ClCA1

1

Brett TJ CLCA1 and TMEM16A: the link towards a potential cure for airway diseases.
Expert Rev Respir Med, 2015 Oct , 9 (503-6).

2

Yang B et al. Low expression of chloride channel accessory 1 predicts a poor prognosis in colorectal cancer.
Cancer, 2015 May 15 , 121 (1570-80).

3

Musrap N et al. Comparative Proteomics of Ovarian Cancer Aggregate Formation Reveals an Increased Expression of Calcium-activated Chloride Channel Regulator 1 (CLCA1).
J. Biol. Chem., 2015 Jul 10 , 290 (17218-27).

4

Traister RS et al. Phenotypic and genotypic association of epithelial IL1RL1 to human TH2-like asthma.
J. Allergy Clin. Immunol., 2015 Jan , 135 (92-9).

5

Sala-Rabanal M et al. Secreted CLCA1 modulates TMEM16A to activate Ca(2+)-dependent chloride currents in human cells.
Elife, 2015 , 4 ().

6

Erickson NA et al. The Goblet Cell Protein Clca1 (Alias mClca3 or Gob-5) Is Not Required for Intestinal Mucus Synthesis, Structure and Barrier Function in Naive or DSS-Challenged Mice.
PLoS ONE, 2015 , 10 (e0131991).

7

Peters MC et al. Measures of gene expression in sputum cells can identify TH2-high and TH2-low subtypes of asthma.
J. Allergy Clin. Immunol., 2014 Feb , 133 (388-94).

8

Dietert K et al. mCLCA3 modulates IL-17 and CXCL-1 induction and leukocyte recruitment in murine Staphylococcus aureus pneumonia.
PLoS ONE, 2014 , 9 (e102606).

9

Song LQ et al. Safety and immunogenicity of a DNA vaccine encoding human calcium-activated chloride channel 1 (hCLCA1) in asthmatic mice.
Int. Arch. Allergy Immunol., 2013 , 161 (243-51).

10

Ching JC et al. Secreted hCLCA1 Is a Signaling Molecule That Activates Airway Macrophages.
PLoS ONE, 2013 , 8 (e83130).

11

Yang B et al. The transition from proliferation to differentiation in colorectal cancer is regulated by the calcium activated chloride channel A1.
PLoS ONE, 2013 , 8 (e60861).

12

Mata M et al. Roflumilast inhibits respiratory syncytial virus infection in human differentiated bronchial epithelial cells.
PLoS ONE, 2013 , 8 (e69670).

13

Song LQ et al. hCLCA1 DNA vaccine suppresses cell hyperplasia and mucin expression of goblet cells in vitro.
Respiration, 2013 , 86 (486-96).

14

Kondo M et al. Niflumic Acid inhibits goblet cell degranulation in a Guinea pig asthma model.
Allergol Int, 2012 Mar , 61 (133-42).

15

Martínez-Morillo E et al. Development of a multiplex selected reaction monitoring assay for quantification of biochemical markers of down syndrome in amniotic fluid samples.
J. Proteome Res., 2012 Jul 6 , 11 (3880-7).

16

Mundhenk L et al. MCLCA3 does not Contribute to the Calcium-Activated Chloride Conductance in Mouse Airways.
, 2012 Feb 23 , ().

17

Yurtsever Z et al. Self-cleavage of human CLCA1 protein by a novel internal metalloprotease domain controls calcium-activated chloride channel activation.
J. Biol. Chem., 2012 Dec 7 , 287 (42138-49).

18

Alevy YG et al. IL-13-induced airway mucus production is attenuated by MAPK13 inhibition.
J. Clin. Invest., 2012 Dec 3 , 122 (4555-68).

19

Iwashita H et al. Increased human Ca²⁺-activated Cl⁻ channel 1 expression and mucus overproduction in airway epithelia of smokers and chronic obstructive pulmonary disease patients.
Respir. Res., 2012 , 13 (55).

20

Seo KY et al. Niflumic Acid Reduces Histamine-Induced MUC5AC Expression in Human Conjunctival Epithelial Cells.
Ophthalmic Res., 2011 Oct , 46 (181-6).

21

Bothe MK et al. The murine goblet cell protein mCLCA3 is a zinc-dependent metalloprotease with autoproteolytic activity.
Mol. Cells, 2011 Dec , 32 (535-41).

