HCN4

1

Du Y et al. β1-Adrenergic blocker bisoprolol reverses down-regulated ion channels in sinoatrial node of heart failure rats.
J. Physiol. Biochem., 2016 Jun , 72 (293-302).

2

Hurtado R et al. Hyperpolarization-activated cation and T-type calcium ion channel expression in porcine and human renal pacemaker tissues.
J. Anat., 2016 Jan 25 , ().

3

Qiu X et al. Therapeutic effect of astragaloside-IV on bradycardia is involved in up-regulating klotho expression.
Life Sci., 2016 Jan 1 , 144 (94-102).

4

Mezzano V et al. Desmosomal junctions are necessary for adult sinus node function.
Cardiovasc. Res., 2016 Apr 20 , ().

5

Liu J et al. Effects of Yiqi Tongyang on HCN4 Protein Phosphorylation in Damaged Rabbit Sinoatrial Node Cells.
Evid Based Complement Alternat Med, 2016 , 2016 (4379139).

6

Zaragoza MV et al. Exome Sequencing Identifies a Novel LMNA Splice-Site Mutation and Multigenic Heterozygosity of Potential Modifiers in a Family with Sick Sinus Syndrome, Dilated Cardiomyopathy, and Sudden Cardiac Death.
PLoS ONE, 2016 , 11 (e0155421).

7

Huang X et al. Age-associated expression of HCN channel isoforms in rat sinoatrial node.
Exp. Biol. Med. (Maywood), 2015 Sep 3 , ().

8

Li YD et al. Altered expression of hyperpolarization-activated cyclic nucleotide-gated channels and microRNA-1 and -133 in patients with age-associated atrial fibrillation.
Mol Med Rep, 2015 Sep , 12 (3243-8).

9

Millat G et al. HCN4 mutation as a molecular explanation on patients with bradycardia and non-compaction cardiomyopathy.
Eur J Med Genet, 2015 Sep , 58 (439-42).

10

Li N et al. Molecular Mapping of Sinoatrial Node HCN Channel Expression in the Human Heart.
Circ Arrhythm Electrophysiol, 2015 Oct , 8 (1219-27).

11

Wu X et al. [Expression of HCN4 protein in ventricular outflow tract of rabbit with idiopathic ventricular tachycardia].
Zhonghua Yi Xue Za Zhi, 2015 Nov 24 , 95 (3620-4).

12

Hou B et al. Characteristics of hyperpolarization-activated cyclic nucleotide-gated channels in dorsal root ganglion neurons at different ages and sizes.
Neuroreport, 2015 Nov 11 , 26 (981-7).

13

O'Donnell AM et al. Decreased expression of hyperpolarisation-activated cyclic nucleotide-gated channel 3 in Hirschsprung's disease.
World J. Gastroenterol., 2015 May 14 , 21 (5635-40).

14

Smith T et al. Increased Expression of HCN2 Channel Protein in L4 Dorsal Root Ganglion Neurons Following Axotomy of L5- and Inflammation of L4-Spinal Nerves in Rats.
Neuroscience, 2015 Mar 23 , ().

15

Notomi T et al. Zinc-Induced Effects on Osteoclastogenesis Involves Activation of Hyperpolarization-Activated Cyclic Nucleotide Modulated Channels Via Changes in Membrane Potential.
J. Bone Miner. Res., 2015 Mar 12 , ().

16

Simmons O et al. Persistent Noggin arrests cardiomyocyte morphogenesis and results in early in utero lethality.
Dev. Dyn., 2015 Mar , 244 (457-67).

17

Kelder TP et al. The sinus venosus myocardium contributes to the atrioventricular canal: potential role during atrioventricular node development?
J. Cell. Mol. Med., 2015 Jun , 19 (1375-89).

18

Yu HD et al. Spironolactone Regulates HCN Protein Expression Through Micro-RNA-1 in Rats With Myocardial Infarction.
J. Cardiovasc. Pharmacol., 2015 Jun , 65 (587-92).

