Kv7.4

1

Mani BK et al. Kv7.5 Potassium Channel Subunits Are the Primary Targets for PKA-Dependent Enhancement of Vascular Smooth Muscle Kv7 Currents.
Mol. Pharmacol., 2016 Mar , 89 (323-34).

2

Schütze S et al. KCNQ Potassium Channels Modulate Sensitivity of Skin D-hair Mechanoreceptors.
J. Biol. Chem., 2016 Jan 5 , ().

3

Sihn CR et al. Mechanisms of Calmodulin Regulation of Different Isoforms of Kv7.4 K+ Channels.
J. Biol. Chem., 2016 Jan 29 , 291 (2499-509).

4

Stott JB et al. G-protein βγ subunits are positive regulators of Kv7.4 and native vascular Kv7 channel activity.
Proc. Natl. Acad. Sci. U.S.A., 2015 May 19 , 112 (6497-502).

5

Kalappa BI et al. Potent KCNQ2/3-specific channel activator suppresses in vivo epileptic activity and prevents the development of tinnitus.
J. Neurosci., 2015 Jun 10 , 35 (8829-42).

6

Sedivy V et al. Role of Kv7 channels in responses of the pulmonary circulation to hypoxia.
Am. J. Physiol. Lung Cell Mol. Physiol., 2015 Jan 1 , 308 (L48-57).

7

Oliván-Viguera A et al. A novel pan-negative-gating modulator of KCa2/3 channels, fluoro-di-benzoate, RA-2, inhibits endothelium-derived hyperpolarization-type relaxation in coronary artery and produces bradycardia in vivo.
Mol. Pharmacol., 2015 Feb , 87 (338-48).

8

Lee S et al. Heterogeneity in Kv7 channel function in the cerebral and coronary circulation.
Microcirculation, 2015 Feb , 22 (109-21).

9

Jepps TA et al. Fundamental role for the KCNE4 ancillary subunit in Kv7.4 regulation of arterial tone.
J. Physiol. (Lond.), 2015 Dec 15 , 593 (5325-40).

10

Wasano K et al. A novel frameshift mutation in KCNQ4 in a family with autosomal recessive non-syndromic hearing loss.
Biochem. Biophys. Res. Commun., 2015 Aug 7 , 463 (582-6).

11

Svalø J et al. Functional and molecular evidence for Kv7 channel subtypes in human detrusor from patients with and without bladder outflow obstruction.
PLoS ONE, 2015 , 10 (e0117350).

12

Li X et al. Overexpression of tau downregulated the mRNA levels of Kv channels and improved proliferation in N2A cells.
PLoS ONE, 2015 , 10 (e0116628).

13

Grigorov A et al. Kv7 potassium channel subunits and M currents in cultured hippocampal interneurons.
Pflugers Arch., 2014 Sep , 466 (1747-58).

14

Brueggemann LI et al. KCNQ (Kv7) potassium channel activators as bronchodilators: combination with a β2-adrenergic agonist enhances relaxation of rat airways.
Am. J. Physiol. Lung Cell Mol. Physiol., 2014 Mar 15 , 306 (L476-86).

15

Jepps TA et al. Vasorelaxant effects of novel Kv7.4 channel enhancers ML213 and NS15370.
Br. J. Pharmacol., 2014 Jun 9 , ().

16

Brueggemann LI et al. Differential Activation of Vascular Smooth Muscle Kv7.4, Kv7.5, and Kv7.4/7.5 Channels by ML213 and ICA-069673.
Mol. Pharmacol., 2014 Jun 18 , ().

17

Iannotti FA et al. The endocannabinoid 2-AG controls skeletal muscle cell differentiation via CB1 receptor-dependent inhibition of Kv7 channels.
Proc. Natl. Acad. Sci. U.S.A., 2014 Jun 17 , 111 (E2472-81).

18

Currò D K+ channels as potential targets for the treatment of gastrointestinal motor disorders.
Eur. J. Pharmacol., 2014 Jun 15 , 733 (97-101).

19

Ishikawa K et al. A Japanese family showing high-frequency hearing loss with KCNQ4 and TECTA mutations.
Acta Otolaryngol., 2014 Jun , 134 (557-63).

20

Brueggemann LI et al. Differential protein kinase C-dependent modulation of Kv7.4 and Kv7.5 subunits of vascular Kv7 channels.
J. Biol. Chem., 2014 Jan 24 , 289 (2099-111).

21

Li P et al. The human ether-a-go-go-related gene activator NS1643 enhances epilepsy-associated KCNQ channels.
J. Pharmacol. Exp. Ther., 2014 Dec , 351 (596-604).