22

Muranen TA et al. Breast tumors from CHEK2 1100delC-mutation carriers: genomic landscape and clinical implications.
Breast Cancer Res., 2011 , 13 (R90).

23

Braun J et al. Quantitative expression analyses of candidates for alternative anion conductance in cystic fibrosis mouse models.
J. Cyst. Fibros., 2010 Sep , 9 (351-64).

24

Furuya M et al. Lymphatic endothelial murine chloride channel calcium-activated 1 is a ligand for leukocyte LFA-1 and Mac-1.
J. Immunol., 2010 Nov 15 , 185 (5769-77).

25

Kim KX et al. Inward-rectifier chloride currents in Reissner's membrane epithelial cells.
, 2010 Mar 9 , ().

26

van der Doef HP et al. Association of the CLCA1 p.S357N variant with meconium ileus in European patients with cystic fibrosis.
J. Pediatr. Gastroenterol. Nutr., 2010 Mar , 50 (347-9).

27

Wu W et al. [Expression and clinical significance of calcium-activated chloride channel and mucins in nasal mucosa with allergic rhinitis].
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi, 2010 Mar , 24 (193-5, 199).

28

Roussa E et al. Cellular distribution and subcellular localization of mCLCA1/2 in murine gastrointestinal epithelia.
J. Histochem. Cytochem., 2010 Jul , 58 (653-68).

29

Hauber HP et al. Effect of Th2 type cytokines on hCLCA1 and mucus expression in cystic fibrosis airways.
J. Cyst. Fibros., 2010 Jul , 9 (277-9).

30

Yu H et al. Interleukin-13 induces mucin 5AC production involving STAT6/SPDEF in human airway epithelial cells.
Cell Commun. Adhes., 2010 Aug , 17 (83-92).

31

Gerber V et al. Differential association of MUC5AC and CLCA1 expression in small cartilaginous airways of RAO-affected and control horses.
Equine Vet. J., 2009 Nov , 41 (817-23).

32

Hamann M et al. Human ClCa1 modulates anionic conduction of calcium-dependent chloride currents.
J. Physiol. (Lond.), 2009 May 15 , 587 (2255-74).

33

Winpenny JP et al. The CLCA gene family: putative therapeutic target for respiratory diseases.
Inflamm Allergy Drug Targets, 2009 Jun , 8 (146-60).

34

Bugno M et al. Interleukin 4 receptor alpha (IL4R) and calcium-activated chloride channel 1 (CLCA1) genes map to donkey chromosome.
Hereditas, 2009 Jun , 146 (118-21).

35

Wahl AS et al. Hypoxic/ischemic conditions induce expression of the putative pro-death gene Clca1 via activation of extrasynaptic N-methyl-D-aspartate receptors.
Neuroscience, 2009 Jan 12 , 158 (344-52).

36

Plog S et al. Genomic, tissue expression, and protein characterization of pCLCA1, a putative modulator of cystic fibrosis in the pig.
J. Histochem. Cytochem., 2009 Dec , 57 (1169-81).

37

Piirsoo M et al. Expression analysis of the CLCA gene family in mouse and human with emphasis on the nervous system.
BMC Dev. Biol., 2009 , 9 (10).

38

Ryhner T et al. Increased mucus accumulation in horses chronically affected with recurrent airway obstruction is not associated with up-regulation of CLCA1, EGFR, MUC5AC, Bcl-2, IL-13 and INF-gamma expression.
Vet. Immunol. Immunopathol., 2008 Sep 15 , 125 (8-17).

39

Woodruff PG et al. Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids.
Proc. Natl. Acad. Sci. U.S.A., 2007 Oct 2 , 104 (15858-63).

40

Range F et al. A soluble secreted glycoprotein (eCLCA1) is overexpressed due to goblet cell hyperplasia and metaplasia in horses with recurrent airway obstruction.
Vet. Pathol., 2007 Nov , 44 (901-11).

41

Zhang SJ et al. Decoding NMDA receptor signaling: identification of genomic programs specifying neuronal survival and death.
Neuron, 2007 Feb 15 , 53 (549-62).

42

Endo Y et al. Interleukin-9 and Interleukin-13 augment UTP-induced Cl ion transport via hCLCA1 expression in a human bronchial epithelial cell line.
Clin. Exp. Allergy, 2007 Feb , 37 (219-24).

