TRPC5

1

Gaunt HJ et al. Transient receptor potential canonical 4 and 5 proteins as targets in cancer therapeutics.
Eur. Biophys. J., 2016 Jun 11 , ().

2

Thakur DP et al. Critical roles of Gi/o proteins and phospholipase C-δ1 in the activation of receptor-operated TRPC4 channels.
Proc. Natl. Acad. Sci. U.S.A., 2016 Jan 26 , 113 (1092-7).

3

Sexton JE et al. The contribution of TRPC1, TRPC3, TRPC5 and TRPC6 to touch and hearing.
Neurosci. Lett., 2016 Jan 1 , 610 (36-42).

4

Wu X et al. Hair-Cell Mechanotransduction Persists in TRP Channel Knockout Mice.
PLoS ONE, 2016 , 11 (e0155577).

5

Hong C et al. Increased TRPC5 glutathionylation contributes to striatal neuron loss in Huntington's disease.
Brain, 2015 Oct , 138 (3030-47).

6

Akbulut Y et al. (-)-Englerin A is a Potent and Selective Activator of TRPC4 and TRPC5 Calcium Channels.
Angew. Chem. Int. Ed. Engl., 2015 Mar 16 , 54 (3787-91).

7

Xu GZ et al. Increased expression of TRPC5 in cortical lesions of the focal cortical dysplasia.
J. Mol. Neurosci., 2015 Mar , 55 (561-9).

8

Zhu Y et al. Enhancement of vascular endothelial growth factor release in long-term drug-treated breast cancer via transient receptor potential channel 5-Ca(2+)-hypoxia-inducible factor 1α pathway.
Pharmacol. Res., 2015 Mar , 93 (36-42).

9

Zhu Y et al. Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels.
Br. J. Pharmacol., 2015 Jul , 172 (3495-509).

10

Maier T et al. Discovery and pharmacological characterization of a novel potent inhibitor of diacylglycerol-sensitive TRPC cation channels.
Br. J. Pharmacol., 2015 Jul , 172 (3650-60).

11

Wang T et al. Inhibition of transient receptor potential channel 5 reverses 5-Fluorouracil resistance in human colorectal cancer cells.
J. Biol. Chem., 2015 Jan 2 , 290 (448-56).

12

Hong C et al. Extracellular disulfide bridges stabilize TRPC5 dimerization, trafficking, and activity.
Pflugers Arch., 2015 Apr , 467 (703-12).

13

Shen B et al. Plasma Membrane Mechanical Stress Activates TRPC5 Channels.
PLoS ONE, 2015 , 10 (e0122227).

14

Nazıroğlu M et al. Psychiatric Disorders and TRP Channels: Focus on Psychotropic Drugs.
Curr Neuropharmacol, 2015 , 13 (248-57).

15

Carson C et al. Englerin A Agonizes the TRPC4/C5 Cation Channels to Inhibit Tumor Cell Line Proliferation.
PLoS ONE, 2015 , 10 (e0127498).

16

Yang LP et al. Acute Treatment with a Novel TRPC4/C5 Channel Inhibitor Produces Antidepressant and Anxiolytic-Like Effects in Mice.
PLoS ONE, 2015 , 10 (e0136255).

17

Revah O et al. The Outwardly Rectifying Current of Layer 5 Neocortical Neurons that was Originally Identified as "Non-Specific Cationic" Is Essentially a Potassium Current.
PLoS ONE, 2015 , 10 (e0132108).

18

He DX et al. A methylation-based regulatory network for microRNA 320a in chemoresistant breast cancer.
Mol. Pharmacol., 2014 Nov , 86 (536-47).

19

Richter JM et al. Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5.
Mol. Pharmacol., 2014 Nov , 86 (514-21).

20

Rosenbaum MA et al. Hypercholesterolemia inhibits re-endothelialization of arterial injuries by TRPC channel activation.
J. Vasc. Surg., 2014 May 10 , ().