22

Chadha PS et al. Contribution of kv7.4/kv7.5 heteromers to intrinsic and calcitonin gene-related peptide-induced cerebral reactivity.
Arterioscler. Thromb. Vasc. Biol., 2014 Apr , 34 (887-93).

23

Wu C et al. Kcnq1-5 (Kv7.1-5) potassium channel expression in the adult zebrafish.
BMC Physiol., 2014 , 14 (1).

24

Wang H et al. Targeted high-throughput sequencing identifies pathogenic mutations in KCNQ4 in two large Chinese families with autosomal dominant hearing loss.
PLoS ONE, 2014 , 9 (e103133).

25

Blom SM et al. From pan-reactive KV7 channel opener to subtype selective opener/inhibitor by addition of a methyl group.
PLoS ONE, 2014 , 9 (e100209).

26

Takahashi H et al. Application of a combination of a knowledge-based algorithm and 2-stage screening to hypothesis-free genomic data on irinotecan-treated patients for identification of a candidate single nucleotide polymorphism related to an adverse effect.
PLoS ONE, 2014 , 9 (e105160).

27

[To the mechanisms of antiarrhythmic action of Allapinine].
Bioorg. Khim., 2013 Jan-Feb , 39 (105-16).

28

Svalø J et al. Bladder contractility is modulated by Kv7 channels in pig detrusor.
Eur. J. Pharmacol., 2013 Sep 5 , 715 (312-20).

29

Abdelfatah N et al. Identification of a novel in-frame deletion in KCNQ4 (DFNA2A) and evidence of multiple phenocopies of unknown origin in a family with ADSNHL.
Eur. J. Hum. Genet., 2013 Oct , 21 (1112-9).

30

Zhang X et al. KCNQ and KCNE potassium channel subunit expression in bovine retinal pigment epithelium.
Exp. Eye Res., 2013 Nov , 116 (424-32).

31

Spitzmaul G et al. Vestibular role of KCNQ4 and KCNQ5 K+ channels revealed by mouse models.
J. Biol. Chem., 2013 Mar 29 , 288 (9334-44).

32

Watabe T et al. Moderate hearing loss associated with a novel KCNQ4 non-truncating mutation located near the N-terminus of the pore helix.
Biochem. Biophys. Res. Commun., 2013 Mar 15 , 432 (475-9).

33

Gao Y et al. Impaired surface expression and conductance of the KCNQ4 channel lead to sensorineural hearing loss.
J. Cell. Mol. Med., 2013 Jun 11 , ().

34

Xu Q et al. Structure of a Ca(2+)/CaM:Kv7.4 (KCNQ4) B-helix complex provides insight into M current modulation.
J. Mol. Biol., 2013 Jan 23 , 425 (378-94).

35

Purcell EK et al. BDNF profoundly and specifically increases KCNQ4 expression in neurons derived from embryonic stem cells.
Stem Cell Res, 2013 Jan , 10 (29-35).

36

Lang F et al. Regulation of ion channels by the serum- and glucocorticoid-inducible kinase SGK1.
FASEB J., 2013 Jan , 27 (3-12).

37

Zavaritskaya O et al. Role of KCNQ channels in skeletal muscle arteries and periadventitial vascular dysfunction.
Hypertension, 2013 Jan , 61 (151-9).

38

Iannotti FA et al. Specification of skeletal muscle differentiation by repressor element-1 silencing transcription factor (REST)-regulated Kv7.4 potassium channels.
Mol. Biol. Cell, 2013 Feb , 24 (274-84).

39

Adduci A et al. Expression and motor functional roles of voltage-dependent type 7 K(+) channels in the human taenia coli.
Eur. J. Pharmacol., 2013 Dec 5 , 721 (12-20).

40

Khanamiri S et al. Contribution of Kv7 channels to basal coronary flow and active response to ischemia.
Hypertension, 2013 Dec , 62 (1090-7).

41

Hosseinzadeh Z et al. Downregulation of KCNQ4 by Janus kinase 2.
J. Membr. Biol., 2013 Apr , 246 (335-41).

42

Martelli A et al. Vasorelaxation by hydrogen sulphide involves activation of Kv7 potassium channels.
Pharmacol. Res., 2013 Apr , 70 (27-34).

43

Gao Y et al. Distinct roles of molecular chaperones HSP90α and HSP90β in the biogenesis of KCNQ4 channels.
PLoS ONE, 2013 , 8 (e57282).

44

Naito T et al. Comprehensive genetic screening of KCNQ4 in a large autosomal dominant nonsyndromic hearing loss cohort: genotype-phenotype correlations and a founder mutation.
PLoS ONE, 2013 , 8 (e63231).

45

Afeli SA et al. Molecular expression and pharmacological evidence for a functional role of kv7 channel subtypes in Guinea pig urinary bladder smooth muscle.
PLoS ONE, 2013 , 8 (e75875).

