med. Sci., 2014 Aug , 76 (1093-8).

95

Weller CM et al. Two novel SCN1A mutations identified in families with familial hemiplegic migraine.
Cephalalgia, 2014 Apr 4 , ().

96

Hullugundi SK et al. A hyperexcitability phenotype in mouse trigeminal sensory neurons expressing the R192Q Cacna1a missense mutation of familial hemiplegic migraine type-1.
Neuroscience, 2014 Apr 25 , 266 (244-54).

97

Davydova D et al. Bassoon specifically controls presynaptic P/Q-type Ca(2+) channels via RIM-binding protein.
Neuron, 2014 Apr 2 , 82 (181-94).

98

Topakian R et al. Rare clinical findings in a patient with sporadic hemiplegic migraine: FDG-PET provides diminished brain metabolism at 10-year follow-up.
Cephalalgia, 2014 Apr , 34 (392-6).

99

Berecki G et al. Differential Cav2.1 and Cav2.3 channel inhibition by baclofen and α-conotoxin Vc1.1 via GABAB receptor activation.
J. Gen. Physiol., 2014 Apr , 143 (465-79).

100

Bürk K et al. A novel missense mutation in CACNA1A evaluated by in silico protein modeling is associated with non-episodic spinocerebellar ataxia with slow progression.
Eur J Med Genet, 2014 Apr , 57 (207-11).

101

Park J et al. Differential trigeminovascular nociceptive responses in the thalamus in the familial hemiplegic migraine 1 knock-in mouse: a Fos protein study.
Neurobiol. Dis., 2014 Apr , 64 (1-7).

102

Tashiro Y et al. Repeated encephalopathy and hemicerebral atrophy in a patient with familial hemiplegic migraine type 1.
Intern. Med., 2014 , 53 (2245-50).

103

Gambardella A et al. The role of calcium channel mutations in human epilepsy.
Prog. Brain Res., 2014 , 213 (87-96).

104

Daschil N et al. Short- and long-term treatment of mouse cortical primary astrocytes with β-amyloid differentially regulates the mRNA expression of L-type calcium channels.
Pharmacology, 2014 , 93 (24-31).

105

Mózsik G Capsaicin as new orally applicable gastroprotective and therapeutic drug alone or in combination with nonsteroidal anti-inflammatory drugs in healthy human subjects and in patients.
Prog Drug Res, 2014 , 68 (209-58).

106

Lin TY et al. Acacetin inhibits glutamate release and prevents kainic acid-induced neurotoxicity in rats.
PLoS ONE, 2014 , 9 (e88644).

107

et al. De novo mutations in epileptic encephalopathies.
Nature, 2013 Sep 12 , 501 (217-21).

108

Choi KD et al. Possible anticipation associated with a novel splice site mutation in episodic ataxia type 2.
Neurol. Sci., 2013 Sep , 34 (1629-32).

109

Cestèle S et al. Nonfunctional NaV1.1 familial hemiplegic migraine mutant transformed into gain of function by partial rescue of folding defects.
Proc. Natl. Acad. Sci. U.S.A., 2013 Oct 22 , 110 (17546-51).

110

Montalbano A et al. Blockade of BDNF signaling turns chemically-induced long-term potentiation into long-term depression.
Hippocampus, 2013 Oct , 23 (879-89).

111

Ramachandra R et al. Identification of CaV channel types expressed in muscle afferent neurons.
J. Neurophysiol., 2013 Oct , 110 (1535-43).

112

Condliffe SB et al. The E1015K variant in the synprint region of the CaV2.1 channel alters channel function and is associated with different migraine phenotypes.
J. Biol. Chem., 2013 Nov 22 , 288 (33873-83).

113

Campiglio M et al. Stable incorporation versus dynamic exchange of β subunits in a native Ca2+ channel complex.
J. Cell. Sci., 2013 May 1 , 126 (2092-101).

114

Nimmakayalu M et al. Apparent germline mosaicism for a novel 19p13.13 deletion disrupting NFIX and CACNA1A.
Am. J. Med. Genet. A, 2013 May , 161A (1105-9).

115

Cestèle S et al. Divergent effects of the T1174S SCN1A mutation associated with seizures and hemiplegic migraine.
Epilepsia, 2013 May , 54 (927-35).

116

Ducros A [Genetics of migraine].
Rev. Neurol. (Paris), 2013 May , 169 (360-71).

117

Maejima T et al. Postnatal loss of P/Q-type channels confined to rhombic-lip-derived neurons alters synaptic transmission at the parallel fiber to purkinje cell synapse and replicates genomic Cacna1a mutation phenotype of ataxia and seizures in mice.
J. Neurosci., 2013 Mar 20 , 33 (5162-74).

118

Franceschini A et al. Effects of LPS on P2X3 receptors of trigeminal sensory neurons and macrophages from mice expressing the R192Q Cacna1a gene mutation of familial hemiplegic migraine-1.
Purinergic Signal., 2013 Mar , 9 (7-13).

119

Takai J et al. Laminar shear stress upregulates endothelial Ca2+-activated K+ channels KCa2.3 and KCa3.1 via a Ca2+/calmodulin-dependent protein kinase kinase/Akt/p300 cascade.
Am. J. Physiol. Heart Circ. Physiol., 2013 Jun 21 , ().

120

Lohmann K et al. Genetics of dystonia: what's known? What's new? What's next?
Mov. Disord., 2013 Jun 15 , 28 (899-905).

121

Molloy A et al. A novel CACNA1A mutation associated with adult-onset, paroxysmal head tremor.
Mov. Disord., 2013 Jun , 28 (842-3).

122

Pisano T et al. Functional characterization of a novel C-terminal ATP1A2 mutation causing hemiplegic migraine and epilepsy.
Cephalalgia, 2013 Jul 9 , ().

123

Du X et al. Second cistron in CACNA1A gene encodes a transcription factor mediating cerebellar development and SCA6.
Cell, 2013 Jul 3 , 154 (118-33).

124

Pietrobon D Calcium channels and migraine.
Biochim. Biophys. Acta, 2013 Jul , 1828 (1655-65).

125

Koch H et al. Stable respiratory activity requires both P/Q-type and N-type voltage-gated calcium channels.
J. Neurosci., 2013 Feb 20 , 33 (3633-45).

126

Indriati DW et al. Quantitative localization of Cav2.1 (P/Q-type) voltage-dependent calcium channels in Purkinje cells: somatodendritic gradient and distinct somatic coclustering with calcium-activated potassium channels.
J. Neurosci., 2013 Feb 20 , 33 (3668-78).

127

Magupalli VG et al. Ca2+-independent activation of Ca2+/calmodulin-dependent protein kinase II bound to the C-terminal domain of CaV2.1 calcium channels.
J. Biol. Chem., 2013 Feb 15 , 288 (4637-48).

128

Wulff H et al. Endothelial small-conductance and intermediate-conductance KCa channels: an update on their pharmacology and usefulness as cardiovascular targets.
J. Cardiovasc. Pharmacol., 2013 Feb , 61 (102-12).

129

Ohmori I et al. CACNA1A variants may modify the epileptic phenotype of Dravet syndrome.
Neurobiol. Dis., 2013 Feb , 50 (209-17).

130

Barros J et al. Cerebellar ataxia, hemiplegic migraine, and related phenotypes due to a CACNA1A missense mutation: 12-year follow-up of a large Portuguese family.
JAMA Neurol, 2013 Feb , 70 (235-40).

131

Girach F et al. RIM1α SUMOylation is required for fast synaptic vesicle exocytosis.
Cell Rep, 2013 Dec 12 , 5 (1294-301).

132

Kipfer S et al. Novel CACNA1A mutation(s) associated with slow saccade velocities.
J. Neurol., 2013 Dec , 260 (3010-4).

133

Shelley C et al. Phosphorylation of a constitutive serine inhibits BK channel variants containing the alternate exon "SRKR".
J. Gen. Physiol., 2013 Dec , 142 (585-98).

134

Chanda ML et al. Behavioral evidence for photophobia and stress-related ipsilateral head pain in transgenic Cacna1a mutant mice.
Pain, 2013 Aug , 154 (1254-62).

135

Rossignol E et al. CaV 2.1 ablation in cortical interneurons selectively impairs fast-spiking basket cells and causes generalized seizures.
Ann. Neurol., 2013 Aug , 74 (209-22).

136

Tian X et al. Analysis of ischemic neuronal injury in Cav2.1 channel α1 subunit mutant mice.
Biochem. Biophys. Res. Commun., 2013 Apr 26 , 434 (60-4).

137

Galliano E et al. Silencing the majority of cerebellar granule cells uncovers their essential role in motor learning and consolidation.
Cell Rep, 2013 Apr 25 , 3 (1239-51).

138

Garza-López E et al. The familial hemiplegic migraine type 1 mutation K1336E affects direct G protein-mediated regulation of neuronal P/Q-type Ca2+ channels.
Cephalalgia, 2013 Apr , 33 (398-407).

139

Mallmann RT et al. Ablation of Ca(V)2.1 voltage-gated Ca²⁺ channels in mouse forebrain generates multiple cognitive impairments.
PLoS ONE, 2013 , 8 (e78598).

140

Wagner-Britz L et al. Protein kinase Cα and P-type Ca channel CaV2.1 in red blood cell calcium signalling.
Cell. Physiol. Biochem., 2013 , 31 (883-91).

141

Mallmann RT et al. Tetraspanin-13 modulates voltage-gated CaV2.2 Ca2+ channels.
Sci Rep, 2013 , 3 (1777).

142

Benton DC et al. The relationship between functional inhibition and binding for K(Ca)2 channel blockers.
PLoS ONE, 2013 , 8 (e73328).

143

Takahashi M et al. Cytoplasmic location of α1A voltage-gated calcium channel C-terminal fragment (Cav2.1-CTF) aggregate is sufficient to cause cell death.
PLoS ONE, 2013 , 8 (e50121).

144

Franceschini A et al. TNFα levels and macrophages expression reflect an inflammatory potential of trigeminal ganglia in a mouse model of familial hemiplegic migraine.
PLoS ONE, 2013 , 8 (e52394).

145

Hu Y et al. Identification of a novel nonsense mutation p.Tyr1957Ter of CACNA1A in a Chinese family with episodic ataxia 2.
PLoS ONE, 2013 , 8 (e56362).

146

Brennan SC et al. Fetal calcium regulates branching morphogenesis in the developing human and mouse lung: involvement of voltage-gated calcium channels.
PLoS ONE, 2013 , 8 (e80294).

147

Hullugundi SK et al. The mechanism of functional up-regulation of P2X3 receptors of trigeminal sensory neurons in a genetic mouse model of familial hemiplegic migraine type 1 (FHM-1).
PLoS ONE, 2013 , 8 (e60677).

148

Gnanasekaran A et al. Mutated CaV2.1 channels dysregulate CASK/P2X3 signaling in mouse trigeminal sensory neurons of R192Q Cacna1a knock-in mice.
Mol Pain, 2013 , 9 (62).

149

Eikermann-Haerter K et al. Spreading depression and the clinical correlates of migraine.
Rev Neurosci, 2013 , 24 (353-63).

150

Gandini MA Channeling headache: novel findings in the study of Ca(2+)-channels and FHM-1.
Channels (Austin), 2012 Nov-Dec , 6 (414-5).

151

Domitrz I et al. A single-fibre electromyography study of neuromuscular transmission in patients with cluster headache.
Neurol. Neurochir. Pol., 2012 Mar-Apr , 46 (140-4).

152

Ovsepian SV et al. Enhanced synaptic inhibition disrupts the efferent code of cerebellar Purkinje neurons in leaner Cav2.1 Ca 2+ channel mutant mice.
Cerebellum, 2012 Sep , 11 (666-80).

153

Asghar SJ et al. Variable manifestations of familial hemiplegic migraine associated with reversible cerebral edema in children.
Pediatr. Neurol., 2012 Sep , 47 (201-4).

154

Choi KH et al. Familial hemiplegic migraine with prolonged coma and cerebellar atrophy: CACNA1A T666M mutation in a Korean family.
J. Korean Med. Sci., 2012 Sep , 27 (1124-7).

155

Ohmura K et al. Sporadic hemiplegic migraine presenting as acute encephalopathy.
Brain Dev., 2012 Sep , 34 (691-5).

156

Aranda-Sicilia MN et al. Arabidopsis KEA2, a homolog of bacterial KefC, encodes a K(+)/H(+) antiporter with a chloroplast transit peptide.
Biochim. Biophys. Acta, 2012 Sep , 1818 (2362-71).

157

Gao Z et al. Cerebellar ataxia by enhanced Ca(V)2.1 currents is alleviated by Ca2+-dependent K+-channel activators in Cacna1a(S218L) mutant mice.
J. Neurosci., 2012 Oct 31 , 32 (15533-46).

158

Lafrenière RG et al. Identification of novel genes involved in migraine.
Headache, 2012 Oct , 52 Suppl 2 (107-10).

