ClCK1

1

Wojciechowski D et al. Tryptophan Scanning Mutagenesis Identifies the Molecular Determinants of Distinct Barttin Functions.
J. Biol. Chem., 2015 Jul 24 , 290 (18732-43).

2

Stölting G et al. Carboxyl-terminal Truncations of ClC-Kb Abolish Channel Activation by Barttin Via Modified Common Gating and Trafficking.
J. Biol. Chem., 2015 Dec 18 , 290 (30406-16).

3

Imbrici P et al. Targeting kidney CLC-K channels: pharmacological profile in a human cell line versus Xenopus oocytes.
Biochim. Biophys. Acta, 2014 Oct , 1838 (2484-91).

4

Bolívar JJ et al. A chloride conductance exhibiting bicarbonate conductivity in renal inner medullary collecting duct cells.
Gen. Physiol. Biophys., 2014 , 33 (321-34).

5

Keck M et al. Novel CLCNKB mutations causing Bartter syndrome affect channel surface expression.
Hum. Mutat., 2013 Sep , 34 (1269-78).

6

L'Hoste S et al. Characterization of the mouse ClC-K1/Barttin chloride channel.
Biochim. Biophys. Acta, 2013 Nov , 1828 (2399-409).

7

Gradogna A et al. Alkaline pH block of CLC-K kidney chloride channels mediated by a pore lysine residue.
Biophys. J., 2013 Jul 2 , 105 (80-90).

8

Urity VB et al. Architecture of kangaroo rat inner medulla: segmentation of descending thin limb of Henle's loop.
Am. J. Physiol. Regul. Integr. Comp. Physiol., 2012 Mar 15 , 302 (R720-6).

9

Küper C et al. Sepsis-induced urinary concentration defect is related to nitric oxide-dependent inactivation of TonEBP/NFAT5, which downregulates renal medullary solute transport proteins and aquaporin-2.
Crit. Care Med., 2012 Jun , 40 (1887-95).

10

Liantonio A et al. In-vivo administration of CLC-K kidney chloride channels inhibitors increases water diuresis in rats: a new drug target for hypertension?
J. Hypertens., 2012 Jan , 30 (153-67).

11

Gradogna A et al. Dissecting a regulatory calcium-binding site of CLC-K kidney chloride channels.
J. Gen. Physiol., 2012 Dec , 140 (681-96).

12

Nomura N et al. Generation and analyses of R8L barttin knockin mouse.
Am. J. Physiol. Renal Physiol., 2011 Aug , 301 (F297-307).

13

Sugawara N et al. Calcium and calcimimetics regulate paracellular Na+ transport in the thin ascending limb of Henle's loop in mouse kidney.
Pflugers Arch., 2010 Jun , 460 (197-205).

14

Fischer M et al. Barttin activates ClC-K channel function by modulating gating.
J. Am. Soc. Nephrol., 2010 Aug , 21 (1281-9).

15

Kim YM et al. Urea and NaCl regulate UT-A1 urea transporter in opposing directions via TonEBP pathway during osmotic diuresis.
Am. J. Physiol. Renal Physiol., 2009 Jan , 296 (F67-77).

16

Bergler T et al. High osmolality induces the kidney-specific chloride channel CLC-K1 by a serum and glucocorticoid-inducible kinase 1 MAPK pathway.
Kidney Int., 2008 Nov , 74 (1170-7).

17

Krämer BK et al. Mechanisms of Disease: the kidney-specific chloride channels ClCKA and ClCKB, the Barttin subunit, and their clinical relevance.
, 2008 Jan , 4 (38-46).

18

Vandewalle A Expression and function of CLC and cystic fibrosis transmembrane conductance regulator chloride channels in renal epithelial tubule cells: pathophysiological implications.
, 2007 Jan-Feb , 30 (17-25).

19

Fenton RA et al. Mouse models and the urinary concentrating mechanism in the new millennium.
Physiol. Rev., 2007 Oct , 87 (1083-112).

20

Picollo A et al. Mechanism of interaction of niflumic acid with heterologously expressed kidney CLC-K chloride channels.
J. Membr. Biol., 2007 Apr , 216 (73-82).

21

Pannabecker TL et al. Three-dimensional architecture of inner medullary vasa recta.
Am. J. Physiol. Renal Physiol., 2006 Jun , 290 (F1355-66).

22

Scholl U et al. Barttin modulates trafficking and function of ClC-K channels.
Proc. Natl. Acad. Sci. U.S.A., 2006 Jul 25 , 103 (11411-6).

