Nav1.5
1259 literature references associated to Nav1.5
1
Aydar E
et al.
Sigma-1 receptors modulate neonatal Nav1.5 ion channels in breast cancer cell lines.
Eur. Biophys. J.,
2016
May
9
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2
Yang J
et al.
FGF13 modulates the gating properties of the cardiac sodium channel Nav1.5 in an isoform-specific manner.
Channels (Austin),
2016
May
31
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3
Hirano-Iwata A
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Reconstitution of Human Ion Channels into Solvent-free Lipid Bilayers Enhanced by Centrifugal Forces.
Biophys. J.,
2016
May
24
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4
Zeng H
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Use of FDSS/μCell imaging platform for preclinical cardiac electrophysiology safety screening of compounds in human induced pluripotent stem cell-derived cardiomyocytes.
J Pharmacol Toxicol Methods,
2016
May
21
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5
Schilling JM
et al.
Electrophysiology and metabolism of caveolin-3-overexpressing mice.
Basic Res. Cardiol.,
2016
May
, 111 (28).
6
Daumy X
et al.
Targeted resequencing identifies TRPM4 as a major gene predisposing to progressive familial heart block type I.
Int. J. Cardiol.,
2016
Mar
15
, 207 (349-58).
7
Tao H
et al.
Molecular determinant for the tarantula toxin Jingzhaotoxin-I slowing the fast inactivation of voltage-gated sodium channels.
Toxicon,
2016
Mar
1
, 111 (13-21).
8
Zhao Y
et al.
Identification of novel mutations including a double mutation in patients with inherited cardiomyopathy by a targeted sequencing approach using the Ion Torrent PGM system.
Int. J. Mol. Med.,
2016
Jun
, 37 (1511-20).
9
Zaklyazminskaya E
et al.
The role of mutations in the SCN5A gene in cardiomyopathies.
Biochim. Biophys. Acta,
2016
Jul
, 1863 (1799-805).
10
Sottas V
et al.
Negative-dominance phenomenon with genetic variants of the cardiac sodium channel Nav1.5.
Biochim. Biophys. Acta,
2016
Jul
, 1863 (1791-8).
11
Van Driest SL
et al.
Association of Arrhythmia-Related Genetic Variants With Phenotypes Documented in Electronic Medical Records.
JAMA,
2016
Jan
5
, 315 (47-57).
12
Wang HG
et al.
A novel NaV1.5 voltage sensor mutation associated with severe atrial and ventricular arrhythmias.
J. Mol. Cell. Cardiol.,
2016
Jan
19
, 92 (52-62).
13
Mohammed FH
et al.
Blockade of voltage-gated sodium channels inhibits invasion of endocrine-resistant breast cancer cells.
Int. J. Oncol.,
2016
Jan
, 48 (73-83).
14
Neubauer J
et al.
Post-mortem whole-exome sequencing (WES) with a focus on cardiac disease-associated genes in five young sudden unexplained death (SUD) cases.
Int. J. Legal Med.,
2016
Feb
4
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15
Poulet C
et al.
Altered physiological functions and ion currents in atrial fibroblasts from patients with chronic atrial fibrillation.
Physiol Rep,
2016
Feb
, 4 ().
16
Crumb WJ
et al.
An evaluation of 30 clinical drugs against the comprehensive in vitro proarrhythmia assay (CiPA) proposed ion channel panel.
J Pharmacol Toxicol Methods,
2016
Apr
6
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17
Shcherbatko A
et al.
Engineering Highly Potent and Selective Microproteins Against Nav1.7 Sodium Channel for Treatment of Pain.
J. Biol. Chem.,
2016
Apr
22
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18
Leo-Macias A
et al.
Nanoscale visualization of functional adhesion/excitability nodes at the intercalated disc.
Nat Commun,
2016
, 7 (10342).
19
Choi JI
et al.
α1-Syntrophin Variant Identified in Drug-Induced Long QT Syndrome Increases Late Sodium Current.
PLoS ONE,
2016
, 11 (e0152355).
21
Portero V
et al.
Dysfunction of the Voltage-Gated K+ Channel β2 Subunit in a Familial Case of Brugada Syndrome.
J Am Heart Assoc,
2016
, 5 ().
22
Zhao Y
et al.
