PubMed 10395579

Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Cav2.1

Title: Calcium channelopathies in the central nervous system.

Authors: J Jen

Journal, date & volume: Curr. Opin. Neurobiol., 1999 Jun , 9, 274-80

PubMed link:

The recent discovery that familial hemiplegic migraine, episodic ataxia type 2, and spinocerebellar ataxia type 6 are allelic disorders caused by different mutations in CACNA1A, a calcium-channel-encoding gene, adds to a growing list of channelopathies causing paroxysmal neurologic disturbance and progressive neurodegeneration. Calcium channelopathies in the central nervous system provide a model to study the important roles that calcium channels play in neuronal function.