Channelpedia

Kir2.1

1111 literature references associated to Kir2.1

used / unused
Pubmed id

1

364897

3

365734

Ye W et al. The K+ channel KIR2.1 functions in tandem with proton influx to mediate sour taste transduction.
Proc. Natl. Acad. Sci. U.S.A., 2016 Jan 12 , 113 (E229-38).

6

365051

Asmar A et al. Membrane channel gene expression in human costal and articular chondrocytes.
Organogenesis, 2016 Apr 2 , 12 (94-107).

9

356252

Climent AM et al. The Role of Atrial Tissue Remodeling on Rotor Dynamics: An In-Vitro Study.
Am. J. Physiol. Heart Circ. Physiol., 2015 Sep 25 , (ajpheart.00055.2015).

11

356702

Wu Y et al. Two inwardly rectifying potassium channels, Irk1 and Irk2, play redundant roles in Drosophila renal tubule function.
Am. J. Physiol. Regul. Integr. Comp. Physiol., 2015 Oct , 309 (R747-56).

13

357548

14

363053

Liu XL et al. Case report: A Chinese child with Andersen-Tawil syndrome due to a de novo KCNJ2 mutation.
J. Neurol. Sci., 2015 May 15 , 352 (105-6).

16

367729

DiFranco M et al. Inward rectifier potassium currents in mammalian skeletal muscle fibres.
J. Physiol. (Lond.), 2015 Mar 1 , 593 (1213-38).

21

366664

22

357437

27

350278

Sacco S et al. The inward rectifier potassium channel Kir2.1 is required for osteoblastogenesis.
Hum. Mol. Genet., 2015 Jan 15 , 24 (471-9).

28

355803

29

358328

31

358937

Amaral AC et al. Prenatal protein malnutrition decreases KCNJ3 and 2DG activity in rat prefrontal cortex.
Neuroscience, 2015 Feb 12 , 286 (79-86).

32

349296

Masia R et al. The inward rectifier potassium channel Kir2.1 is expressed in mouse neutrophils from bone marrow and liver.
Am. J. Physiol., Cell Physiol., 2015 Feb 1 , 308 (C264-76).

34

351583

36

365692

Li WP et al. [Function and expression of inwardly rectifying potassium channel Kir2.1].
Sheng Li Ke Xue Jin Zhan, 2015 Aug , 46 (287-9).

38

357716

Huang Y et al. [Combined transgenic inhibition of CaMKII and Ik1 on cardiac remodeling].
Sheng Li Xue Bao, 2015 Apr 25 , 67 (201-6).

39

355666

Willis BC et al. Protein Assemblies of Sodium and Inward Rectifier Potassium Channels Control Cardiac Excitability and Arrhythmogenesis.
Am. J. Physiol. Heart Circ. Physiol., 2015 Apr 10 , (ajpheart.00176.2015).

40

358375

Lee JY et al. The role of K⁺ conductances in regulating membrane excitability in human gastric corpus smooth muscle.
Am. J. Physiol. Gastrointest. Liver Physiol., 2015 Apr 1 , 308 (G625-33).

41

357760

Cannon SC Channelopathies of skeletal muscle excitability.
Compr Physiol, 2015 Apr , 5 (761-90).

42

349242

Okada M et al. A pore forming peptide from spider Lachesana sp. venom induced neuronal depolarization and pain.
Biochim. Biophys. Acta, 2015 Apr , 1850 (657-66).

43

363895

44

357726

53

363198

Wu CL et al. A single pair of neurons modulates egg-laying decisions in Drosophila.
PLoS ONE, 2015 , 10 (e0121335).

63

350028

66

349534

Rosenhouse-Dantsker A et al. Interplay Between Lipid Modulators of Kir2 Channels: Cholesterol and PIP2.
Comput Struct Biotechnol J, 2014 Sep , 11 (131-7).

68

350425

Singhal R et al. Colchicine suppresses atrial fibrillation in failing heart.
Int. J. Cardiol., 2014 Oct 20 , 176 (651-60).

69

350720

Shi D et al. Reduction in dynamin-2 is implicated in ischaemic cardiac arrhythmias.
J. Cell. Mol. Med., 2014 Oct , 18 (1992-9).

70

364239

Gómez R et al. Structural basis of drugs that increase cardiac inward rectifier Kir2.1 currents.
Cardiovasc. Res., 2014 Nov 1 , 104 (337-46).

72

352522

76

345161

Zhang YY et al. Characterization of functional ion channels in human cardiac c-kit+ progenitor cells.
Basic Res. Cardiol., 2014 May , 109 (407).

78

345519

Kokunai Y et al. A Kir3.4 mutation causes Andersen-Tawil syndrome by an inhibitory effect on Kir2.1.
Neurology, 2014 Mar 25 , 82 (1058-64).

80

345290

Raphemot R et al. Direct activation of β-cell KATP channels with a novel xanthine derivative.
Mol. Pharmacol., 2014 Jun , 85 (858-65).

81

351097

82

341449

Hassinen M et al. Seasonal acclimatization of the cardiac action potential in the Arctic navaga cod (Eleginus navaga, Gadidae).
J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol., 2014 Jan 7 , ().

84

354363

87

353190

88

341823

Kolb AR et al. ESCRT regulates surface expression of the Kir2.1 potassium channel.
Mol. Biol. Cell, 2014 Jan , 25 (276-89).

89

345901

Sheng J et al. Electrophysiology of human cardiac atrial and ventricular telocytes.
J. Cell. Mol. Med., 2014 Feb , 18 (355-62).

92

367747

Fürst O et al. Identification of a cholesterol-binding pocket in inward rectifier K(+) (Kir) channels.
Biophys. J., 2014 Dec 16 , 107 (2786-96).

95

364008

Lefter S et al. Andersen-Tawil syndrome with early fixed myopathy.
J Clin Neuromuscul Dis, 2014 Dec , 16 (79-82).

96

359758

Xynogalos P et al. Class III antiarrhythmic drug dronedarone inhibits cardiac inwardly rectifying Kir2.1 channels through binding at residue E224.
Naunyn Schmiedebergs Arch. Pharmacol., 2014 Dec , 387 (1153-61).

99

364493

Díaz-Manera J et al. Severe exacerbation of Andersen-Tawil syndrome secondary to thyrotoxicosis.
J. Hum. Genet., 2014 Aug , 59 (465-6).

101

345317

Farhy Tselnicker I et al. Dual regulation of G proteins and the G-protein-activated K+ channels by lithium.
Proc. Natl. Acad. Sci. U.S.A., 2014 Apr 1 , 111 (5018-23).

104

345608

Munoz C et al. Up-regulation of Kir2.1 (KCNJ2) by the serum & glucocorticoid inducible SGK3.
Cell. Physiol. Biochem., 2014 , 33 (491-500).

108

358466

Kumar M et al. Focus on Kir7.1: physiology and channelopathy.
Channels (Austin), 2014 , 8 (488-95).

110

367910

111

339654

Rosenhouse-Dantsker A et al. Identification of novel cholesterol-binding regions in Kir2 channels.
J. Biol. Chem., 2013 Sep 9 , ().

112

339524

Duan X Ion Channels, Channelopathies, and Tooth Formation.
J. Dent. Res., 2013 Sep 27 , ().

113

347177

Ramos-Hunter SJ et al. Discovery and SAR of a novel series of GIRK1/2 and GIRK1/4 activators.
Bioorg. Med. Chem. Lett., 2013 Sep 15 , 23 (5195-8).

114

339621

Cordeiro JM et al. Developmental changes in expression and biophysics of ion channels in the canine ventricle.
J. Mol. Cell. Cardiol., 2013 Sep 10 , 64C (79-89).

115

346752

Fernlund E et al. Novel mutation in the KCNJ2 gene is associated with a malignant arrhythmic phenotype of Andersen-Tawil syndrome.
Ann Noninvasive Electrocardiol, 2013 Sep , 18 (471-8).

116

347141

118

342059

120

339984

Gunnarsson TP et al. Effect of intensified training on muscle ion kinetics, fatigue development, and repeated short-term performance in endurance-trained cyclists.
Am. J. Physiol. Regul. Integr. Comp. Physiol., 2013 Oct , 305 (R811-R821).

122

346513

Lee YS et al. Long QT syndrome: a Korean single center study.
J. Korean Med. Sci., 2013 Oct , 28 (1454-60).

123

346806

124

347526

Wu XN et al. Sucrose-induced receptor kinase SIRK1 regulates a plasma membrane aquaporin in Arabidopsis.
Mol. Cell Proteomics, 2013 Oct , 12 (2856-73).