Regulation of SCN3B/scn3b by Interleukin 2 (IL-2): IL-2 modulates SCN3B/scn3b transcript expression and increases sodium current in myocardial cells.
BMC Cardiovasc Disord,
2016
, 16 (1).
23
Nassal DM
et al.
Myocardial KChIP2 Expression in Guinea Pig Resolves an Expanded Electrophysiologic Role.
PLoS ONE,
2016
, 11 (e0146561).
24
Hertz CL
et al.
Genetic investigations of sudden unexpected deaths in infancy using next-generation sequencing of 100 genes associated with cardiac diseases.
Eur. J. Hum. Genet.,
2015
Sep
9
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25
Eberhardt E
et al.
Pattern of Functional TTX-Resistant Sodium Channels Reveals a Developmental Stage of Human iPSC- and ESC-Derived Nociceptors.
Stem Cell Reports,
2015
Sep
8
, 5 (305-13).
26
Climent AM
et al.
The Role of Atrial Tissue Remodeling on Rotor Dynamics: An In-Vitro Study.
Am. J. Physiol. Heart Circ. Physiol.,
2015
Sep
25
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27
Abdelsayed M
et al.
Differential thermosensitivity in mixed syndrome cardiac sodium channel mutants.
J. Physiol. (Lond.),
2015
Sep
15
, 593 (4201-23).
28
Neshatian L
et al.
Ranolazine inhibits voltage-gated mechanosensitive sodium channels in human colon circular smooth muscle cells.
Am. J. Physiol. Gastrointest. Liver Physiol.,
2015
Sep
15
, 309 (G506-12).
29
Berghuis B
et al.
Complex SCN8A DNA-abnormalities in an individual with therapy resistant absence epilepsy.
Epilepsy Res.,
2015
Sep
, 115 (141-4).
30
Aktas CC
et al.
In vitro effects of phenytoin and DAPT on MDA-MB-231 breast cancer cells.
Acta Biochim. Biophys. Sin. (Shanghai),
2015
Sep
, 47 (680-6).
31
Farrugia A
et al.
Targeted next generation sequencing application in cardiac channelopathies: Analysis of a cohort of autopsy-negative sudden unexplained deaths.
Forensic Sci. Int.,
2015
Sep
, 254 (5-11).
32
Musa H
et al.
SCN5A variant that blocks fibroblast growth factor homologous factor regulation causes human arrhythmia.
Proc. Natl. Acad. Sci. U.S.A.,
2015
Oct
6
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33
Nunn LM
et al.
Diagnostic yield of molecular autopsy in patients with sudden arrhythmic death syndrome using targeted exome sequencing.
Europace,
2015
Oct
25
, ().
34
Endo R
et al.
Carvedilol Suppresses Apoptosis and Ion Channel Remodelling of HL-1 Cardiac Myocytes Expressing E334K cMyBPC.
Drug Res (Stuttg),
2015
Oct
19
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35
Beyder A
et al.
Expression and function of the Scn5a-encoded voltage-gated sodium channel NaV 1.5 in the rat jejunum.
Neurogastroenterol. Motil.,
2015
Oct
13
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36
Chiang DY
et al.
Loss-of-Function SCN5A Mutations Associated With Sinus Node Dysfunction, Atrial Arrhythmias, and Poor Pacemaker Capture.
Circ Arrhythm Electrophysiol,
2015
Oct
, 8 (1105-12).
37
Detta N
et al.
The multi-faceted aspects of the complex cardiac Nav1.5 protein in membrane function and pathophysiology.
Biochim. Biophys. Acta,
2015
Oct
, 1854 (1502-9).
38
Murray JK
et al.
Sustained inhibition of the NaV1.7 sodium channel by engineered dimers of the domain II binding peptide GpTx-1.
Bioorg. Med. Chem. Lett.,
2015
Nov
1
, 25 (4866-71).
39
Han Z
et al.
The effects of A-803467 on cardiac Nav1.5 channels.
Eur. J. Pharmacol.,
2015
May
5
, 754 (52-60).
40
Le Scouarnec S
et al.
Testing the burden of rare variation in arrhythmia-susceptibility genes provides new insights into molecular diagnosis for Brugada syndrome.
Hum. Mol. Genet.,
2015
May
15
, 24 (2757-63).
41
Liu GX
et al.