159

Haerteis S et al. Plasmin and chymotrypsin have distinct preferences for channel activating cleavage sites in the γ subunit of the human epithelial sodium channel.
J. Gen. Physiol., 2012 Oct , 140 (375-89).

160

Pringos E et al. Synthesis and characterization of a cyclooctapeptide analogue of ω-agatoxin IVB enhancing the activity of Cav2.1 calcium channels activity in cultured hippocampal neurons.
Neurochem. Int., 2012 Oct , 61 (632-9).

161

Fujioka S et al. A novel de novo pathogenic mutation in the CACNA1A gene.
Mov. Disord., 2012 Oct , 27 (1578-9).

162

Kotagal V Acetazolamide-responsive ataxia.
Semin Neurol, 2012 Nov , 32 (533-7).

163

Magis D et al. A novel CACNA1A mutation results in episodic ataxia with migrainous features without headache.
Cephalalgia, 2012 Nov , 32 (1147-9).

164

Ding X et al. Oligopeptides functionalized surface plasmon resonance biosensors for detecting thiacloprid and imidacloprid.
Biosens Bioelectron, 2012 May 15 , 35 (271-6).

165

Tao J et al. Effects of familial hemiplegic migraine type 1 mutation T666M on voltage-gated calcium channel activities in trigeminal ganglion neurons.
J. Neurophysiol., 2012 Mar , 107 (1666-80).

166

Todorov B et al. Purkinje cell-specific ablation of Cav2.1 channels is sufficient to cause cerebellar ataxia in mice.
Cerebellum, 2012 Mar , 11 (246-58).

167

Tatalovic M et al. Expression of the P/Q (Cav2.1) calcium channel in nodose sensory neurons and arterial baroreceptors.
Neurosci. Lett., 2012 Jun 27 , 520 (38-42).

168

Müller M et al. Transsynaptic control of presynaptic Ca²⁺ influx achieves homeostatic potentiation of neurotransmitter release.
Curr. Biol., 2012 Jun 19 , 22 (1102-8).

169

Holderith N et al. Release probability of hippocampal glutamatergic terminals scales with the size of the active zone.
Nat. Neurosci., 2012 Jul , 15 (988-97).

170

Di Cristofori A et al. R583Q CACNA1A variant in SHM1 and ataxia: case report and literature update.
J Headache Pain, 2012 Jul , 13 (419-23).

171

Low SE et al. Touch responsiveness in zebrafish requires voltage-gated calcium channel 2.1b.
J. Neurophysiol., 2012 Jul , 108 (148-59).

172

Billings SE et al. ELKS1 and Ca(2+) channel subunit β4 interact and colocalize at cerebellar synapses.
Neuroreport, 2012 Jan 4 , 23 (49-54).

173

Miyazaki T et al. Cav2.1 in cerebellar Purkinje cells regulates competitive excitatory synaptic wiring, cell survival, and cerebellar biochemical compartmentalization.
J. Neurosci., 2012 Jan 25 , 32 (1311-28).

174

Nanou E et al. Molecular determinants of modulation of CaV2.1 channels by visinin-like protein 2.
J. Biol. Chem., 2012 Jan 2 , 287 (504-13).

175

Eikermann-Haerter K et al. Migraine mutations increase stroke vulnerability by facilitating ischemic depolarizations.
Circulation, 2012 Jan 17 , 125 (335-45).

176

Rajakulendran S et al. Neuronal P/Q-type calcium channel dysfunction in inherited disorders of the CNS.
, 2012 Jan 17 , ().

177

Braun AP Structural remodeling of the N-terminus tunes TRPA1 channel activation and regulates behavioral responses in Drosophila.
, 2012 Jan 1 , 6 ().

178

Passero CJ et al. TMPRSS4-dependent activation of the epithelial sodium channel requires cleavage of the γ-subunit distal to the furin cleavage site.
Am. J. Physiol. Renal Physiol., 2012 Jan , 302 (F1-8).

179

Stuart S et al. Detection of a novel mutation in the CACNA1A gene.
Twin Res Hum Genet, 2012 Feb , 15 (120-5).

180

Chang Y et al. Coenzyme Q10 inhibits the release of glutamate in rat cerebrocortical nerve terminals by suppression of voltage-dependent calcium influx and mitogen-activated protein kinase signaling pathway.
J. Agric. Food Chem., 2012 Dec 5 , 60 (11909-18).

181

Inchauspe CG et al. Presynaptic CaV2.1 calcium channels carrying familial hemiplegic migraine mutation R192Q allow faster recovery from synaptic depression in mouse calyx of Held.
J. Neurophysiol., 2012 Dec , 108 (2967-76).

182

Patel AB et al. Tissue kallikrein activation of the epithelial Na channel.
Am. J. Physiol. Renal Physiol., 2012 Aug 15 , 303 (F540-50).

183

Garza-López E et al. Familial hemiplegic migraine type 1 mutations W1684R and V1696I alter G protein-mediated regulation of Ca(V)2.1 voltage-gated calcium channels.
Biochim. Biophys. Acta, 2012 Aug , 1822 (1238-46).

184

Hernández-Vivanco A et al. Selectivity of action of pregabalin on Ca(2+) channels but not on fusion pore, exocytotic machinery, or mitochondria in chromaffin cells of the adrenal gland.
J. Pharmacol. Exp. Ther., 2012 Aug , 342 (263-72).

185

Li W et al. New ataxic tottering-6j mouse allele containing a Cacna1a gene mutation.
PLoS ONE, 2012 , 7 (e44230).

186

Baloh RW Episodic ataxias 1 and 2.
Handb Clin Neurol, 2012 , 103 (595-602).

187

Solodkin A et al. Spinocerebellar ataxia type 6.
Handb Clin Neurol, 2012 , 103 (461-73).

188

Franceschini A et al. Functional crosstalk in culture between macrophages and trigeminal sensory neurons of a mouse genetic model of migraine.
BMC Neurosci, 2012 , 13 (143).

189

Carreño O et al. Acute striatal necrosis in hemiplegic migraine with de novo CACNA1A mutation.
Headache, 2011 Nov-Dec , 51 (1542-6).

190

Tottene A et al. Role of different voltage-gated Ca2+ channels in cortical spreading depression: specific requirement of P/Q-type Ca2+ channels.
Channels (Austin), 2011 Mar-Apr , 5 (110-4).

191

Tsou WL et al. Splice isoform-specific suppression of the Cav2.1 variant underlying spinocerebellar ataxia type 6.
Neurobiol. Dis., 2011 Sep , 43 (533-42).

192

Geerlings RP et al. Head tremor related to CACNA1A mutations.
Cephalalgia, 2011 Sep , 31 (1315-9).

193

Hansen JM et al. Trigger factors for familial hemiplegic migraine.
Cephalalgia, 2011 Sep , 31 (1274-81).

194

Yamazaki S et al. Hemiconvulsion-hemiplegia-epilepsy syndrome associated with CACNA1A S218L mutation.
Pediatr. Neurol., 2011 Sep , 45 (193-6).

195

Horvath GA et al. Hemiplegic migraine, seizures, progressive spastic paraparesis, mood disorder, and coma in siblings with low systemic serotonin.
, 2011 Oct 19 , ().

196

Mathew R et al. Immunohistochemical characterization of calcitonin gene-related peptide in the trigeminal system of the familial hemiplegic migraine 1 knock-in mouse.
Cephalalgia, 2011 Oct , 31 (1368-80).

197

Chen S et al. Trs65p, a subunit of the Ypt1p GEF TRAPPII, interacts with the Arf1p exchange factor Gea2p to facilitate COPI-mediated vesicle traffic.
Mol. Biol. Cell, 2011 Oct , 22 (3634-44).

198

Uchitel OD et al. Ca(V)2.1 voltage activated calcium channels and synaptic transmission in familial hemiplegic migraine pathogenesis.
, 2011 Nov 2 , ().

199

Naik S et al. Early-onset cerebellar atrophy associated with mutation in the CACNA1A gene.
Pediatr. Neurol., 2011 Nov , 45 (328-30).

200

Bhatia KP Paroxysmal dyskinesias.
Mov. Disord., 2011 May , 26 (1157-65).

201

Ceruti S et al. Calcitonin gene-related peptide-mediated enhancement of purinergic neuron/glia communication by the algogenic factor bradykinin in mouse trigeminal ganglia from wild-type and R192Q Cav2.1 Knock-in mice: implications for basic mechanisms of migraine pain.
J. Neurosci., 2011 Mar 9 , 31 (3638-49).

202

Mark MD et al. Delayed postnatal loss of P/Q-type calcium channels recapitulates the absence epilepsy, dyskinesia, and ataxia phenotypes of genomic Cacna1a mutations.
J. Neurosci., 2011 Mar 16 , 31 (4311-26).

203

Veneziano L et al. Dramatically different levels of Cacna1a gene expression between pre-weaning wild type and leaner mice.
J. Neurol. Sci., 2011 Jun 15 , 305 (71-4).

204

Nikaido K et al. New mutation of CACNA1A gene in episodic ataxia type 2.
Pediatr Int, 2011 Jun , 53 (415-6).

205

Strupp M et al. A randomized trial of 4-aminopyridine in EA2 and related familial episodic ataxias.
Neurology, 2011 Jul 19 , 77 (269-75).

206

Bezprozvanny I Role of inositol 1,4,5-trisphosphate receptors in pathogenesis of Huntington's disease and spinocerebellar ataxias.
Neurochem. Res., 2011 Jul , 36 (1186-97).

207

Borroto-Escuela DO et al. Moonlighting characteristics of G protein-coupled receptors: Focus on receptor heteromers and relevance for neurodegeneration.
IUBMB Life, 2011 Jul , 63 (463-72).

208

Freilinger T et al. A novel mutation in CACNA1A associated with hemiplegic migraine, cerebellar dysfunction and late-onset cognitive decline.
J. Neurol. Sci., 2011 Jan 15 , 300 (160-3).

209

Stam AH et al. A long-term follow-up study of 18 patients with sporadic hemiplegic migraine.
Cephalalgia, 2011 Jan , 31 (199-205).

210

Kahle JJ et al. Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia.
Hum. Mol. Genet., 2011 Feb 1 , 20 (510-27).

211

Knierim E et al. Recurrent stroke due to a novel voltage sensor mutation in Cav2.1 responds to verapamil.
Stroke, 2011 Feb , 42 (e14-7).

212

Few AP et al. Molecular determinants of CaV2.1 channel regulation by calcium-binding protein-1.
J. Biol. Chem., 2011 Dec 9 , 286 (41917-23).

213

Yalçın O Genes and molecular mechanisms involved in the epileptogenesis of idiopathic absence epilepsies.
, 2011 Dec 27 , ().

214

Fioretti B et al. Trigeminal ganglion neuron subtype-specific alterations of Ca(V)2.1 calcium current and excitability in a Cacna1a mouse model of migraine.
J. Physiol. (Lond.), 2011 Dec 1 , 589 (5879-95).

215

Cens T et al. Two sets of amino acids of the domain I of Cav2.3 Ca(2+) channels contribute to their high sensitivity to extracellular protons.
Pflugers Arch., 2011 Aug , 462 (303-14).

216

Figueroa KP et al. Frequency of KCNC3 DNA variants as causes of spinocerebellar ataxia 13 (SCA13).
PLoS ONE, 2011 , 6 (e17811).

217

Currie KP G protein modulation of CaV2 voltage-gated calcium channels.
Channels (Austin), 2010 Nov-Dec , 4 (497-509).

218

Allen SE et al. The neuronal splicing factor Nova controls alternative splicing in N-type and P-type CaV2 calcium channels.
Channels (Austin), 2010 Nov-Dec , 4 (483-9).

219

Sułek-Piatkowska A et al. The occurrence of spinocerebellar ataxias caused by dynamic mutations in Polish patients.
Neurol. Neurochir. Pol., 2010 May-Jun , 44 (238-45).

220

Cohen-Kutner M et al. CaV2.1 (P/Q channel) interaction with synaptic proteins is essential for depolarization-evoked release.
Channels (Austin), 2010 Jul-Aug , 4 (266-77).

221

Melzer N et al. Fluctuating neuromuscular transmission defects and inverse acetazolamide response in episodic ataxia type 2 associated with the novel CaV2.1 single amino acid substitution R2090Q.
J. Neurol. Sci., 2010 Sep 15 , 296 (104-6).

222

Riant F et al. De novo mutations in ATP1A2 and CACNA1A are frequent in early-onset sporadic hemiplegic migraine.
Neurology, 2010 Sep 14 , 75 (967-72).

223

Hansen JM Familial hemiplegic migraine.
Dan Med Bull, 2010 Sep , 57 (B4183).

224

Abouda H et al. Familial form of typical childhood absence epilepsy in a consanguineous context.
Epilepsia, 2010 Sep , 51 (1889-93).

