Referenced in: none

Automatically associated channels: Cav2.1 , Slo1

Title: Channeling headache: novel findings in the study of Ca(2+)-channels and FHM-1.

Authors: María A Gandini

Journal, date & volume: Channels (Austin), 2012 Nov-Dec , 6, 414-5

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/22991044

Abstract
Familial hemiplegic migraine type 1 (FMH-1) is a rare form of migraine with aura, which is characterized by transient hemiparesis, sensory loss and visual disturbances. This monogenic disease shares many common features with classic migraine, suggesting a similar molecular pathophysiology. Migraine is triggered by activation and sensitization of the trigeminovascular system, specifically the trigeminal nociceptive afferents innervating the meninges. Aura migraine is associated with cortical spreading depression (CSD), which is a short-lasting intense wave of neuronal and glial cell depolarization that slowly progresses over the cortex and is followed by long-lasting neuronal activity depression.