Overexpression of SCN5A in mouse heart mimics human syndrome of enhanced atrioventricular nodal conduction.
Heart Rhythm,
2015
May
, 12 (1036-45).
42
Marionneau C
et al.
Regulation of the cardiac Na+ channel NaV1.5 by post-translational modifications.
J. Mol. Cell. Cardiol.,
2015
May
, 82 (36-47).
43
Chahine M
Gating pore current is a novel biophysical defect of Nav1.5 mutations associated with unusual cardiac arrhythmias and dilation.
Future Cardiol,
2015
May
, 11 (287-91).
44
Zhu JF
et al.
Novel heterozygous mutation c.4282G>T in the SCN5A gene in a family with Brugada syndrome.
Exp Ther Med,
2015
May
, 9 (1639-1645).
45
Tan BY
et al.
A Brugada syndrome proband with compound heterozygote SCN5A mutations identified from a Chinese family in Singapore.
Europace,
2015
Mar
31
, ().
46
Mishra S
et al.
Contribution of sodium channel neuronal isoform Nav1.1 to late sodium current in ventricular myocytes from failing hearts.
J. Physiol. (Lond.),
2015
Mar
15
, 593 (1409-27).
47
Murray JK
et al.
Engineering Potent and Selective Analogues of GpTx-1, a Tarantula Venom Peptide Antagonist of the NaV1.7 Sodium Channel.
J. Med. Chem.,
2015
Mar
12
, 58 (2299-314).
48
Ossola D
et al.
Force-controlled patch clamp of beating cardiac cells.
Nano Lett.,
2015
Mar
11
, 15 (1743-50).
49
Liang W
et al.
Wnt signalling suppresses voltage-dependent Na(+) channel expression in postnatal rat cardiomyocytes.
J. Physiol. (Lond.),
2015
Mar
1
, 593 (1147-57).
50
De Filippo P
et al.
Cavotricuspid isthmus ablation and subcutaneous monitoring device implantation in a 2-year-old baby with 2 SCN5A mutations, sinus node dysfunction, atrial flutter recurrences, and drug induced long-QT syndrome: a tricky case of pediatric overlap syndrome?
J. Cardiovasc. Electrophysiol.,
2015
Mar
, 26 (346-9).
51
Hayashi K
et al.
Functional Characterization of Rare Variants Implicated in Susceptibility to Lone Atrial Fibrillation.
Circ Arrhythm Electrophysiol,
2015
Jun
30
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52
Behr ER
et al.
Role of common and rare variants in SCN10A: results from the Brugada syndrome QRS locus gene discovery collaborative study.
Cardiovasc. Res.,
2015
Jun
1
, 106 (520-9).
53
Daimi H
et al.
Regulation of SCN5A by microRNAs: miR-219 modulates SCN5A transcript expression and the effects of flecainide intoxication in mice.
Heart Rhythm,
2015
Jun
, 12 (1333-42).
54
Stroemlund LW
et al.
Gap junctions - guards of excitability.
Biochem. Soc. Trans.,
2015
Jun
, 43 (508-12).
55
Nikulina SY
et al.
An investigation of the association of the H558R polymorphism of the SCN5A gene with idiopathic cardiac conduction disorders.
Genet Test Mol Biomarkers,
2015
Jun
, 19 (288-94).
56
Huang Y
et al.
Molecular basis of the inhibition of the fast inactivation of voltage-gated sodium channel Nav1.5 by tarantula toxin Jingzhaotoxin-II.
Peptides,
2015
Jun
, 68 (175-82).
57
Daimi H
et al.
Absence of family history and phenotype-genotype correlation in pediatric Brugada syndrome: more burden to bear in clinical and genetic diagnosis.
Pediatr Cardiol,
2015
Jun
, 36 (1090-6).
58
Winkel BG
et al.
The role of the sodium current complex in a nonreferred nationwide cohort of sudden infant death syndrome.
Heart Rhythm,
2015
Jun
, 12 (1241-9).
59
Cai T
et al.
Mapping the interaction site for the tarantula toxin hainantoxin-IV (β-TRTX-Hn2a) in the voltage sensor module of domain II of voltage-gated sodium channels.
Peptides,
2015
Jun
, 68 (148-56).
60
Wannous R
et al.
Suppression of PPARβ, and DHA treatment, inhibit NaV1.5 and NHE-1 pro-invasive activities.