225

Kaja S et al. Severe and progressive neurotransmitter release aberrations in familial hemiplegic migraine type 1 Cacna1a S218L knock-in mice.
J. Neurophysiol., 2010 Sep , 104 (1445-55).

226

Adams PJ et al. Contribution of calcium-dependent facilitation to synaptic plasticity revealed by migraine mutations in the P/Q-type calcium channel.
Proc. Natl. Acad. Sci. U.S.A., 2010 Oct 26 , 107 (18694-9).

227

Takahashi E et al. Subthreshold pharmacological and genetic approaches to analyzing CaV2.1-mediated NMDA receptor signaling in short-term memory.
Eur. J. Pharmacol., 2010 Oct 25 , 645 (113-8).

228

Watase K et al. [SCA6: From gene identification to recent progress on pathogenesis].
Rinsho Shinkeigaku, 2010 Nov , 50 (858-60).

229

Rajakulendran S et al. PAW31 Clinical and genetic spectrum of the episodic ataxias: the UK perspective.
J. Neurol. Neurosurg. Psychiatr., 2010 Nov , 81 (e32).

230

Alviña K et al. KCa channels as therapeutic targets in episodic ataxia type-2.
J. Neurosci., 2010 May 26 , 30 (7249-57).

231

Kim JM et al. The wide clinical spectrum and nigrostriatal dopaminergic damage in spinocerebellar ataxia type 6.
J. Neurol. Neurosurg. Psychiatr., 2010 May , 81 (529-32).

232

Takahashi E et al. Neonatal motor functions in Cacna1a-mutant rolling Nagoya mice.
Behav. Brain Res., 2010 Mar 5 , 207 (273-9).

233

Russell MB Management of sporadic and familial hemiplegic migraine.
Expert Rev Neurother, 2010 Mar , 10 (381-7).

234

Vick KA et al. In vivo pharmacological manipulation of small conductance Ca(2+)-activated K(+) channels influences motor behavior, object memory and fear conditioning.
Neuropharmacology, 2010 Mar , 58 (650-9).

235

Pietrobon D Insights into migraine mechanisms and CaV2.1 calcium channel function from mouse models of familial hemiplegic migraine.
J. Physiol. (Lond.), 2010 Jun 1 , 588 (1871-8).

236

Rajakulendran S et al. Genetic and functional characterisation of the P/Q calcium channel in episodic ataxia with epilepsy.
J. Physiol. (Lond.), 2010 Jun 1 , 588 (1905-13).

237

Wang X et al. A neuropathological study at autopsy of early onset spinocerebellar ataxia 6.
J Clin Neurosci, 2010 Jun , 17 (751-5).

238

Cleves C et al. Link between confusional migraine, hemiplegic migraine and episodic ataxia type 2: hypothesis, family genealogy, gene typing and classification.
Cephalalgia, 2010 Jun , 30 (740-3).

239

Inchauspe CG et al. Gain of function in FHM-1 Ca(V)2.1 knock-in mice is related to the shape of the action potential.
J. Neurophysiol., 2010 Jul , 104 (291-9).

240

Pietrobon D CaV2.1 channelopathies.
Pflugers Arch., 2010 Jul , 460 (375-93).

241

Klychnikov OI et al. Quantitative cortical synapse proteomics of a transgenic migraine mouse model with mutated Ca(V)2.1 calcium channels.
Proteomics, 2010 Jul , 10 (2531-5).

242

Blumkin L et al. Congenital ataxia, mental retardation, and dyskinesia associated with a novel CACNA1A mutation.
J. Child Neurol., 2010 Jul , 25 (892-7).

243

Serra SA et al. A mutation in the first intracellular loop of CACNA1A prevents P/Q channel modulation by SNARE proteins and lowers exocytosis.
Proc. Natl. Acad. Sci. U.S.A., 2010 Jan 26 , 107 (1672-7).

244

Perez-Burgos A et al. CaV2.1 channels are modulated by muscarinic M1 receptors through phosphoinositide hydrolysis in neostriatal neurons.
Neuroscience, 2010 Jan 20 , 165 (293-9).

245

Wong FK et al. Rab3a interacting molecule (RIM) and the tethering of pre-synaptic transmitter release site-associated CaV2.2 calcium channels.
J. Neurochem., 2010 Jan , 112 (463-73).

246

Van Den Maagdenberg AM et al. High cortical spreading depression susceptibility and migraine-associated symptoms in Ca(v)2.1 S218L mice.
Ann. Neurol., 2010 Jan , 67 (85-98).

247

Kreiner L et al. Compensatory regulation of Cav2.1 Ca2+ channels in cerebellar Purkinje neurons lacking parvalbumin and calbindin D-28k.
J. Neurophysiol., 2010 Jan , 103 (371-81).

248

Malpas TJ et al. Sporadic hemiplegic migraine and delayed cerebral oedema after minor head trauma: a novel de novo CACNA1A gene mutation.
Dev Med Child Neurol, 2010 Jan , 52 (103-4).

249

Zangaladze A et al. Sporadic hemiplegic migraine and epilepsy associated with CACNA1A gene mutation.
Epilepsy Behav, 2010 Feb , 17 (293-5).

250

Choi S et al. Subthreshold membrane potential oscillations in inferior olive neurons are dynamically regulated by P/Q- and T-type calcium channels: a study in mutant mice.
J. Physiol. (Lond.), 2010 Aug 15 , 588 (3031-43).

251

Romaniello R et al. A wide spectrum of clinical, neurophysiological and neuroradiological abnormalities in a family with a novel CACNA1A mutation.
J. Neurol. Neurosurg. Psychiatr., 2010 Aug , 81 (840-3).

252

Mantuano E et al. Identification of novel and recurrent CACNA1A gene mutations in fifteen patients with episodic ataxia type 2.
J. Neurol. Sci., 2010 Apr 15 , 291 (30-6).

253

Chai Y et al. Stimulation of neuronal KATP channels by cGMP-dependent protein kinase: involvement of ROS and 5-hydroxydecanoate-sensitive factors in signal transduction.
Am. J. Physiol., Cell Physiol., 2010 Apr , 298 (C875-92).

254

Ishiguro T et al. The carboxy-terminal fragment of alpha(1A) calcium channel preferentially aggregates in the cytoplasm of human spinocerebellar ataxia type 6 Purkinje cells.
Acta Neuropathol., 2010 Apr , 119 (447-64).

255

Pietrobon D Biological science of headache channels.
, 2010 , 97C (73-83).

256

Sawada K et al. Zebrin II expressing Purkinje cell phenotype-related and -unrelated cerebellar abnormalities in Cav2.1 mutant, rolling mouse Nagoya.
ScientificWorldJournal, 2010 , 10 (2032-8).

257

Jung J et al. Phenotypic variability of episodic ataxia type 2 mutations: a family study.
Eur. Neurol., 2010 , 64 (114-6).

258

Fosgerau K et al. Increased susceptibility to cardiovascular effects of dihydrocapcaicin in resuscitated rats. Cardiovascular effects of dihydrocapsaicin.
BMC Cardiovasc Disord, 2010 , 10 (39).

259

Nair A et al. Familial hemiplegic migraine Ca(v)2.1 channel mutation R192Q enhances ATP-gated P2X3 receptor activity of mouse sensory ganglion neurons mediating trigeminal pain.
Mol Pain, 2010 , 6 (48).

260

Tavraz NN et al. Impaired plasma membrane targeting or protein stability by certain ATP1A2 mutations identified in sporadic or familial hemiplegic migraine.
Channels (Austin), 2009 Mar-Apr , 3 (82-7).

261

Adams PJ et al. Ca(V)2.1 P/Q-type calcium channel alternative splicing affects the functional impact of familial hemiplegic migraine mutations: implications for calcium channelopathies.
Channels (Austin), 2009 Mar-Apr , 3 (110-21).

262

Sones WR et al. Inhibition of vascular calcium-gated chloride currents by blockers of KCa1.1, but not by modulators of KCa2.1 or KCa2.3 channels.
Br. J. Pharmacol., 2009 Sep , 158 (521-31).

263

Plomp JJ et al. The ataxic Cacna1a-mutant mouse rolling nagoya: an overview of neuromorphological and electrophysiological findings.
Cerebellum, 2009 Sep , 8 (222-30).

264

Stam AH et al. Early seizures and cerebral oedema after trivial head trauma associated with the CACNA1A S218L mutation.
J. Neurol. Neurosurg. Psychiatr., 2009 Oct , 80 (1125-9).

265

Selmer KK et al. Parental SCN1A mutation mosaicism in familial Dravet syndrome.
Clin. Genet., 2009 Oct , 76 (398-403).

266

Tomlinson SE et al. Clinical neurophysiology of the episodic ataxias: insights into ion channel dysfunction in vivo.
Clin Neurophysiol, 2009 Oct , 120 (1768-76).

267

Eikermann-Haerter K et al. Androgenic suppression of spreading depression in familial hemiplegic migraine type 1 mutant mice.
Ann. Neurol., 2009 Oct , 66 (564-8).

268

Bertholon P et al. Episodic ataxia type 2: unusual aspects in clinical and genetic presentation. Special emphasis in childhood.
J. Neurol. Neurosurg. Psychiatr., 2009 Nov , 80 (1289-92).

269

Auvin S et al. Array-CGH detection of a de novo 0.7-Mb deletion in 19p13.13 including CACNA1A associated with mental retardation and epilepsy with infantile spasms.
Epilepsia, 2009 Nov , 50 (2501-3).

270

Li L et al. Deficit of heat shock transcription factor 1-heat shock 70 kDa protein 1A axis determines the cell death vulnerability in a model of spinocerebellar ataxia type 6.
Genes Cells, 2009 Nov , 14 (1253-69).

271

Lewis BB et al. Cloning and characterization of voltage-gated calcium channel alpha1 subunits in Xenopus laevis during development.
Dev. Dyn., 2009 Nov , 238 (2891-902).

272

Labrum RW et al. Large scale calcium channel gene rearrangements in episodic ataxia and hemiplegic migraine: implications for diagnostic testing.
J. Med. Genet., 2009 Nov , 46 (786-91).

273

Ishikawa K et al. [Molecular genetic approach to spinocerebellar ataxias]
Rinsho Shinkeigaku, 2009 Nov , 49 (907-9).

274

Cuenca-León E et al. Late-onset episodic ataxia type 2 associated with a novel loss-of-function mutation in the CACNA1A gene.
J. Neurol. Sci., 2009 May 15 , 280 (10-4).

275

Damak M et al. Late onset hereditary episodic ataxia.
J. Neurol. Neurosurg. Psychiatr., 2009 May , 80 (566-8).

276

Iwanaka Y et al. [Case of sporadic hemiplegic migraine with cerebellar ataxia]
Rinsho Shinkeigaku, 2009 May , 49 (267-70).

277

Jen JC et al. Familial episodic ataxia: a model for migrainous vertigo.
Ann. N. Y. Acad. Sci., 2009 May , 1164 (252-6).

278

Vahedi K et al. Elicited repetitive daily blindness: a new phenotype associated with hemiplegic migraine and SCN1A mutations.
Neurology, 2009 Mar 31 , 72 (1178-83).

279

D'Onofrio M et al. The interplay of two single nucleotide polymorphisms in the CACNA1A gene may contribute to migraine susceptibility.
Neurosci. Lett., 2009 Mar 27 , 453 (12-5).

280

Ohba T et al. Modified autonomic regulation in mice with a P/Q-type calcium channel mutation.
Biochem. Biophys. Res. Commun., 2009 Mar 27 , 381 (27-32).

281

Tottene A et al. Enhanced excitatory transmission at cortical synapses as the basis for facilitated spreading depression in Ca(v)2.1 knockin migraine mice.
Neuron, 2009 Mar 12 , 61 (762-73).

282

Zafeiriou DI et al. Episodic ataxia type 2 showing ictal hyperhidrosis with hypothermia and interictal chronic diarrhea due to a novel CACNA1A mutation.
Eur. J. Paediatr. Neurol., 2009 Mar , 13 (191-3).

283

Castro MJ et al. First mutation in the voltage-gated Nav1.1 subunit gene SCN1A with co-occurring familial hemiplegic migraine and epilepsy.
Cephalalgia, 2009 Mar , 29 (308-13).

284

Takahashi E et al. Motor coordination impairment in aged heterozygous rolling Nagoya, Cav2.1 mutant mice.
Brain Res., 2009 Jul 7 , 1279 (50-7).

285

Riant F et al. Identification of CACNA1A large deletions in four patients with episodic ataxia.
Neurogenetics, 2009 Jul 25 , ().

286

de Vries B et al. Molecular genetics of migraine.
Hum. Genet., 2009 Jul , 126 (115-32).

287

Robbins MS et al. CACNA1A nonsense mutation is associated with basilar-type migraine and episodic ataxia type 2.
Headache, 2009 Jul , 49 (1042-6).