46

Mattmann ME et al. Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator.
Bioorg. Med. Chem. Lett., 2012 Sep 15 , 22 (5936-41).

47

Liu Y et al. The voltage-gated potassium channel subfamily KQT member 4 (KCNQ4) displays parallel evolution in echolocating bats.
Mol. Biol. Evol., 2012 May , 29 (1441-50).

48

Cui Y et al. Selective disruption of high sensitivity heat activation but not capsaicin activation of TRPV1 channels by pore turret mutations.
, 2012 Mar 12 , ().

49

Pattnaik BR et al. Effects of KCNQ channel modulators on the M-type potassium current in primate retinal pigment epithelium.
Am. J. Physiol., Cell Physiol., 2012 Mar , 302 (C821-33).

50

Choveau FS et al. Pore helix-S6 interactions are critical in governing current amplitudes of KCNQ3 K+ channels.
Biophys. J., 2012 Jun 6 , 102 (2499-509).

51

Heidenreich M et al. KCNQ4 K(+) channels tune mechanoreceptors for normal touch sensation in mouse and man.
Nat. Neurosci., 2012 Jan , 15 (138-45).

52

Lang F et al. Serum- and glucocorticoid-inducible kinase 1 in the regulation of renal and extrarenal potassium transport.
Clin. Exp. Nephrol., 2012 Feb , 16 (73-80).

53

Sliwinska-Kowalska M et al. Contribution of genetic factors to noise-induced hearing loss: A human studies review.
Mutat. Res., 2012 Dec 1 , ().

54

Brinch M et al. Identification of circulating fetal cell markers by microarray analysis.
Prenat. Diagn., 2012 Aug , 32 (742-51).

55

Fang Q et al. Genetic background of Prop1(df) mutants provides remarkable protection against hypothyroidism-induced hearing impairment.
J. Assoc. Res. Otolaryngol., 2012 Apr , 13 (173-84).

56

Chadha PS et al. Reduced KCNQ4-encoded voltage-dependent potassium channel activity underlies impaired β-adrenoceptor-mediated relaxation of renal arteries in hypertension.
Hypertension, 2012 Apr , 59 (877-84).

57

Namba K et al. In silico modeling of the pore region of a KCNQ4 missense mutant from a patient with hearing loss.
BMC Res Notes, 2012 , 5 (145).

58

Leitner MG et al. Rescue of ion channel function in deafness-causing KCNQ4 mutants by synthetic channel openers.
, 2011 Sep 26 , ().

59

Mistry HD et al. Novel expression and regulation of voltage-dependent potassium channels in placentas from women with preeclampsia.
Hypertension, 2011 Sep , 58 (497-504).

60

Ipavec V et al. KV7 channels regulate muscle tone and nonadrenergic noncholinergic relaxation of the rat gastric fundus.
Pharmacol. Res., 2011 Oct , 64 (397-409).

61

Zhang X et al. KCNQ5/K(v)7.5 potassium channel expression and subcellular localization in primate retinal pigment epithelium and neural retina.
Am. J. Physiol., Cell Physiol., 2011 Nov , 301 (C1017-26).

62

Kristensen LV et al. Kv7 (KCNQ) channel openers induce hypothermia in the mouse.
Neurosci. Lett., 2011 Jan 20 , 488 (178-82).

63

Kim HJ et al. Cellular and molecular mechanisms of autosomal dominant form of progressive hearing loss, DFNA2.
J. Biol. Chem., 2011 Jan 14 , 286 (1517-27).

64

Leitner MG et al. Aminoglycosides inhibit KCNQ4 channels in cochlear outer hair cells via depletion of phosphatidylinositol(4,5)bisphosphate.
Mol. Pharmacol., 2011 Jan , 79 (51-60).

65

Brueggemann LI et al. Diclofenac distinguishes among homomeric and heteromeric potassium channels composed of KCNQ4 and KCNQ5 subunits.
Mol. Pharmacol., 2011 Jan , 79 (10-23).

66

Arnett J et al. Autosomal dominant progressive sensorineural hearing loss due to a novel mutation in the KCNQ4 gene.
Arch. Otolaryngol. Head Neck Surg., 2011 Jan , 137 (54-9).

67

Jepps TA et al. Downregulation of Kv7.4 channel activity in primary and secondary hypertension.
Circulation, 2011 Aug 2 , 124 (602-11).

68

Baek JI et al. Pathogenic effects of a novel mutation (c.664_681del) in KCNQ4 channels associated with auditory pathology.
Biochim. Biophys. Acta, 2011 Apr , 1812 (536-43).