126

344177

Mishra B et al. Sodium and potassium currents influence Wallerian degeneration of injured Drosophila axons.
J. Neurosci., 2013 Nov 27 , 33 (18728-39).

127

341770

128

340181

Waters CW et al. Huntington disease skeletal muscle is hyperexcitable owing to chloride and potassium channel dysfunction.
Proc. Natl. Acad. Sci. U.S.A., 2013 May 28 , 110 (9160-5).

129

335733

130

336167

Deo M et al. KCNJ2 mutation in short QT syndrome 3 results in atrial fibrillation and ventricular proarrhythmia.
Proc. Natl. Acad. Sci. U.S.A., 2013 Mar 12 , 110 (4291-6).

133

340324

D'Avanzo N et al. Energetics and location of phosphoinositide binding in human Kir2.1 channels.
J. Biol. Chem., 2013 Jun 7 , 288 (16726-37).

134

334975

Rosenhouse-Dantsker A et al. Cholesterol sensitivity of KIR2.1 depends on Functional inter-links between the N and C termini.
Channels (Austin), 2013 Jun 27 , 7 ().

136

347680

137

334799

141

335463

Takanari H et al. Efficient and specific cardiac IK1 inhibition by a new pentamidine analogue.
Cardiovasc. Res., 2013 Jul 1 , 99 (203-14).

142

347948

143

335394

144

336084

147

336607

148

340832

Yamamoto Y et al. Amiodarone inhibits tissue factor expression in monocytic THP-1 cells.
Eur. J. Pharmacol., 2013 Feb 15 , 701 (14-9).

150

336403

Lieu DK et al. Mechanism-based facilitated maturation of human pluripotent stem cell-derived cardiomyocytes.
Circ Arrhythm Electrophysiol, 2013 Feb , 6 (191-201).

151

338259

Chang HK et al. Voltage-dependent inhibition of outward Kir2.1 currents by extracellular spermine.
Biochim. Biophys. Acta, 2013 Feb , 1828 (765-75).

152

353493

Nguyen HL et al. Andersen-Tawil syndrome: clinical and molecular aspects.
Int. J. Cardiol., 2013 Dec 5 , 170 (1-16).

154

354732

156

339438

157

347462

160

344282

Huang W et al. Antiarrhythmic effects and ionic mechanisms of allicin on myocardial injury of diabetic rats induced by streptozotocin.
Naunyn Schmiedebergs Arch. Pharmacol., 2013 Aug , 386 (697-704).

161

339969

Szuts V et al. Altered expression of genes for Kir ion channels in dilated cardiomyopathy.
Can. J. Physiol. Pharmacol., 2013 Aug , 91 (648-56).

163

335877

165

336655

169

334905

171

347537

177

348031

178

355052

179

331378

181

331739

184

331350

Dahal GR et al. An inwardly rectifying K+ channel is required for patterning.
Development, 2012 Oct , 139 (3653-64).

187

337516

Kirkton RD et al. Genetic engineering of somatic cells to study and improve cardiac function.
Europace, 2012 Nov , 14 Suppl 5 (v40-v49).

188

337526

Yang L et al. Interactions of external K+ and internal blockers in a weak inward-rectifier K+ channel.
J. Gen. Physiol., 2012 Nov , 140 (529-40).

191

333628

194

326727

Troncoso Brindeiro CM et al. Tempol prevents altered K(+) channel regulation of afferent arteriolar tone in diabetic rat kidney.
Hypertension, 2012 Mar , 59 (657-64).

196

333375

Sitaraman D et al. Serotonin is critical for rewarded olfactory short-term memory in Drosophila.
J. Neurogenet., 2012 Jun , 26 (238-44).

197

328011

Gönczi M et al. Age-dependent changes in ion channel mRNA expression in canine cardiac tissues.
Gen. Physiol. Biophys., 2012 Jun , 31 (153-62).

198

332769

Kimura H et al. Phenotype variability in patients carrying KCNJ2 mutations.
Circ Cardiovasc Genet, 2012 Jun , 5 (344-53).

199

333117

200

332116

Kulzer M et al. Inhibition of cardiac Kir2.1-2.3 channels by beta3 adrenoreceptor antagonist SR 59230A.
Biochem. Biophys. Res. Commun., 2012 Jul 27 , 424 (315-20).

203

333565

Marjamaa A et al. A common variant near the KCNJ2 gene is associated with T-peak to T-end interval.
Heart Rhythm, 2012 Jul , 9 (1099-103).

204

338971

Hocking JC et al. Neural activity and branching of embryonic retinal ganglion cell dendrites.
Mech. Dev., 2012 Jul , 129 (125-35).

205

327697

209

326701

211

326574

213

336961

Wydeven N et al. Structural elements in the Girk1 subunit that potentiate G protein-gated potassium channel activity.
Proc. Natl. Acad. Sci. U.S.A., 2012 Dec 26 , 109 (21492-7).

216

338334

Song YW et al. Normokalemic periodic paralysis is not a distinct disease.
Muscle Nerve, 2012 Dec , 46 (914-6).

217

331368

Robertson JL et al. Multi-ion distributions in the cytoplasmic domain of inward rectifier potassium channels.
Biophys. J., 2012 Aug 8 , 103 (434-43).

220

331867

221

334695

225

328736

Adeniran I et al. Proarrhythmia in KCNJ2-linked short QT syndrome: insights from modelling.
Cardiovasc. Res., 2012 Apr 1 , 94 (66-76).

230

336819

232

321461

Lü Q et al. Identification of GIRK2-4 subunits in human esophageal smooth muscle cells.
Mol Med Report, 2011 Sep-Oct , 4 (941-5).

235

324185

Ferrer T et al. Carvedilol inhibits Kir2.3 channels by interference with PIP₂-channel interaction.
Eur. J. Pharmacol., 2011 Oct 1 , 668 (72-7).

241

323998

242

320676

Parvez B et al. The "missing" link in atrial fibrillation heritability.
J Electrocardiol, 2011 Nov , 44 (641-4).

243

326289

244

319711

245

319741

Alesutan I et al. Inhibition of Kir2.1 (KCNJ2) by the AMP-activated protein kinase.
Biochem. Biophys. Res. Commun., 2011 May 20 , 408 (505-10).

247

317643

Dassau L et al. Kir2.6 regulates the surface expression of Kir2.x inward rectifier potassium channels.
J. Biol. Chem., 2011 Mar 18 , 286 (9526-41).

250

319384

251

322114

Wu Y et al. GABAB receptor-mediated tonic inhibition of noradrenergic A7 neurons in the rat.
J. Neurophysiol., 2011 Jun , 105 (2715-28).

254

318870

255

322147

Jang SS et al. Endothelial progenitor cells functionally express inward rectifier potassium channels.
Am. J. Physiol., Cell Physiol., 2011 Jul , 301 (C150-61).

256

322173

Vortherms TA et al. Comparative analysis of inactivated-state block of N-type (Ca(v)2.2) calcium channels.
Inflamm. Res., 2011 Jul , 60 (683-93).

257

316240

259

316777

Rosenhouse-Dantsker A et al. Cholesterol sensitivity of KIR2.1 is controlled by a belt of residues around the cytosolic pore.
Biophys. J., 2011 Jan 19 , 100 (381-9).

263

314035

Cheng WW et al. Dual-mode phospholipid regulation of human inward rectifying potassium channels.
Biophys. J., 2011 Feb 2 , 100 (620-8).

265

316875

268

326364

272

319547

El Gebeily G et al. Upregulation of ventricular potassium channels by chronic tamoxifen treatment.
Cardiovasc. Res., 2011 Apr 1 , 90 (68-76).

273

319739

282

140085

Vaidyanathan R et al. Regulation of cardiac inward rectifier potassium current (I(K1)) by synapse-associated protein-97.
J. Biol. Chem., 2010 Sep 3 , 285 (28000-9).

284

139583

Arora D et al. Altered neurotransmission in the mesolimbic reward system of Girk mice.
J. Neurochem., 2010 Sep 1 , 114 (1487-97).

288

138329

Sordel T et al. The development of high quality seals for silicon patch-clamp chips.
Biomaterials, 2010 Oct , 31 (7398-410).

289

314847

Panama BK et al. Functional consequences of Kir2.1/Kir2.2 subunit heteromerization.
Pflugers Arch., 2010 Oct , 460 (839-49).

293

139127

294

138562

Kurata HT et al. Locale and chemistry of spermine binding in the archetypal inward rectifier Kir2.1.
J. Gen. Physiol., 2010 May , 135 (495-508).