288

Horak S et al. Use-dependent block of voltage-gated Cav2.1 Ca2+ channels by petasins and eudesmol isomers.
J. Pharmacol. Exp. Ther., 2009 Jul , 330 (220-6).

289

Serra SA et al. The hemiplegic migraine-associated Y1245C mutation in CACNA1A results in a gain of channel function due to its effect on the voltage sensor and G-protein-mediated inhibition.
Pflugers Arch., 2009 Jul , 458 (489-502).

290

Veneziano L et al. Newly characterised 5' and 3' regions of CACNA1A gene harbour mutations associated with Familial Hemiplegic Migraine and Episodic Ataxia.
J. Neurol. Sci., 2009 Jan 15 , 276 (31-7).

291

Nakatani Y et al. Cav2.1 voltage-dependent Ca2+ channel current is inhibited by serum from select patients with Guillain-Barré syndrome.
Neurochem. Res., 2009 Jan , 34 (149-57).

292

Gargus JJ Genetic calcium signaling abnormalities in the central nervous system: seizures, migraine, and autism.
Ann. N. Y. Acad. Sci., 2009 Jan , 1151 (133-56).

293

Yu-Wai-Man P et al. Vertigo and vestibular abnormalities in spinocerebellar ataxia type 6.
J. Neurol., 2009 Jan , 256 (78-82).

294

Eikermann-Haerter K et al. Genetic and hormonal factors modulate spreading depression and transient hemiparesis in mouse models of familial hemiplegic migraine type 1.
J. Clin. Invest., 2009 Jan , 119 (99-109).

295

Takano T et al. Deciphering migraine.
J. Clin. Invest., 2009 Jan , 119 (16-9).

296

Frank CA et al. A presynaptic homeostatic signaling system composed of the Eph receptor, ephexin, Cdc42, and CaV2.1 calcium channels.
Neuron, 2009 Feb 26 , 61 (556-69).

297

Villmann C et al. Functional complementation of Glra1(spd-ot), a glycine receptor subunit mutant, by independently expressed C-terminal domains.
J. Neurosci., 2009 Feb 25 , 29 (2440-52).

298

Wiwanitkit V FHM3 in familial hemiplegic migraine is more resistant to mutation than FHM1 and FHM2.
J. Neurol. Sci., 2009 Feb 15 , 277 (76-9).

299

Wang Z et al. [Implanting the conducting electrode in rat and investigating its effect on the rat's penicillin-induced seizure]
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi, 2009 Feb , 26 (63-6).

300

Sankaranarayanan A et al. Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressure.
Mol. Pharmacol., 2009 Feb , 75 (281-95).

301

Smyth LM et al. N-type and P/Q-type calcium channels regulate differentially the release of noradrenaline, ATP and beta-NAD in blood vessels.
Neuropharmacology, 2009 Feb , 56 (368-78).

302

Bawa B et al. Alterations in Intracellular Calcium Ion Concentrations in Cerebellar Granule Cells of the CACNA1A Mutant Mouse, Leaner, During Postnatal Development.
, 2009 Dec 31 , ().

303

Zamponi GW et al. Role of voltage-gated calcium channels in epilepsy.
, 2009 Dec 20 , ().

304

Saito H et al. Knockdown of Cav2.1 calcium channels is sufficient to induce neurological disorders observed in natural occurring Cacna1a mutants in mice.
Biochem. Biophys. Res. Commun., 2009 Dec 18 , 390 (1029-33).

305

Takahashi E et al. Age-related spatial and nonspatial short-term memory in Cav2.1alpha1 mutant mice, Rolling Nagoya.
Behav. Brain Res., 2009 Dec 1 , 204 (241-5).

306

Lonchamp E et al. Deletion of Cav2.1(alpha1(A)) subunit of Ca2+-channels impairs synaptic GABA and glutamate release in the mouse cerebellar cortex in cultured slices.
Eur. J. Neurosci., 2009 Dec , 30 (2293-307).

307

Iturralde-Torres P et al. [Genetic in long QT syndromes]
Arch Cardiol Mex, 2009 Dec , 79 Suppl 2 (26-30).

308

Chen P et al. [Copy number variation of trinucleotide repeat in dynamic mutation sites of autosomal dominant cerebellar ataxias related genes]
Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2009 Dec , 26 (626-33).

309

Self J et al. Infantile nystagmus and late onset ataxia associated with a CACNA1A mutation in the intracellular loop between s4 and s5 of domain 3.
Eye (Lond), 2009 Dec , 23 (2251-5).

310

Debiais S et al. The FHM1 mutation S218L: a severe clinical phenotype? A case report and review of the literature.
Cephalalgia, 2009 Dec , 29 (1337-9).

311

Leyris JP et al. RGK GTPase-dependent CaV2.1 Ca2+ channel inhibition is independent of CaVbeta-subunit-induced current potentiation.
FASEB J., 2009 Aug , 23 (2627-38).

312

Takahashi E et al. Spatial learning deficit in aged heterozygous Cav2.1 channel mutant mice, rolling mouse Nagoya.
Exp. Gerontol., 2009 Apr , 44 (274-9).

313

Gerola S et al. CACNA1A gene non-synonymous single nucleotide polymorphisms and common migraine in Italy: a case-control association study with a micro-array technology.
Clin. Chem. Lab. Med., 2009 , 47 (783-5).

314

Sawada K et al. Striking pattern of Purkinje cell loss in cerebellum of an ataxic mutant mouse, tottering.
, 2009 , 69 (138-45).

315

Kapur J Is epilepsy a disease of synaptic transmission?
, 2008 Sep-Oct , 8 (139-41).

316

Carattino MD et al. Proteolytic processing of the epithelial sodium channel gamma subunit has a dominant role in channel activation.
J. Biol. Chem., 2008 Sep 12 , 283 (25290-5).

317

Teive HA et al. Spinocerebellar ataxia type 6 in Brazil.
Arq Neuropsiquiatr, 2008 Sep , 66 (691-4).

318

van Oosterhout F et al. Enhanced circadian phase resetting in R192Q Cav2.1 calcium channel migraine mice.
Ann. Neurol., 2008 Sep , 64 (315-24).

319

Haan J et al. Migraine and epilepsy: genetically linked?
, 2008 Sep , 8 (1307-11).

320

Mich PM et al. Alternative splicing of the Ca2+ channel beta4 subunit confers specificity for gabapentin inhibition of Cav2.1 trafficking.
Mol. Pharmacol., 2008 Sep , 74 (904-12).

321

Thomsen LL et al. Screen for CACNA1A and ATP1A2 mutations in sporadic hemiplegic migraine patients.
Cephalalgia, 2008 Sep , 28 (914-21).

322

Yabe I et al. Downbeat positioning nystagmus is a common clinical feature despite variable phenotypes in an FHM1 family.
J. Neurol., 2008 Oct , 255 (1541-4).

323

Cuenca-León E et al. Genetic analysis of 27 Spanish patients with hemiplegic migraine, basilar-type migraine and childhood periodic syndromes.
Cephalalgia, 2008 Oct , 28 (1039-47).

324

Graves TD et al. Premature stop codons in a facilitating EF-hand splice variant of CaV2.1 cause episodic ataxia type 2.
Neurobiol. Dis., 2008 Oct , 32 (10-5).

325

Roubertie A et al. Benign paroxysmal tonic upgaze, benign paroxysmal torticollis, episodic ataxia and CACNA1A mutation in a family.
J. Neurol., 2008 Oct , 255 (1600-2).

326

Globas C et al. Early symptoms in spinocerebellar ataxia type 1, 2, 3, and 6.
Mov. Disord., 2008 Nov 15 , 23 (2232-8).

327

Nyholt DR et al. A high-density association screen of 155 ion transport genes for involvement with common migraine.
Hum. Mol. Genet., 2008 Nov 1 , 17 (3318-31).

328

Alonso I et al. Motor and cognitive deficits in the heterozygous leaner mouse, a Cav2.1 voltage-gated Ca2+ channel mutant.
Neurobiol. Aging, 2008 Nov , 29 (1733-43).

329

Weiss N et al. The S218L familial hemiplegic migraine mutation promotes deinhibition of Ca(v)2.1 calcium channels during direct G-protein regulation.
Pflugers Arch., 2008 Nov , 457 (315-26).

330

Stam AH et al. CACNA1A R1347Q: a frequent recurrent mutation in hemiplegic migraine.
Clin. Genet., 2008 Nov , 74 (481-5).

331

Guerin AA et al. Stepwise developmental regression associated with novel CACNA1A mutation.
Pediatr. Neurol., 2008 Nov , 39 (363-4).

332

Kaja S et al. Reduced ACh release at neuromuscular synapses of heterozygous leaner Ca(v)2.1-mutant mice.
Synapse, 2008 May , 62 (337-44).

333

Krishnan AV et al. Axonal function in a family with episodic ataxia type 2 due to a novel mutation.
J. Neurol., 2008 May , 255 (750-5).

334

Rajapaksha WR et al. Novel splice variants of rat CaV2.1 that lack much of the synaptic protein interaction site are expressed in neuroendocrine cells.
J. Biol. Chem., 2008 Jun 6 , 283 (15997-6003).

335

Stam AH et al. Genetics of migraine: an update with special attention to genetic comorbidity.
Curr. Opin. Neurol., 2008 Jun , 21 (288-93).

336

Su X et al. Role of spinal Cav2.2 and Cav2.1 ion channels in bladder nociception.
J. Urol., 2008 Jun , 179 (2464-9).

337

Riant F et al. Large CACNA1A deletion in a family with episodic ataxia type 2.
Arch. Neurol., 2008 Jun , 65 (817-20).

338

Miki T et al. Two novel alleles of tottering with distinct Ca(v)2.1 calcium channel neuropathologies.
Neuroscience, 2008 Jul 31 , 155 (31-44).

339

Cestèle S et al. Self-limited hyperexcitability: functional effect of a familial hemiplegic migraine mutation of the Nav1.1 (SCN1A) Na+ channel.
J. Neurosci., 2008 Jul 16 , 28 (7273-83).

340

Kahlig KM et al. Divergent sodium channel defects in familial hemiplegic migraine.
Proc. Natl. Acad. Sci. U.S.A., 2008 Jul 15 , 105 (9799-804).

341

Marquèze-Pouey B et al. Toxicity and endocytosis of spinocerebellar ataxia type 6 polyglutamine domains: role of myosin IIb.
Traffic, 2008 Jul , 9 (1088-100).

342

Jiang X et al. Modulation of CaV2.1 channels by Ca2+/calmodulin-dependent protein kinase II bound to the C-terminal domain.
Proc. Natl. Acad. Sci. U.S.A., 2008 Jan 8 , 105 (341-6).

343

Ovsepian SV et al. The leaner P/Q-type calcium channel mutation renders cerebellar Purkinje neurons hyper-excitable and eliminates Ca2+-Na+ spike bursts.
Eur. J. Neurosci., 2008 Jan , 27 (93-103).

344

Fernandez DM et al. A novel ATP1A2 gene mutation in an Irish familial hemiplegic migraine kindred.
Headache, 2008 Jan , 48 (101-8).

345

Lee H et al. [Familial hemiplegic migraine resulting in recurrent coma]
, 2008 Feb 16 , 152 (393-6).

346

Jeng CJ et al. Dominant-negative effects of episodic ataxia type 2 mutations involve disruption of membrane trafficking of human P/Q-type Ca2+ channels.
J. Cell. Physiol., 2008 Feb , 214 (422-33).

347

Jen JC Recent advances in the genetics of recurrent vertigo and vestibulopathy.
Curr. Opin. Neurol., 2008 Feb , 21 (3-7).

348

Tsunemi T et al. Cell-type-specific alternative splicing in spinocerebellar ataxia type 6.
Neurosci. Lett., 2008 Dec 5 , 447 (78-81).

349

Watase K et al. Spinocerebellar ataxia type 6 knockin mice develop a progressive neuronal dysfunction with age-dependent accumulation of mutant CaV2.1 channels.
Proc. Natl. Acad. Sci. U.S.A., 2008 Aug 19 , 105 (11987-92).

350

Berkefeld H et al. Repolarizing responses of BKCa-Cav complexes are distinctly shaped by their Cav subunits.
J. Neurosci., 2008 Aug 13 , 28 (8238-45).

351

Chai Y et al. Dual regulation of the ATP-sensitive potassium channel by activation of cGMP-dependent protein kinase.
Pflugers Arch., 2008 Aug , 456 (897-915).

352

Chan YC et al. Electroencephalographic changes and seizures in familial hemiplegic migraine patients with the CACNA1A gene S218L mutation.
, 2008 Aug , 15 (891-4).

353

Morey Kinney SR et al. Stage-specific alterations of DNA methyltransferase expression, DNA hypermethylation, and DNA hypomethylation during prostate cancer progression in the transgenic adenocarcinoma of mouse prostate model.
Mol. Cancer Res., 2008 Aug , 6 (1365-74).