69

de Heer AM et al. Audioprofile-directed successful mutation analysis in a DFNA2/KCNQ4 (p.Leu274His) family.
Ann. Otol. Rhinol. Laryngol., 2011 Apr , 120 (243-8).

70

Cavaliere S et al. Drosophila KCNQ channel displays evolutionarily conserved electrophysiology and pharmacology with mammalian KCNQ channels.
PLoS ONE, 2011 , 6 (e23898).

71

Liu Z et al. Parallel evolution of KCNQ4 in echolocating bats.
PLoS ONE, 2011 , 6 (e26618).

72

Ng FL et al. Expression and function of the K(+) channel KCNQ genes in human arteries.
, 2010 Sep 14 , ().

73

Zhong XZ et al. Participation of KCNQ (Kv7) potassium channels in myogenic control of cerebral arterial diameter.
J. Physiol. (Lond.), 2010 Sep 1 , 588 (3277-93).

74

Lv P et al. Kv7-type channel currents in spiral ganglion neurons: involvement in sensorineural hearing loss.
J. Biol. Chem., 2010 Nov 5 , 285 (34699-707).

75

Kimitsuki T et al. Property of I(K,)(n) in inner hair cells isolated from guinea-pig cochlea.
Hear. Res., 2010 Mar , 261 (57-62).

76

Bal M et al. Ca2+/calmodulin disrupts AKAP79/150 interactions with KCNQ (M-Type) K+ channels.
J. Neurosci., 2010 Feb 10 , 30 (2311-23).

77

Soh H et al. The specific slow afterhyperpolarization inhibitor UCL2077 is a subtype-selective blocker of the epilepsy associated KCNQ channels.
Mol. Pharmacol., 2010 Dec , 78 (1088-95).

78

Wu T et al. Effect of salicylate on KCNQ4 of the guinea pig outer hair cell.
J. Neurophysiol., 2010 Apr , 103 (1969-77).

79

Sciarretta C et al. PLCγ-activated signalling is essential for TrkB mediated sensory neuron structural plasticity.
BMC Dev. Biol., 2010 , 10 (103).

80

Su TR et al. Functional study of the effect of phosphatase inhibitors on KCNQ4 channels expressed in Xenopus oocytes.
Acta Pharmacol. Sin., 2009 Sep , 30 (1220-6).

81

Vanoye CG et al. Distinct subdomains of the KCNQ1 S6 segment determine channel modulation by different KCNE subunits.
J. Gen. Physiol., 2009 Sep , 134 (207-17).

82

Hernandez CC et al. Affinity for phosphatidylinositol 4,5-bisphosphate determines muscarinic agonist sensitivity of Kv7 K+ channels.
J. Gen. Physiol., 2009 Nov , 134 (437-48).

83

Sousa AD et al. The septate junction protein caspr is required for structural support and retention of KCNQ4 at calyceal synapses of vestibular hair cells.
J. Neurosci., 2009 Mar 11 , 29 (3103-8).

84

Sotty F et al. Antipsychotic-like effect of retigabine [N-(2-Amino-4-(fluorobenzylamino)-phenyl)carbamic acid ester], a KCNQ potassium channel opener, via modulation of mesolimbic dopaminergic neurotransmission.
J. Pharmacol. Exp. Ther., 2009 Mar , 328 (951-62).

85

Jepps TA et al. Molecular and functional characterization of Kv7 K+ channel in murine gastrointestinal smooth muscles.
Am. J. Physiol. Gastrointest. Liver Physiol., 2009 Jul , 297 (G107-15).

86

Pawelczyk M et al. Analysis of gene polymorphisms associated with K ion circulation in the inner ear of patients susceptible and resistant to noise-induced hearing loss.
Ann. Hum. Genet., 2009 Jul , 73 (411-21).

87

Mustapha M et al. Deafness and permanently reduced potassium channel gene expression and function in hypothyroid Pit1dw mutants.
J. Neurosci., 2009 Jan 28 , 29 (1212-23).

88

Joshi S et al. KCNQ modulators reveal a key role for KCNQ potassium channels in regulating the tone of rat pulmonary artery smooth muscle.
J. Pharmacol. Exp. Ther., 2009 Apr , 329 (368-76).

89

Roura-Ferrer M et al. Functional implications of KCNE subunit expression for the Kv7.5 (KCNQ5) channel.
Cell. Physiol. Biochem., 2009 , 24 (325-34).

90

Maeda Y et al. Therapeutic regulation of gene expression in the inner ear using RNA interference.
Adv. Otorhinolaryngol., 2009 , 66 (13-36).

91

Blom SM et al. The acrylamide (S)-2 as a positive and negative modulator of Kv7 channels expressed in Xenopus laevis oocytes.
PLoS ONE, 2009 , 4 (e8251).