295

319614

296

124980

297

136108

Tristani-Firouzi M et al. Kir 2.1 channelopathies: the Andersen-Tawil syndrome.
, 2010 Mar 21 , ().

300

138576

Ciurzyński M et al. [QTU pattern in a patient with the Anderson-Tawil syndrome]
Kardiol Pol, 2010 Mar , 68 (339-41; discussion 342).

305

140114

López-Izquierdo A et al. Thiopental inhibits function of different inward rectifying potassium channel isoforms by a similar mechanism.
Eur. J. Pharmacol., 2010 Jul 25 , 638 (33-41).

307

139059

308

121214

Rosenhouse-Dantsker A et al. Comparative analysis of cholesterol sensitivity of Kir channels: Role of the CD loop.
Channels (Austin), 2010 Jan 20 , 4 ().

310

122420

314

136914

Kristensen M et al. Potassium-transporting proteins in skeletal muscle: cellular location and fibre-type differences.
Acta Physiol (Oxf), 2010 Feb , 198 (105-23).

315

315375

Serratrice G et al. [Potassium channelopathies and Morvan's syndromes].
Bull. Acad. Natl. Med., 2010 Feb , 194 (391-406; discussion 406-7).

317

318667

Walsh KB A real-time screening assay for GIRK1/4 channel blockers.
J Biomol Screen, 2010 Dec , 15 (1229-37).

318

140948

Caballero R et al. Flecainide increases Kir2.1 currents by interacting with cysteine 311, decreasing the polyamine-induced rectification.
Proc. Natl. Acad. Sci. U.S.A., 2010 Aug 31 , 107 (15631-6).

319

139379

Zhang T et al. LQTS gene LOVD database.
, 2010 Aug 31 , ().

320

138218

Rajakulendran S et al. Muscle weakness, palpitations and a small chin: the Andersen-Tawil syndrome.
Pract Neurol, 2010 Aug , 10 (227-31).

321

137553

Yamada A et al. Role of pre- and postsynaptic activity in thalamocortical axon branching.
Proc. Natl. Acad. Sci. U.S.A., 2010 Apr 20 , 107 (7562-7).

330

6832

Lee HA et al. Cellular mechanism of the QT prolongation induced by sulpiride.
Int. J. Toxicol., 2009 May-Jun , 28 (207-12).

331

122163

332

131542

333

122689

335

124353

Sacconi S et al. Mechanisms underlying Andersen's syndrome pathology in skeletal muscle are revealed in human myotubes.
Am. J. Physiol., Cell Physiol., 2009 Oct , 297 (C876-85).

338

121201

344

2431

Schweizer PA et al. Transcription profiling of HCN-channel isotypes throughout mouse cardiac development.
Basic Res. Cardiol., 2009 May 7 , ().

345

2525

Epshtein Y et al. Identification of a C-terminus domain critical for the sensitivity of Kir2.1 to cholesterol.
Proc. Natl. Acad. Sci. U.S.A., 2009 May 12 , 106 (8055-60).

346

131768

Chen J et al. PKA phosphorylation of HERG protein regulates the rate of channel synthesis.
Am. J. Physiol. Heart Circ. Physiol., 2009 May , 296 (H1244-54).

347

3457

Ishihara K et al. Heteromeric assembly of inward rectifier channel subunit Kir2.1 with Kir3.1 and with Kir3.4.
Biochem. Biophys. Res. Commun., 2009 Mar 20 , 380 (832-7).

348

3295

Kim Y et al. High throughput screening assay of alpha(1G) T-type Ca2+ channels and comparison with patch-clamp studies.
Comb. Chem. High Throughput Screen., 2009 Mar , 12 (296-302).

349

5550

Zaks-Makhina E et al. Specific and slow inhibition of the kir2.1 K+ channel by gambogic acid.
J. Biol. Chem., 2009 Jun 5 , 284 (15432-8).

350

8578

Aryal P et al. A discrete alcohol pocket involved in GIRK channel activation.
Nat. Neurosci., 2009 Jun 28 , ().

352

2254

Ureche ON et al. Differential modulation of cardiac potassium channels by Grb adaptor proteins.
Biochem. Biophys. Res. Commun., 2009 Jun 19 , 384 (28-31).

355

123687

Wagner S et al. Ca/calmodulin kinase II differentially modulates potassium currents.
Circ Arrhythm Electrophysiol, 2009 Jun , 2 (285-94).

357

5109

Sridhar A et al. Chronic heart failure and the substrate for atrial fibrillation.
Cardiovasc. Res., 2009 Jul 17 , ().

359

131606

361

1322

362

3946

363

6230

Boyer SB et al. Regulation of Kir2.1 channels by the Rho-GTPase, Rac1.
J. Cell. Physiol., 2009 Feb , 218 (385-93).

365

8494

Chang HK et al. K+ binding in the G-loop and water cavity facilitates Ba2+ movement in the Kir2.1 channel.
Biochim. Biophys. Acta, 2009 Feb , 1788 (500-6).

366

3599

Félétou M Calcium-activated potassium channels and endothelial dysfunction: therapeutic options?
Br. J. Pharmacol., 2009 Feb , 156 (545-62).

367

136403

Iturralde-Torres P et al. [Genetic in long QT syndromes]
Arch Cardiol Mex, 2009 Dec , 79 Suppl 2 (26-30).

368

121355

Kim JB et al. Novel de novo mutation in the KCNJ2 gene in a patient with Andersen-Tawil syndrome.
Pediatr. Neurol., 2009 Dec , 41 (464-6).

369

315236

Girmatsion Z et al. Changes in microRNA-1 expression and IK1 up-regulation in human atrial fibrillation.
Heart Rhythm, 2009 Dec , 6 (1802-9).

370

120431

372

121048

373

131720

Pfeufer A et al. Common variants at ten loci modulate the QT interval duration in the QTSCD Study.
Nat. Genet., 2009 Apr , 41 (407-14).

376

131500

377

131386

Hodge JJ Ion channels to inactivate neurons in Drosophila.
Front Mol Neurosci, 2009 , 2 (13).

378

131344

381

6748

382

7622

Grunnet M et al. hERG1 channel activators: a new anti-arrhythmic principle.
Prog. Biophys. Mol. Biol., 2008 Oct-Nov , 98 (347-62).

383

5965

Jin T et al. Stoichiometry of Kir channels with phosphatidylinositol bisphosphate.
Channels (Austin), 2008 Jan-Feb , 2 (19-33).

387

1521

Saenz del Burgo L et al. Distribution and neurochemical characterization of neurons expressing GIRK channels in the rat brain.
J. Comp. Neurol., 2008 Oct 20 , 510 (581-606).

389

4551

Park WS et al. Physiological role of inward rectifier K(+) channels in vascular smooth muscle cells.
Pflugers Arch., 2008 Oct , 457 (137-47).

390

7591

Yontar OC et al. Short QT syndrome: a very rare arrhythmogenic entity.
Acta Cardiol, 2008 Oct , 63 (553-5).

393

1004

Pouget J [A new type of periodic paralysis: Andersen-Tawil syndrome]
Bull. Acad. Natl. Med., 2008 Nov , 192 (1551-6; discussion 1556-7).

394

9829

Zhao Z et al. Molecular basis for genistein-induced inhibition of Kir2.3 currents.
Pflugers Arch., 2008 May , 456 (413-23).

395

3123

Schimpf R et al. Clinical and molecular genetics of the short QT syndrome.
Curr. Opin. Cardiol., 2008 May , 23 (192-8).

396

14782

Millar ID et al. Kv1 and Kir2 potassium channels are expressed in rat brain endothelial cells.
Pflugers Arch., 2008 May , 456 (379-91).

397

1352

Jansen JA et al. Lysosome mediated Kir2.1 breakdown directly influences inward rectifier current density.
Biochem. Biophys. Res. Commun., 2008 Mar 14 , 367 (687-92).

398

13484

Veeraraghavan R et al. Mechanisms underlying increased right ventricular conduction sensitivity to flecainide challenge.
Cardiovasc. Res., 2008 Mar 1 , 77 (749-56).

402

2507

Perry CA et al. Predisposition to late-onset obesity in GIRK4 knockout mice.
Proc. Natl. Acad. Sci. U.S.A., 2008 Jun 10 , 105 (8148-53).

403

1084

Tsai CT et al. Molecular genetics of atrial fibrillation.
J. Am. Coll. Cardiol., 2008 Jul 22 , 52 (241-50).

404

4633

Pravetoni M et al. Behavioral characterization of mice lacking GIRK/Kir3 channel subunits.
Genes Brain Behav., 2008 Jul , 7 (523-31).