354

de Vries B et al. CACNA1A mutation linking hemiplegic migraine and alternating hemiplegia of childhood.
Cephalalgia, 2008 Aug , 28 (887-91).

355

Hu P et al. Crystal structure of Natratoxin, a novel snake secreted phospholipaseA2 neurotoxin from Naja atra venom inhibiting A-type K+ currents.
Proteins, 2008 Aug , 72 (673-83).

356

Mezghrani A et al. A destructive interaction mechanism accounts for dominant-negative effects of misfolded mutants of voltage-gated calcium channels.
J. Neurosci., 2008 Apr 23 , 28 (4501-11).

357

Christova P et al. Impaired eye movements in presymptomatic spinocerebellar ataxia type 6.
Arch. Neurol., 2008 Apr , 65 (530-6).

358

Freilinger T et al. Expansion of the phenotypic spectrum of the CACNA1A T666M mutation: a family with familial hemiplegic migraine type 1, cerebellar atrophy and mental retardation.
Cephalalgia, 2008 Apr , 28 (403-7).

359

Marti S et al. Progressive cerebellar ataxia with variable episodic symptoms--phenotypic diversity of R1668W CACNA1A mutation.
Eur. Neurol., 2008 , 60 (16-20).

360

Johnson J et al. Clinical and genetic analysis of spinocerebellar ataxia type 11.
Cerebellum, 2008 , 7 (159-64).

361

Jones HM et al. An NH2-terminal multi-basic RKR motif is required for the ATP-dependent regulation of hIK1.
Channels (Austin), 2007 Mar-Apr , 1 (80-91).

362

Jordan BD Genetic influences on outcome following traumatic brain injury.
Neurochem. Res., 2007 Apr-May , 32 (905-15).

363

Tanaka K et al. Increased Ca2+ channel currents in cerebellar Purkinje cells of the ataxic groggy rat.
Neurosci. Lett., 2007 Oct 16 , 426 (75-80).

364

Jen JC et al. Primary episodic ataxias: diagnosis, pathogenesis and treatment.
Brain, 2007 Oct , 130 (2484-93).

365

Gazulla J et al. [P/Q-type voltage-dependent calcium channels in neurological disease]
, 2007 Oct , 22 (511-6).

366

Llinás RR et al. Gamma-band deficiency and abnormal thalamocortical activity in P/Q-type channel mutant mice.
Proc. Natl. Acad. Sci. U.S.A., 2007 Nov 6 , 104 (17819-24).

367

Richards KS et al. Novel CaV2.1 clone replicates many properties of Purkinje cell CaV2.1 current.
Eur. J. Neurosci., 2007 Nov , 26 (2950-61).

368

Xie G et al. Forward genetic screen of mouse reveals dominant missense mutation in the P/Q-type voltage-dependent calcium channel, CACNA1A.
Genes Brain Behav., 2007 Nov , 6 (717-27).

369

Gazulla J et al. The P/Q-type voltage-dependent calcium channel: a therapeutic target in spinocerebellar ataxia type 6.
Acta Neurol. Scand., 2007 May , 115 (356-63).

370

Van De Ven RC et al. Genetic models of migraine.
Arch. Neurol., 2007 May , 64 (643-6).

371

Vanmolkot KR et al. The novel p.L1649Q mutation in the SCN1A epilepsy gene is associated with familial hemiplegic migraine: genetic and functional studies. Mutation in brief #957. Online.
Hum. Mutat., 2007 May , 28 (522).

372

Montagna P Recent advances in the pharmacogenomics of pain and headache.
Neurol. Sci., 2007 May , 28 Suppl 2 (S208-12).

373

Chaudhuri D et al. Elementary mechanisms producing facilitation of Cav2.1 (P/Q-type) channels.
J. Gen. Physiol., 2007 May , 129 (385-401).

374

Zaitsev AV et al. P/Q-type, but not N-type, calcium channels mediate GABA release from fast-spiking interneurons to pyramidal cells in rat prefrontal cortex.
J. Neurophysiol., 2007 May , 97 (3567-73).

375

Cricchi F et al. Early-onset progressive ataxia associated with the first CACNA1A mutation identified within the I-II loop.
J. Neurol. Sci., 2007 Mar 15 , 254 (69-71).

376

Chen H et al. Altered frequency-dependent inactivation and steady-state inactivation of polyglutamine-expanded alpha1A in SCA6.
Am. J. Physiol., Cell Physiol., 2007 Mar , 292 (C1078-86).

377

Mao X et al. Dual regulation of the ATP-sensitive potassium channel by caffeine.
Am. J. Physiol., Cell Physiol., 2007 Jun , 292 (C2239-58).

378

Van Den Maagdenberg AM et al. Migraine: gene mutations and functional consequences.
Curr. Opin. Neurol., 2007 Jun , 20 (299-305).

379

Yin XZ et al. [The clinical features and gene mutation analysis in a pedigree of spinocerebellar ataxia type 7]
Yi Chuan, 2007 Jun , 29 (688-92).

380

Vincent M et al. The cerebellum and migraine.
Headache, 2007 Jun , 47 (820-33).

381

Goadsby PJ Recent advances in understanding migraine mechanisms, molecules and therapeutics.
, 2007 Jan , 13 (39-44).

382

Meza U et al. Neurokinin 1 receptors trigger overlapping stimulation and inhibition of CaV2.3 (R-type) calcium channels.
Mol. Pharmacol., 2007 Jan , 71 (284-93).

383

Weiss N et al. [Role of P/Q calcium channel in familial hemiplegic migraine]
Med Sci (Paris), 2007 Jan , 23 (53-63).

384

Kaja S et al. Characterization of acetylcholine release and the compensatory contribution of non-Ca(v)2.1 channels at motor nerve terminals of leaner Ca(v)2.1-mutant mice.
Neuroscience, 2007 Feb 23 , 144 (1278-87).

385

Tokuda S et al. The ataxic groggy rat has a missense mutation in the P/Q-type voltage-gated Ca2+ channel alpha1A subunit gene and exhibits absence seizures.
Brain Res., 2007 Feb 16 , 1133 (168-77).

386

Saegusa H et al. Properties of human Cav2.1 channel with a spinocerebellar ataxia type 6 mutation expressed in Purkinje cells.
Mol. Cell. Neurosci., 2007 Feb , 34 (261-70).

387

Raike RS et al. Dominant-negative suppression of Cav2.1 currents by alpha(1)2.1 truncations requires the conserved interaction domain for beta subunits.
Mol. Cell. Neurosci., 2007 Feb , 34 (168-77).

388

Colson NJ et al. The search for migraine genes: an overview of current knowledge.
Cell. Mol. Life Sci., 2007 Feb , 64 (331-44).

389

Thomsen LL et al. The genetic spectrum of a population-based sample of familial hemiplegic migraine.
Brain, 2007 Feb , 130 (346-56).

390

de Vries B et al. Systematic analysis of three FHM genes in 39 sporadic patients with hemiplegic migraine.
Neurology, 2007 Dec 4 , 69 (2170-6).

391

Mantuano E et al. Early onset progressive ataxia associated with the first CACNA1A mutation identified within the I-II loop.
J. Neurol. Sci., 2007 Dec 15 , 263 (226; author reply 226-7).

392

Tonelli A et al. Amino acid changes in the amino terminus of the Na,K-adenosine triphosphatase alpha-2 subunit associated to familial and sporadic hemiplegic migraine.
Clin. Genet., 2007 Dec , 72 (517-23).

393

Katsura M et al. Up-regulation of L-type high voltage-gated calcium channel subunits by sustained exposure to 1,4- and 1,5-benzodiazepines in cerebrocortical neurons.
J. Neurochem., 2007 Dec , 103 (2518-28).

394

Glasscock E et al. Masking epilepsy by combining two epilepsy genes.
Nat. Neurosci., 2007 Dec , 10 (1554-8).

395

Gargus JJ et al. Novel mutation confirms seizure locus SCN1A is also familial hemiplegic migraine locus FHM3.
Pediatr. Neurol., 2007 Dec , 37 (407-10).

396

Kaja S et al. Aberrant cerebellar granule cell-specific GABAA receptor expression in the epileptic and ataxic mouse mutant, Tottering.
Neuroscience, 2007 Aug 10 , 148 (115-25).

397

Etheredge JA et al. Functional compensation by other voltage-gated Ca2+ channels in mouse basal forebrain neurons with Ca(V)2.1 mutations.
Brain Res., 2007 Apr 6 , 1140 (105-19).

398

Kaja S et al. Redundancy of Cav2.1 channel accessory subunits in transmitter release at the mouse neuromuscular junction.
Brain Res., 2007 Apr 27 , 1143 (92-101).

399

Kaja S et al. Severely impaired neuromuscular synaptic transmission causes muscle weakness in the Cacna1a-mutant mouse rolling Nagoya.
Eur. J. Neurosci., 2007 Apr , 25 (2009-20).

400

Bozzola E et al. [Spinocerebellar ataxias in infancy: pathogenesis of potassium and calcium channels' diseases, clinical features and therapeutical approach]
Minerva Pediatr., 2007 Apr , 59 (149-56).

401

Kordasiewicz HB et al. Molecular pathogenesis of spinocerebellar ataxia type 6.
, 2007 Apr , 4 (285-94).

402

Pietrobon D Familial hemiplegic migraine.
, 2007 Apr , 4 (274-84).

403

Strupp M et al. Episodic ataxia type 2.
, 2007 Apr , 4 (267-73).

404

Wulff H et al. Modulators of small- and intermediate-conductance calcium-activated potassium channels and their therapeutic indications.
Curr. Med. Chem., 2007 , 14 (1437-57).

405

Gazulla J et al. The P/Q-type voltage-dependent calcium channel as pharmacological target in spinocerebellar ataxia type 6: gabapentin and pregabalin may be of therapeutic benefit.
Med. Hypotheses, 2007 , 68 (131-6).

406

von Brevern M et al. Migrainous vertigo: mutation analysis of the candidate genes CACNA1A, ATP1A2, SCN1A, and CACNB4.
Headache, 2006 Jul-Aug , 46 (1136-41).

407

Andrés-Mateos E et al. Bovine CACNA1A gene and comparative analysis of the CAG repeats associated to human spinocerebellar ataxia type-6.
Gene, 2006 Sep 15 , 380 (54-61).

408

Lopes LR et al. Mutation analysis of CACNA1A and ATP1A2 genes in Brazilian FHM families.
, 2006 Sep , 64 (549-52).

409

Berkefeld H et al. BKCa-Cav channel complexes mediate rapid and localized Ca2+-activated K+ signaling.
Science, 2006 Oct 27 , 314 (615-20).

410

Estevez AO et al. Both insulin and calcium channel signaling are required for developmental regulation of serotonin synthesis in the chemosensory ADF neurons of Caenorhabditis elegans.
Dev. Biol., 2006 Oct 1 , 298 (32-44).

411

Freilinger T et al. [Genetics of migraine]
, 2006 Oct , 77 (1186, 1188-95).

412

Yang SN et al. The role of voltage-gated calcium channels in pancreatic beta-cell physiology and pathophysiology.
Endocr. Rev., 2006 Oct , 27 (621-76).

413

Vinet J et al. Expression pattern of voltage-dependent calcium channel subunits in hippocampal inhibitory neurons in mice.
Neuroscience, 2006 Nov 17 , 143 (189-212).

414

Kordasiewicz HB et al. C-termini of P/Q-type Ca2+ channel alpha1A subunits translocate to nuclei and promote polyglutamine-mediated toxicity.
Hum. Mol. Genet., 2006 May 15 , 15 (1587-99).

415

Vendel AC et al. Alternative splicing of the voltage-gated Ca2+ channel beta4 subunit creates a uniquely folded N-terminal protein binding domain with cell-specific expression in the cerebellar cortex.
J. Neurosci., 2006 Mar 8 , 26 (2635-44).

416

Kirchmann M et al. Basilar-type migraine: clinical, epidemiologic, and genetic features.
Neurology, 2006 Mar 28 , 66 (880-6).

417

Sasaki S et al. Impaired feedforward inhibition of the thalamocortical projection in epileptic Ca2+ channel mutant mice, tottering.
J. Neurosci., 2006 Mar 15 , 26 (3056-65).

418

Stahl JS et al. Eye movements of the murine P/Q calcium channel mutant tottering, and the impact of aging.
J. Neurophysiol., 2006 Mar , 95 (1588-607).

419

Walter JT et al. Decreases in the precision of Purkinje cell pacemaking cause cerebellar dysfunction and ataxia.
Nat. Neurosci., 2006 Mar , 9 (389-97).

420

Estevez M Invertebrate modeling of a migraine channelopathy.
Headache, 2006 Jun , 46 Suppl 1 (S25-31).