19

Sun C et al. The short stature homeobox 2 (Shox2)-bone morphogenetic protein (BMP) pathway regulates dorsal mesenchymal protrusion development and its temporary function as a pacemaker during cardiogenesis.
J. Biol. Chem., 2015 Jan 23 , 290 (2007-23).

20

Liang X et al. Insights into cardiac conduction system formation provided by HCN4 expression.
Trends Cardiovasc. Med., 2015 Jan , 25 (1-9).

21

Tsai CT et al. Next-generation sequencing of nine atrial fibrillation candidate genes identified novel de novo mutations in patients with extreme trait of atrial fibrillation.
J. Med. Genet., 2015 Jan , 52 (28-36).

22

Huang J et al. PP2 prevents isoproterenol stimulation of cardiac pacemaker activity.
J. Cardiovasc. Pharmacol., 2015 Feb , 65 (193-202).

23

Lees-Miller JP et al. Ivabradine prolongs phase 3 of cardiac repolarization and blocks the hERG1 (KCNH2) current over a concentration-range overlapping with that required to block HCN4.
J. Mol. Cell. Cardiol., 2015 Aug , 85 (71-8).

24

Chen XF et al. [Changes of HCN4, Cx43 Expression in the Sinoatrial Node of Electric Shock Death].
Fa Yi Xue Za Zhi, 2015 Aug , 31 (266-8).

25

Melgari D et al. hERG potassium channel blockade by the HCN channel inhibitor bradycardic agent ivabradine.
J Am Heart Assoc, 2015 Apr , 4 ().

26

Allegue C et al. Genetic Analysis of Arrhythmogenic Diseases in the Era of NGS: The Complexity of Clinical Decision-Making in Brugada Syndrome.
PLoS ONE, 2015 , 10 (e0133037).

27

Feng Y et al. Electric-Pulse Current Stimulation Increases If Current in mShox2 Genetically Modified Canine Mesenchymal Stem Cells.
Cardiology, 2015 , 132 (49-57).

28

Saito Y et al. Enhancement of Spontaneous Activity by HCN4 Overexpression in Mouse Embryonic Stem Cell-Derived Cardiomyocytes - A Possible Biological Pacemaker.
PLoS ONE, 2015 , 10 (e0138193).

29

Günther A et al. Distinct expression patterns of HCN channels in HL-1 cardiomyocytes.
BMC Cell Biol., 2015 , 16 (18).

30

Seo H et al. Differential expression of hyperpolarization-activated cyclic nucleotide-gated channel subunits during hippocampal development in the mouse.
Mol Brain, 2015 , 8 (13).

31

Fürst O et al. Isoform dependent regulation of human HCN channels by cholesterol.
Sci Rep, 2015 , 5 (14270).

32

Verkerk AO et al. Pacemaker activity of the human sinoatrial node: an update on the effects of mutations in HCN4 on the hyperpolarization-activated current.
Int J Mol Sci, 2015 , 16 (3071-94).

33

Chen H et al. Berberine attenuates spontaneous action potentials in sinoatrial node cells and the currents of human HCN4 channels expressed in Xenopus laevis oocytes.
Mol Med Rep, 2014 Sep , 10 (1576-82).

34

Li H et al. Dual effects of amiodarone on pacemaker currents in hypertrophied ventricular myocytes isolated from spontaneously hypertensive rats.
Clin. Exp. Pharmacol. Physiol., 2014 Sep , 41 (698-707).

35

Wen W et al. Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.
Hum. Mol. Genet., 2014 Oct 15 , 23 (5492-504).

36

Pauza DH et al. Innervation of sinoatrial nodal cardiomyocytes in mouse. A combined approach using immunofluorescent and electron microscopy.
J. Mol. Cell. Cardiol., 2014 Oct , 75 (188-97).

37

Lai MH et al. BK channels regulate sinoatrial node firing rate and cardiac pacing in vivo.
Am. J. Physiol. Heart Circ. Physiol., 2014 Nov 1 , 307 (H1327-38).

