Referenced in: none

Automatically associated channels: Cav2.1

Title: Decreased hemispheric water mobility in hemiplegic migraine related to mutation of CACNA1A gene.

Authors: H Chabriat, K Vahedi, C A Clark, C Poupon, A Ducros, C Denier, D Le Bihan, M G Bousser

Journal, date & volume: Neurology, 2000 Jan 25 , 54, 510-2

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/10668728

Abstract
We report a reversible reduction of water diffusion in the brain during a prolonged attack of hemiplegic migraine. The patient had a sporadic mutation of the CACNA1A gene. The diffusion changes were observed in the contralateral hemisphere 3 and 5 weeks after the onset of hemiplegia. These results suggest the occurrence of hemispheric cytotoxic edema during severe attacks of hemiplegic aura. The mechanisms underlying such ultrastructural modifications are unknown but an abnormal release of excitatory amino acids can be hypothesized.