421

Liu WL et al. [Novel mutations of potassium channel KCNQ1 S145L and KCNH2 Y475C genes in Chinese pedigrees of long QT syndrome]
Zhonghua Nei Ke Za Zhi, 2006 Jun , 45 (463-6).

422

Macleod GT et al. The Drosophila cacts2 mutation reduces presynaptic Ca2+ entry and defines an important element in Cav2.1 channel inactivation.
Eur. J. Neurosci., 2006 Jun , 23 (3230-44).

423

Rapedius M et al. Structural and functional analysis of the putative pH sensor in the Kir1.1 (ROMK) potassium channel.
EMBO Rep., 2006 Jun , 7 (611-6).

424

Halling DB et al. Regulation of voltage-gated Ca2+ channels by calmodulin.
Sci. STKE, 2006 Jan 17 , 2006 (er1).

425

Kanumilli S et al. Alternative splicing generates a smaller assortment of CaV2.1 transcripts in cerebellar Purkinje cells than in the cerebellum.
Physiol. Genomics, 2006 Jan 12 , 24 (86-96).

426

Srivastava S et al. Phosphatidylinositol 3-phosphate indirectly activates KCa3.1 via 14 amino acids in the carboxy terminus of KCa3.1.
Mol. Biol. Cell, 2006 Jan , 17 (146-54).

427

Jackson SN et al. Phosphate stabilization of intermolecular interactions.
J. Proteome Res., 2006 Jan , 5 (122-6).

428

Tonelli A et al. Early onset, non fluctuating spinocerebellar ataxia and a novel missense mutation in CACNA1A gene.
J. Neurol. Sci., 2006 Feb 15 , 241 (13-7).

429

Lindquist SG et al. Meiotic CAG repeat instability in spinocerebellar ataxia type 6: maternally transmitted elongation in a presumed sporadic case.
J. Neurol. Sci., 2006 Feb 15 , 241 (95-8).

430

Zhang C et al. Identification and characterization of a novel member of the ATP-sensitive K+ channel subunit family, Kir6.3, in zebrafish.
Physiol. Genomics, 2006 Feb 14 , 24 (290-7).

431

Scoggan KA et al. CACNA1A mutation in a EA-2 patient responsive to acetazolamide and valproic acid.
, 2006 Feb , 33 (68-72).

432

Park JY et al. Activation of protein kinase C augments T-type Ca2+ channel activity without changing channel surface density.
J. Physiol. (Lond.), 2006 Dec 1 , 577 (513-23).

433

Kodama T et al. A CaV2.1 calcium channel mutation rocker reduces the number of postsynaptic AMPA receptors in parallel fiber-Purkinje cell synapses.
Eur. J. Neurosci., 2006 Dec , 24 (2993-3007).

434

Todorov B et al. Conditional inactivation of the Cacna1a gene in transgenic mice.
Genesis, 2006 Dec , 44 (589-94).

435

Davies A et al. The calcium channel alpha2delta-2 subunit partitions with CaV2.1 into lipid rafts in cerebellum: implications for localization and function.
J. Neurosci., 2006 Aug 23 , 26 (8748-57).

436

Schenning M et al. Glycerotoxin stimulates neurotransmitter release from N-type Ca2+ channel expressing neurons.
J. Neurochem., 2006 Aug , 98 (894-904).

437

Kirchmann M et al. The CACNA1A and ATP1A2 genes are not involved in dominantly inherited migraine with aura.
Am. J. Med. Genet. B Neuropsychiatr. Genet., 2006 Apr 5 , 141B (250-6).

438

Andreasen D et al. Coexpression of voltage-dependent calcium channels Cav1.2, 2.1a, and 2.1b in vascular myocytes.
Hypertension, 2006 Apr , 47 (735-41).

439

Kaja S et al. Compensatory contribution of Cav2.3 channels to acetylcholine release at the neuromuscular junction of tottering mice.
J. Neurophysiol., 2006 Apr , 95 (2698-704).

440

Jeng CJ et al. Dominant-negative effects of human P/Q-type Ca2+ channel mutations associated with episodic ataxia type 2.
Am. J. Physiol., Cell Physiol., 2006 Apr , 290 (C1209-20).

441

Martin-Moutot N et al. Phoneutria nigriventer omega-Phonetoxin IIA: a new tool for anti-calcium channel autoantibody assays in Lambert-Eaton myasthenic syndrome.
Neurobiol. Dis., 2006 Apr , 22 (57-63).

442

Johnson R et al. Identification of the REST regulon reveals extensive transposable element-mediated binding site duplication.
Nucleic Acids Res., 2006 , 34 (3862-77).

443

Dichgans M et al. Mutation in the neuronal voltage-gated sodium channel SCN1A in familial hemiplegic migraine.
Lancet, 2005 Jul 30-Aug 5 , 366 (371-7).

444

Chaudhuri D et al. Developmental activation of calmodulin-dependent facilitation of cerebellar P-type Ca2+ current.
J. Neurosci., 2005 Sep 7 , 25 (8282-94).

445

Imbrici P et al. Late-onset episodic ataxia type 2 due to an in-frame insertion in CACNA1A.
Neurology, 2005 Sep 27 , 65 (944-6).

446

Khan NL et al. Parkinsonism and nigrostriatal dysfunction are associated with spinocerebellar ataxia type 6 (SCA6).
Mov. Disord., 2005 Sep , 20 (1115-9).

447

Buraei Z et al. Slowed N-type calcium channel (CaV2.2) deactivation by the cyclin-dependent kinase inhibitor roscovitine.
Biophys. J., 2005 Sep , 89 (1681-91).

448

Shikano S et al. Genetic isolation of transport signals directing cell surface expression.
Nat. Cell Biol., 2005 Oct , 7 (985-92).

449

Pulst SM et al. Spinocerebellar ataxia type 2: polyQ repeat variation in the CACNA1A calcium channel modifies age of onset.
Brain, 2005 Oct , 128 (2297-303).

450

Spacey SD et al. Familial hemiplegic migraine presenting as recurrent encephalopathy in a Native Indian family.
Headache, 2005 Oct , 45 (1244-9).

451

Takeshima T et al. [Genetic analysis of migraine headache: a review]
Nippon Rinsho, 2005 Oct , 63 (1727-32).

452

Goldberg JA et al. Control of spontaneous firing patterns by the selective coupling of calcium currents to calcium-activated potassium currents in striatal cholinergic interneurons.
J. Neurosci., 2005 Nov 2 , 25 (10230-8).

453

Fureman BE et al. Noradrenergic blockade prevents attacks in a model of episodic dysfunction caused by a channelopathy.
Neurobiol. Dis., 2005 Nov , 20 (227-32).

454

Andrés-Mateos E et al. Dynamic association of the Ca2+ channel alpha1A subunit and SNAP-25 in round or neurite-emitting chromaffin cells.
Eur. J. Neurosci., 2005 Nov , 22 (2187-98).

455

Tottene A et al. Specific kinetic alterations of human CaV2.1 calcium channels produced by mutation S218L causing familial hemiplegic migraine and delayed cerebral edema and coma after minor head trauma.
J. Biol. Chem., 2005 May 6 , 280 (17678-86).

456

Jiang H et al. Frequency analysis of autosomal dominant spinocerebellar ataxias in mainland Chinese patients and clinical and molecular characterization of spinocerebellar ataxia type 6.
Chin. Med. J., 2005 May 20 , 118 (837-43).

457

Yu GY et al. Spinocerebellar ataxia type 26 maps to chromosome 19p13.3 adjacent to SCA6.
Ann. Neurol., 2005 Mar , 57 (349-54).

458

Juvonen V et al. The occurrence of dominant spinocerebellar ataxias among 251 Finnish ataxia patients and the role of predisposing large normal alleles in a genetically isolated population.
Acta Neurol. Scand., 2005 Mar , 111 (154-62).

459

Wan J et al. CACNA1A mutations causing episodic and progressive ataxia alter channel trafficking and kinetics.
Neurology, 2005 Jun 28 , 64 (2090-7).

460

Barrett CF et al. Gating deficiency in a familial hemiplegic migraine type 1 mutant P/Q-type calcium channel.
J. Biol. Chem., 2005 Jun 24 , 280 (24064-71).

461

Haan J et al. Migraine genetics: an update.
, 2005 Jun , 9 (213-20).

462

Strupp M et al. Dysfunction of the brain calcium channel CaV2.1 in absence epilepsy and episodic ataxia--a comment.
Brain, 2005 Jun , 128 (E32; author reply E33).

463

Lautermilch NJ et al. Modulation of CaV2.1 channels by the neuronal calcium-binding protein visinin-like protein-2.
J. Neurosci., 2005 Jul 27 , 25 (7062-70).

464

Few AP et al. Differential regulation of CaV2.1 channels by calcium-binding protein 1 and visinin-like protein-2 requires N-terminal myristoylation.
J. Neurosci., 2005 Jul 27 , 25 (7071-80).

465

Eunson LH et al. New calcium channel mutations predict aberrant RNA splicing in episodic ataxia.
Neurology, 2005 Jul 26 , 65 (308-10).

466

Kaunisto MA et al. Chromosome 19p13 loci in Finnish migraine with aura families.
Am. J. Med. Genet. B Neuropsychiatr. Genet., 2005 Jan 5 , 132B (85-9).

467

Richman RW et al. RGS12 interacts with the SNARE-binding region of the Cav2.2 calcium channel.
J. Biol. Chem., 2005 Jan 14 , 280 (1521-8).

468

Yang SN et al. Beta-cell CaV channel regulation in physiology and pathophysiology.
Am. J. Physiol. Endocrinol. Metab., 2005 Jan , 288 (E16-28).

469

Wan J et al. Nonconsensus intronic mutations cause episodic ataxia.
Ann. Neurol., 2005 Jan , 57 (131-5).

470

Harno H et al. Decreased cerebellar total creatine in episodic ataxia type 2: a 1H MRS study.
Neurology, 2005 Feb 8 , 64 (542-4).

471

Dichgans M et al. 1H-MRS alterations in the cerebellum of patients with familial hemiplegic migraine type 1.
Neurology, 2005 Feb 22 , 64 (608-13).

472

Cao YQ et al. Effects of familial hemiplegic migraine type 1 mutations on neuronal P/Q-type Ca2+ channel activity and inhibitory synaptic transmission.
Proc. Natl. Acad. Sci. U.S.A., 2005 Feb 15 , 102 (2590-5).

473

Hu Q et al. The carboxy-terminal tail region of human Cav2.1 (P/Q-type) channel is not an essential determinant for its subcellular localization in cultured neurones.
Genes Cells, 2005 Feb , 10 (87-96).

474

Spacey SD et al. Two novel CACNA1A gene mutations associated with episodic ataxia type 2 and interictal dystonia.
Arch. Neurol., 2005 Feb , 62 (314-6).

475

Mössner R et al. A highly polymorphic poly-glutamine stretch in the potassium channel KCNN3 in migraine.
Headache, 2005 Feb , 45 (132-6).

476

Halling DB et al. Regulation of voltage-gated Ca2+ channels by calmodulin.
Sci. STKE, 2005 Dec 20 , 2005 (re15).

477

Tuteja D et al. Differential expression of small-conductance Ca2+-activated K+ channels SK1, SK2, and SK3 in mouse atrial and ventricular myocytes.
Am. J. Physiol. Heart Circ. Physiol., 2005 Dec , 289 (H2714-23).

478

Jen JC et al. Mutation in the glutamate transporter EAAT1 causes episodic ataxia, hemiplegia, and seizures.
Neurology, 2005 Aug 23 , 65 (529-34).

479

Herrmann A et al. [Episodic ataxias]
Tidsskr. Nor. Laegeforen., 2005 Aug 11 , 125 (2005-7).

480

Wada T et al. Effects of calmodulin and Ca2+ channel blockers on omega-conotoxin GVIA binding to crude membranes from alpha1B subunit (Cav2.2) expressed BHK cells and mice brain lacking the alpha1B subunits.
Neurochem. Res., 2005 Aug , 30 (1045-54).

481

Weisz CJ et al. Potassium channel blockers inhibit the triggers of attacks in the calcium channel mouse mutant tottering.
J. Neurosci., 2005 Apr 20 , 25 (4141-5).

482

Ichida S et al. Characteristics of omega-conotoxin GVI A and MVIIC binding to Cav 2.1 and Cav 2.2 channels captured by anti-Ca2+ channel peptide antibodies.
Neurochem. Res., 2005 Apr , 30 (457-66).

483

Ying SH et al. Relative atrophy of the flocculus and ocular motor dysfunction in SCA2 and SCA6.
Ann. N. Y. Acad. Sci., 2005 Apr , 1039 (430-5).

484

Rucker JC et al. Internuclear ophthalmoparesis in episodic ataxia type 2.
Ann. N. Y. Acad. Sci., 2005 Apr , 1039 (571-4).

485

Stahl JS et al. Neural integrator function in murine CACNA1A mutants.
Ann. N. Y. Acad. Sci., 2005 Apr , 1039 (580-2).