Pflugers Arch.,
2015
Jun
, 467 (1249-59).
61
Mercier A
et al.
Nav1.5 channels can reach the plasma membrane through distinct N-glycosylation states.
Biochim. Biophys. Acta,
2015
Jun
, 1850 (1215-23).
62
Stattin EL
et al.
Genetic screening in sudden cardiac death in the young can save future lives.
Int. J. Legal Med.,
2015
Jul
31
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64
Torregrosa R
et al.
Chimeric derivatives of functionalized amino acids and α-aminoamides: compounds with anticonvulsant activity in seizure models and inhibitory actions on central, peripheral, and cardiac isoforms of voltage-gated sodium channels.
Bioorg. Med. Chem.,
2015
Jul
1
, 23 (3655-66).
65
Verstraelen TE
et al.
The role of the SCN5A-encoded channelopathy in irritable bowel syndrome and other gastrointestinal disorders.
Neurogastroenterol. Motil.,
2015
Jul
, 27 (906-13).
66
Hasdemir C
et al.
High prevalence of concealed Brugada syndrome in patients with atrioventricular nodal reentrant tachycardia.
Heart Rhythm,
2015
Jul
, 12 (1584-94).
67
Chow CY
et al.
Three Peptide Modulators of the Human Voltage-Gated Sodium Channel 1.7, an Important Analgesic Target, from the Venom of an Australian Tarantula.
Toxins (Basel),
2015
Jul
, 7 (2494-513).
68
Zhang J
et al.
Electrophysiological and trafficking defects of the SCN5A T353I mutation in Brugada syndrome are rescued by alpha-allocryptopine.
Eur. J. Pharmacol.,
2015
Jan
5
, 746 (333-43).
69
Chong E
et al.
Resveratrol, a red wine antioxidant, reduces atrial fibrillation susceptibility in the failing heart by PI3K/AKT/eNOS signaling pathway activation.
Heart Rhythm,
2015
Jan
30
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70
Saber S
et al.
Complex genetic background in a large family with Brugada syndrome.
Physiol Rep,
2015
Jan
1
, 3 ().
71
Kirchhof P
et al.
First report on an inotropic peptide activating tetrodotoxin-sensitive, "neuronal" sodium currents in the heart.
Circ Heart Fail,
2015
Jan
, 8 (79-88).
72
Baruteau AE
et al.
Inherited progressive cardiac conduction disorders.
Curr. Opin. Cardiol.,
2015
Jan
, 30 (33-9).
73
Wilde AA
et al.
Bringing home the bacon? The next step in cardiac sodium channelopathies.
J. Clin. Invest.,
2015
Jan
, 125 (99-101).
74
Park DS
et al.
Genetically engineered SCN5A mutant pig hearts exhibit conduction defects and arrhythmias.
J. Clin. Invest.,
2015
Jan
, 125 (403-12).
75
Hothi SS
et al.
p.Y1449C SCN5A mutation associated with overlap disorder comprising conduction disease, Brugada syndrome, and atrial flutter.
J. Cardiovasc. Electrophysiol.,
2015
Jan
, 26 (93-7).
76
Riuró H
et al.
Genetic analysis, in silico prediction, and family segregation in long QT syndrome.
Eur. J. Hum. Genet.,
2015
Jan
, 23 (79-85).
77
Huang CW
et al.
The inhibitory actions by lacosamide, a functionalized amino acid, on voltage-gated Na+ currents.
Neuroscience,
2015
Feb
26
, 287 (125-36).
78
Schwoerer AP
et al.
A Comparative Analysis of Bupivacaine and Ropivacaine Effects on Human Cardiac SCN5A Channels.
Anesth. Analg.,
2015
Feb
16
, ().
79
Zhang H
et al.
Reporting sodium channel activity using calcium flux: pharmacological promiscuity of cardiac Nav1.5.
Mol. Pharmacol.,
2015
Feb
, 87 (207-17).
80
de Llano CT
et al.
Further evidence of the association between LQT syndrome and epilepsy in a family with KCNQ1 pathogenic variant.
Seizure,
2015
Feb
, 25 (65-7).
81
Moreau A
et al.
Gating pore currents are defects in common with two Nav1.5 mutations in patients with mixed arrhythmias and dilated cardiomyopathy.
