Cavα2δ1

Description: calcium channel, voltage-dependent, alpha2/delta subunit 1
Gene: Cacna2d1
Alias: cacna2d1

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Gene

Species	NCBI gene ID	Chromosome	Position
Human	781	7	497512
Mouse	12293	5	440119
Rat	25399	4	424358

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Transcript

Species	NCBI accession	Length (nt)
Human	NM_000722.4	7542
Mouse	NM_001110843.1	7472
Rat	NM_012919.3	3964

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Protein Isoforms

Species	Uniprot ID	Length (aa)
Human	P54289	1103
Mouse	O08532	1103
Rat	P54290	1091

Isoforms

Transcript

Length (nt)

Protein

Length (aa)

Variant

Isoform

Known

NM_001366867.1

7757

NP_001353796.1

1103

transcript variant 3

isoform 3 preproprotein

NM_000722.4

7542

NP_000713.2

1091

transcript variant 1

isoform 1 preproprotein

NM_001302890.2

1486

NP_001289819.1

309

transcript variant 2

isoform 2 precursor

Predicted

XR_001744873.3

2869

transcript variant X13

XM_005250574.4

7685

XP_005250631.1

1079

transcript variant X10

isoform X10

XM_005250572.4

7706

XP_005250629.1

1086

transcript variant X6

isoform X6

XM_005250573.4

7700

XP_005250630.1

1084

transcript variant X8

isoform X8

XM_011516572.4

7742

XP_011514874.1

1098

transcript variant X5

isoform X5

XM_011516571.4

7763

XP_011514873.1

1105

transcript variant X3

isoform X3

XM_006716118.4

7778

XP_006716181.1

1110

transcript variant X1

isoform X1

XM_006716120.4

7324

XP_006716183.1

1071

transcript variant X12

isoform X12

XM_006716121.3

6586

XP_006716184.1

580

transcript variant X14

isoform X13

XM_047420822.1

4124

XP_047276778.1

1079

transcript variant X11

isoform X11

XM_047420820.1

4145

XP_047276776.1

1086

transcript variant X7

isoform X7

XM_047420821.1

4139

XP_047276777.1

1084

transcript variant X9

isoform X9

XM_047420819.1

4196

XP_047276775.1

1103

transcript variant X4

isoform X4

XM_011516570.4

4217

XP_011514872.1

1110

transcript variant X2

isoform X2

XR_008487750.1

2869

transcript variant X13

XM_054358980.1

7685

XP_054214955.1

1079

transcript variant X10

isoform X10

XM_054358975.1

7706

XP_054214950.1

1086

transcript variant X6

isoform X6

XM_054358978.1

7700

XP_054214953.1

1084

transcript variant X8

isoform X8

XM_054358974.1

7742

XP_054214949.1

1098

transcript variant X5

isoform X5

XM_054358972.1

7763

XP_054214947.1

1105

transcript variant X3

isoform X3

XM_054358970.1

7778

XP_054214945.1

1110

transcript variant X1

isoform X1

XM_054358982.1

9209

XP_054214957.1

1071

transcript variant X12

isoform X12

XM_054358977.1

9521

XP_054214952.1

1085

transcript variant X15

isoform X14

XM_054358983.1

6586

XP_054214958.1

580

transcript variant X14

isoform X13

XM_054358981.1

5164

XP_054214956.1

1079

transcript variant X11

isoform X11

XM_054358976.1

4111

XP_054214951.1

1086

transcript variant X7

isoform X7

XM_054358973.1

4162

XP_054214948.1

1103

transcript variant X4

isoform X4

XM_054358971.1

4183

XP_054214946.1

1110

transcript variant X2

isoform X2

XM_054358979.1

4104

XP_054214954.1

1084

transcript variant X9

isoform X9

Known

NM_001110843.1

7472

NP_001104313.1

1103

transcript variant a

isoform a preproprotein

NM_001110844.1

7436

NP_001104314.1

1091

transcript variant b

isoform b preproprotein

NM_009784.2

7415

NP_033914.1

1084

transcript variant e

isoform e preproprotein

NM_001110845.1

7421

NP_001104315.1

1086

transcript variant c

isoform c preproprotein

NM_001110846.1

7400

NP_001104316.1

1079

transcript variant d

isoform d preproprotein

Predicted

XM_036164761.1

12774

XP_036020654.1

299

transcript variant X6

isoform X6

XM_011249743.4

12764

XP_011248045.1

294