23

Teulon J et al. Exploration of the basolateral chloride channels in the renal tubule using.
Nephron Physiol, 2005 , 99 (p64-8).

24

Pannabecker TL et al. Three-dimensional lateral and vertical relationships of inner medullary loops of Henle and collecting ducts.
Am. J. Physiol. Renal Physiol., 2004 Oct , 287 (F767-74).

25

Picollo A et al. Molecular determinants of differential pore blocking of kidney CLC-K chloride channels.
EMBO Rep., 2004 Jun , 5 (584-9).

26

Liantonio A et al. Investigations of pharmacologic properties of the renal CLC-K1 chloride channel co-expressed with barttin by the use of 2-(p-Chlorophenoxy)propionic acid derivatives and other structurally unrelated chloride channels blockers.
J. Am. Soc. Nephrol., 2004 Jan , 15 (13-20).

27

Jeck N et al. A common sequence variation of the CLCNKB gene strongly activates ClC-Kb chloride channel activity.
Kidney Int., 2004 Jan , 65 (190-7).

28

Pannabecker TL et al. Three-dimensional functional reconstruction of inner medullary thin limbs of Henle's loop.
Am. J. Physiol. Renal Physiol., 2004 Jan , 286 (F38-45).

29

Nissant A et al. Heterogeneous distribution of chloride channels along the distal convoluted tubule probed by single-cell RT-PCR and patch clamp.
Am. J. Physiol. Renal Physiol., 2004 Dec , 287 (F1233-43).

30

Wolf K et al. Parallel down-regulation of chloride channel CLC-K1 and barttin mRNA in the thin ascending limb of the rat nephron by furosemide.
Pflugers Arch., 2003 Sep , 446 (665-71).

31

Furukawa T [Various functions of ClC-type Cl- channels]
Nippon Yakurigaku Zasshi, 2003 Nov , 122 (375-83).

32

Lourdel S et al. A chloride channel at the basolateral membrane of the distal-convoluted tubule: a candidate ClC-K channel.
J. Gen. Physiol., 2003 Apr , 121 (287-300).

33

Klein JD et al. Impaired urine concentration and absence of tissue ACE: involvement of medullary transport proteins.
Am. J. Physiol. Renal Physiol., 2002 Sep , 283 (F517-24).

34

Miyazaki H et al. Kidney-specific chloride channel, OmClC-K, predominantly expressed in the diluting segment of freshwater-adapted tilapia kidney.
Proc. Natl. Acad. Sci. U.S.A., 2002 Nov 26 , 99 (15782-7).

35

Liu W et al. Analysis of NaCl transport in thin ascending limb of Henle's loop in CLC-K1 null mice.
Am. J. Physiol. Renal Physiol., 2002 Mar , 282 (F451-7).

36

Mejia R et al. Immunomorphometric study of rat renal inner medulla.
Am. J. Physiol. Renal Physiol., 2002 Mar , 282 (F553-7).

37

Waldegger S et al. Barttin increases surface expression and changes current properties of ClC-K channels.
Pflugers Arch., 2002 Jun , 444 (411-8).

38

Kobayashi K et al. Human CLC-KB gene promoter drives the EGFP expression in the specific distal nephron segments and inner ear.
J. Am. Soc. Nephrol., 2002 Aug , 13 (1992-8).

39

Vandewalle A [Function of the CLC chloride channels and their implication in human pathology]
, 2002 , 23 (113-8).

40

Kobayashi K et al. Intrarenal and cellular localization of CLC-K2 protein in the mouse kidney.
J. Am. Soc. Nephrol., 2001 Jul , 12 (1327-34).

41

Kobayashi K et al. Developmental expression of CLC-K1 in the postnatal rat kidney.
Histochem. Cell Biol., 2001 Jul , 116 (49-56).

42

Akizuki N et al. Impaired solute accumulation in inner medulla of Clcnk1-/- mice kidney.
Am. J. Physiol. Renal Physiol., 2001 Jan , 280 (F79-87).

43

Liu W et al. "Avian-type" renal medullary tubule organization causes immaturity of urine-concentrating ability in neonates.
Kidney Int., 2001 Aug , 60 (680-93).

44

Uchida S et al. Isolation of a novel zinc finger repressor that regulates the kidney-specific CLC-K1 promoter.
Kidney Int., 2001 Aug , 60 (416-21).

45

Scherer CR et al. Gene expression profiles of CLC chloride channels in animal models with different cardiovascular diseases.
Cell. Physiol. Biochem., 2001 , 11 (321-30).