38

Nam YJ et al. Induction of diverse cardiac cell types by reprogramming fibroblasts with cardiac transcription factors.
Development, 2014 Nov , 141 (4267-78).

39

Akimoto M et al. A Mechanism for the Auto-Inhibition of Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channel Opening and its Relief by cAMP.
J. Biol. Chem., 2014 May 30 , ().

40

Möller S et al. Cyclic nucleotide mapping of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels.
ACS Chem. Biol., 2014 May 16 , 9 (1128-37).

41

Zhao J et al. Relationship between two arrhythmias: sinus node dysfunction and atrial fibrillation.
Arch. Med. Res., 2014 May , 45 (351-5).

42

Verkerk AO et al. Pacemaker activity of the human sinoatrial node: effects of HCN4 mutations on the hyperpolarization-activated current.
Europace, 2014 Mar , 16 (384-95).

43

Macri V et al. A novel trafficking-defective HCN4 mutation is associated with early-onset atrial fibrillation.
Heart Rhythm, 2014 Jun , 11 (1055-62).

44

Schroeder C et al. Pacemaker current inhibition in experimental human cardiac sympathetic activation: a double-blind, randomized, crossover study.
Clin. Pharmacol. Ther., 2014 Jun , 95 (601-7).

45

Borbas Z et al. 161  novel immunohistochemical and structural features of subsidiary atrial pacemakers in the goat; relevance to potential sites for biological pacemakers.
Heart, 2014 Jun , 100 Suppl 3 (A92-3).

46

Mackiewicz U et al. Ivabradine protects against ventricular arrhythmias in acute myocardial infarction in the rat.
J. Cell. Physiol., 2014 Jun , 229 (813-23).

47

Shahi PK et al. The possible roles of hyperpolarization-activated cyclic nucleotide channels in regulating pacemaker activity in colonic interstitial cells of Cajal.
J. Gastroenterol., 2014 Jun , 49 (1001-10).

48

Huang J et al. PP2 prevents β-adrenergic stimulation of cardiac pacemaker activity.
J. Cardiovasc. Pharmacol., 2014 Jun , 63 (533-43).

49

Lolicato M et al. Cyclic dinucleotides bind the C-linker of HCN4 to control channel cAMP responsiveness.
Nat. Chem. Biol., 2014 Jun , 10 (457-62).

50

Scheruebel S et al. I(f) blocking potency of ivabradine is preserved under elevated endotoxin levels in human atrial myocytes.
J. Mol. Cell. Cardiol., 2014 Jul , 72 (64-73).

51

Calejo AI et al. Differences in the expression pattern of HCN isoforms among mammalian tissues: sources and implications.
Mol. Biol. Rep., 2014 Jan , 41 (297-307).

52

Wu M et al. Inducible gene deletion in the entire cardiac conduction system using Hcn4-CreERT2 BAC transgenic mice.
Genesis, 2014 Feb , 52 (134-40).

53

Schweizer PA et al. The symptom complex of familial sinus node dysfunction and myocardial noncompaction is associated with mutations in the HCN4 channel.
J. Am. Coll. Cardiol., 2014 Aug 26 , 64 (757-67).

54

Milano A et al. HCN4 mutations in multiple families with bradycardia and left ventricular noncompaction cardiomyopathy.
J. Am. Coll. Cardiol., 2014 Aug 26 , 64 (745-56).

55

Kentish SJ et al. Diet-dependent modulation of gastro-oesphageal vagal afferent mechanosensitivity by endogenous nitric oxide.
J. Physiol. (Lond.), 2014 Aug 1 , 592 (3287-301).

56

Liu Q et al. I h and HCN channels in murine spiral ganglion neurons: tonotopic variation, local heterogeneity, and kinetic model.
J. Assoc. Res. Otolaryngol., 2014 Aug , 15 (585-99).

57

Dufour MA et al. Somatodendritic ion channel expression in substantia nigra pars compacta dopaminergic neurons across postnatal development.
J. Neurosci. Res., 2014 Aug , 92 (981-99).

