TREK1

Description: Potassium channel subfamily K member 2
Gene: KCNK2
Alias: KCNK2, K2p2.1, TPKC1, TREK, TREK-1, TREK1, hTREK-1c, hTREK-1e

Experimental data

Rat TREK1 gene in CHO host cells
	Click for details 25 °C show 43 cells	Click for details 35 °C show 61 cells

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Gene

Species	NCBI gene ID	Chromosome	Position
Human	3776	1	231548
Mouse	16526	1	194852
Rat	170899	13	197334

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Transcript

Species	NCBI accession	Length (nt)
Human	NM_001017424.3	3594
Mouse	NM_001159850.1	3423
Rat	NM_172041.2	1371

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Protein Isoforms

Species	Uniprot ID	Length (aa)
Human	O95069	426
Mouse	P97438	426
Rat	Q920B6	426

Isoforms

Transcript

Length (nt)

Protein

Length (aa)

Variant

Isoform

Known

NM_001017424.3

3594

NP_001017424.1

422

transcript variant 1

isoform a

NM_001017425.3

3875

NP_001017425.2

426

transcript variant 3

isoform c

NM_014217.4

3751

NP_055032.1

411

transcript variant 2

isoform b

Predicted

XM_017001249.2

3682

XP_016856738.1

412

transcript variant X1

isoform X1

XM_011509524.3

3522

XP_011507826.1

370

transcript variant X2

isoform X2

XM_011509522.3

3241

XP_011507824.1

370

transcript variant X3

isoform X2

XM_047419881.1

3284

XP_047275837.1

370

transcript variant X4

isoform X2

XM_054336482.1

3701

XP_054192457.1

412

transcript variant X1

isoform X1

XM_054336483.1

4809

XP_054192458.1

370

transcript variant X3

isoform X2

Known

NM_001281848.1

3155

NP_001268777.1

329

transcript variant 4

isoform 4

NM_001281847.1

3314

NP_001268776.1

414

transcript variant 3

isoform 3

NM_010607.3

3519

NP_034737.2

411

transcript variant 2

isoform 2

NM_001357119.1

3288

NP_001344048.1

329

transcript variant 5

isoform 4

NM_001159850.1

3423

NP_001153322.1

426

transcript variant 1

isoform 1

NM_001402827.1

3293

NP_001389756.1

310

isoform 7

NM_001402776.1

3179

NP_001389705.1

329

isoform 4

NM_001402826.1

3191

NP_001389755.1

333

isoform 6

NM_001402774.1

3737

NP_001389703.1

422

isoform 5

NM_001402775.1

3393

NP_001389704.1

329

isoform 4

Predicted

XM_006497121.4

3765

XP_006497184.1

422

transcript variant X1

isoform X1

XM_006497122.5

3460

XP_006497185.1

329

transcript variant X2

isoform X2

XM_030251361.2

3638

XP_030107221.1

329

transcript variant X3

isoform X2

Known

NM_172042.2

3159

NP_742039.1

426

transcript variant 2

isoform 2

NM_172041.2

1371

NP_742038.2

422

transcript variant 1

isoform 1

Predicted

XM_006250433.4

3352

XP_006250495.1

414

transcript variant X1

isoform X1

XM_006250434.4

3215

XP_006250496.1

411

transcript variant X2

isoform X2

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Post-Translational Modifications

PTM

Position

Type

Modified residue

348

Phosphoserine; by PKA

Glycosylation

110

N-linked (GlcNAc...) asparagine

Glycosylation

134

N-linked (GlcNAc...) asparagine

Disulfide bond

108

Interchain

Modified residue

348

Phosphoserine

Glycosylation

110

N-linked (GlcNAc...) asparagine

Glycosylation

134

N-linked (GlcNAc...) asparagine

Disulfide bond

108

Interchain

Modified residue

348

Phosphoserine; by PKA

Glycosylation

110

N-linked (GlcNAc...) asparagine

Glycosylation

134

N-linked (GlcNAc...) asparagine

Disulfide bond

108

Interchain

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Structure

TREK1 predicted AlphaFold size

Species	Area (Å²)	Reference
Human	7207.46	source
Mouse	4270.07	source
Rat	5688.45	source

Methodology for AlphaFold size prediction and disclaimer are available here

References

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Credits

To cite this page: [Contributors] Channelpedia https://channelpedia.epfl.ch/wikipages/222/ , accessed on 2024 Apr 20

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TREK1

Experimental data

Rat TREK1 gene in CHO host cells

25 °C

35 °C

Gene

Transcript

Protein Isoforms

Isoforms

Post-Translational Modifications

Structure

TREK1 predicted AlphaFold size

References

Credits