TREK1

1

Jorgensen C et al. Lateral Fenestrations in K(+)-Channels Explored Using Molecular Dynamics Simulations.
Mol. Pharm., 2016 May 26 , ().

2

Wiedmann F et al. Therapeutic targeting of two-pore-domain potassium (K2P) channels in the cardiovascular system.
Clin. Sci., 2016 May 1 , 130 (643-50).

3

Veale EL et al. Aristolochic acid, a plant extract used in the treatment of pain and linked to Balkan endemic nephropathy, is a regulator of K2P channels.
Br. J. Pharmacol., 2016 May , 173 (1639-52).

4

Woo J et al. Inhibition of TREK-2 K(+) channels by PI(4,5)P2: an intrinsic mode of regulation by intracellular ATP via phosphatidylinositol kinase.
Pflugers Arch., 2016 Jun 9 , ().

5

McClenaghan C et al. Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states.
J. Gen. Physiol., 2016 Jun , 147 (497-505).

6

Ghatak S et al. Lactate modulates the intracellular pH sensitivity of human TREK1 channels.
Pflugers Arch., 2016 Feb 3 , ().

7

Banerjee A et al. L-Lactate mediates neuroprotection against ischaemia by increasing TREK1 channel expression in rat hippocampal astrocytes in vitro.
J. Neurochem., 2016 Apr 9 , ().

8

Lengyel M et al. Formation of Functional Heterodimers by TREK-1 and TREK-2 Two-pore Domain Potassium Channel Subunits.
J. Biol. Chem., 2016 Apr 28 , ().

9

Levitz J et al. Heterodimerization within the TREK channel subfamily produces a diverse family of highly regulated potassium channels.
Proc. Natl. Acad. Sci. U.S.A., 2016 Apr 12 , 113 (4194-9).

10

Kubanek J et al. Ultrasound modulates ion channel currents.
Sci Rep, 2016 , 6 (24170).

11

Weller J et al. pH-Sensitive K(+) Currents and Properties of K2P Channels in Murine Hippocampal Astrocytes.
Adv Protein Chem Struct Biol, 2016 , 103 (263-94).

12

Brohawn SG How ion channels sense mechanical force: insights from mechanosensitive K2P channels TRAAK, TREK1, and TREK2.
Ann. N. Y. Acad. Sci., 2015 Sep , 1352 (20-32).

13

Ghatak S et al. Ischaemic concentrations of lactate increase TREK1 channel activity by interacting with a single histidine residue in the carboxy terminal domain.
J. Physiol. (Lond.), 2015 Oct 7 , ().

14

Lee AK et al. Arginine Vasopressin Potentiates the Stimulatory Action of CRH on Pituitary Corticotropes via a Protein Kinase C-Dependent Reduction of the Background TREK-1 Current.
Endocrinology, 2015 Oct , 156 (3661-72).

15

Bodnar M et al. The potassium current carried by TREK-1 channels in rat cardiac ventricular muscle.
Pflugers Arch., 2015 May , 467 (1069-79).

16

Ehling P et al. The CNS under pathophysiologic attack--examining the role of K₂p channels.
Pflugers Arch., 2015 May , 467 (959-72).

17

MacKenzie G et al. Two-pore domain potassium channels enable action potential generation in the absence of voltage-gated potassium channels.
Pflugers Arch., 2015 May , 467 (989-99).

18

Kim D et al. Role of K₂p channels in stimulus-secretion coupling.
Pflugers Arch., 2015 May , 467 (1001-11).

19

Mathie A et al. Two-pore domain potassium channels: potential therapeutic targets for the treatment of pain.
Pflugers Arch., 2015 May , 467 (931-43).

20

Bista P et al. The role of two-pore-domain background K⁺ (K₂p) channels in the thalamus.
Pflugers Arch., 2015 May , 467 (895-905).

21

Bandulik S et al. Two-pore domain potassium channels in the adrenal cortex.
Pflugers Arch., 2015 May , 467 (1027-42).

22

Göb E et al. The two-pore domain potassium channel KCNK5 deteriorates outcome in ischemic neurodegeneration.
Pflugers Arch., 2015 May , 467 (973-87).

23

Dong YY et al. K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac.
Science, 2015 Mar 13 , 347 (1256-9).