406

5945

Rodríguez-Menchaca AA et al. The molecular basis of chloroquine block of the inward rectifier Kir2.1 channel.
Proc. Natl. Acad. Sci. U.S.A., 2008 Jan 29 , 105 (1364-8).

407

5063

Chilton L et al. Inward rectifier K+ currents and Kir2.1 expression in renal afferent and efferent arterioles.
J. Am. Soc. Nephrol., 2008 Jan , 19 (69-76).

408

11771

Park HJ et al. Parasympathetic response in chick myocytes and mouse heart is controlled by SREBP.
J. Clin. Invest., 2008 Jan , 118 (259-71).

409

11392

410

1607

Kang SJ et al. Expression of Kir2.1 channels in astrocytes under pathophysiological conditions.
Mol. Cells, 2008 Feb 29 , 25 (124-30).

411

8402

Yankelson L et al. Cell therapy for modification of the myocardial electrophysiological substrate.
Circulation, 2008 Feb 12 , 117 (720-31).

416

200

Robertson JL et al. Long-pore electrostatics in inward-rectifier potassium channels.
J. Gen. Physiol., 2008 Dec , 132 (613-32).

417

123925

418

2880

Lewandowski R et al. RXP-E: a connexin43-binding peptide that prevents action potential propagation block.
Circ. Res., 2008 Aug 29 , 103 (519-26).

419

2720

Brevet M et al. Expression of K+ channels in normal and cancerous human breast.
Histol. Histopathol., 2008 Aug , 23 (965-72).

420

9508

Ehrlich JR Inward rectifier potassium currents as a target for atrial fibrillation therapy.
J. Cardiovasc. Pharmacol., 2008 Aug , 52 (129-35).

422

2188

Hernandez CC et al. Regulation of neural KCNQ channels: signalling pathways, structural motifs and functional implications.
J. Physiol. (Lond.), 2008 Apr 1 , 586 (1811-21).

423

8034

424

5502

427

7840

428

3451

431

9201

432

17833

Inanobe A et al. Structural diversity in the cytoplasmic region of G protein-gated inward rectifier K+ channels.
Channels (Austin), 2007 Jan-Feb , 1 (39-45).

434

18887

439

18078

Piao L et al. Transgenic upregulation of IK1 in the mouse heart is proarrhythmic.
Basic Res. Cardiol., 2007 Sep , 102 (416-28).

440

16061

Ohno Y et al. Inhibition of astroglial Kir4.1 channels by selective serotonin reuptake inhibitors.
Brain Res., 2007 Oct 31 , 1178 (44-51).

442

11127

Putzke C et al. Differential effects of volatile and intravenous anesthetics on the activity of human TASK-1.
Am. J. Physiol., Cell Physiol., 2007 Oct , 293 (C1319-26).

443

15137

444

11119

Tao R et al. Functional ion channels in mouse bone marrow mesenchymal stem cells.
Am. J. Physiol., Cell Physiol., 2007 Nov , 293 (C1561-7).

447

137889

Wei YP et al. [Primary cultured neonate rat sinus node cells: morphology and expression of kir2.1 protein]
Nan Fang Yi Ke Da Xue Xue Bao, 2007 Nov , 27 (1701-5).

448

13391

450

17868

Wolpert C et al. [Short QT syndrome]
, 2007 May , 32 (206-10).

451

18471

Liu B et al. Selective inhibition of Kir currents by antihistamines.
Eur. J. Pharmacol., 2007 Mar 8 , 558 (21-6).

453

18776

Peters S et al. Sudden cardiac death in Andersen-Tawil syndrome.
, 2007 Mar , 9 (162-6).

454

132706

Extramiana F Screening for KCNJ2 mutations: the physician's perspective.
Heart Rhythm, 2007 Mar , 4 (330-1).

456

14813

Jakobsen LP et al. Pierre Robin sequence may be caused by dysregulation of SOX9 and KCNJ2.
J. Med. Genet., 2007 Jun , 44 (381-6).

457

19134

Hassinen M et al. Cloning and expression of cardiac Kir2.1 and Kir2.2 channels in thermally acclimated rainbow trout.
Am. J. Physiol. Regul. Integr. Comp. Physiol., 2007 Jun , 292 (R2328-39).

458

16611

459

132632

462

132779

Arnestad M et al. Prevalence of long-QT syndrome gene variants in sudden infant death syndrome.
Circulation, 2007 Jan 23 , 115 (361-7).

465

18090

468

13039

469

18406

Brouillette J et al. Characterization of ventricular repolarization in male and female guinea pigs.
J. Mol. Cell. Cardiol., 2007 Feb , 42 (357-66).

470

11000

474

18908

Panama BK et al. Heterogeneity of IK1 in the mouse heart.
Am. J. Physiol. Heart Circ. Physiol., 2007 Dec , 293 (H3558-67).

476

14333

Juel C et al. K+ as a vasodilator in resting human muscle: implications for exercise hyperaemia.
Acta Physiol (Oxf), 2007 Aug , 190 (311-8).

477

13741

Kurata HT et al. The role of the cytoplasmic pore in inward rectification of Kir2.1 channels.
J. Gen. Physiol., 2007 Aug , 130 (145-55).

479

13434

480

19494

481

11659

Bendahhou S et al. Corticosteroid-exacerbated symptoms in an Andersen's syndrome kindred.
Hum. Mol. Genet., 2007 Apr 15 , 16 (900-6).

483

19848

Kawano T et al. Interaction of Galphaq and Kir3, G protein-coupled inwardly rectifying potassium channels.
Mol. Pharmacol., 2007 Apr , 71 (1179-84).

484

18974

Sansone V et al. Management and treatment of Andersen-Tawil syndrome (ATS).
, 2007 Apr , 4 (233-7).

486

132676

487

132678

Volders PG et al. Mapping a novel locus for familial atrial fibrillation on chromosome 10p11-q21.
Heart Rhythm, 2007 Apr , 4 (469-75).

488

17813

489

5296

Steinecker B et al. The GIRK1 brain variant GIRK1d and its functional impact on heteromultimeric GIRK channels.
J. Recept. Signal Transduct. Res., 2007 , 27 (369-82).

490

17185

Fülöp L et al. Effects of sex hormones on ECG parameters and expression of cardiac ion channels in dogs.
Acta Physiol (Oxf), 2006 Nov-Dec , 188 (163-71).

491

19424

Thum AS et al. Differential potencies of effector genes in adult Drosophila.
J. Comp. Neurol., 2006 Sep 10 , 498 (194-203).

492

26120

Shumilina E et al. Cytoplasmic accumulation of long-chain coenzyme A esters activates KATP and inhibits Kir2.1 channels.
J. Physiol. (Lond.), 2006 Sep 1 , 575 (433-42).

493

28210

Jantzi MC et al. Inward rectifying potassium channels facilitate cell-to-cell communication in hamster retractor muscle feed arteries.
Am. J. Physiol. Heart Circ. Physiol., 2006 Sep , 291 (H1319-28).

496

17684

497

14205

Kobayashi T et al. Inhibition of G protein-activated inwardly rectifying K+ channels by the antidepressant paroxetine.
J. Pharmacol. Sci., 2006 Nov , 102 (278-87).

500

25047

501

26323

Sackin H et al. Role of conserved glycines in pH gating of Kir1.1 (ROMK).
Biophys. J., 2006 May 15 , 90 (3582-9).

502

27625

Iandiev I et al. Glial cell reactivity in a porcine model of retinal detachment.
Invest. Ophthalmol. Vis. Sci., 2006 May , 47 (2161-71).

503

25768

Fernández-Velasco M et al. I K1 and I f in ventricular myocytes isolated from control and hypertrophied rat hearts.
Pflugers Arch., 2006 May , 452 (146-54).

504

22768

Kurata HT et al. The polyamine binding site in inward rectifier K+ channels.
J. Gen. Physiol., 2006 May , 127 (467-80).

507

27887

Iandiev I et al. Differential regulation of Kir4.1 and Kir2.1 expression in the ischemic rat retina.
Neurosci. Lett., 2006 Mar 27 , 396 (97-101).

508

28952

Panama BK et al. Differential polyamine sensitivity in inwardly rectifying Kir2 potassium channels.
J. Physiol. (Lond.), 2006 Mar 1 , 571 (287-302).

510

25802

Kristensen M et al. Membrane proteins involved in potassium shifts during muscle activity and fatigue.
Am. J. Physiol. Regul. Integr. Comp. Physiol., 2006 Mar , 290 (R766-72).

511

23278

Kobayashi T et al. Inhibition of G protein-activated inwardly rectifying K+ channels by ifenprodil.
Neuropsychopharmacology, 2006 Mar , 31 (516-24).