58

Mesirca P et al. T-type channels in the sino-atrial and atrioventricular pacemaker mechanism.
Pflugers Arch., 2014 Apr , 466 (791-9).

59

Feeney MM et al. Urinary tract pacemaker cells: current knowledge and insights from nonrenal pacemaker cells provide a basis for future discovery.
Pediatr. Nephrol., 2014 Apr , 29 (629-35).

60

Horwitz GC et al. Mechanotransduction and hyperpolarization-activated currents contribute to spontaneous activity in mouse vestibular ganglion neurons.
J. Gen. Physiol., 2014 Apr , 143 (481-97).

61

Zhang C et al. Triptolide improves early survival of mesenchymal stem cells transplanted into rat myocardium.
Cardiology, 2014 , 128 (73-85).

62

D'Souza A et al. Exercise training reduces resting heart rate via downregulation of the funny channel HCN4.
Nat Commun, 2014 , 5 (3775).

63

Zhou J et al. A novel HCN4 mutation, G1097W, is associated with atrioventricular block.
Circ. J., 2014 , 78 (938-42).

64

Mitrofanova LB et al. Evidence of specialized tissue in human interatrial septum: histological, immunohistochemical and ultrastructural findings.
PLoS ONE, 2014 , 9 (e113343).

65

Li YD et al. Association between reversal in the expression of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel and age-related atrial fibrillation.
Med. Sci. Monit., 2014 , 20 (2292-7).

66

Mesirca P et al. Cardiac arrhythmia induced by genetic silencing of 'funny' (f) channels is rescued by GIRK4 inactivation.
Nat Commun, 2014 , 5 (4664).

67

St Clair JR et al. PKA-independent activation of I(f) by cAMP in mouse sinoatrial myocytes.
Channels (Austin), 2013 Jul-Aug , 7 (318-21).

68

DiFrancesco D Funny channel gene mutations associated with arrhythmias.
J. Physiol. (Lond.), 2013 Sep 1 , 591 (4117-24).

69

Später D et al. A HCN4+ cardiomyogenic progenitor derived from the first heart field and human pluripotent stem cells.
Nat. Cell Biol., 2013 Sep , 15 (1098-106).

70

Chiu SN et al. Long-term outcomes of pediatric sinus bradycardia.
J. Pediatr., 2013 Sep , 163 (885-9.e1).

71

Zuo GF et al. Capsazepine concentration dependently inhibits currents in HEK 293 cells mediated by human hyperpolarization-activated cyclic nucleotide-gated 2 and 4 channels.
Exp. Biol. Med. (Maywood), 2013 Sep , 238 (1055-61).

72

Nawathe PA et al. An LQTS6 MiRP1 mutation suppresses pacemaker current and is associated with sinus bradycardia.
J. Cardiovasc. Electrophysiol., 2013 Sep , 24 (1021-7).

73

Duhme N et al. Altered HCN4 channel C-linker interaction is associated with familial tachycardia-bradycardia syndrome and atrial fibrillation.
Eur. Heart J., 2013 Sep , 34 (2768-75).

74

Kim YH et al. Functional contributions of HCN channels in the primary auditory neurons of the mouse inner ear.
J. Gen. Physiol., 2013 Sep , 142 (207-23).

75

Lu W et al. mHCN4 genetically modified canine mesenchymal stem cells provide biological pacemaking function in complete dogs with atrioventricular block.
Pacing Clin Electrophysiol, 2013 Sep , 36 (1138-49).

76

Hurtado R et al. A molecular signature of tissues with pacemaker activity in the heart and upper urinary tract involves coexpressed hyperpolarization-activated cation and T-type Ca2+ channels.
FASEB J., 2013 Nov 4 , ().

77

Hashem SI et al. Shox2 regulates the pacemaker gene program in embryoid bodies.
Stem Cells Dev., 2013 Nov 1 , 22 (2915-26).

