PubMed 19795515

Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Cav1.2 , Cav1.3 , Cav2.1 , Cav2.2 , Cav2.3 , Cav3.1 , Cav3.2

Title: Cloning and characterization of voltage-gated calcium channel alpha1 subunits in Xenopus laevis during development.

Authors: Brittany B Lewis, Matthew R Wester, Lauren E Miller, Maitreyi D Nagarkar, M Brittany Johnson, Margaret S Saha

Journal, date & volume: Dev. Dyn., 2009 Nov , 238, 2891-902

PubMed link:

Voltage-gated calcium channels play a critical role in regulating the Ca2+ activity that mediates many aspects of neural development, including neural induction, neurotransmitter phenotype specification, and neurite outgrowth. Using Xenopus laevis embryos, we describe the spatial and temporal expression patterns during development of the 10 pore-forming alpha1 subunits that define the channels' kinetic properties. In situ hybridization indicates that CaV1.2, CaV2.1, CaV2.2, and CaV3.2 are expressed during neurula stages throughout the neural tube. These, along with CaV1.3 and CaV2.3, beginning at early tail bud stages, and CaV3.1 at late tail bud stages, are detected in complex patterns within the brain and spinal cord through swimming tadpole stages. Additional expression of various alpha1 subunits was observed in the cranial ganglia, retina, olfactory epithelium, pineal gland, and heart. The unique expression patterns for the different alpha1 subunits suggests they are under precise spatial and temporal regulation and are serving specific functions during embryonic development.