Referenced in: none

Automatically associated channels: Cav2.1

Title: Treatment of episodic ataxia type 2 with the potassium channel blocker 4-aminopyridine.

Authors: M Strupp, R Kalla, M Dichgans, T Freilinger, S Glasauer, T Brandt

Journal, date & volume: Neurology, 2004 May 11 , 62, 1623-5

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/15136697

Abstract
Patients with episodic ataxia type 2 (EA2) can often be successfully treated with acetazolamide. The authors report three patients with EA2 (two with proven mutations in the CACNA1A gene) whose attacks were prevented with the potassium channel blocker 4-aminopyridine (4-AP; 5 mg tid). Attacks recurred after treatment was stopped; subsequent treatment alleviated the symptoms (mean follow-up time 6 months). These effects might be due to an improvement of the impaired functioning of Purkinje cells.