24

Lin DH et al. The Role of the Two-Pore Domain Potassium Channel TREK-1 in the Therapeutic Effects of Escitalopram in a Rat Model of Poststroke Depression.
CNS Neurosci Ther, 2015 Jun , 21 (504-12).

25

Zhang GM et al. Prognostic significance of the TREK-1 K2P potassium channels in prostate cancer.
Oncotarget, 2015 Jul 30 , 6 (18460-8).

26

Rivas-Ramírez P et al. Muscarinic modulation of TREK currents in mouse sympathetic superior cervical ganglion neurons.
Eur. J. Neurosci., 2015 Jul , 42 (1797-807).

27

Bista P et al. Differential phospholipase C-dependent modulation of TASK and TREK two-pore domain K+ channels in rat thalamocortical relay neurons.
J. Physiol. (Lond.), 2015 Jan 1 , 593 (127-44).

28

Wang Y et al. Regulation of Trek1 expression in nasal mucosa with allergic rhinitis by specific immunotherapy.
Cell Biochem. Funct., 2015 Jan , 33 (23-8).

29

Chen C et al. Effects of fluoxetine on protein expression of potassium ion channels in the brain of chronic mild stress rats.
Acta Pharm Sin B, 2015 Jan , 5 (55-61).

30

Congiu C et al. The role of the potassium channel gene KCNK2 in major depressive disorder.
Psychiatry Res, 2015 Feb 28 , 225 (489-92).

31

Veyssiere J et al. Retroinverso analogs of spadin display increased antidepressant effects.
Psychopharmacology (Berl.), 2015 Feb , 232 (561-74).

32

Borsotto M et al. Targeting two-pore domain K(+) channels TREK-1 and TASK-3 for the treatment of depression: a new therapeutic concept.
Br. J. Pharmacol., 2015 Feb , 172 (771-84).

33

Pei HX et al. [The two pore notassium channel TREK-1 and its related diseases].
Sheng Li Ke Xue Jin Zhan, 2015 Dec , 46 (468-72).

34

Zhuo RG et al. Insights into the stimulatory mechanism of 2-aminoethoxydiphenyl borate on TREK-2 potassium channel.
Neuroscience, 2015 Aug 6 , 300 (85-93).

35

Zhuo RG et al. The isoforms generated by alternative translation initiation adopt similar conformation in the selectivity filter in TREK-2.
J. Physiol. Biochem., 2015 Aug 14 , ().

36

Schwartz ES et al. Nociceptive and inflammatory mediator upregulation in a mouse model of chronic prostatitis.
Pain, 2015 Aug , 156 (1537-44).

37

Brune K et al. Pulmonary epithelial barrier function: some new players and mechanisms.
Am. J. Physiol. Lung Cell Mol. Physiol., 2015 Apr 15 , 308 (L731-45).

38

Braun G et al. Differential sensitivity of TREK-1, TREK-2 and TRAAK background potassium channels to the polycationic dye ruthenium red.
Br. J. Pharmacol., 2015 Apr , 172 (1728-38).

39

Kim SH et al. Electrogenic transport and K(+) ion channel expression by the human endolymphatic sac epithelium.
Sci Rep, 2015 , 5 (18110).

40

Okada M et al. Increase in the titer of lentiviral vectors expressing potassium channels by current blockade during viral vector production.
BMC Neurosci, 2015 , 16 (30).

41

Jiang J et al. Trek1 contributes to maintaining nasal epithelial barrier integrity.
Sci Rep, 2015 , 5 (9191).

42

Schwingshackl A et al. TREK-1 Regulates Cytokine Secretion from Cultured Human Alveolar Epithelial Cells Independently of Cytoskeletal Rearrangements.
PLoS ONE, 2015 , 10 (e0126781).

43

Rivera-Pagán AF et al. Up-regulation of TREK-2 potassium channels in cultured astrocytes requires de novo protein synthesis: relevance to localization of TREK-2 channels in astrocytes after transient cerebral ischemia.
PLoS ONE, 2015 , 10 (e0125195).

44

Schmidt C et al. Inhibition of cardiac two-pore-domain K+ (K2P) channels--an emerging antiarrhythmic concept.
Eur. J. Pharmacol., 2014 Sep 5 , 738 (250-5).

45

Comoglio Y et al. Phospholipase D2 specifically regulates TREK potassium channels via direct interaction and local production of phosphatidic acid.
Proc. Natl. Acad. Sci. U.S.A., 2014 Sep 16 , 111 (13547-52).