78

El Khoury N et al. Upregulation of the hyperpolarization-activated current increases pacemaker activity of the sinoatrial node and heart rate during pregnancy in mice.
Circulation, 2013 May 21 , 127 (2009-20).

79

Hughes DI et al. HCN4 subunit expression in fast-spiking interneurons of the rat spinal cord and hippocampus.
Neuroscience, 2013 May 1 , 237 (7-18).

80

Rusznák Z et al. The hyperpolarization-activated non-specific cation current (In ) adjusts the membrane properties, excitability, and activity pattern of the giant cells in the rat dorsal cochlear nucleus.
Eur. J. Neurosci., 2013 Mar , 37 (876-90).

81

Morris GM et al. Characterisation of a Right Atrial Subsidiary Pacemaker and acceleration of the pacing rate by HCN over-expression.
Cardiovasc. Res., 2013 Jun 19 , ().

82

Cai Y et al. [Study on the effect of Klotho gene interferred by plasmid-mediated short hairpin RNA (shRNA) on sinoatrial node pacing channel gene].
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi, 2013 Jun , 30 (588-91).

83

Tibbs GR et al. HCN1 channels as targets for anesthetic and nonanesthetic propofol analogs in the amelioration of mechanical and thermal hyperalgesia in a mouse model of neuropathic pain.
J. Pharmacol. Exp. Ther., 2013 Jun , 345 (363-73).

84

Sah R et al. Timing of myocardial trpm7 deletion during cardiogenesis variably disrupts adult ventricular function, conduction, and repolarization.
Circulation, 2013 Jul 9 , 128 (101-14).

85

Hashem SI et al. Genetic isolation of stem cell-derived pacemaker-nodal cardiac myocytes.
Mol. Cell. Biochem., 2013 Jul 23 , ().

86

Sah R et al. Ion channel-kinase TRPM7 is required for maintaining cardiac automaticity.
Proc. Natl. Acad. Sci. U.S.A., 2013 Jul 22 , ().

87

Stoenica L et al. HCN1 subunits contribute to the kinetics of Ih in neonatal cortical plate neurons.
Dev Neurobiol, 2013 Jul 2 , ().

88

Al Madhoun AS et al. Testosterone enhances cardiomyogenesis in stem cells and recruits the androgen receptor to the MEF2C and HCN4 genes.
J. Mol. Cell. Cardiol., 2013 Jul , 60 (164-71).

89

Bosman A et al. Molecular and functional evidence of HCN4 and caveolin-3 interaction during cardiomyocyte differentiation from human embryonic stem cells.
Stem Cells Dev., 2013 Jan 11 , ().

90

Vedantham V et al. Spatiotemporal regulation of an Hcn4 enhancer defines a role for Mef2c and HDACs in cardiac electrical patterning.
Dev. Biol., 2013 Jan 1 , 373 (149-62).

91

Cao-Ehlker X et al. Upregulation of hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) by specific interaction with K+ channel tetramerization-domain containing protein 3 (KCTD3).
J. Biol. Chem., 2013 Feb 4 , ().

92

Riesen SC et al. Myocardial expression of hyperpolarization-activated, cyclic nucleotide-gated proteins in healthy cats and cats with hypertrophic cardiomyopathy.
Schweiz. Arch. Tierheilkd., 2013 Feb , 155 (143-7).

93

Fenske S et al. Sick Sinus Syndrome in HCN1-Deficient Mice.
Circulation, 2013 Dec 17 , 128 (2585-94).

94

Wilson CM et al. Phylogeny and effects of anoxia on hyperpolarization-activated cyclic nucleotide-gated channel gene expression in the heart of a primitive chordate, the Pacific hagfish (Eptatretus stoutii).
J. Exp. Biol., 2013 Dec 1 , 216 (4462-72).

95

Stillitano F et al. Chronic atrial fibrillation alters the functional properties of If in the human atrium.
J. Cardiovasc. Electrophysiol., 2013 Dec , 24 (1391-400).