92

Mruk K et al. Discovery of a novel activator of KCNQ1-KCNE1 K channel complexes.
PLoS ONE, 2009 , 4 (e4236).

93

Jin Z et al. Expression and localization of K channels KCNQ2 and KCNQ3 in the mammalian cochlea.
Audiol. Neurootol., 2009 , 14 (98-105).

94

Yeung S et al. Bimodal effects of the Kv7 channel activator retigabine on vascular K+ currents.
Br. J. Pharmacol., 2008 Sep , 155 (62-72).

95

Nie L KCNQ4 mutations associated with nonsyndromic progressive sensorineural hearing loss.
, 2008 Oct , 16 (441-4).

96

Bal M et al. Homomeric and heteromeric assembly of KCNQ (Kv7) K+ channels assayed by total internal reflection fluorescence/fluorescence resonance energy transfer and patch clamp analysis.
J. Biol. Chem., 2008 Nov 7 , 283 (30668-76).

97

Hildebrand MS et al. Audioprofile-directed screening identifies novel mutations in KCNQ4 causing hearing loss at the DFNA2 locus.
Genet. Med., 2008 Nov , 10 (797-804).

98

Bal M et al. Calmodulin binding to M-type K+ channels assayed by TIRF/FRET in living cells.
J. Physiol. (Lond.), 2008 May 1 , 586 (2307-20).

99

Kesser BW et al. Gene transfer in human vestibular epithelia and the prospects for inner ear gene therapy.
Laryngoscope, 2008 May , 118 (821-31).

100

Mackie AR et al. Vascular KCNQ potassium channels as novel targets for the control of mesenteric artery constriction by vasopressin, based on studies in single cells, pressurized arteries, and in vivo measurements of mesenteric vascular resistance.
J. Pharmacol. Exp. Ther., 2008 May , 325 (475-83).

101

Wickenden AD et al. N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide (ICA-27243): a novel, selective KCNQ2/Q3 potassium channel activator.
Mol. Pharmacol., 2008 Mar , 73 (977-86).

102

Nakajo K et al. Second coiled-coil domain of KCNQ channel controls current expression and subfamily specific heteromultimerization by salt bridge networks.
J. Physiol. (Lond.), 2008 Jun 15 , 586 (2827-40).

103

Moser SL et al. Multiple KCNQ potassium channel subtypes mediate basal anion secretion from the human airway epithelial cell line Calu-3.
J. Membr. Biol., 2008 Feb , 221 (153-63).

104

Mencía A et al. A novel KCNQ4 pore-region mutation (p.G296S) causes deafness by impairing cell-surface channel expression.
Hum. Genet., 2008 Feb , 123 (41-53).

105

Miceli F et al. Molecular pharmacology and therapeutic potential of neuronal Kv7-modulating drugs.
, 2008 Feb , 8 (65-74).

106

Zaika O et al. Determinants within the turret and pore-loop domains of KCNQ3 K+ channels governing functional activity.
Biophys. J., 2008 Dec , 95 (5121-37).

107

Gao Z et al. Desensitization of chemical activation by auxiliary subunits: convergence of molecular determinants critical for augmenting KCNQ1 potassium channels.
J. Biol. Chem., 2008 Aug 15 , 283 (22649-58).

108

Maljevic S et al. Nervous system KV7 disorders: breakdown of a subthreshold brake.
J. Physiol. (Lond.), 2008 Apr 1 , 586 (1791-801).

109

Hernandez CC et al. Regulation of neural KCNQ channels: signalling pathways, structural motifs and functional implications.
J. Physiol. (Lond.), 2008 Apr 1 , 586 (1811-21).

110

Hansen HH et al. Kv7 channels: interaction with dopaminergic and serotonergic neurotransmission in the CNS.
J. Physiol. (Lond.), 2008 Apr 1 , 586 (1823-32).

111

Pauli-Magnus D et al. Detection and differentiation of sensorineural hearing loss in mice using auditory steady-state responses and transient auditory brainstem responses.
Neuroscience, 2007 Nov 9 , 149 (673-84).

112

Kros CJ How to build an inner hair cell: challenges for regeneration.
Hear. Res., 2007 May , 227 (3-10).

113

Rocha-Sanchez SM et al. Developmental expression of Kcnq4 in vestibular neurons and neurosensory epithelia.
Brain Res., 2007 Mar 30 , 1139 (117-25).

114

Howard RJ et al. Structural insight into KCNQ (Kv7) channel assembly and channelopathy.
Neuron, 2007 Mar 1 , 53 (663-75).

115

Winter H et al. Thyroid hormone receptor alpha1 is a critical regulator for the expression of ion channels during final differentiation of outer hair cells.
Histochem. Cell Biol., 2007 Jul , 128 (65-75).