43

Young FD et al. Amelioration of cystic fibrosis intestinal mucous disease in mice by restoration of mCLCA3.
Gastroenterology, 2007 Dec , 133 (1928-37).

44

Hegab AE et al. Niflumic acid and AG-1478 reduce cigarette smoke-induced mucin synthesis: the role of hCLCA1.
Chest, 2007 Apr , 131 (1149-56).

45

Hauber HP et al. LPS-induced mucin expression in human sinus mucosa can be attenuated by hCLCA inhibitors.
J. Endotoxin Res., 2007 , 13 (109-16).

46

Kim YM et al. Histamine induces MUC5AC expression via a hCLCA1 pathway.
Pharmacology, 2007 , 80 (219-26).

47

Elble RC et al. The putative chloride channel hCLCA2 has a single C-terminal transmembrane segment.
J. Biol. Chem., 2006 Oct 6 , 281 (29448-54).

48

Mundhenk L et al. Both cleavage products of the mCLCA3 protein are secreted soluble proteins.
J. Biol. Chem., 2006 Oct 6 , 281 (30072-80).

49

Zhang Y et al. Molecular expression and functional involvement of the bovine calcium-activated chloride channel 1 (bCLCA1) in apical HCO3- permeability of bovine corneal endothelium.
Exp. Eye Res., 2006 Nov , 83 (1215-24).

50

Yoon IS et al. Cloning and heterologous expression of a Ca2+-activated chloride channel isoform from rat brain.
Biol. Pharm. Bull., 2006 Nov , 29 (2168-73).

51

Pawłowski K et al. Novel conserved hydrolase domain in the CLCA family of alleged calcium-activated chloride channels.
Proteins, 2006 May 15 , 63 (424-39).

52

Park JH et al. Segmental heterogeneity of electrogenic secretions in human ascending colon and rectum.
, 2006 May , 21 (357-64).

53

Nakano T et al. Niflumic acid suppresses interleukin-13-induced asthma phenotypes.
Am. J. Respir. Crit. Care Med., 2006 Jun 1 , 173 (1216-21).

54

Klukowska-Rötzler J et al. Chromosomal assignment of the two candidate genes (EGFR, CLCA1) for equine recurrent airway obstruction (RAO) by FISH and RH mapping.
Hereditas, 2006 Dec , 143 (138-41).

55

Leverkoehne I et al. Differential expression of calcium-activated chloride channels (CLCA) gene family members in the small intestine of cystic fibrosis mouse models.
Histochem. Cell Biol., 2006 Aug , 126 (239-50).

56

Yasuo M et al. Relationship between calcium-activated chloride channel 1 and MUC5AC in goblet cell hyperplasia induced by interleukin-13 in human bronchial epithelial cells.
, 2006 , 73 (347-59).

57

Yamazaki J et al. Characterization of CLCA protein expressed in ductal cells of rat salivary glands.
Biochim. Biophys. Acta, 2005 Sep 15 , 1715 (132-44).

58

Gibson A et al. hCLCA1 and mCLCA3 are secreted non-integral membrane proteins and therefore are not ion channels.
J. Biol. Chem., 2005 Jul 22 , 280 (27205-12).

59

Loewen ME et al. Structure and function of CLCA proteins.
Physiol. Rev., 2005 Jul , 85 (1061-92).

60

Hauber HP et al. Niflumic acid and MSI-2216 reduce TNF-alpha-induced mucin expression in human airway mucosa.
J. Allergy Clin. Immunol., 2005 Feb , 115 (266-71).

61

Thai P et al. Differential regulation of MUC5AC/Muc5ac and hCLCA-1/mGob-5 expression in airway epithelium.
Am. J. Respir. Cell Mol. Biol., 2005 Dec , 33 (523-30).

62

Busse PJ et al. Chronic exposure to TNF-alpha increases airway mucus gene expression in vivo.
J. Allergy Clin. Immunol., 2005 Dec , 116 (1256-63).

63

Jeong SM et al. Cloning and expression of Ca2+-activated chloride channel from rat brain.
Biochem. Biophys. Res. Commun., 2005 Aug 26 , 334 (569-76).

64

Anton F et al. Overexpression of eCLCA1 in small airways of horses with recurrent airway obstruction.
J. Histochem. Cytochem., 2005 Aug , 53 (1011-21).