96

Yu F et al. [Experimental research of recombinant lentivirus mediated hyperpolarization-activated cyclic nucleotide-gated cation channel 4 gene transfecting bone mesenchymal stem cells].
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi, 2013 Dec , 27 (1512-6).

97

Stevens SM et al. HCN4 charges up the first heart field.
Circ. Res., 2013 Aug 2 , 113 (350-1).

98

Liang X et al. HCN4 dynamically marks the first heart field and conduction system precursors.
Circ. Res., 2013 Aug 2 , 113 (399-407).

99

Scavone A et al. Embryonic stem cell-derived CD166+ precursors develop into fully functional sinoatrial-like cells.
Circ. Res., 2013 Aug 2 , 113 (389-98).

100

Nong Y et al. In situ investigation of allografted mouse HCN4 gene-transfected rat bone marrow mesenchymal stromal cells with the use of patch-clamp recording of ventricular slices.
Cytotherapy, 2013 Aug , 15 (905-19).

101

Chen M et al. Time-dependent regulation of neuregulin-1β/ErbB/ERK pathways in cardiac differentiation of mouse embryonic stem cells.
Mol. Cell. Biochem., 2013 Aug , 380 (67-72).

102

Evans A et al. Postmortem review and genetic analysis in sudden infant death syndrome: an 11-year review.
Hum. Pathol., 2013 Apr 25 , ().

103

Nakashima N et al. Hyperpolarisation-activated cyclic nucleotide-gated channels regulate the spontaneous firing rate of olfactory receptor neurons and affect glomerular formation in mice.
J. Physiol. (Lond.), 2013 Apr 1 , 591 (1749-69).

104

Reetz O et al. Protein kinase C activation inhibits rat and human hyperpolarization activated cyclic nucleotide gated channel (HCN)1--mediated current in mammalian cells.
Cell. Physiol. Biochem., 2013 , 31 (532-41).

105

Atkinson AJ et al. Functional, anatomical, and molecular investigation of the cardiac conduction system and arrhythmogenic atrioventricular ring tissue in the rat heart.
J Am Heart Assoc, 2013 , 2 (e000246).

106

Groenke S et al. Complete atrial-specific knockout of sodium-calcium exchange eliminates sinoatrial node pacemaker activity.
PLoS ONE, 2013 , 8 (e81633).

107

Bucchi A et al. Identification of the molecular site of ivabradine binding to HCN4 channels.
PLoS ONE, 2013 , 8 (e53132).

108

Yeh CB et al. Hyperpolarisation-activated cyclic nucleotide channel 4 (HCN4) involvement in Tourette's syndrome autoimmunity.
J. Neuroimmunol., 2012 Sep 15 , 250 (18-26).

109

Yu L et al. [Endothelin-1 stimulates the expression of pacemaker channel I(f) in cardiomyocytes through a p38 MAPK-independent signaling pathway].
Nan Fang Yi Ke Da Xue Xue Bao, 2012 Sep , 32 (1274-9).

110

Almanza A et al. Molecular identity, ontogeny, and cAMP modulation of the hyperpolarization-activated current in vestibular ganglion neurons.
J. Neurophysiol., 2012 Oct , 108 (2264-75).

111

Ramakrishnan NA et al. HCN1 and HCN2 proteins are expressed in cochlear hair cells: HCN1 can form a ternary complex with protocadherin 15 CD3 and F-actin-binding filamin A or can interact with HCN2.
J. Biol. Chem., 2012 Nov 2 , 287 (37628-46).

112

Liao Z et al. Cellular context and multiple channel domains determine cAMP sensitivity of HCN4 channels: ligand-independent relief of autoinhibition in HCN4.
J. Gen. Physiol., 2012 Nov , 140 (557-66).

113

Greene D et al. Adrenergic regulation of HCN4 channel requires protein association with beta 2 adrenergic receptor.
, 2012 May 21 , ().

114

Herrmann S et al. HCN channels in the heart: lessons from mouse mutants.
Br. J. Pharmacol., 2012 May , 166 (501-9).