21

Lee KP et al. Molecular determinants mediating gating of Transient Receptor Potential Canonical (TRPC) channels by stromal interaction molecule 1 (STIM1).
J. Biol. Chem., 2014 Mar 7 , 289 (6372-82).

22

Riccio A et al. Decreased anxiety-like behavior and Gαq/11-dependent responses in the amygdala of mice lacking TRPC4 channels.
J. Neurosci., 2014 Mar 5 , 34 (3653-67).

23

Dong Y et al. Tumor endothelial expression of P-glycoprotein upon microvesicular transfer of TrpC5 derived from adriamycin-resistant breast cancer cells.
Biochem. Biophys. Res. Commun., 2014 Mar 28 , 446 (85-90).

24

Kim J et al. Isoform- and receptor-specific channel property of canonical transient receptor potential (TRPC)1/4 channels.
Pflugers Arch., 2014 Mar , 466 (491-504).

25

Sonneveld R et al. Glucose specifically regulates TRPC6 expression in the podocyte in an AngII-dependent manner.
Am. J. Pathol., 2014 Jun , 184 (1715-26).

26

Dhar M et al. Leptin-induced spine formation requires TrpC channels and the CaM kinase cascade in the hippocampus.
J. Neurosci., 2014 Jul 23 , 34 (10022-33).

27

Richter JM et al. Riluzole activates TRPC5 channels independently of PLC activity.
Br. J. Pharmacol., 2014 Jan , 171 (158-70).

28

Jiang Y et al. Expression and localization of TRPC proteins in rat ventricular myocytes at various developmental stages.
Cell Tissue Res., 2014 Jan , 355 (201-12).

29

Kozai D et al. Redox regulation of transient receptor potential channels.
Antioxid. Redox Signal., 2014 Aug 20 , 21 (971-86).

30

Mignon-Ravix C et al. Intragenic rearrangements in X-linked intellectual deficiency: results of a-CGH in a series of 54 patients and identification of TRPC5 and KLHL15 as potential XLID genes.
Am. J. Med. Genet. A, 2014 Aug , 164A (1991-7).

31

Zimmermann J et al. Trans-activation response (TAR) RNA-binding protein 2 is a novel modulator of transient receptor potential canonical 4 (TRPC4) protein.
J. Biol. Chem., 2014 Apr 4 , 289 (9766-80).

32

Ma X et al. Essential role for TrpC5-containing extracellular vesicles in breast cancer with chemotherapeutic resistance.
Proc. Natl. Acad. Sci. U.S.A., 2014 Apr 29 , 111 (6389-94).

33

Qiu J et al. Insulin excites anorexigenic proopiomelanocortin neurons via activation of canonical transient receptor potential channels.
Cell Metab., 2014 Apr 1 , 19 (682-93).

34

Steinberg X et al. A structural view of ligand-dependent activation in thermoTRP channels.
Front Physiol, 2014 , 5 (171).

35

Baez D et al. Gating of thermally activated channels.
Curr Top Membr, 2014 , 74 (51-87).

36

Shimizu S et al. TRPs as chemosensors (ROS, RNS, RCS, gasotransmitters).
Handb Exp Pharmacol, 2014 , 223 (767-94).

37

Zholos AV TRPC5.
Handb Exp Pharmacol, 2014 , 222 (129-56).

38

Freichel M et al. TRPC4- and TRPC4-containing channels.
Handb Exp Pharmacol, 2014 , 222 (85-128).

39

Jeon JP et al. Activation of TRPC4β by Gαi subunit increases Ca(2+) selectivity and controls neurite morphogenesis in cultured hippocampal neuron.
Cell Calcium, 2013 Oct , 54 (307-19).

40

Jemal I et al. G protein-coupled receptor signalling potentiates the osmo-mechanical activation of TRPC5 channels.
Pflugers Arch., 2013 Nov 1 , ().

