Channelpedia

PubMed 19007941


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Cav2.1



Title: FHM3 in familial hemiplegic migraine is more resistant to mutation than FHM1 and FHM2.

Authors: Viroj Wiwanitkit

Journal, date & volume: J. Neurol. Sci., 2009 Feb 15 , 277, 76-9

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/19007941


Abstract
Familial hemiplegic migraine (FHM) is a rare subtype of migraine with aura and transient hemiplegia. CACNA1A (FHM1) gene, the ATP1A2 (FHM2) and the SCN1A (FHM3) are reported for their correlation to FHM. Here, a bioinformatics analysis was done to study the risk positions for mutation within the amino acid sequence of the three mentioned molecules. In this work, the author can identify many mutant prone positions within the studied FHM. Of interest, the author detected that FHM3 is a high resistant molecule when compared to FHM1 and FHM2.