65

Hauber HP et al. Increased expression of the calcium-activated chloride channel hCLCA1 in airways of patients with obstructive chronic bronchitis.
Can. Respir. J., 2005 Apr , 12 (143-6).

66

Kamada F et al. Association of the hCLCA1 gene with childhood and adult asthma.
Genes Immun., 2004 Nov , 5 (540-7).

67

McNamara N et al. Adenosine up-regulation of the mucin gene, MUC2, in asthma.
FASEB J., 2004 Nov , 18 (1770-2).

68

Ritzka M et al. The CLCA gene locus as a modulator of the gastrointestinal basic defect in cystic fibrosis.
Hum. Genet., 2004 Nov , 115 (483-91).

69

Hegab AE et al. CLCA1 gene polymorphisms in chronic obstructive pulmonary disease.
J. Med. Genet., 2004 Mar , 41 (e27).

70

Hauber HP et al. Expression of HCLCA1 in cystic fibrosis lungs is associated with mucus overproduction.
Eur. Respir. J., 2004 Jun , 23 (846-50).

71

Loewen ME et al. pCLCA1 lacks inherent chloride channel activity in an epithelial colon carcinoma cell line.
Am. J. Physiol. Gastrointest. Liver Physiol., 2004 Jul , 287 (G33-41).

72

Song LQ et al. [Inhibitive effect on airway mucus overproduction with DNA vaccine based on xenogeneic homologous calcium-activated chloride channel in asthmatic mice]
Zhonghua Yi Xue Za Zhi, 2004 Feb 17 , 84 (329-33).

73

Currid A et al. Chloride secretion in a morphologically differentiated human colonic cell line that expresses the epithelial Na+ channel.
J. Physiol. (Lond.), 2004 Feb 15 , 555 (241-50).

74

Davies N et al. Chloride channel gene expression in the rabbit cornea.
Mol. Vis., 2004 Dec 30 , 10 (1028-37).

75

Loewen ME et al. CLCA protein and chloride transport in canine retinal pigment epithelium.
Am. J. Physiol., Cell Physiol., 2003 Nov , 285 (C1314-21).

76

Hauber HP et al. Increased expression of interleukin-9, interleukin-9 receptor, and the calcium-activated chloride channel hCLCA1 in the upper airways of patients with cystic fibrosis.
Laryngoscope, 2003 Jun , 113 (1037-42).

77

Thévenod F et al. Relationship between a HCO3- -permeable conductance and a CLCA protein from rat pancreatic zymogen granules.
Biochem. Biophys. Res. Commun., 2003 Jan 10 , 300 (546-54).

78

Abdel-Ghany M et al. The interacting binding domains of the beta(4) integrin and calcium-activated chloride channels (CLCAs) in metastasis.
J. Biol. Chem., 2003 Dec 5 , 278 (49406-16).

79

Abdel-Ghany M et al. Focal adhesion kinase activated by beta(4) integrin ligation to mCLCA1 mediates early metastatic growth.
J. Biol. Chem., 2002 Sep 13 , 277 (34391-400).

80

Loewen ME et al. pCLCA1 becomes a cAMP-dependent chloride conductance mediator in Caco-2 cells.
Biochem. Biophys. Res. Commun., 2002 Nov 8 , 298 (531-6).

81

Banks MR et al. Fluid and electrolyte transport in the small intestine.
Curr. Opin. Gastroenterol., 2002 Mar , 18 (176-81).

82

Greenwood IA et al. The large conductance potassium channel beta-subunit can interact with and modulate the functional properties of a calcium-activated chloride channel, CLCA1.
J. Biol. Chem., 2002 Jun 21 , 277 (22119-22).

83

Leverkoehne I et al. Real-time RT-PCR quantitation of mCLCA1 and mCLCA2 reveals differentially regulated expression in pre- and postnatal murine tissues.
Histochem. Cell Biol., 2002 Jul , 118 (11-7).

84

Britton FC et al. Comparison of the properties of CLCA1 generated currents and I(Cl(Ca)) in murine portal vein smooth muscle cells.
J. Physiol. (Lond.), 2002 Feb 15 , 539 (107-17).

85

Toda M et al. A calcium-activated chloride channel (HCLCA1) is strongly related to IL-9 expression and mucus production in bronchial epithelium of patients with asthma.
J. Allergy Clin. Immunol., 2002 Feb , 109 (246-50).