41

Yang H et al. High glucose-induced apoptosis in cultured podocytes involves TRPC6-dependent calcium entry via the RhoA/ROCK pathway.
Biochem. Biophys. Res. Commun., 2013 May 3 , 434 (394-400).

42

Bradshaw HB et al. Opportunistic activation of TRP receptors by endogenous lipids: exploiting lipidomics to understand TRP receptor cellular communication.
Life Sci., 2013 Mar 19 , 92 (404-9).

43

Bon RS et al. In pursuit of small molecule chemistry for calcium-permeable non-selective TRPC channels - mirage or pot of gold?
Br. J. Pharmacol., 2013 Jun 14 , ().

44

Beck A et al. Conserved Gating Elements in TRPC4 and TRPC5 Channels.
J. Biol. Chem., 2013 Jul 5 , 288 (19471-83).

45

Dasari S et al. Do canonical transient receptor potential channels mediate cholinergic excitation of cortical pyramidal neurons?
Neuroreport, 2013 Jul 10 , 24 (550-4).

46

Phelan KD et al. Canonical transient receptor channel 5 (TRPC5) and TRPC1/4 contribute to seizure and excitotoxicity by distinct cellular mechanisms.
Mol. Pharmacol., 2013 Feb , 83 (429-38).

47

Schaldecker T et al. Inhibition of the TRPC5 ion channel protects the kidney filter.
J. Clin. Invest., 2013 Dec 2 , 123 (5298-309).

48

Vandewauw I et al. Systematic and quantitative mRNA expression analysis of TRP channel genes at the single trigeminal and dorsal root ganglion level in mouse.
BMC Neurosci, 2013 , 14 (21).

49

Pomrenze MB et al. Cocaine self-administration in mice with forebrain knock-down of trpc5 ion channels.
F1000Res, 2013 , 2 ().

50

Lee JH et al. Characteristics of the cholecystokinin-induced depolarization of pacemaking activity in cultured interstitial cells of Cajal from murine small intestine.
Cell. Physiol. Biochem., 2013 , 31 (542-54).

51

Kim H et al. The roles of G proteins in the activation of TRPC4 and TRPC5 transient receptor potential channels.
Channels (Austin), 2012 Sep-Oct , 6 (333-43).

52

Ma X et al. Transient receptor potential channel TRPC5 is essential for P-glycoprotein induction in drug-resistant cancer cells.
Proc. Natl. Acad. Sci. U.S.A., 2012 Oct 2 , 109 (16282-7).

53

Schindl R et al. Canonical transient receptor potential (TRPC) 1 acts as a negative regulator for vanilloid TRPV6-mediated Ca2+ influx.
J. Biol. Chem., 2012 Oct 12 , 287 (35612-20).

54

Amer MS et al. Inhibition of endothelial cell Ca(2+) entry and Transient Receptor Potential channels by Sigma-1 receptor ligands.
Br. J. Pharmacol., 2012 Nov 2 , ().

55

Jeon JP et al. Selective Gαi subunits as novel direct activators of transient receptor potential canonical (TRPC)4 and TRPC5 channels.
J. Biol. Chem., 2012 May 18 , 287 (17029-39).

56

Kaczmarek JS et al. Calpain cleaves and activates the TRPC5 channel to participate in semaphorin 3A-induced neuronal growth cone collapse.
Proc. Natl. Acad. Sci. U.S.A., 2012 May 15 , 109 (7888-92).

57

Lembrechts R et al. NEUROEPITHELIAL BODIES AS MECHANOTRANSDUCERS IN THE INTRAPULMONARY AIRWAY EPITHELIUM: INVOLVEMENT OF TRPC5.
, 2012 Mar 29 , ().

58

Fortin DA et al. Brain-derived neurotrophic factor activation of CaM-kinase kinase via transient receptor potential canonical channels induces the translation and synaptic incorporation of GluA1-containing calcium-permeable AMPA receptors.
J. Neurosci., 2012 Jun 13 , 32 (8127-37).