115

Del Lungo M et al. Novel blockers of hyperpolarization-activated current with isoform selectivity in recombinant cells and native tissue.
Br. J. Pharmacol., 2012 May , 166 (602-16).

116

Jun C et al. Canine bone marrow mesenchymal stromal cells with lentiviral mHCN4 gene transfer create cardiac pacemakers.
Cytotherapy, 2012 May , 14 (529-39).

117

Surges R et al. Hyperpolarization-activated cation current Ih of dentate gyrus granule cells is upregulated in human and rat temporal lobe epilepsy.
Biochem. Biophys. Res. Commun., 2012 Mar 30 , 420 (156-60).

118

Suffredini S et al. Long-term treatment with ivabradine in post-myocardial infarcted rats counteracts f-channel overexpression.
Br. J. Pharmacol., 2012 Mar , 165 (1457-66).

119

Battefeld A et al. Distinct perinatal features of the hyperpolarization-activated non-selective cation current Ih in the rat cortical plate.
, 2012 Jun 13 , 7 (21).

120

Xue L et al. Investigation of hyperpolarization-activated cyclic nucleotide-gated channels in interstitial cells of Cajal of human bladder.
Urology, 2012 Jul , 80 (224.e13-8).

121

Zhang X et al. Endothelin-induced differentiation of Nkx2.5⁺ cardiac progenitor cells into pacemaking cells.
Mol. Cell. Biochem., 2012 Jul , 366 (309-18).

122

Fan X et al. Blocking effects of acehytisine on pacemaker currents (I(f)) in sinoatrial node cells and human HCN4 channels expressed in Xenopus laevis oocytes.
J Ethnopharmacol, 2012 Jan 6 , 139 (42-51).

123

Partida GJ et al. Thy1 Associates with the Cation Channel Subunit HCN4 in Adult Rat Retina.
, 2012 Jan 26 , ().

124

Chow SS et al. Energetics of cyclic AMP binding to HCN channel C terminus reveal negative cooperativity.
J. Biol. Chem., 2012 Jan 2 , 287 (600-6).

125

Shi Z et al. Requirement for the paired-like homeodomain transcription factor VSX1 in type 3a mouse retinal bipolar cell terminal differentiation.
J. Comp. Neurol., 2012 Jan 1 , 520 (117-29).

126

Kanyshkova T et al. Differential regulation of HCN channel isoform expression in thalamic neurons of epileptic and non-epileptic rat strains.
Neurobiol. Dis., 2012 Jan , 45 (450-61).

127

Kretschmannova K et al. The expression and role of hyperpolarization-activated and cyclic nucleotide-gated channels in endocrine anterior pituitary cells.
Mol. Endocrinol., 2012 Jan , 26 (153-64).

128

Yang J et al. Differentiation potential of human mesenchymal stem cells derived from adipose tissue and bone marrow to sinus node-like cells.
Mol Med Report, 2012 Jan , 5 (108-13).

129

Harris BS et al. Remodeling of the Peripheral Cardiac Conduction System in Response to Pressure-Overload.
, 2012 Feb 3 , ().

130

Khurana S et al. An essential role for modulation of hyperpolarization-activated current in the development of binaural temporal precision.
J. Neurosci., 2012 Feb 22 , 32 (2814-23).

131

Song B et al. [Expression of connexin 40 and hyperpolarization-activated cyclic nucleotide-gated cation channel 4 in rat bone marrow mesenchymal stem cells cocultured with sinoatrial node tissues in vitro].
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi, 2012 Feb , 26 (146-51).

132

Xu X et al. Local and global interpretations of a disease-causing mutation near the ligand entry path in hyperpolarization-activated cAMP-gated channel.
Structure, 2012 Dec 5 , 20 (2116-23).

133

Schild JH et al. Differential distribution of voltage-gated channels in myelinated and unmyelinated baroreceptor afferents.
Auton Neurosci, 2012 Dec 24 , 172 (4-12).

134

Chen Y et al. Ethanol enhances human hyperpolarization-activated cyclic nucleotide-gated currents.
Alcohol. Clin. Exp. Res., 2012 Dec , 36 (2036-46).