86

Loewen ME et al. The calcium-dependent chloride conductance mediator pCLCA1.
Am. J. Physiol., Cell Physiol., 2002 Aug , 283 (C412-21).

87

Zhang Y et al. Enhancement of HCO(3)(-) permeability across the apical membrane of bovine corneal endothelium by multiple signaling pathways.
Invest. Ophthalmol. Vis. Sci., 2002 Apr , 43 (1146-53).

88

Zhou Y et al. A calcium-activated chloride channel blocker inhibits goblet cell metaplasia and mucus overproduction.
Novartis Found. Symp., 2002 , 248 (150-65; discussion 165-70, 277-82).

89

Zhou Y et al. Characterization of a calcium-activated chloride channel as a shared target of Th2 cytokine pathways and its potential involvement in asthma.
Am. J. Respir. Cell Mol. Biol., 2001 Oct , 25 (486-91).

90

Elble RC et al. Tumor suppression by a proapoptotic calcium-activated chloride channel in mammary epithelium.
J. Biol. Chem., 2001 Nov 2 , 276 (40510-7).

91

Papassotiriou J et al. Ca(2+)-activated Cl- channels in Ehrlich ascites tumor cells are distinct from mCLCA1, 2 and 3.
Pflugers Arch., 2001 May , 442 (273-9).

92

Bustin SA et al. Expression of the Ca2+-activated chloride channel genes CLCA1 and CLCA2 is downregulated in human colorectal cancer.
DNA Cell Biol., 2001 Jun , 20 (331-8).

93

Sakai H et al. Is rabbit CLCA1 related to the basolateral Ca2+ -dependent Cl- channel of gastric parietal cells?
Jpn. J. Physiol., 2001 Feb , 51 (121-5).

94

Nakanishi A et al. Role of gob-5 in mucus overproduction and airway hyperresponsiveness in asthma.
Proc. Natl. Acad. Sci. U.S.A., 2001 Apr 24 , 98 (5175-80).

95

Pauli BU et al. Molecular characteristics and functional diversity of CLCA family members.
Clin. Exp. Pharmacol. Physiol., 2000 Nov , 27 (901-5).

96

Boese SH et al. Ca2+ and cAMP-activated Cl- conductances mediate Cl- secretion in a mouse renal inner medullary collecting duct cell line.
J. Physiol. (Lond.), 2000 Mar 1 , 523 Pt 2 (325-38).

97

Hume JR et al. Anion transport in heart.
Physiol. Rev., 2000 Jan , 80 (31-81).

98

Kose H et al. Bradykinin regulation of salt transport across mouse inner medullary collecting duct epithelium involves activation of a Ca(2+)-dependent Cl(-) conductance.
Br. J. Pharmacol., 2000 Dec , 131 (1689-99).

99

Gaspar KJ et al. Cloning a chloride conductance mediator from the apical membrane of porcine ileal enterocytes.
Physiol. Genomics, 2000 Aug 9 , 3 (101-11).

100

Leverkoehne I et al. Assignment of the murine calcium-activated chloride channel genes Clca1 and Clca3 (alias gob-5) to chromosome 3 band H2-H3 using somatic cell hybrids.
Cytogenet. Cell Genet., 2000 , 88 (208-9).

101

Gruber AD et al. Clustering of the human CLCA gene family on the short arm of chromosome 1 (1p22-31).
Genome, 1999 Oct , 42 (1030-2).

102

Lee D et al. Induction of mouse Ca(2+)-sensitive chloride channel 2 gene during involution of mammary gland.
Biochem. Biophys. Res. Commun., 1999 Nov 2 , 264 (933-7).

103

Gruber AD et al. Molecular cloning and biochemical characterization of a truncated, secreted member of the human family of Ca2+-activated Cl- channels.
Biochim. Biophys. Acta, 1999 Mar 19 , 1444 (418-23).

104

Gandhi R et al. Molecular and functional characterization of a calcium-sensitive chloride channel from mouse lung.
J. Biol. Chem., 1998 Nov 27 , 273 (32096-101).

105

Gruber AD et al. Genomic cloning, molecular characterization, and functional analysis of human CLCA1, the first human member of the family of Ca2+-activated Cl- channel proteins.
Genomics, 1998 Dec 1 , 54 (200-14).