Referenced in: none

Automatically associated channels: Cav2.1

Title: Electroencephalographic changes and seizures in familial hemiplegic migraine patients with the CACNA1A gene S218L mutation.

Authors: Yee-Cheun Chan, Jean-Marc Burgunder, Einar Wilder-Smith, Soh-Eng Chew, Karen M J Lam-Mok-Sing, Vijay Sharma, Benjamin K C Ong

Journal, date & volume: , 2008 Aug , 15, 891-4

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/18313928

Abstract
The S218L CACNA1A mutation has been previously described in two families with familial hemiplegic migraine. We present three siblings with the mutation with the novel association of childhood seizures, and highlight the dynamic changes seen on electroencephalography during hemiplegic migraine attacks. Depressed activity contralateral to the hemiparesis was seen on electroencephalography during acute hemiplegic migraine attacks, which may be due to changes to calcium channels caused by the S218L mutation. Both parents were asymptomatic and did not carry the S218L mutation in their blood. This suggests the presence of mosaicism in the transmitting parent.