486

Goadsby PJ Migraine pathophysiology.
Headache, 2005 Apr , 45 Suppl 1 (S14-24).

487

Layton MG et al. Cellular localization of voltage-gated calcium channels and synaptic vesicle-associated proteins in the guinea pig cochlea.
J. Mol. Neurosci., 2005 , 27 (225-44).

488

Kaja S et al. Gene dosage-dependent transmitter release changes at neuromuscular synapses of CACNA1A R192Q knockin mice are non-progressive and do not lead to morphological changes or muscle weakness.
Neuroscience, 2005 , 135 (81-95).

489

Kuiper H et al. Assignment of the calcium channel, voltage-dependent, P/Q type, alpha 1A subunit gene (CACNA1A), and the ataxin 7 gene (ATXN7) to canine chromosome 20 by fluorescence in situ hybridization and confirmation by radiation hybrid mapping.
Cytogenet. Genome Res., 2005 , 111 (96).

490

Kors EE et al. Childhood epilepsy, familial hemiplegic migraine, cerebellar ataxia, and a new CACNA1A mutation.
Neurology, 2004 Sep 28 , 63 (1136-7).

491

Kors EE et al. [From gene to disease; familial hemiplegic migraine as a result of mutations in a sodium-potassium pump gene]
, 2004 Sep 25 , 148 (1919-20).

492

Ivanov SV et al. Cerebellar ataxia, seizures, premature death, and cardiac abnormalities in mice with targeted disruption of the Cacna2d2 gene.
Am. J. Pathol., 2004 Sep , 165 (1007-18).

493

Rousset M et al. Ca2+-dependent interaction of BAPTA with phospholipids.
FEBS Lett., 2004 Oct 8 , 576 (41-5).

494

Kim MJ et al. Immunohistochemical study of the distribution of neuronal voltage-gated calcium channels in the nNOS knock-out mouse cerebellum.
Neurosci. Lett., 2004 Oct 7 , 369 (39-43).

495

Tedford HW et al. Scanning mutagenesis of omega-atracotoxin-Hv1a reveals a spatially restricted epitope that confers selective activity against insect calcium channels.
J. Biol. Chem., 2004 Oct 15 , 279 (44133-40).

496

Mochizuki Y et al. Hereditary paroxysmal ataxia with mental retardation: a clinicopathological study in relation to episodic ataxia type 2.
Acta Neuropathol., 2004 Oct , 108 (345-9).

497

Kors EE et al. Alternating hemiplegia of childhood: no mutations in the second familial hemiplegic migraine gene ATP1A2.
Neuropediatrics, 2004 Oct , 35 (293-6).

498

Terwindt GM et al. Single-fiber EMG in familial hemiplegic migraine.
Neurology, 2004 Nov 23 , 63 (1942-3).

499

Scheuber A et al. Presynaptic Cav2.1 and Cav2.2 differentially influence release dynamics at hippocampal excitatory synapses.
J. Neurosci., 2004 Nov 17 , 24 (10402-9).

500

Matsuyama Z et al. Polyglutamine repeats of spinocerebellar ataxia 6 impair the cell-death-preventing effect of CaV2.1 Ca2+ channel--loss-of-function cellular model of SCA6.
Neurobiol. Dis., 2004 Nov , 17 (198-204).

501

Luvisetto S et al. Modal gating of human CaV2.1 (P/Q-type) calcium channels: I. The slow and the fast gating modes and their modulation by beta subunits.
J. Gen. Physiol., 2004 Nov , 124 (445-61).

502

Fellin T et al. Modal gating of human CaV2.1 (P/Q-type) calcium channels: II. the b mode and reversible uncoupling of inactivation.
J. Gen. Physiol., 2004 Nov , 124 (463-74).

503

Strupp M et al. Treatment of episodic ataxia type 2 with the potassium channel blocker 4-aminopyridine.
Neurology, 2004 May 11 , 62 (1623-5).

504

Stahl JS Eye movements of the murine P/Q calcium channel mutant rocker, and the impact of aging.
J. Neurophysiol., 2004 May , 91 (2066-78).

505

Tsai HF et al. Analysis of trinucleotide repeats in different SCA loci in spinocerebellar ataxia patients and in normal population of Taiwan.
Acta Neurol. Scand., 2004 May , 109 (355-60).

506

Brusco A et al. Molecular genetics of hereditary spinocerebellar ataxia: mutation analysis of spinocerebellar ataxia genes and CAG/CTG repeat expansion detection in 225 Italian families.
Arch. Neurol., 2004 May , 61 (727-33).

507

Van Den Maagdenberg AM et al. A Cacna1a knockin migraine mouse model with increased susceptibility to cortical spreading depression.
Neuron, 2004 Mar 4 , 41 (701-10).

508

Jönsson EG et al. Monoamine related functional gene variants and relationships to monoamine metabolite concentrations in CSF of healthy volunteers.
BMC Psychiatry, 2004 Mar 4 , 4 (4).

509

Terasawa H et al. A novel haplotype of spinocerebellar ataxia type 6 contributes to the highest prevalence in western Japan.
Neurosci. Lett., 2004 Mar 25 , 358 (107-10).

510

Verbeek DS et al. Haplotype study in Dutch SCA3 and SCA6 families: evidence for common founder mutations.
Eur. J. Hum. Genet., 2004 Jun , 12 (441-6).

511

Kors EE et al. Recent findings in headache genetics.
Curr. Opin. Neurol., 2004 Jun , 17 (283-8).

512

Jen JC et al. No mutations in CACNA1A and ATP1A2 in probands with common types of migraine.
Arch. Neurol., 2004 Jun , 61 (926-8).

513

Fumal A et al. [Genetics of migraines: from ionic channels to single nucleotide polymorphisms?]
, 2004 Jun , 59 (367-77).

514

Le Fort D et al. Elicited repetitive daily blindness: a new familial disorder related to migraine and epilepsy.
Neurology, 2004 Jul 27 , 63 (348-50).

515

Vogensen SB et al. A stereochemical anomaly: the cyclised (R)-AMPA analogue (R)-3-hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridine-5-carboxylic acid [(R)-5-HPCA] resembles (S)-AMPA at glutamate receptors.
Org. Biomol. Chem., 2004 Jan 21 , 2 (206-13).

516

Jen J et al. Clinical spectrum of episodic ataxia type 2.
Neurology, 2004 Jan 13 , 62 (17-22).

517

Estevez M et al. The voltage-gated calcium channel UNC-2 is involved in stress-mediated regulation of tryptophan hydroxylase.
J. Neurochem., 2004 Jan , 88 (102-13).

518

Nakanishi I et al. [A case of spinocerebellar ataxia 6 accompanied with schizophrenia]
No To Shinkei, 2004 Jan , 56 (49-52).

519

Taverna E et al. Role of lipid microdomains in P/Q-type calcium channel (Cav2.1) clustering and function in presynaptic membranes.
J. Biol. Chem., 2004 Feb 13 , 279 (5127-34).

520

Kaunisto MA et al. Novel splice site CACNA1A mutation causing episodic ataxia type 2.
Neurogenetics, 2004 Feb , 5 (69-73).

521

Estevez M et al. Update on the genetics of migraine.
Hum. Genet., 2004 Feb , 114 (225-35).

522

Scamps F et al. Activation of P-type calcium channel regulates a unique thapsigargin-sensitive calcium pool in embryonic motoneurons.
Eur. J. Neurosci., 2004 Feb , 19 (977-82).

523

Kinoshita-Kawada M et al. A Purkinje cell specific GoLoco domain protein, L7/Pcp-2, modulates receptor-mediated inhibition of Cav2.1 Ca2+ channels in a dose-dependent manner.
Brain Res. Mol. Brain Res., 2004 Dec 6 , 132 (73-86).

524

Müllner C et al. Familial hemiplegic migraine type 1 mutations K1336E, W1684R, and V1696I alter Cav2.1 Ca2+ channel gating: evidence for beta-subunit isoform-specific effects.
J. Biol. Chem., 2004 Dec 10 , 279 (51844-50).

525

Lee H et al. A novel mutation in KCNA1 causes episodic ataxia without myokymia.
Hum. Mutat., 2004 Dec , 24 (536).

526

Imbrici P et al. Dysfunction of the brain calcium channel CaV2.1 in absence epilepsy and episodic ataxia.
Brain, 2004 Dec , 127 (2682-92).

527

Cao YQ et al. Presynaptic Ca2+ channels compete for channel type-preferring slots in altered neurotransmission arising from Ca2+ channelopathy.
Neuron, 2004 Aug 5 , 43 (387-400).

528

Spacey SD et al. Functional implications of a novel EA2 mutation in the P/Q-type calcium channel.
Ann. Neurol., 2004 Aug , 56 (213-20).

529

Ebersberger A et al. Effects of N-, P/Q- and L-type calcium channel blockers on nociceptive neurones of the trigeminal nucleus with input from the dura.
Cephalalgia, 2004 Apr , 24 (250-61).

530

Beauvais K et al. New CACNA1A gene mutation in a case of familial hemiplegic migraine with status epilepticus.
Eur. Neurol., 2004 , 52 (58-61).

531

Takahashi H et al. A clinical and genetic study in a large cohort of patients with spinocerebellar ataxia type 6.
J. Hum. Genet., 2004 , 49 (256-64).

532

Wessman M et al. The molecular genetics of migraine.
Ann. Med., 2004 , 36 (462-73).

533

Ogawa M Pharmacological treatments of cerebellar ataxia.
Cerebellum, 2004 , 3 (107-11).

534

Lau FC et al. Postnatal apoptosis in cerebellar granule cells of homozygous leaner (tg1a/tg1a) mice.
, 2004 , 6 (267-80).

535

Moss FJ et al. Human neuronal stargazin-like proteins, gamma2, gamma3 and gamma4; an investigation of their specific localization in human brain and their influence on CaV2.1 voltage-dependent calcium channels expressed in Xenopus oocytes.
, 2003 Sep 23 , 4 (23).

536

Liang H et al. Unified mechanisms of Ca2+ regulation across the Ca2+ channel family.
Neuron, 2003 Sep 11 , 39 (951-60).

537

Tomaszewska-Zaremba D et al. The role of GabaA receptors in the neural systems of the ventromedial hypothalamus-nucleus infundibular region in the control of GnRH release in ewes during follicular phase.
Exp. Clin. Endocrinol. Diabetes, 2003 Sep , 111 (335-40).

538

Chapman KM et al. Pseudomigraine with lymphocytic pleocytosis: a calcium channelopathy? Clinical description of 10 cases and genetic analysis of the familial hemiplegic migraine gene CACNA1A.
Headache, 2003 Sep , 43 (892-5).

539

Vanmolkot KR et al. Novel mutations in the Na+, K+-ATPase pump gene ATP1A2 associated with familial hemiplegic migraine and benign familial infantile convulsions.
Ann. Neurol., 2003 Sep , 54 (360-6).

540

Maselli RA et al. Effect of inherited abnormalities of calcium regulation on human neuromuscular transmission.
Ann. N. Y. Acad. Sci., 2003 Sep , 998 (18-28).

541

Plomp JJ et al. Transmitter release deficits at the neuromuscular synapse of mice with mutations in the Cav2.1 (alpha1A) subunit of the P/Q-type Ca2+ channel.
Ann. N. Y. Acad. Sci., 2003 Sep , 998 (29-32).

542

Cader ZM et al. Significant linkage to migraine with aura on chromosome 11q24.
Hum. Mol. Genet., 2003 Oct 1 , 12 (2511-7).

543

Akerman S et al. Voltage-dependent calcium channels are involved in neurogenic dural vasodilatation via a presynaptic transmitter release mechanism.
Br. J. Pharmacol., 2003 Oct , 140 (558-66).

544

Hashimoto T et al. Periodic alternating nystagmus and rebound nystagmus in spinocerebellar ataxia type 6.
Mov. Disord., 2003 Oct , 18 (1201-4).

545

Sadtler S et al. A basic cluster determines topology of the cytoplasmic M3-M4 loop of the glycine receptor alpha1 subunit.
J. Biol. Chem., 2003 May 9 , 278 (16782-90).

546

Tomaszewska-Zaremba D et al. The role of GABA(A) receptors in the neural systems of the medial preoptic area in the control of GnRH release in ewes during follicular phase.
Anim. Reprod. Sci., 2003 May 15 , 77 (71-83).

547

Kors EE et al. Expanding the phenotypic spectrum of the CACNA1A gene T666M mutation: a description of 5 families with familial hemiplegic migraine.
Arch. Neurol., 2003 May , 60 (684-8).

548

Butteriss DJ et al. Serial MRI in a case of familial hemiplegic migraine.
, 2003 May , 45 (300-3).

549

Jardim L et al. Searching for modulating effects of SCA2, SCA6 and DRPLA CAG tracts on the Machado-Joseph disease (SCA3) phenotype.
Acta Neurol. Scand., 2003 Mar , 107 (211-4).