116

Yeung SY et al. Molecular expression and pharmacological identification of a role for K(v)7 channels in murine vascular reactivity.
Br. J. Pharmacol., 2007 Jul , 151 (758-70).

117

Panaghie G et al. The role of S4 charges in voltage-dependent and voltage-independent KCNQ1 potassium channel complexes.
J. Gen. Physiol., 2007 Feb , 129 (121-33).

118

Xu T et al. Roles of alternative splicing in the functional properties of inner ear-specific KCNQ4 channels.
J. Biol. Chem., 2007 Aug 17 , 282 (23899-909).

119

Holt JR et al. Dominant-negative inhibition of M-like potassium conductances in hair cells of the mouse inner ear.
J. Neurosci., 2007 Aug 15 , 27 (8940-51).

120

Kesser BW et al. An in vitro model system to study gene therapy in the human inner ear.
Gene Ther., 2007 Aug , 14 (1121-31).

121

Jensen HS et al. Inactivation as a new regulatory mechanism for neuronal Kv7 channels.
Biophys. J., 2007 Apr 15 , 92 (2747-56).

122

Su CC et al. Identification of novel mutations in the KCNQ4 gene of patients with nonsyndromic deafness from Taiwan.
Audiol. Neurootol., 2007 , 12 (20-6).

123

Su CC et al. Studies of the effect of ionomycin on the KCNQ4 channel expressed in Xenopus oocytes.
Biochem. Biophys. Res. Commun., 2006 Sep 15 , 348 (295-300).

124

Hansen HH et al. The KCNQ channel opener retigabine inhibits the activity of mesencephalic dopaminergic systems of the rat.
J. Pharmacol. Exp. Ther., 2006 Sep , 318 (1006-19).

125

Hurley KM et al. M-like K+ currents in type I hair cells and calyx afferent endings of the developing rat utricle.
J. Neurosci., 2006 Oct 4 , 26 (10253-69).

126

Van Eyken E et al. KCNQ4: a gene for age-related hearing impairment?
Hum. Mutat., 2006 Oct , 27 (1007-16).

127

Bentzen BH et al. The acrylamide (S)-1 differentially affects Kv7 (KCNQ) potassium channels.
Neuropharmacology, 2006 Nov , 51 (1068-77).

128

Mazurek B et al. High potassium concentrations protect inner and outer hair cells in the newborn rat culture from ischemia-induced damage.
Hear. Res., 2006 May , 215 (31-8).

129

Winter H et al. Thyroid hormone receptors TRalpha1 and TRbeta differentially regulate gene expression of Kcnq4 and prestin during final differentiation of outer hair cells.
J. Cell. Sci., 2006 Jul 15 , 119 (2975-84).

130

Kharkovets T et al. Mice with altered KCNQ4 K+ channels implicate sensory outer hair cells in human progressive deafness.
EMBO J., 2006 Feb 8 , 25 (642-52).

131

Van Laer L et al. The contribution of genes involved in potassium-recycling in the inner ear to noise-induced hearing loss.
Hum. Mutat., 2006 Aug , 27 (786-95).

132

Liang GH et al. Molecular analyses of KCNQ1-5 potassium channel mRNAs in rat and guinea pig inner ears: expression, cloning, and alternative splicing.
Acta Otolaryngol., 2006 Apr , 126 (346-52).

133

Strutz-Seebohm N et al. Functional coassembly of KCNQ4 with KCNE-beta- subunits in Xenopus oocytes.
Cell. Physiol. Biochem., 2006 , 18 (57-66).

134

Kamada F et al. A novel KCNQ4 one-base deletion in a large pedigree with hearing loss: implication for the genotype-phenotype correlation.
J. Hum. Genet., 2006 , 51 (455-60).

135

Beisel KW et al. Differential expression of KCNQ4 in inner hair cells and sensory neurons is the basis of progressive high-frequency hearing loss.
J. Neurosci., 2005 Oct 5 , 25 (9285-93).

136

Li Y et al. Regulation of Kv7 (KCNQ) K+ channel open probability by phosphatidylinositol 4,5-bisphosphate.
J. Neurosci., 2005 Oct 26 , 25 (9825-35).

137

Schenzer A et al. Molecular determinants of KCNQ (Kv7) K+ channel sensitivity to the anticonvulsant retigabine.
J. Neurosci., 2005 May 18 , 25 (5051-60).

138

Topsakal V et al. Phenotype determination guides swift genotyping of a DFNA2/KCNQ4 family with a hot spot mutation (W276S).
Otol. Neurotol., 2005 Jan , 26 (52-8).