J. Gen. Physiol.,
2015
Feb
, 145 (93-106).
82
Beltran-Alvarez P
et al.
Interplay between R513 methylation and S516 phosphorylation of the cardiac voltage-gated sodium channel.
Amino Acids,
2015
Feb
, 47 (429-34).
83
Zhu W
et al.
Molecular motions that shape the cardiac action potential: Insights from voltage clamp fluorometry.
Prog. Biophys. Mol. Biol.,
2015
Dec
25
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84
Peters CH
et al.
Triggers for arrhythmogenesis in the Brugada and long QT 3 syndromes.
Prog. Biophys. Mol. Biol.,
2015
Dec
20
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85
Veerman CC
et al.
The cardiac sodium channel gene SCN5A and its gene product NaV1.5: Role in physiology and pathophysiology.
Gene,
2015
Dec
1
, 573 (177-87).
86
Qureshi SF
et al.
Mutational analysis of SCN5A gene in long QT syndrome.
Meta Gene,
2015
Dec
, 6 (26-35).
87
Glynn P
et al.
Voltage-Gated Sodium Channel Phosphorylation at Ser571 Regulates Late Current, Arrhythmia, and Cardiac Function In Vivo.
Circulation,
2015
Aug
18
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88
Varga Z
et al.
Direct Measurement of Cardiac Na+ Channel Conformations Reveals Molecular Pathologies of Inherited Mutations.
Circ Arrhythm Electrophysiol,
2015
Aug
17
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89
Lo YC
et al.
Actions of KMUP-1, a xanthine and piperazine derivative, on voltage-gated Na(+) and Ca(2+) -activated K(+) currents in GH3 pituitary tumor cells.
Br. J. Pharmacol.,
2015
Aug
15
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90
Potet F
et al.
Intracellular calcium attenuates late current conducted by mutant human cardiac sodium channels.
Circ Arrhythm Electrophysiol,
2015
Aug
, 8 (933-41).
91
Kapplinger JD
et al.
Enhanced Classification of Brugada Syndrome-Associated and Long-QT Syndrome-Associated Genetic Variants in the SCN5A-Encoded Na(v)1.5 Cardiac Sodium Channel.
Circ Cardiovasc Genet,
2015
Aug
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92
Pucca MB
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Electrophysiological characterization of the first Tityus serrulatus alpha-like toxin, Ts5: Evidence of a pro-inflammatory toxin on macrophages.
Biochimie,
2015
Aug
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93
Peigneur S
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A gamut of undiscovered electrophysiological effects produced by Tityus serrulatus toxin 1 on NaV-type isoforms.
Neuropharmacology,
2015
Apr
7
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94
Willis BC
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Protein Assemblies of Sodium and Inward Rectifier Potassium Channels Control Cardiac Excitability and Arrhythmogenesis.
Am. J. Physiol. Heart Circ. Physiol.,
2015
Apr
10
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95
Algalarrondo V
et al.
Abnormal sodium current properties contribute to cardiac electrical and contractile dysfunction in a mouse model of myotonic dystrophy type 1.
Neuromuscul. Disord.,
2015
Apr
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96
Williams VS
et al.
Multiplex ligation-dependent probe amplification copy number variant analysis in patients with acquired long QT syndrome.
Europace,
2015
Apr
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97
Marcsa B
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A Common Polymorphism of the Human Cardiac Sodium Channel Alpha Subunit (SCN5A) Gene Is Associated with Sudden Cardiac Death in Chronic Ischemic Heart Disease.
PLoS ONE,
2015
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98
Wang Y
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Comparison of Gating Properties and Use-Dependent Block of Nav1.5 and Nav1.7 Channels by Anti-Arrhythmics Mexiletine and Lidocaine.
PLoS ONE,
2015
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99
House CD
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Voltage-gated Na+ Channel Activity Increases Colon Cancer Transcriptional Activity and Invasion Via Persistent MAPK Signaling.
Sci Rep,
2015
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100
Poulet C
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Late Sodium Current in Human Atrial Cardiomyocytes from Patients in Sinus Rhythm and Atrial Fibrillation.
PLoS ONE,
2015
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101
Hu RM
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Arrhythmogenic Biophysical Phenotype for SCN5A Mutation S1787N Depends upon Splice Variant Background and Intracellular Acidosis.