512

24990

Yoon G et al. Andersen-Tawil syndrome: definition of a neurocognitive phenotype.
Neurology, 2006 Jun 13 , 66 (1703-10).

514

25235

520

25475

521

25854

Venance SL et al. The primary periodic paralyses: diagnosis, pathogenesis and treatment.
Brain, 2006 Jan , 129 (8-17).

522

24220

524

23544

Yoon G et al. Andersen-Tawil syndrome: prospective cohort analysis and expansion of the phenotype.
Am. J. Med. Genet. A, 2006 Feb 15 , 140 (312-21).

527

10319

He Y et al. Stretch-induced alterations of human Kir2.1 channel currents.
Biochem. Biophys. Res. Commun., 2006 Dec 15 , 351 (462-7).

529

26791

Sordel T et al. Hourglass SiO2 coating increases the performance of planar patch-clamp.
J. Biotechnol., 2006 Aug 20 , 125 (142-54).

533

16367

Lei XJ et al. [Inhibition of human macrophage-derived foam cell differentiation by blocking Kv1.3 and Kir2.1 channels]
Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2006 Aug , 31 (493-8).

534

21437

535

21649

Fujiwara Y et al. Functional roles of charged amino acid residues on the wall of the cytoplasmic pore of Kir2.1.
J. Gen. Physiol., 2006 Apr , 127 (401-19).

536

14997

Rinne A et al. Gene silencing in adult rat cardiac myocytes in vitro by adenovirus-mediated RNA interference.
J. Muscle Res. Cell. Motil., 2006 , 27 (413-21).

541

19584

Ellinor PT et al. Potassium channel gene mutations rarely cause atrial fibrillation.
BMC Med. Genet., 2006 , 7 (70).

543

26289

544

133409

Chatelain FC et al. The pore helix dipole has a minor role in inward rectifier channel function.
Neuron, 2005 Sep 15 , 47 (833-43).

546

28199

Kanjhan R et al. Tertiapin-Q blocks recombinant and native large conductance K+ channels in a use-dependent manner.
J. Pharmacol. Exp. Ther., 2005 Sep , 314 (1353-61).

547

28132

548

25138

552

20903

Fang Y et al. Functional expression of Kir2.x in human aortic endothelial cells: the dominant role of Kir2.2.
Am. J. Physiol., Cell Physiol., 2005 Nov , 289 (C1134-44).

555

27220

557

35987

Rose J et al. Molecular correlates of altered expression of potassium currents in failing rabbit myocardium.
Am. J. Physiol. Heart Circ. Physiol., 2005 May , 288 (H2077-87).

558

39839

Ariano MA et al. Striatal potassium channel dysfunction in Huntington's disease transgenic mice.
J. Neurophysiol., 2005 May , 93 (2565-74).

563

24967

Wang R et al. Determinant role of membrane helices in K ATP channel gating.
J. Membr. Biol., 2005 Mar , 204 (1-10).

565

24106

Bendahhou S et al. In vivo and in vitro functional characterization of Andersen's syndrome mutations.
J. Physiol. (Lond.), 2005 Jun 15 , 565 (731-41).

567

38461

Akar FG et al. Molecular mechanisms underlying K+ current downregulation in canine tachycardia-induced heart failure.
Am. J. Physiol. Heart Circ. Physiol., 2005 Jun , 288 (H2887-96).

568

29255

Xia M et al. A Kir2.1 gain-of-function mutation underlies familial atrial fibrillation.
Biochem. Biophys. Res. Commun., 2005 Jul 15 , 332 (1012-9).

569

25663

Gu Y et al. Mechanisms of light adaptation in Drosophila photoreceptors.
Curr. Biol., 2005 Jul 12 , 15 (1228-34).

570

27407

Wolpert C et al. Clinical characteristics and treatment of short QT syndrome.
, 2005 Jul , 3 (611-7).

573

30089

Collins A et al. Regulation of inward rectifier K+ channels by shift of intracellular pH dependence.
J. Cell. Physiol., 2005 Jan , 202 (76-86).

574

22229

576

25457

Koyrakh L et al. Molecular and cellular diversity of neuronal G-protein-gated potassium channels.
J. Neurosci., 2005 Dec 7 , 25 (11468-78).

579

24574

Park WS et al. Activation of inward rectifier K+ channels by hypoxia in rabbit coronary arterial smooth muscle cells.
Am. J. Physiol. Heart Circ. Physiol., 2005 Dec , 289 (H2461-7).

580

29071

581

27330

584

25236

Lei XJ et al. Expression of Kir2.1 channel during differentiation of human macrophages into foam cells.
Di Yi Jun Yi Da Xue Xue Bao, 2005 Dec , 25 (1461-7).

585

21309

586

25049

Schimpf R et al. Short QT syndrome.
Cardiovasc. Res., 2005 Aug 15 , 67 (357-66).

588

22056

589

29432

591

24597

592

20386

Koike-Tani M et al. Signal transduction pathway for the substance P-induced inhibition of rat Kir3 (GIRK) channel.
J. Physiol. (Lond.), 2005 Apr 15 , 564 (489-500).

593

133570

594

133600

Priori SG et al. A novel form of short QT syndrome (SQT3) is caused by a mutation in the KCNJ2 gene.
Circ. Res., 2005 Apr 15 , 96 (800-7).

595

26603

596

29472

Takahashi T et al. KCNJ2 mutation in intractable ventricular arrhythmia with Andersen's syndrome.
Pediatr Int, 2005 Apr , 47 (220-3).

598

20277

603

37370

Satin J et al. Mechanism of spontaneous excitability in human embryonic stem cell derived cardiomyocytes.
J. Physiol. (Lond.), 2004 Sep 1 , 559 (479-96).

606

39133

607

32939

608

33198

610

38766

Sun H et al. Inward rectifier potassium channels in the basilar artery during chronic alcohol consumption.
Alcohol. Clin. Exp. Res., 2004 Oct , 28 (1557-61).

611

39773

Kobayashi T et al. Inhibition of G protein-activated inwardly rectifying K+ channels by various antidepressant drugs.
Neuropsychopharmacology, 2004 Oct , 29 (1841-51).

612

133711

Miller TM et al. Correlating phenotype and genotype in the periodic paralyses.
Neurology, 2004 Nov 9 , 63 (1647-55).

613

36526

614

31806

Sun H et al. Function recovery after chemobleaching (FRAC): evidence for activity silent membrane receptors on cell surface.
Proc. Natl. Acad. Sci. U.S.A., 2004 Nov 30 , 101 (16964-9).

615

38959

Mutai H et al. Characterization of the chicken inward rectifier K+ channel IRK1/Kir2.1 gene.
BMC Genomics, 2004 Nov 29 , 5 (90).

616

32763

Xie LH et al. Regulation of gating by negative charges in the cytoplasmic pore in the Kir2.1 channel.
J. Physiol. (Lond.), 2004 Nov 15 , 561 (159-68).

620

32487

621

39441

Nikolov EN et al. Coordination of membrane excitability through a GIRK1 signaling complex in the atria.
J. Biol. Chem., 2004 May 28 , 279 (23630-6).

625

37065

Pil J et al. Synthesis and electrophysiological characterization of cyclic morphiceptin analogues.
Biochem. Pharmacol., 2004 May 15 , 67 (1887-95).

626

38224

Pouget J et al. [Andersen syndrome: a particular form of paralysis with cardiac dysrhythmia]
Rev. Neurol. (Paris), 2004 May , 160 (S38-42).

628

38427

631

33192

Malinowska DH et al. Gastric parietal cell secretory membrane contains PKA- and acid-activated Kir2.1 K+ channels.
Am. J. Physiol., Cell Physiol., 2004 Mar , 286 (C495-506).

634

36573

Edwards G et al. Potassium and potassium clouds in endothelium-dependent hyperpolarizations.
Pharmacol. Res., 2004 Jun , 49 (535-41).

636

133561

Tristani-Firouzi M Polymorphic ventricular tachycardia associated with mutations in KCNJ2.
Heart Rhythm, 2004 Jul , 1 (242-3).

637

133562

Chun TU et al. Polymorphic ventricular tachycardia and KCNJ2 mutations.
Heart Rhythm, 2004 Jul , 1 (235-41).

638

33136

Mao J et al. Molecular basis for the inhibition of G protein-coupled inward rectifier K(+) channels by protein kinase C.
Proc. Natl. Acad. Sci. U.S.A., 2004 Jan 27 , 101 (1087-92).

