Channelpedia

PubMed 15827027


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Cav2.1



Title: Neural integrator function in murine CACNA1A mutants.

Authors: John S Stahl, Robert A James

Journal, date & volume: Ann. N. Y. Acad. Sci., 2005 Apr , 1039, 580-2

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/15827027


Abstract
Time constants of gaze holding are shortened in rocker and tottering mice, two strains whose cerebellar dysfunction stems from genetic alterations of the P/Q calcium channel. The finding suggests that in mice as in primates, the cerebellum contributes to the function of the neural integrator. Studying CACNA1A mutants may elucidate how cerebellar signals support gaze holding.