59

Nazıroğlu M Molecular role of catalase on oxidative stress-induced Ca(2+) signaling and TRP cation channel activation in nervous system.
J. Recept. Signal Transduct. Res., 2012 Jun , 32 (134-41).

60

Sukumar P et al. Constitutively active TRPC channels of adipocytes confer a mechanism for sensing dietary fatty acids and regulating adiponectin.
Circ. Res., 2012 Jul 6 , 111 (191-200).

61

He Z et al. TRPC5 channel is the mediator of neurotrophin-3 in regulating dendritic growth via CaMKIIα in rat hippocampal neurons.
J. Neurosci., 2012 Jul 4 , 32 (9383-95).

62

Kučka M et al. Dependence of spontaneous electrical activity and basal prolactin release on nonselective cation channels in pituitary lactotrophs.
Physiol Res, 2012 Jul 20 , 61 (267-75).

63

Jiang H et al. Effect of non-steroidal anti-inflammatory drugs and new fenamate analogues on TRPC4 and TRPC5 channels.
, 2012 Jan 20 , ().

64

Shi J et al. TRPC1 proteins confer PKC and phosphoinositol activation on native heteromeric TRPC1/C5 channels in vascular smooth muscle: comparative study of wild-type and TRPC1-/- mice.
FASEB J., 2012 Jan , 26 (409-19).

65

Xu SZ et al. Activation of TRPC cationic channels by mercurial compounds confers the cytotoxicity of mercury exposure.
Toxicol. Sci., 2012 Jan , 125 (56-68).

66

Antigny F et al. Transient receptor potential canonical channels are required for in vitro endothelial tube formation.
J. Biol. Chem., 2012 Feb 17 , 287 (5917-27).

67

Kim EY et al. Insulin increases surface expression of TRPC6 channels in podocytes: role of NADPH oxidases and reactive oxygen species.
Am. J. Physiol. Renal Physiol., 2012 Feb , 302 (F298-307).

68

Peters M et al. Carvacrol together with TRPC1 elimination improve functional recovery after traumatic brain injury in mice.
J. Neurotrauma, 2012 Dec 10 , 29 (2831-4).

69

Grisanti LA et al. Phospholipase C not protein kinase C is required for the activation of TRPC5 channels by cholecystokinin.
Eur. J. Pharmacol., 2012 Aug 15 , 689 (17-24).

70

Hong C et al. Gs cascade regulates canonical transient receptor potential 5 (TRPC5) through cAMP mediated intracellular Ca(2+) release and ion channel trafficking.
, 2012 Apr 3 , ().

71

Kumar S et al. Mechanisms controlling neurite outgrowth in a pheochromocytoma cell line: the role of TRPC channels.
J. Cell. Physiol., 2012 Apr , 227 (1408-19).

72

Heo DK et al. Opposite regulatory effects of TRPC1 and TRPC5 on neurite outgrowth in PC12 cells.
Cell. Signal., 2012 Apr , 24 (899-906).

73

Miehe S et al. Inhibition of Diacylglycerol-Sensitive TRPC Channels by Synthetic and Natural Steroids.
PLoS ONE, 2012 , 7 (e35393).

74

Tabarean IV Persistent histamine excitation of glutamatergic preoptic neurons.
PLoS ONE, 2012 , 7 (e47700).

75

Wu G et al. Ganglioside GM1 deficiency in effector T cells from NOD mice induces resistance to regulatory T-cell suppression.
Diabetes, 2011 Sep , 60 (2341-9).

76

Wang S et al. Cholecystokinin facilitates neuronal excitability in the entorhinal cortex via activation of TRPC-like channels.
J. Neurophysiol., 2011 Sep , 106 (1515-24).

77

Tai C et al. Plasma membrane insertion of TRPC5 channels contributes to the cholinergic plateau potential in hippocampal CA1 pyramidal neurons.
Hippocampus, 2011 Sep , 21 (958-67).