transcript variant X7

isoform X7

XM_011249741.4

4783

XP_011248043.1

318

transcript variant X5

isoform X5

XM_011249744.4

7494

XP_011248046.1

1110

transcript variant X1

isoform X1

XM_006535619.5

2088

XP_006535682.1

562

transcript variant X4

isoform X4

XM_006535618.1

6657

XP_006535681.1

573

transcript variant X3

isoform X3

XM_017320631.1

5689

XP_017176120.1

580

transcript variant X2

isoform X2

Known

NM_012919.3

3964

NP_037051.2

1091

transcript variant 1

isoform 1 precursor

NM_001110847.1

3264

NP_001104317.1

1079

transcript variant 3

isoform 3 precursor

NM_001110848.1

3264

NP_001104318.1

1084

transcript variant 2

isoform 2 precursor

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Post-Translational Modifications

PTM

Position

Type

Modified residue

119

Phosphoserine

Glycosylation

N-linked (GlcNAc...) asparagine

Glycosylation

136

N-linked (GlcNAc...) asparagine

Glycosylation

184

N-linked (GlcNAc...) asparagine

Glycosylation

324

N-linked (GlcNAc...) asparagine

Glycosylation

348

N-linked (GlcNAc...) asparagine

Glycosylation

468

N-linked (GlcNAc...) asparagine

Glycosylation

475

N-linked (GlcNAc...) asparagine

Glycosylation

604

N-linked (GlcNAc...) asparagine

Glycosylation

613

N-linked (GlcNAc...) asparagine

Glycosylation

675

N-linked (GlcNAc...) asparagine

Glycosylation

781

N-linked (GlcNAc...) asparagine

Glycosylation

824

N-linked (GlcNAc...) asparagine

Glycosylation

888

N-linked (GlcNAc...) asparagine

Glycosylation

895

N-linked (GlcNAc...) asparagine

Glycosylation

985

N-linked (GlcNAc...) asparagine

Glycosylation

998

N-linked (GlcNAc...) asparagine

Disulfide bond

655

Interchain (between alpha-2-1 and delta-1 chains)

Modified residue

119

Phosphoserine

Glycosylation

N-linked (GlcNAc...) asparagine

Glycosylation

136

N-linked (GlcNAc...) asparagine

Glycosylation

184

N-linked (GlcNAc...) asparagine

Glycosylation

324

N-linked (GlcNAc...) asparagine

Glycosylation

348

N-linked (GlcNAc...) asparagine

Glycosylation

613

N-linked (GlcNAc...) asparagine

Glycosylation

781

N-linked (GlcNAc...) asparagine

Glycosylation

888

N-linked (GlcNAc...) asparagine

Disulfide bond

655

Interchain (between alpha-2-1 and delta-1 chains)

Modified residue

119

Phosphoserine

Glycosylation

N-linked (GlcNAc...) asparagine

Glycosylation

136

N-linked (GlcNAc...) asparagine

Glycosylation

184

N-linked (GlcNAc...) asparagine

Glycosylation

323

N-linked (GlcNAc...) asparagine

Glycosylation

347

N-linked (GlcNAc...) asparagine

Glycosylation

593

N-linked (GlcNAc...) asparagine

Glycosylation

769

N-linked (GlcNAc...) asparagine

Glycosylation

876

N-linked (GlcNAc...) asparagine

Glycosylation

973

N-linked (GlcNAc...) asparagine

Disulfide bond

644

Interchain (between alpha-2-1 and delta-1 chains)

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Structure

Cavα2δ1 predicted AlphaFold size

Species	Area (Å²)	Reference
Human	6608.11	source
Mouse	7249.72	source
Rat	6128.32	source

Methodology for AlphaFold size prediction and disclaimer are available here

References

241

Tuluc P et al. Computer modeling of siRNA knockdown effects indicates an essential role of the Ca2+ channel alpha2delta-1 subunit in cardiac excitation-contraction coupling.
Proc. Natl. Acad. Sci. U.S.A., 2007 Jun 26 , 104 (11091-6).

242

Hatano S et al. Molecular and electrophysiological differences in the L-type Ca2+ channel of the atrium and ventricle of rat hearts.
Circ. J., 2006 May , 70 (610-4).

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Credits

To cite this page: [Contributors] Channelpedia https://channelpedia.epfl.ch/wikipages/100/ , accessed on 2024 Nov 21

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