550

Wieser T et al. Absence of known familial hemiplegic migraine (FHM) mutations in the CACNA1A gene in patients with common migraine: implications for genetic testing.
Clin. Chem. Lab. Med., 2003 Mar , 41 (272-5).

551

Ambrosini A et al. Acetazolamide acts on neuromuscular transmission abnormalities found in some migraineurs.
Cephalalgia, 2003 Mar , 23 (75-8).

552

Izumi Y et al. SCA8 repeat expansion: large CTA/CTG repeat alleles are more common in ataxic patients, including those with SCA6.
Am. J. Hum. Genet., 2003 Mar , 72 (704-9).

553

Spafford JD et al. Expression and modulation of an invertebrate presynaptic calcium channel alpha1 subunit homolog.
J. Biol. Chem., 2003 Jun 6 , 278 (21178-87).

554

Matsuyama Z et al. A novel insertion mutation of acetazolamide-responsive episodic ataxia in a Japanese family.
J. Neurol. Sci., 2003 Jun 15 , 210 (91-3).

555

Agler HL et al. Custom distinctions in the interaction of G-protein beta subunits with N-type (CaV2.2) versus P/Q-type (CaV2.1) calcium channels.
J. Gen. Physiol., 2003 Jun , 121 (495-510).

556

Kitano J et al. Direct interaction and functional coupling between metabotropic glutamate receptor subtype 1 and voltage-sensitive Cav2.1 Ca2+ channel.
J. Biol. Chem., 2003 Jul 4 , 278 (25101-8).

557

Matsumura R et al. Frequency of spinocerebellar ataxia mutations in the Kinki district of Japan.
Acta Neurol. Scand., 2003 Jan , 107 (38-41).

558

Hirose H et al. A family of episodic ataxia type 2: no evidence of genetic linkage to the CACNA1A gene.
Int. J. Mol. Med., 2003 Feb , 11 (187-9).

559

De Fusco M et al. Haploinsufficiency of ATP1A2 encoding the Na+/K+ pump alpha2 subunit associated with familial hemiplegic migraine type 2.
Nat. Genet., 2003 Feb , 33 (192-6).

560

Lee A et al. Molecular determinants of Ca(2+)/calmodulin-dependent regulation of Ca(v)2.1 channels.
Proc. Natl. Acad. Sci. U.S.A., 2003 Dec 23 , 100 (16059-64).

561

Maselli RA et al. Presynaptic failure of neuromuscular transmission and synaptic remodeling in EA2.
Neurology, 2003 Dec 23 , 61 (1743-8).

562

Subramony SH et al. Novel CACNA1A mutation causes febrile episodic ataxia with interictal cerebellar deficits.
Ann. Neurol., 2003 Dec , 54 (725-31).

563

Kubodera T et al. Proteolytic cleavage and cellular toxicity of the human alpha1A calcium channel in spinocerebellar ataxia type 6.
Neurosci. Lett., 2003 Apr 24 , 341 (74-8).

564

Mantuano E et al. Spinocerebellar ataxia type 6 and episodic ataxia type 2: differences and similarities between two allelic disorders.
Cytogenet. Genome Res., 2003 , 100 (147-53).

565

Zhou J et al. Phosphorylation and putative ER retention signals are required for protein kinase A-mediated potentiation of cardiac sodium current.
Circ. Res., 2002 Sep 20 , 91 (540-6).

566

Gallo A et al. Micro-processing events in mRNAs identified by DHPLC analysis.
Nucleic Acids Res., 2002 Sep 15 , 30 (3945-53).

567

Ducros A et al. The genetics of migraine.
, 2002 Sep , 1 (285-93).

568

Noble-Topham SE et al. Migraine with aura is not linked to the FHM gene CACNA1A or the chromosomal region, 19p13.
Neurology, 2002 Oct 8 , 59 (1099-101).

569

Tottene A et al. Familial hemiplegic migraine mutations increase Ca(2+) influx through single human CaV2.1 channels and decrease maximal CaV2.1 current density in neurons.
Proc. Natl. Acad. Sci. U.S.A., 2002 Oct 1 , 99 (13284-9).

570

Tomaszewska-Zaremba D et al. The Involvement of GABAA receptors in the control of GnRH and beta-endorphin release, and catecholaminergic activity in the preoptic area in anestrous ewes.
Exp. Clin. Endocrinol. Diabetes, 2002 Oct , 110 (336-42).

571

Helton TD et al. Alternative splicing of a beta4 subunit proline-rich motif regulates voltage-dependent gating and toxin block of Cav2.1 Ca2+ channels.
J. Neurosci., 2002 Nov 1 , 22 (9331-9).

572

van den Maagdenberg AM et al. Episodic ataxia type 2. Three novel truncating mutations and one novel missense mutation in the CACNA1A gene.
J. Neurol., 2002 Nov , 249 (1515-9).

573

Taschenberger G et al. Identification of a familial hyperinsulinism-causing mutation in the sulfonylurea receptor 1 that prevents normal trafficking and function of KATP channels.
J. Biol. Chem., 2002 May 10 , 277 (17139-46).

574

Takahashi T et al. Japanese cases of familial hemiplegic migraine with cerebellar ataxia carrying a T666M mutation in the CACNA1A gene.
J. Neurol. Neurosurg. Psychiatr., 2002 May , 72 (676-7).

575

Dorschner MO et al. Diagnosis of five spinocerebellar ataxia disorders by multiplex amplification and capillary electrophoresis.
, 2002 May , 4 (108-13).

576

Fukutake T et al. A patient homozygous for the SCA6 gene with retinitis pigmentosa.
Clin. Genet., 2002 May , 61 (375-9).

577

Geib S et al. The interaction between the I-II loop and the III-IV loop of Cav2.1 contributes to voltage-dependent inactivation in a beta -dependent manner.
J. Biol. Chem., 2002 Mar 22 , 277 (10003-13).

578

Wappl E et al. Functional consequences of P/Q-type Ca2+ channel Cav2.1 missense mutations associated with episodic ataxia type 2 and progressive ataxia.
J. Biol. Chem., 2002 Mar 1 , 277 (6960-6).

579

Tsunemi T et al. Novel Cav2.1 splice variants isolated from Purkinje cells do not generate P-type Ca2+ current.
J. Biol. Chem., 2002 Mar 1 , 277 (7214-21).

580

Kors EE et al. Calcium channel mutations and migraine.
Curr. Opin. Neurol., 2002 Jun , 15 (311-6).

581

Terwindt G et al. Mutation analysis of the CACNA1A calcium channel subunit gene in 27 patients with sporadic hemiplegic migraine.
Arch. Neurol., 2002 Jun , 59 (1016-8).

582

Maruyama H et al. Difference in disease-free survival curve and regional distribution according to subtype of spinocerebellar ataxia: a study of 1,286 Japanese patients.
Am. J. Med. Genet., 2002 Jul 8 , 114 (578-83).

583

Giffin NJ et al. Benign paroxysmal torticollis of infancy: four new cases and linkage to CACNA1A mutation.
, 2002 Jul , 44 (490-3).

584

Chioza B et al. CACNA1A and P/Q-type calcium channels in epilepsy.
Lancet, 2002 Jan 19 , 359 (258).

585

Wada T et al. Wide clinical variability in a family with a CACNA1A T666m mutation: hemiplegic migraine, coma, and progressive ataxia.
Pediatr. Neurol., 2002 Jan , 26 (47-50).

586

Baloh RW Episodic vertigo: central nervous system causes.
Curr. Opin. Neurol., 2002 Feb , 15 (17-21).

587

Pietrobon D Calcium channels and channelopathies of the central nervous system.
Mol. Neurobiol., 2002 Feb , 25 (31-50).

588

Vahedi K et al. Efficacy and tolerability of acetazolamide in migraine prophylaxis: a randomised placebo-controlled trial.
J. Neurol., 2002 Feb , 249 (206-11).

589

Gäddnäs H et al. Pineal melatonin and brain transmitter monoamines in CBA mice during chronic oral nicotine administration.
Brain Res., 2002 Dec 6 , 957 (76-83).

590

Arikkath J et al. Molecular characterization of a two-domain form of the neuronal voltage-gated P/Q-type calcium channel alpha(1)2.1 subunit.
FEBS Lett., 2002 Dec 18 , 532 (300-8).

591

Chioza B et al. Haplotype and linkage disequilibrium analysis to characterise a region in the calcium channel gene CACNA1A associated with idiopathic generalised epilepsy.
Eur. J. Hum. Genet., 2002 Dec , 10 (857-64).

592

Zamponi GW et al. Modulating modulation: crosstalk between regulatory pathways of presynaptic calcium channels.
Mol. Interv., 2002 Dec , 2 (476-8).

593

Tomaszewska-Zaremba D et al. The role of GABA(A) receptors in the neural systems of the ventromedial-infundibular region of the hypothalamus in the control of gonadotropin release during the luteal phase in ewes.
J. Physiol. Pharmacol., 2002 Dec , 53 (835-45).

594

Zhang Y et al. Mutations in high-voltage-activated calcium channel genes stimulate low-voltage-activated currents in mouse thalamic relay neurons.
J. Neurosci., 2002 Aug 1 , 22 (6362-71).

595

Kinoshita M [Binding of G alpha o N-terminus is responsible for the voltage-resistant inhibition of alpha 1A (P/Q-type, Cav2.1) Ca2+ channels]
Yakugaku Zasshi, 2002 Aug , 122 (565-72).

596

Baloh RW et al. Genetics of familial episodic vertigo and ataxia.
Ann. N. Y. Acad. Sci., 2002 Apr , 956 (338-45).

597

De Laet A et al. Immunohistochemical localization of voltage-activated calcium channels in the rat oesophagus.
Neurogastroenterol. Motil., 2002 Apr , 14 (173-81).

598

Sander T et al. Failure to replicate an allelic association between an exon 8 polymorphism of the human alpha(1A) calcium channel gene and common syndromes of idiopathic generalized epilepsy.
Epilepsy Res., 2002 Apr , 49 (173-7).

599

Brugnoni R et al. Is the CACNA1A gene involved in familial migraine with aura?
Neurol. Sci., 2002 Apr , 23 (1-5).

600

Cevoli S et al. Familial hemiplegic migraine: clinical features and probable linkage to chromosome 1 in an Italian family.
Neurol. Sci., 2002 Apr , 23 (7-10).

601

Ferrari MD et al. The genetics of migraine: implication for treatment approaches.
J. Neural Transm. Suppl., 2002 , (111-27).

602

Carrera P et al. Familial hemiplegic migraine: a ion channel disorder.
Brain Res. Bull., 2001 Oct-Nov 1 , 56 (239-41).

603

Frontali M Spinocerebellar ataxia type 6: channelopathy or glutamine repeat disorder?
Brain Res. Bull., 2001 Oct-Nov 1 , 56 (227-31).

604

Jouvenceau A et al. Human epilepsy associated with dysfunction of the brain P/Q-type calcium channel.
Lancet, 2001 Sep 8 , 358 (801-7).

605

Ambrosini A et al. Neuromuscular transmission in migraine patients with prolonged aura.
, 2001 Sep , 101 (166-70).

606

Tomaszewska-Zaremba D et al. The involvement of GABA(A) receptors in the control of GnRH and beta-endorphin release, and catecholaminergic activity in the ventromedial-infundibular region of hypothalamus in anestrous ewes.
J. Physiol. Pharmacol., 2001 Sep , 52 (489-500).

607

Stange M et al. Two domains in dihydropyridine receptor activate the skeletal muscle Ca(2+) release channel.
Biophys. J., 2001 Sep , 81 (1419-29).

608

Plomp JJ et al. Mutant P/Q-type calcium channel electrophysiology and migraine.
, 2001 Sep , 2 (1250-60).

609

Mariotti C et al. Pathogenic effect of an intermediate-size SCA-6 allele (CAG)(19) in a homozygous patient.
Neurology, 2001 Oct 23 , 57 (1502-4).

610

Østergaard E et al. [Molecular genetic findings in migraine]
Ugeskr. Laeg., 2001 Nov 5 , 163 (6260-5).

611

Jen J et al. Loss-of-function EA2 mutations are associated with impaired neuromuscular transmission.
Neurology, 2001 Nov 27 , 57 (1843-8).

612

Komeichi K et al. Twenty CAG repeats are sufficient to cause the SCA6 phenotype.
J. Med. Genet., 2001 Nov , 38 (E38).

613

Chioza B et al. Association between the alpha(1a) calcium channel gene CACNA1A and idiopathic generalized epilepsy.
Neurology, 2001 May 8 , 56 (1245-6).

614

Fletcher CF et al. Dystonia and cerebellar atrophy in Cacna1a null mice lacking P/Q calcium channel activity.
FASEB J., 2001 May , 15 (1288-90).