78

Sung TS et al. Molecular determinants of PKA-dependent inhibition of TRPC5 channel.
Am. J. Physiol., Cell Physiol., 2011 Oct , 301 (C823-32).

79

Al-Shawaf E et al. GVI phospholipase A2 role in the stimulatory effect of sphingosine-1-phosphate on TRPC5 cationic channels.
Cell Calcium, 2011 Oct , 50 (343-50).

80

Zimmermann K et al. Transient receptor potential cation channel, subfamily C, member 5 (TRPC5) is a cold-transducer in the peripheral nervous system.
Proc. Natl. Acad. Sci. U.S.A., 2011 Nov 1 , 108 (18114-9).

81

Greka A et al. Balancing calcium signals through TRPC5 and TRPC6 in podocytes.
J. Am. Soc. Nephrol., 2011 Nov , 22 (1969-80).

82

Chakraborty S et al. Bromoenol lactone inhibits voltage-gated Ca2+ and transient receptor potential canonical channels.
J. Pharmacol. Exp. Ther., 2011 Nov , 339 (329-40).

83

Jiang LH et al. Properties and therapeutic potential of transient receptor potential channels with putative roles in adversity: focus on TRPC5, TRPM2 and TRPA1.
Curr Drug Targets, 2011 May , 12 (724-36).

84

Majeed Y et al. Rapid and contrasting effects of rosiglitazone on transient receptor potential TRPM3 and TRPC5 channels.
Mol. Pharmacol., 2011 Jun , 79 (1023-30).

85

Cui N et al. Involvement of TRP channels in the CO₂ chemosensitivity of locus coeruleus neurons.
J. Neurophysiol., 2011 Jun , 105 (2791-801).

86

Sousa CT et al. Sildenafil decreases rat tracheal hyperresponsiveness to carbachol and changes canonical transient receptor potential gene expression after antigen challenge.
Braz. J. Med. Biol. Res., 2011 Jun , 44 (562-72).

87

Naylor J et al. TRPC5 channel sensitivities to antioxidants and hydroxylated stilbenes.
J. Biol. Chem., 2011 Feb 18 , 286 (5078-86).

88

Gilliam JC et al. TRP channel gene expression in the mouse retina.
Vision Res., 2011 Dec 8 , 51 (2440-52).

89

Puram SV et al. A TRPC5-regulated calcium signaling pathway controls dendrite patterning in the mammalian brain.
Genes Dev., 2011 Dec 15 , 25 (2659-73).

90

Liu Y et al. Erythropoietin increases expression and function of transient receptor potential canonical 5 channels.
Hypertension, 2011 Aug , 58 (317-24).

91

Tomic M et al. Role of nonselective cation channels in spontaneous and protein kinase A-stimulated calcium signaling in pituitary cells.
Am. J. Physiol. Endocrinol. Metab., 2011 Aug , 301 (E370-9).

92

Majeed Y et al. Stereo-selective inhibition of transient receptor potential TRPC5 cation channels by neuroactive steroids.
Br. J. Pharmacol., 2011 Apr , 162 (1509-20).

93

Mori Y et al. Receptor signaling integration by TRP channelsomes.
Adv. Exp. Med. Biol., 2011 , 704 (373-89).

94

Thilo F et al. Decreased expression of transient receptor potential channels in cerebral vascular tissue from patients after hypertensive intracerebral hemorrhage.
Clin. Exp. Hypertens., 2011 , 33 (533-7).

95

Horinouchi T et al. Function and regulation of endothelin type A receptor-operated transient receptor potential canonical channels.
J. Pharmacol. Sci., 2011 , 117 (295-306).

96

Cvetkovic-Lopes V et al. Rat hypocretin/orexin neurons are maintained in a depolarized state by TRPC channels.
PLoS ONE, 2010 , 5 (e15673).