639

34472

Zaks-Makhina E et al. Novel neuroprotective K+ channel inhibitor identified by high-throughput screening in yeast.
Mol. Pharmacol., 2004 Jan , 65 (214-9).

641

39154

Kobori A et al. Additional gene variants reduce effectiveness of beta-blockers in the LQT1 form of long QT syndrome.
J. Cardiovasc. Electrophysiol., 2004 Feb , 15 (190-9).

643

36748

645

38190

Wellner-Kienitz MC et al. Voltage dependence of ATP-dependent K+ current in rat cardiac myocytes is affected by IK1 and IK(ACh).
J. Physiol. (Lond.), 2004 Dec 1 , 561 (459-69).

646

38235

Bender K et al. Acute desensitization of GIRK current in rat atrial myocytes is related to K+ current flow.
J. Physiol. (Lond.), 2004 Dec 1 , 561 (471-83).

647

38867

Sánchez-Chapula JA et al. Block of wild-type and inactivation-deficient human ether-a-go-go-related gene K+ channels by halofantrine.
Naunyn Schmiedebergs Arch. Pharmacol., 2004 Dec , 370 (484-91).

648

30979

Romanenko VG et al. Cholesterol sensitivity and lipid raft targeting of Kir2.1 channels.
Biophys. J., 2004 Dec , 87 (3850-61).

649

37883

Zhang YY et al. Carboxy-terminal determinants of conductance in inward-rectifier K channels.
J. Gen. Physiol., 2004 Dec , 124 (729-39).

650

39327

Li J et al. Transgenic upregulation of IK1 in the mouse heart leads to multiple abnormalities of cardiac excitability.
Am. J. Physiol. Heart Circ. Physiol., 2004 Dec , 287 (H2790-802).

653

39224

656

37319

Chen L et al. Inwardly rectifying potassium channels in rat retinal ganglion cells.
Eur. J. Neurosci., 2004 Aug , 20 (956-64).

657

30702

Fodstad H et al. Loss-of-function mutations of the K(+) channel gene KCNJ2 constitute a rare cause of long QT syndrome.
J. Mol. Cell. Cardiol., 2004 Aug , 37 (593-602).

659

32774

661

34812

Sackin H et al. Potassium-dependent slow inactivation of Kir1.1 (ROMK) channels.
Biophys. J., 2004 Apr , 86 (2145-55).

662

36921

Dahlmann A et al. Regulation of Kir channels by intracellular pH and extracellular K(+): mechanisms of coupling.
J. Gen. Physiol., 2004 Apr , 123 (441-54).

663

38886

Ricardo Pérez Riera A et al. Andersen syndrome: the newest variant of the hereditary-familial long QT syndrome.
Ann Noninvasive Electrocardiol, 2004 Apr , 9 (175-9).

664

39231

Charpentier F et al. Cardiac channelopathies: from men to mice.
Ann. Med., 2004 , 36 Suppl 1 (28-34).

665

31519

669

30931

671

36222

Zhao Q et al. Interaction of G protein beta subunit with inward rectifier K(+) channel Kir3.
Mol. Pharmacol., 2003 Nov , 64 (1085-91).

672

134017

Guo D et al. Interaction mechanisms between polyamines and IRK1 inward rectifier K+ channels.
J. Gen. Physiol., 2003 Nov , 122 (485-500).

673

48435

Stockklausner C et al. Surface expression of inward rectifier potassium channels is controlled by selective Golgi export.
J. Biol. Chem., 2003 May 9 , 278 (17000-5).

676

44514

Kobayashi T et al. Inhibition of G protein-activated inwardly rectifying K+ channels by fluoxetine (Prozac).
Br. J. Pharmacol., 2003 Mar , 138 (1119-28).

677

40159

Pil J et al. Serine 329 of the mu-opioid receptor interacts differently with agonists.
J. Pharmacol. Exp. Ther., 2003 Mar , 304 (924-30).

678

49726

Donaldson MR et al. PIP2 binding residues of Kir2.1 are common targets of mutations causing Andersen syndrome.
Neurology, 2003 Jun 10 , 60 (1811-6).

679

42607

680

42807

Karkanis T et al. Plasticity of KIR channels in human smooth muscle cells from internal thoracic artery.
Am. J. Physiol. Heart Circ. Physiol., 2003 Jun , 284 (H2325-34).

681

45364

683

42975

Tian M et al. Expression patterns of inwardly rectifying potassium channel subunits in rat retina.
Neurosci. Lett., 2003 Jul 10 , 345 (9-12).

684

40400

685

42763

Rohacs T et al. Specificity of activation by phosphoinositides determines lipid regulation of Kir channels.
Proc. Natl. Acad. Sci. U.S.A., 2003 Jan 21 , 100 (745-50).

687

40729

Chang HK et al. Conformational changes in Kir2.1 channels during NH4+-induced inactivation.
J. Biol. Chem., 2003 Jan 10 , 278 (908-18).

688

48522

Takano M et al. Regulation of cardiac inwardly rectifying potassium channels by membrane lipid metabolism.
Prog. Biophys. Mol. Biol., 2003 Jan , 81 (67-79).

689

43784

Mao J et al. Inhibition of G-protein-coupled inward rectifying K+ channels by intracellular acidosis.
J. Biol. Chem., 2003 Feb 28 , 278 (7091-8).

690

45377

Prüss H et al. Kir2 potassium channels in rat striatum are strategically localized to control basal ganglia function.
Brain Res. Mol. Brain Res., 2003 Feb 20 , 110 (203-19).

691

41711

Hayashi M et al. An inwardly rectifying K+ channel in bovine parotid acinar cells: possible involvement of Kir2.1.
J. Physiol. (Lond.), 2003 Feb 15 , 547 (255-69).

692

48994

695

38144

Bendahhou S et al. Defective potassium channel Kir2.1 trafficking underlies Andersen-Tawil syndrome.
J. Biol. Chem., 2003 Dec 19 , 278 (51779-85).

698

46586

699

40429

703

41150

Hoang QV et al. Effects of orexin (hypocretin) on GIRK channels.
J. Neurophysiol., 2003 Aug , 90 (693-702).

704

42436

Xiao J et al. Localization of PIP2 activation gate in inward rectifier K+ channels.
Nat. Neurosci., 2003 Aug , 6 (811-8).

705

48618

Yang D et al. Expression of the inwardly rectifying K+ channel Kir2.1 in native bovine corneal endothelial cells.
Invest. Ophthalmol. Vis. Sci., 2003 Aug , 44 (3511-9).

706

43839

707

43607

McLerie M et al. Dominant-negative suppression of I(K1) in the mouse heart leads to altered cardiac excitability.
J. Mol. Cell. Cardiol., 2003 Apr , 35 (367-78).

708

47165

709

45447

Konstas AA et al. Identification of domains that control the heteromeric assembly of Kir5.1/Kir4.0 potassium channels.
Am. J. Physiol., Cell Physiol., 2003 Apr , 284 (C910-7).

710

134205

Guo D et al. Mechanism of rectification in inward-rectifier K+ channels.
J. Gen. Physiol., 2003 Apr , 121 (261-75).

712

48427

714

49695

Melnyk P et al. Differential distribution of Kir2.1 and Kir2.3 subunits in canine atrium and ventricle.
Am. J. Physiol. Heart Circ. Physiol., 2002 Sep , 283 (H1123-33).

715

40144

716

48697

718

49427

Guo D et al. IRK1 inward rectifier K(+) channels exhibit no intrinsic rectification.
J. Gen. Physiol., 2002 Oct , 120 (539-51).

723

40900

Preisig-Müller R et al. Heteromerization of Kir2.x potassium channels contributes to the phenotype of Andersen's syndrome.
Proc. Natl. Acad. Sci. U.S.A., 2002 May 28 , 99 (7774-9).

724

46138

Hoger JH et al. Shear stress regulates the endothelial Kir2.1 ion channel.
Proc. Natl. Acad. Sci. U.S.A., 2002 May 28 , 99 (7780-5).

725

41182

726

47281

728

56341

729

43334

731

49656

Ai T et al. Novel KCNJ2 mutation in familial periodic paralysis with ventricular dysrhythmia.
Circulation, 2002 Jun 4 , 105 (2592-4).

732

45636

Vanoye CG et al. The carboxyl termini of K(ATP) channels bind nucleotides.
J. Biol. Chem., 2002 Jun 28 , 277 (23260-70).

733

47844

734

47874

737

43637

738

48898

740

40857

Kobayashi T et al. Functional characterization of an endogenous Xenopus oocyte adenosine receptor.
Br. J. Pharmacol., 2002 Jan , 135 (313-22).