135

Zong X et al. Regulation of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel activity by cCMP.
J. Biol. Chem., 2012 Aug 3 , 287 (26506-12).

136

Hofmann F et al. Ventricular HCN channels decrease the repolarization reserve in the hypertrophic heart.
Cardiovasc. Res., 2012 Aug 1 , 95 (317-26).

137

Barbuti A et al. A caveolin-binding domain in the HCN4 channels mediates functional interaction with caveolin proteins.
J. Mol. Cell. Cardiol., 2012 Aug , 53 (187-95).

138

Abd Allah ES et al. Postnatal development of transmural gradients in expression of ion channels and Ca(2+)-handling proteins in the ventricle.
, 2012 Apr 17 , ().

139

Weng X et al. Chronic inflammatory pain is associated with increased excitability and hyperpolarization-activated current (Ih) in C- but not Aδ-nociceptors.
Pain, 2012 Apr , 153 (900-14).

140

Netter MF et al. The HCN4 channel mutation D553N associated with bradycardia has a C-linker mediated gating defect.
Cell. Physiol. Biochem., 2012 , 30 (1227-40).

141

Speranza L et al. The biological effects of ivabradine in cardiovascular disease.
Molecules, 2012 , 17 (4924-35).

142

Scicchitano P et al. HCN channels and heart rate.
Molecules, 2012 , 17 (4225-35).

143

Lippi G et al. Genetic and clinical aspects of Brugada syndrome: an update.
Adv Clin Chem, 2012 , 56 (197-208).

144

Ying SW et al. Targeted deletion of Kcne2 impairs HCN channel function in mouse thalamocortical circuits.
PLoS ONE, 2012 , 7 (e42756).

145

Fujii H et al. Electrophysiological properties of prion-positive cardiac progenitors derived from murine embryonic stem cells.
Circ. J., 2012 , 76 (2875-83).

146

Khazen G et al. Combinatorial Expression Rules of Ion Channel Genes in Juvenile Rat (Rattus norvegicus) Neocortical Neurons.
PLoS ONE, 2012 , 7 (e34786).

147

Song T et al. Spironolactone diminishes spontaneous ventricular premature beats by reducing HCN4 protein expression in rats with myocardial infarction.
Mol Med Report, 2011 May-Jun , 4 (569-73).

148

Liao Z et al. Myristoylated peptides potentiate the funny current (I(f)) in sinoatrial myocytes.
Channels (Austin), 2011 Mar-Apr , 5 (115-9).

149

Wei-qing H et al. Expression of hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN4) is increased in hypertrophic cardiomyopathy.
Cardiovasc. Pathol., 2011 Mar-Apr , 20 (110-3).

150

Fenske S et al. HCN3 contributes to the ventricular action potential waveform in the murine heart.
Circ. Res., 2011 Oct 14 , 109 (1015-23).

151

Poller WC et al. Lateral habenular neurons projecting to reward-processing monoaminergic nuclei express hyperpolarization-activated cyclic nucleotid-gated cation channels.
Neuroscience, 2011 Oct 13 , 193 (205-16).

152

Sklar P et al. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
Nat. Genet., 2011 Oct , 43 (977-83).

153

Cho HJ et al. Postnatal maturation of the hyperpolarization-activated cation current, I(h), in trigeminal sensory neurons.
J. Neurophysiol., 2011 Oct , 106 (2045-56).

154

Bahrudin U et al. Impairment of ubiquitin-proteasome system by E334K cMyBPC modifies channel proteins, leading to electrophysiological dysfunction.
J. Mol. Biol., 2011 Nov 4 , 413 (857-78).

155

Fenske S et al. The role of HCN channels in ventricular repolarization.
Trends Cardiovasc. Med., 2011 Nov , 21 (216-20).

156

Nistri S et al. Relaxin promotes growth and maturation of mouse neonatal cardiomyocytes in vitro: clues for cardiac regeneration.
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