PLoS ONE,
2015
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102
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Comprehensive Genetic Characterization of a Spanish Brugada Syndrome Cohort.
PLoS ONE,
2015
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103
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Deletion of PDK1 causes cardiac sodium current reduction in mice.
PLoS ONE,
2015
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104
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Genetic Analysis of Arrhythmogenic Diseases in the Era of NGS: The Complexity of Clinical Decision-Making in Brugada Syndrome.
PLoS ONE,
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105
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De Novo Mutation in the SCN5A Gene Associated with Brugada Syndrome.
Cell. Physiol. Biochem.,
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106
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Enhancement of Spontaneous Activity by HCN4 Overexpression in Mouse Embryonic Stem Cell-Derived Cardiomyocytes - A Possible Biological Pacemaker.
PLoS ONE,
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107
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Mutation Analysis of KCNQ1, KCNH2 and SCN5A Genes in Taiwanese Long QT Syndrome Patients.
Int Heart J,
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108
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Comparison of formaldehyde and methanol fixatives used in the detection of ion channel proteins in isolated rat ventricular myocytes by immunofluorescence labelling and confocal microscopy.
Folia Morphol. (Warsz),
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109
Leong IU
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Assessment of the predictive accuracy of five in silico prediction tools, alone or in combination, and two metaservers to classify long QT syndrome gene mutations.
BMC Med. Genet.,
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110
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The sodium channel-blocking antiepileptic drug phenytoin inhibits breast tumour growth and metastasis.
Mol. Cancer,
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111
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Quantitative Profiling of the Effects of Vanoxerine on Human Cardiac Ion Channels and its Application to Cardiac Risk.
Sci Rep,
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112
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Differential Modulation of Fast Inactivation in Cardiac Sodium Channel Splice Variants by Fyn Tyrosine Kinase.
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113
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Prediction of Thorough QT study results using action potential simulations based on ion channel screens.
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Brugada syndrome.
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115
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Brugada syndrome with a novel missense mutation in SCN5A gene: a case report from Bangladesh.
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Pharmacokinetic-pharmacodynamic modeling of QRS-prolongation by flecainide: Heart rate-dependent effects during sinus rhythm in conscious telemetered dogs.
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117
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The discovery of benzenesulfonamide-based potent and selective inhibitors of voltage-gated sodium channel Na(v)1.7.
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118
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Discovery of pyrrolo-benzo-1,4-diazines as potent Na(v)1.7 sodium channel blockers.
Bioorg. Med. Chem. Lett.,
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119
Frenz CT
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NaV1.5 sodium channel window currents contribute to spontaneous firing in olfactory sensory neurons.
J. Neurophysiol.,
2014
Sep
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120
Cai B
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Deletion of FoxO1 leads to shortening of QRS by increasing Na(+) channel activity through enhanced expression of both cardiac NaV1.5 and β3 subunit.
J. Mol. Cell. Cardiol.,
2014
Sep
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121
Bartok A
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Margatoxin is a non-selective inhibitor of human Kv1.3 K(+) channels.
Toxicon,
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122
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Cardiac sodium channels and inherited electrophysiological disorders: an update on the pharmacotherapy.
Expert Opin Pharmacother,
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123
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Dynamics of sodium channel Nav1.5 expression in astrocytes in mouse models of multiple sclerosis.
Neuroreport,
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124
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SCN5A mutations and polymorphisms in patients with ventricular fibrillation during acute myocardial infarction.
Mol Med Rep,
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125
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Reduction in dynamin-2 is implicated in ischaemic cardiac arrhythmias.
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126
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Fluoxetine blocks Nav1.5 channels via a mechanism similar to that of class 1 antiarrhythmics.
Mol. Pharmacol.,
2014
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127
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Cardiac sodium channel mutations: why so many phenotypes?
Nat Rev Cardiol,
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128
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Angiotensin-(1-7) prevent atrial tachycardia induced sodium channel remodeling.
Pacing Clin Electrophysiol,
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Oct
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129
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Targeting the sodium channel NaV1.5 to specific membrane compartments of cardiac cells: not a simple task!
Circ. Res.,
2014
Nov
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130
Makara MA
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Ankyrin-G coordinates intercalated disc signaling platform to regulate cardiac excitability in vivo.
Circ. Res.,
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