741

49079

Wickman K et al. Structural characterization of the mouse Girk genes.
Gene, 2002 Feb 6 , 284 (241-50).

743

52234

Brochiero E et al. Cloning of rabbit Kir6.1, SUR2A, and SUR2B: possible candidates for a renal K(ATP) channel.
Am. J. Physiol. Renal Physiol., 2002 Feb , 282 (F289-300).

744

47481

745

48027

Bernheim L et al. Human myoblast differentiation: Ca(2+) channels are activated by K(+) channels.
News Physiol. Sci., 2002 Feb , 17 (22-6).

748

41320

750

43770

Sadja R et al. Graded contribution of the Gbeta gamma binding domains to GIRK channel activation.
Proc. Natl. Acad. Sci. U.S.A., 2002 Aug 6 , 99 (10783-8).

751

46096

753

45000

Tristani-Firouzi M et al. Functional and clinical characterization of KCNJ2 mutations associated with LQT7 (Andersen syndrome).
J. Clin. Invest., 2002 Aug , 110 (381-8).

754

43606

Giovannardi S et al. Modulation of the inward rectifier potassium channel IRK1 by the Ras signaling pathway.
J. Biol. Chem., 2002 Apr 5 , 277 (12158-63).

757

58818

Jongsma HJ et al. Channelopathies: Kir2.1 mutations jeopardize many cell functions.
Curr. Biol., 2001 Sep 18 , 11 (R747-50).

758

59669

Shieh RC et al. Ammonium ions induce inactivation of Kir2.1 potassium channels expressed in Xenopus oocytes.
J. Physiol. (Lond.), 2001 Sep 1 , 535 (359-70).

759

52631

Horio Y Potassium channels of glial cells: distribution and function.
Jpn. J. Pharmacol., 2001 Sep , 87 (1-6).

760

51575

Llobet A et al. Identification of Kir2.1 channel activity in cultured trabecular meshwork cells.
Invest. Ophthalmol. Vis. Sci., 2001 Sep , 42 (2371-9).

761

54813

762

58059

Nilius B et al. Ion channels and their functional role in vascular endothelium.
Physiol. Rev., 2001 Oct , 81 (1415-59).

764

50768

Jeong JS et al. Characterization of inwardly rectifying K(+) conductance across the basolateral membrane of rat tracheal epithelia.
Biochem. Biophys. Res. Commun., 2001 Nov 9 , 288 (914-20).

767

58237

Choe H et al. Gating properties of inward-rectifier potassium channels: effects of permeant ions.
J. Membr. Biol., 2001 Nov 1 , 184 (81-9).

768

56011

769

52426

Zhou W et al. Mechanism underlying bupivacaine inhibition of G protein-gated inwardly rectifying K+ channels.
Proc. Natl. Acad. Sci. U.S.A., 2001 May 22 , 98 (6482-7).

772

134760

Fischer-Lougheed J et al. Human myoblast fusion requires expression of functional inward rectifier Kir2.1 channels.
J. Cell Biol., 2001 May 14 , 153 (677-86).

773

57358

Liu Y et al. Direct activation of an inwardly rectifying potassium channel by arachidonic acid.
Mol. Pharmacol., 2001 May , 59 (1061-8).

775

53063

Komarova SV et al. Osteoclast ion channels: potential targets for antiresorptive drugs.
Curr. Pharm. Des., 2001 May , 7 (637-54).

776

53571

777

50249

Tytgat J et al. New polypeptide components purified from mamba venom.
FEBS Lett., 2001 Mar 2 , 491 (217-21).

778

56222

Derst C et al. Genetic and functional linkage of Kir5.1 and Kir2.1 channel subunits.
FEBS Lett., 2001 Mar 2 , 491 (305-11).

780

54530

Leonoudakis D et al. Inward rectifier potassium channel Kir2.2 is associated with synapse-associated protein SAP97.
J. Cell. Sci., 2001 Mar , 114 (987-98).

782

52559

Proks P et al. Interaction of stilbene disulphonates with cloned K(ATP) channels.
Br. J. Pharmacol., 2001 Mar , 132 (973-82).

783

58256

784

55820

787

58117

Shui Z et al. Evidence of involvement of GIRK1/GIRK4 in long-term desensitization of cardiac muscarinic K+ channels.
Am. J. Physiol. Heart Circ. Physiol., 2001 Jun , 280 (H2554-62).

791

41210

Tong XY et al. [The expression levels of GIRK1 and IRK1 in memory deficit rats]
Yao Xue Xue Bao, 2001 Jul , 36 (485-8).

793

58755

Soom M et al. Multiple PIP2 binding sites in Kir2.1 inwardly rectifying potassium channels.
FEBS Lett., 2001 Feb 9 , 490 (49-53).

796

58819

Sackin H et al. Regulation of ROMK by extracellular cations.
Biophys. J., 2001 Feb , 80 (683-97).

800

58645

804

54906

806

58632

812

57838

Medina I et al. A switch mechanism for G beta gamma activation of I(KACh).
J. Biol. Chem., 2000 Sep 22 , 275 (29709-16).

813

57095

816

56825

817

59538

Mark MD et al. G-protein mediated gating of inward-rectifier K+ channels.
Eur. J. Biochem., 2000 Oct , 267 (5830-6).

818

55072

Schilling T et al. Upregulation of Kv1.3 K(+) channels in microglia deactivated by TGF-beta.
Am. J. Physiol., Cell Physiol., 2000 Oct , 279 (C1123-34).

821

53637

824

59968

Xie A et al. [The blocking effects of extracellular Mn2+ on the inward rectifier potassium channel (IRK1)]
Zhongguo Ying Yong Sheng Li Xue Za Zhi, 2000 Nov , 16 (331-4).

825

61721

Yakubovich D et al. Slow modal gating of single G protein-activated K+ channels expressed in Xenopus oocytes.
J. Physiol. (Lond.), 2000 May 1 , 524 Pt 3 (737-55).

828

55411

Guo D et al. Mechanism of IRK1 channel block by intracellular polyamines.
J. Gen. Physiol., 2000 Jun , 115 (799-814).

830

134987

832

55487

833

52944

834

50898

Bloms-Funke P et al. Agonistic effects of the opioid buprenorphine on the nociceptin/OFQ receptor.
Peptides, 2000 Jul , 21 (1141-6).

835

60331

838

62655

Rae JL et al. Kir2.1 Potassium channels and corneal epithelia.
Curr. Eye Res., 2000 Feb , 20 (144-52).

841

51204

Kim SJ et al. Inwardly rectifying K+ channels in the basolateral membrane of rat pancreatic acini.
Pflugers Arch., 2000 Dec , 441 (331-40).

842

58125

Chrissobolis S et al. Role of inwardly rectifying K(+) channels in K(+)-induced cerebral vasodilatation in vivo.
Am. J. Physiol. Heart Circ. Physiol., 2000 Dec , 279 (H2704-12).

843

57562

Gögelein H et al. Inhibition of IKs channels by HMR 1556.
Naunyn Schmiedebergs Arch. Pharmacol., 2000 Dec , 362 (480-8).

845

55179

Keren-Raifman T et al. Expression cloning of KCRF, a potassium channel regulatory factor.
Biochem. Biophys. Res. Commun., 2000 Aug 11 , 274 (852-8).

846

50206

Wickman K et al. Brain localization and behavioral impact of the G-protein-gated K+ channel subunit GIRK4.
J. Neurosci., 2000 Aug 1 , 20 (5608-15).

847

65150

848

62271

Wang H et al. Direct block of inward rectifier potassium channels by nicotine.
Toxicol. Appl. Pharmacol., 2000 Apr 1 , 164 (97-101).

849

60323

850

60964

852

64082

Jin W et al. Mechanisms of inward-rectifier K+ channel inhibition by tertiapin-Q.
Biochemistry, 1999 Oct 26 , 38 (14294-301).

853

69481

855

68625

856

63813

Barrett-Jolley R et al. Direct block of native and cloned (Kir2.1) inward rectifier K+ channels by chloroethylclonidine.
Br. J. Pharmacol., 1999 Oct , 128 (760-6).

858

135132

Ho IH et al. Molecular mechanism for sodium-dependent activation of G protein-gated K+ channels.
J. Physiol. (Lond.), 1999 Nov 1 , 520 Pt 3 (645-51).

860

67298

Leyland ML et al. The possible role of a disulphide bond in forming functional Kir2.1 potassium channels.
Pflugers Arch., 1999 Nov , 438 (778-81).

