Channelpedia

Kv12.3

Description: potassium voltage-gated channel, subfamily H (eag-related), member 4
Gene: Kcnh4
Alias: Kv12.3

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Introduction

Kv12.3 (also known as BEC2; ELK1), encoded by the gene KCNH4, is a sodium, voltage-gated, type I, alpha subunit channel. Kv12.3 is is brain-specific, and located in the neocortex and the striatum. It may be involved in cellular excitability of restricted neurons in the central nervous system.


Experimental data

Rat Kv12.3 gene in CHO host cells       datasheet
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show 73 cells

Mouse Kv12.3 gene in CHO host cells       datasheet
25 °C
show 64 cells
Human Kv12.3 gene in CHO host cells       datasheet
25 °C
show 68 cells

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Gene

Kv10-12 phylogenetic tree
Phylogenetic tree for the Kv10–12 families. [606]

Species NCBI gene ID Chromosome Position
Human 23415 17 24251
Mouse 380728 11 19737
Rat 114032 10 19834

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Transcript

Species NCBI accession Length (nt)
Human NM_012285.3 3788
Mouse NM_001081194.2 3784
Rat NM_053630.2 3746

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Protein Isoforms

Species Uniprot ID Length (aa)
Human Q9UQ05 1017
Mouse A2A5F7 1018
Rat Q9R1T9 1017

Isoforms

Transcript
Length (nt)
Protein
Length (aa)
Variant
Isoform

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Post-Translational Modifications

PTM
Position
Type

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Structure

Kv12.3
Visual Representation of Kv12.3 Structure
Methodology for visual representation of structure available here

There are light oxygen voltage (LOV) and cyclic nucleotide binding (CNB) domains in the N and C terminus, respectively. [606]

Kv12.3 predicted AlphaFold size

Species Area (Å2) Reference
Human 7753.35 source
Mouse 7534.22 source
Rat 5946.38 source

Methodology for AlphaFold size prediction and disclaimer are available here


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Kinetics

Kv12.3 is a slowly activating voltage-gated potassium channel with threshold for activation at 90 mV [809].


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Expression and Distribution

Kv12.3 was identified in the brain (telencephalon),[809], [810] neuroblastoma, esophagus, oligodendroglioma, lung, primary B-cell neoplasia, cerebellum, pituitary gland [795].


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Function

Angiogenesis

ELK3 suppresses angiogenesis by inhibiting the transcriptional activity of ETS-1 on MT1-MMP [1760]

Ovarian Cancer influenced by Angiogenesis

MiR-378 was overexpressed in ovarian cancer cells and tumors vs. normal ovarian epithelial cells. Overexpressing miR-378 in ovarian cancer cells altered expression of genes associated with angiogenesis (ALCAM, EHD1, ELK3, TLN1), apoptosis (RPN2, HIPK3), and cell cycle regulation (SWAP-70, LSM14A, RDX) [1761]


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Interaction

Ba2+

Ba2+ blocks Kv12.3. [809]

KCNH8

Coexpression of KCNH8 with dominant-negative KCNH8, KCNH3, and KCNH4 subunits led to suppression of the KCNH8 currents, suggesting that Elk channels can form heteromultimers. [808]

pH

Kv.12.3 Kv10.2, Kv12.2, and Kv12.3 are similarly modulated by external pH. Thus high pH sensitivity has now been observed for six of eight mammalian EAG superfamily orthologues, including all members of the Eag and Elk gene families. The Erg family channels Kv11.2 and Kv11.3 have not yet been examined for pH sensitivity, but they also have the EAG-specific acidic residues [1832]

Tau protein and KCNH4 mRNA levels

Overexpression of tau protein lead to the reduction of KCNH4 mRNA levels in mouse neuroplastoma cells [2087]and human neuroplastoma cells [2088]


References

327

808

Zou A et al. Distribution and functional properties of human KCNH8 (Elk1) potassium channels.
Am. J. Physiol., Cell Physiol., 2003 Dec , 285 (C1356-66).

809

Engeland B et al. Cloning and functional expression of rat ether-à-go-go-like K+ channel genes.
J. Physiol. (Lond.), 1998 Dec 15 , 513 ( Pt 3) (647-54).

810

Miyake A et al. New ether-à-go-go K(+) channel family members localized in human telencephalon.
J. Biol. Chem., 1999 Aug 27 , 274 (25018-25).

Chan JK et al. MiR-378 as a biomarker for response to anti-angiogenic treatment in ovarian cancer.
Gynecol. Oncol., 2014 Jun , 133 (568-74).


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Credits

Contributors: Rajnish Ranjan, Katherine Johnston

To cite this page: [Contributors] Channelpedia https://channelpedia.epfl.ch/wikipages/40/ , accessed on 2024 Dec 12



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