46

Uchida S et al. Severely impaired urine-concentrating ability in mice lacking the CLC-K1 chloride channel.
Exp. Nephrol., 2000 Nov-Dec , 8 (361-5).

47

Castrop H et al. Overexpression of chloride channel CLC-K2 mRNA in the renal medulla of Dahl salt-sensitive rats.
J. Hypertens., 2000 Sep , 18 (1289-95).

48

Uchida S et al. Transcriptional regulation of the CLC-K1 promoter by myc-associated zinc finger protein and kidney-enriched Krüppel-like factor, a novel zinc finger repressor.
Mol. Cell. Biol., 2000 Oct , 20 (7319-31).

49

Uchida S In vivo role of CLC chloride channels in the kidney.
Am. J. Physiol. Renal Physiol., 2000 Nov , 279 (F802-8).

50

Pannabecker TL et al. Mixed descending- and ascending-type thin limbs of Henle's loop in mammalian renal inner medulla.
Am. J. Physiol. Renal Physiol., 2000 Feb , 278 (F202-8).

51

Sauvé R et al. pH and external Ca(2+) regulation of a small conductance Cl(-) channel in kidney distal tubule.
Biochim. Biophys. Acta, 2000 Dec 20 , 1509 (73-85).

52

Kawasaki E et al. mRNA expression of kidney-specific ClC-K1 chloride channel in single-cell reverse transcription-polymerase chain reaction analysis of outer hair cells of rat cochlea.
Neurosci. Lett., 2000 Aug 18 , 290 (76-8).

53

Waldegger S et al. Functional and structural analysis of ClC-K chloride channels involved in renal disease.
J. Biol. Chem., 2000 Aug 11 , 275 (24527-33).

54

Ando M et al. mRNA encoding 'ClC-K1, a kidney Cl(-)- channel' is expressed in marginal cells of the stria vascularis of rat cochlea: its possible contribution to Cl(-) currents.
Neurosci. Lett., 2000 Apr 28 , 284 (171-4).

55

Uchida S Physiological role of CLC-K1 chloride channel in the kidney.
Nephrol. Dial. Transplant., 2000 , 15 Suppl 6 (14-5).

56

Tanaka K et al. Characterization of novel promoter and enhancer elements of the mouse homologue of the Dent disease gene, CLCN5, implicated in X-linked hereditary nephrolithiasis.
Genomics, 1999 Jun 15 , 58 (281-92).

57

Matsumura Y et al. Overt nephrogenic diabetes insipidus in mice lacking the CLC-K1 chloride channel.
Nat. Genet., 1999 Jan , 21 (95-8).

58

Rai T et al. Isolation and characterization of kidney-specific CLC-K2 chloride channel gene promoter.
Biochem. Biophys. Res. Commun., 1999 Aug 2 , 261 (432-8).

59

Yoshikawa M et al. Localization of rat CLC-K2 chloride channel mRNA in the kidney.
Am. J. Physiol., 1999 Apr , 276 (F552-8).

60

Uchida S et al. Isolation and characterization of kidney-specific ClC-K1 chloride channel gene promoter.
Am. J. Physiol., 1998 Mar , 274 (F602-10).

61

Vandewalle A et al. Localization and induction by dehydration of ClC-K chloride channels in the rat kidney.
Am. J. Physiol., 1997 May , 272 (F678-88).

62

Uchida S [Structure and function of ClC chloride channels]
Nippon Rinsho, 1996 Mar , 54 (667-71).

63

Uchida S et al. Chloride transport across kidney epithelia through CLC chloride channels.
, 1996 Jul , 38 (285-9).

64

Takeuchi Y et al. Cloning, tissue distribution, and intrarenal localization of ClC chloride channels in human kidney.
Kidney Int., 1995 Nov , 48 (1497-503).

65

Uchida S et al. Localization and functional characterization of rat kidney-specific chloride channel, ClC-K1.
J. Clin. Invest., 1995 Jan , 95 (104-13).

66

Kieferle S et al. Two highly homologous members of the ClC chloride channel family in both rat and human kidney.
Proc. Natl. Acad. Sci. U.S.A., 1994 Jul 19 , 91 (6943-7).

67

Adachi S et al. Two isoforms of a chloride channel predominantly expressed in thick ascending limb of Henle's loop and collecting ducts of rat kidney.
J. Biol. Chem., 1994 Jul 1 , 269 (17677-83).

68

Sasaki S et al. ClC family in the kidney.
Jpn. J. Physiol., 1994 , 44 Suppl 2 (S3-8).