139

Gamper N et al. Structural requirements for differential sensitivity of KCNQ K+ channels to modulation by Ca2+/calmodulin.
Mol. Biol. Cell, 2005 Aug , 16 (3538-51).

140

Chambard JM et al. Regulation of the voltage-gated potassium channel KCNQ4 in the auditory pathway.
Pflugers Arch., 2005 Apr , 450 (34-44).

141

Seebohm G et al. Regulation of KCNQ4 potassium channel prepulse dependence and current amplitude by SGK1 in Xenopus oocytes.
Cell. Physiol. Biochem., 2005 , 16 (255-62).

142

Wong WH et al. Differences between the negatively activating potassium conductances of Mammalian cochlear and vestibular hair cells.
J. Assoc. Res. Otolaryngol., 2004 Sep , 5 (270-84).

143

Gomez-Casati ME et al. Linopirdine blocks alpha9alpha10-containing nicotinic cholinergic receptors of cochlear hair cells.
J. Assoc. Res. Otolaryngol., 2004 Sep , 5 (261-9).

144

Li Y et al. Single-channel analysis of KCNQ K+ channels reveals the mechanism of augmentation by a cysteine-modifying reagent.
J. Neurosci., 2004 Jun 2 , 24 (5079-90).

145

Hougaard C et al. Modulation of KCNQ4 channel activity by changes in cell volume.
Biochim. Biophys. Acta, 2004 Jan 28 , 1660 (1-6).

146

Rüttiger L et al. Deletion of the Ca2+-activated potassium (BK) alpha-subunit but not the BKbeta1-subunit leads to progressive hearing loss.
Proc. Natl. Acad. Sci. U.S.A., 2004 Aug 31 , 101 (12922-7).

147

Ljungstrom T et al. Functional coupling between heterologously expressed dopamine D(2) receptors and KCNQ channels.
Pflugers Arch., 2003 Sep , 446 (684-94).

148

Kutchinsky J et al. Characterization of potassium channel modulators with QPatch automated patch-clamp technology: system characteristics and performance.
, 2003 Oct , 1 (685-93).

149

Oliver D et al. Resting potential and submembrane calcium concentration of inner hair cells in the isolated mouse cochlea are set by KCNQ-type potassium channels.
J. Neurosci., 2003 Mar 15 , 23 (2141-9).

150

Grunnet M et al. KCNQ1 channels sense small changes in cell volume.
J. Physiol. (Lond.), 2003 Jun 1 , 549 (419-27).

151

Nouvian R et al. Degeneration of sensory outer hair cells following pharmacological blockade of cochlear KCNQ channels in the adult guinea pig.
Eur. J. Neurosci., 2003 Jun , 17 (2553-62).

152

Gamper N et al. Subunit-specific modulation of KCNQ potassium channels by Src tyrosine kinase.
J. Neurosci., 2003 Jan 1 , 23 (84-95).

153

Schwake M et al. A carboxy-terminal domain determines the subunit specificity of KCNQ K+ channel assembly.
EMBO Rep., 2003 Jan , 4 (76-81).

154

Gribkoff VK The therapeutic potential of neuronal KCNQ channel modulators.
Expert Opin. Ther. Targets, 2003 Dec , 7 (737-48).

155

Schrøder RL et al. Voltage-independent KCNQ4 currents induced by (+/-)BMS-204352.
Pflugers Arch., 2003 Aug , 446 (607-16).

156

Cooper EC et al. M-channels: neurological diseases, neuromodulation, and drug development.
Arch. Neurol., 2003 Apr , 60 (496-500).

157

Wangemann P K(+) cycling and its regulation in the cochlea and the vestibular labyrinth.
Audiol. Neurootol., 2002 Jul-Aug , 7 (199-205).

158

Shah MM et al. Molecular correlates of the M-current in cultured rat hippocampal neurons.
J. Physiol. (Lond.), 2002 Oct 1 , 544 (29-37).

159

Stern RE et al. Audiologic evidence for further genetic heterogeneity at DFNA2.
Acta Otolaryngol., 2002 Oct , 122 (730-5).

160

Wang Q et al. [KCNQ4 gene mutations affected a pedigree with autosomal dominant hereditary hearing loss]
Zhonghua Er Bi Yan Hou Ke Za Zhi, 2002 Oct , 37 (343-7).

161

Jespersen T et al. Dual-function vector for protein expression in both mammalian cells and Xenopus laevis oocytes.
BioTechniques, 2002 Mar , 32 (536-8, 540).

162

Wangemann P K+ cycling and the endocochlear potential.
Hear. Res., 2002 Mar , 165 (1-9).

163

De Leenheer EM et al. Longitudinal and cross-sectional phenotype analysis in a new, large Dutch DFNA2/KCNQ4 family.
Ann. Otol. Rhinol. Laryngol., 2002 Mar , 111 (267-74).