861

63084

862

63053

864

65545

865

67237

Otero AS et al. Wild-type NM23-H1, but not its S120 mutants, suppresses desensitization of muscarinic potassium current.
Biochim. Biophys. Acta, 1999 Mar 8 , 1449 (157-68).

866

64981

Ho IH et al. Molecular determinants for sodium-dependent activation of G protein-gated K+ channels.
J. Biol. Chem., 1999 Mar 26 , 274 (8639-48).

867

67530

Fernández-Fernández JM et al. Selective activation of heterologously expressed G protein-gated K+ channels by M2 muscarinic receptors in rat sympathetic neurones.
J. Physiol. (Lond.), 1999 Mar 15 , 515 ( Pt 3) (631-7).

868

65631

Bradley KK et al. Kir2.1 encodes the inward rectifier potassium channel in rat arterial smooth muscle cells.
J. Physiol. (Lond.), 1999 Mar 15 , 515 ( Pt 3) (639-51).

872

64870

874

64872

Flynn ER et al. Inward rectifier potassium conductance regulates membrane potential of canine colonic smooth muscle.
J. Physiol. (Lond.), 1999 Jul 1 , 518 ( Pt 1) (247-56).

875

61819

876

68213

877

61034

Klein H et al. Molecular characterization of an inwardly rectifying K+ channel from HeLa cells.
J. Membr. Biol., 1999 Jan 1 , 167 (43-52).

878

64550

879

65853

Pearson WL et al. Expression of a functional Kir4 family inward rectifier K+ channel from a gene cloned from mouse liver.
J. Physiol. (Lond.), 1999 Feb 1 , 514 ( Pt 3) (639-53).

881

61150

Ulens C et al. The dual modulation of GIRK1/GIRK2 channels by opioid receptor ligands.
Eur. J. Pharmacol., 1999 Dec 3 , 385 (239-45).

883

65782

Rohács T et al. Distinct specificities of inwardly rectifying K(+) channels for phosphoinositides.
J. Biol. Chem., 1999 Dec 17 , 274 (36065-72).

884

67889

Lewohl JM et al. G-protein-coupled inwardly rectifying potassium channels are targets of alcohol action.
Nat. Neurosci., 1999 Dec , 2 (1084-90).

885

66385

Kobayashi T et al. Ethanol opens G-protein-activated inwardly rectifying K+ channels.
Nat. Neurosci., 1999 Dec , 2 (1091-7).

886

66085

Stonehouse AH et al. Characterisation of Kir2.0 proteins in the rat cerebellum and hippocampus by polyclonal antibodies.
Histochem. Cell Biol., 1999 Dec , 112 (457-65).

888

69728

889

67058

890

63974

Dart C et al. Topology of the pore region of an inward rectifier K+ channel, Kir2.1.
Ann. N. Y. Acad. Sci., 1999 Apr 30 , 868 (414-7).

893

68312

Saitoh O et al. RGS7 and RGS8 differentially accelerate G protein-mediated modulation of K+ currents.
J. Biol. Chem., 1999 Apr 2 , 274 (9899-904).

894

60862

896

65262

Choe H et al. Structural determinants of gating in inward-rectifier K+ channels.
Biophys. J., 1999 Apr , 76 (1988-2003).

897

60031

898

62858

901

67097

Jin W et al. A novel high-affinity inhibitor for inward-rectifier K+ channels.
Biochemistry, 1998 Sep 22 , 37 (13291-9).

905

66308

Pearson WL et al. Block of the Kir2.1 channel pore by alkylamine analogues of endogenous polyamines.
J. Gen. Physiol., 1998 Sep , 112 (351-63).

907

64141

908

65912

Stampe P et al. Nonindependent K+ movement through the pore in IRK1 potassium channels.
J. Gen. Physiol., 1998 Oct , 112 (475-84).

911

71607

912

73952

913

71722

Arcangeli A et al. Long-term exposure to retinoic acid induces the expression of IRK1 channels in HERG channel-endowed neuroblastoma cells.
Biochem. Biophys. Res. Commun., 1998 Mar 27 , 244 (706-11).

914

70797

Nakamura TY et al. Inhibition of rat ventricular IK1 with antisense oligonucleotides targeted to Kir2.1 mRNA.
Am. J. Physiol., 1998 Mar , 274 (H892-900).

915

72714

916

71347

917

72640

Raab-Graham KF et al. Tetrameric subunit structure of the native brain inwardly rectifying potassium channel Kir 2.2.
J. Biol. Chem., 1998 Jul 31 , 273 (19699-707).

918

72681

Krapivinsky G et al. Gbeta binding to GIRK4 subunit is critical for G protein-gated K+ channel activation.
J. Biol. Chem., 1998 Jul 3 , 273 (16946-52).

919

75948

Luchian T et al. Ion permeation through a G-protein activated (GIRK1/GIRK5) inwardly rectifying potassium channel.
Biochim. Biophys. Acta, 1998 Jan 19 , 1368 (167-70).

920

70601

Tare M et al. Inwardly rectifying whole cell potassium current in human blood eosinophils.
J. Physiol. (Lond.), 1998 Jan 15 , 506 ( Pt 2) (303-18).

922

79334

925

79072

Sun L et al. Regulation of K+ and Ca++ channels by a family of neuropeptide Y receptors.
J. Pharmacol. Exp. Ther., 1998 Feb , 284 (625-32).

927

64815

Wischmeyer E et al. Acute suppression of inwardly rectifying Kir2.1 channels by direct tyrosine kinase phosphorylation.
J. Biol. Chem., 1998 Dec 18 , 273 (34063-8).

928

63105

Ruiz-Velasco V et al. Heterologous expression and coupling of G protein-gated inwardly rectifying K+ channels in adult rat sympathetic neurons.
J. Physiol. (Lond.), 1998 Dec 15 , 513 ( Pt 3) (761-73).

930

61068

Standen NB et al. K+ channel modulation in arterial smooth muscle.
Acta Physiol. Scand., 1998 Dec , 164 (549-57).

931

62825

932

77643

933

73277

935

68990

Ivanova-Nikolova TT et al. Muscarinic K+ channel in the heart. Modal regulation by G protein beta gamma subunits.
J. Gen. Physiol., 1998 Aug , 112 (199-210).

937

66926

939

78948

Höllerer-Beitz G et al. Influence of detergents on the function of cloned potassium channels.
Recept. Channels, 1998 , 5 (61-78).

940

70318

Suessbrich H et al. Specific block of cloned Herg channels by clofilium and its tertiary analog LY97241.
FEBS Lett., 1997 Sep 8 , 414 (435-8).

943

77154

Taglialatela M et al. Regulation of the human ether-a-gogo related gene (HERG) K+ channels by reactive oxygen species.
Proc. Natl. Acad. Sci. U.S.A., 1997 Oct 14 , 94 (11698-703).

945

135436

946

74714

Kamouchi M et al. Modulation of inwardly rectifying potassium channels in cultured bovine pulmonary artery endothelial cells.
J. Physiol. (Lond.), 1997 Nov 1 , 504 ( Pt 3) (545-56).

947

76473

Collins A et al. Scanning mutagenesis of the putative transmembrane segments of Kir2.1, an inward rectifier potassium channel.
Proc. Natl. Acad. Sci. U.S.A., 1997 May 13 , 94 (5456-60).

949

78093

950

78513

Wickman K et al. Partial structure, chromosome localization, and expression of the mouse Girk4 gene.
Genomics, 1997 Mar 15 , 40 (395-401).

951

75745

954

76650

957

72859

Nelson CS et al. Cloning and characterization of Kir3.1 (GIRK1) C-terminal alternative splice variants.
Brain Res. Mol. Brain Res., 1997 Jun , 46 (185-96).

959

73128

960

77782

Gribble FM et al. Properties of cloned ATP-sensitive K+ currents expressed in Xenopus oocytes.
J. Physiol. (Lond.), 1997 Jan 1 , 498 ( Pt 1) (87-98).

961

79546

963

78824

965

77966

Yang J et al. Stabilization of ion selectivity filter by pore loop ion pairs in an inwardly rectifying potassium channel.
Proc. Natl. Acad. Sci. U.S.A., 1997 Feb 18 , 94 (1568-72).

967

77046

Isomoto S et al. Inwardly rectifying potassium channels: their molecular heterogeneity and function.
Jpn. J. Physiol., 1997 Feb , 47 (11-39).

968

73389

Sabirov RZ et al. Two-sided action of protons on an inward rectifier K+ channel (IRK1).
Pflugers Arch., 1997 Feb , 433 (428-34).

969

77221

Jones SV Dual modulation of an inwardly rectifying potassium conductance.
Neuropharmacology, 1997 Feb , 36 (209-15).

978

78867