164

Van Camp G et al. A mutational hot spot in the KCNQ4 gene responsible for autosomal dominant hearing impairment.
Hum. Mutat., 2002 Jul , 20 (15-9).

165

Boettger T et al. Deafness and renal tubular acidosis in mice lacking the K-Cl co-transporter Kcc4.
Nature, 2002 Apr 25 , 416 (874-8).

166

Goldstein JA et al. Further evidence for a third deafness gene within the DFNA2 locus.
Am. J. Med. Genet., 2002 Apr 1 , 108 (304-9).

167

De Leenheer EM et al. DFNA2/KCNQ4 and its manifestations.
Adv. Otorhinolaryngol., 2002 , 61 (41-6).

168

Bom SJ et al. Speech recognition scores related to age and degree of hearing impairment in DFNA2/KCNQ4 and DFNA9/COCH.
Arch. Otolaryngol. Head Neck Surg., 2001 Sep , 127 (1045-8).

169

Korolkova YV et al. An ERG channel inhibitor from the scorpion Buthus eupeus.
J. Biol. Chem., 2001 Mar 30 , 276 (9868-76).

170

Schrøder RL et al. KCNQ4 channel activation by BMS-204352 and retigabine.
Neuropharmacology, 2001 Jun , 40 (888-98).

171

Tatulian L et al. Activation of expressed KCNQ potassium currents and native neuronal M-type potassium currents by the anti-convulsant drug retigabine.
J. Neurosci., 2001 Aug 1 , 21 (5535-45).

172

Søgaard R et al. KCNQ4 channels expressed in mammalian cells: functional characteristics and pharmacology.
Am. J. Physiol., Cell Physiol., 2001 Apr , 280 (C859-66).

173

Robbins J KCNQ potassium channels: physiology, pathophysiology, and pharmacology.
Pharmacol. Ther., 2001 Apr , 90 (1-19).

174

Akita J et al. Clinical and genetic features of nonsyndromic autosomal dominant sensorineural hearing loss: KCNQ4 is a gene responsible in Japanese.
J. Hum. Genet., 2001 , 46 (355-61).

175

Cooper EC Potassium channels: how genetic studies of epileptic syndromes open paths to new therapeutic targets and drugs.
Epilepsia, 2001 , 42 Suppl 5 (49-54).

176

Beisel KW et al. Longitudinal gradients of KCNQ4 expression in spiral ganglion and cochlear hair cells correlate with progressive hearing loss in DFNA2.
Brain Res. Mol. Brain Res., 2000 Oct 20 , 82 (137-49).

177

Van Hauwe P et al. Mutations in the KCNQ4 K+ channel gene, responsible for autosomal dominant hearing loss, cluster in the channel pore region.
Am. J. Med. Genet., 2000 Jul 31 , 93 (184-7).

178

Schroeder BC et al. A constitutively open potassium channel formed by KCNQ1 and KCNE3.
Nature, 2000 Jan 13 , 403 (196-9).

179

Hadley JK et al. Differential tetraethylammonium sensitivity of KCNQ1-4 potassium channels.
Br. J. Pharmacol., 2000 Feb , 129 (413-5).

180

Miraglia del Giudice E et al. Benign familial neonatal convulsions (BFNC) resulting from mutation of the KCNQ2 voltage sensor.
Eur. J. Hum. Genet., 2000 Dec , 8 (994-7).

181

Kharkovets T et al. KCNQ4, a K+ channel mutated in a form of dominant deafness, is expressed in the inner ear and the central auditory pathway.
Proc. Natl. Acad. Sci. U.S.A., 2000 Apr 11 , 97 (4333-8).

182

Van Hauwe P et al. The DFNA2 locus for hearing impairment: two genes regulating K+ ion recycling in the inner ear.
, 1999 Oct , 33 (285-9).

183

Marcotti W et al. Developmental expression of the potassium current IK,n contributes to maturation of mouse outer hair cells.
J. Physiol. (Lond.), 1999 Nov 1 , 520 Pt 3 (653-60).

184

Van Hauwe P et al. Deafness linked to DFNA2: one locus but how many genes?
Nat. Genet., 1999 Mar , 21 (263).

185

Coucke PJ et al. Mutations in the KCNQ4 gene are responsible for autosomal dominant deafness in four DFNA2 families.
Hum. Mol. Genet., 1999 Jul , 8 (1321-8).

186

Kubisch C et al. KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness.
Cell, 1999 Feb 5 , 96 (437-46).

187

Talebizadeh Z et al. Novel mutation in the KCNQ4 gene in a large kindred with dominant progressive hearing loss.
Hum. Mutat., 1999 , 14 (493-501).