46

Bond RC et al. Inhibition of a TREK-like K+ channel current by noradrenaline requires both β1- and β2-adrenoceptors in rat atrial myocytes.
Cardiovasc. Res., 2014 Oct 1 , 104 (206-15).

47

Schwingshackl A et al. Deficiency of the two-pore-domain potassium channel TREK-1 promotes hyperoxia-induced lung injury.
Crit. Care Med., 2014 Nov , 42 (e692-701).

48

Henstock JR et al. Remotely Activated Mechanotransduction via Magnetic Nanoparticles Promotes Mineralization Synergistically With Bone Morphogenetic Protein 2: Applications for Injectable Cell Therapy.
Stem Cells Transl Med, 2014 Nov , 3 (1363-74).

49

Xiao Z et al. Activation of neurotensin receptor 1 facilitates neuronal excitability and spatial learning and memory in the entorhinal cortex: beneficial actions in an Alzheimer's disease model.
J. Neurosci., 2014 May 14 , 34 (7027-42).

50

Veale EL et al. Influence of the N terminus on the biophysical properties and pharmacology of TREK1 potassium channels.
Mol. Pharmacol., 2014 May , 85 (671-81).

51

Brohawn SG et al. Mechanosensitivity is mediated directly by the lipid membrane in TRAAK and TREK1 K+ channels.
Proc. Natl. Acad. Sci. U.S.A., 2014 Mar 4 , 111 (3614-9).

52

Schmidt C et al. Cardiac expression and atrial fibrillation-associated remodeling of K₂p2.1 (TREK-1) K⁺ channels in a porcine model.
Life Sci., 2014 Mar 3 , 97 (107-15).

53

Rodrigues N et al. Synthesis and structure-activity relationship study of substituted caffeate esters as antinociceptive agents modulating the TREK-1 channel.
Eur J Med Chem, 2014 Mar 21 , 75 (391-402).

54

Tran VT et al. Mechanotransduction channels of the trabecular meshwork.
Curr. Eye Res., 2014 Mar , 39 (291-303).

55

Zappia KJ et al. Cold hypersensitivity increases with age in mice with sickle cell disease.
Pain, 2014 Jun 3 , ().

56

Retailleau K et al. Polycystins and partners: proposed role in mechanosensitivity.
J. Physiol. (Lond.), 2014 Jun 15 , 592 (2453-2471).

57

Bittner S et al. TREK-king the blood-brain-barrier.
J Neuroimmune Pharmacol, 2014 Jun , 9 (293-301).

58

Lei Q et al. Response of the human detrusor to stretch is regulated by TREK-1, a two-pore-domain (K2P) mechano-gated potassium channel.
J. Physiol. (Lond.), 2014 Jul 15 , 592 (3013-30).

59

Tong L et al. Activation of K(2)P channel-TREK1 mediates the neuroprotection induced by sevoflurane preconditioning.
Br J Anaesth, 2014 Jul , 113 (157-67).

60

Acosta C et al. TREK2 expressed selectively in IB4-binding C-fiber nociceptors hyperpolarizes their membrane potentials and limits spontaneous pain.
J. Neurosci., 2014 Jan 22 , 34 (1494-509).

61

Gohlke BO et al. SuperPain--a resource on pain-relieving compounds targeting ion channels.
Nucleic Acids Res., 2014 Jan 1 , 42 (D1107-12).

62

Lalo U et al. Exocytosis of ATP from astrocytes modulates phasic and tonic inhibition in the neocortex.
PLoS Biol., 2014 Jan , 12 (e1001747).

63

Dey D et al. A potassium leak channel silences hyperactive neurons and ameliorates status epilepticus.
Epilepsia, 2014 Feb , 55 (203-13).

64

Shin HW et al. The inhibitory effects of bupivacaine, levobupivacaine, and ropivacaine on K2P (two-pore domain potassium) channel TREK-1.
J Anesth, 2014 Feb , 28 (81-6).

65

Pereira V et al. Role of the TREK2 potassium channel in cold and warm thermosensation and in pain perception.
Pain, 2014 Dec , 155 (2534-44).

66

Seyler C et al. Vernakalant activates human cardiac K(2P)17.1 background K(+) channels.
Biochem. Biophys. Res. Commun., 2014 Aug 29 , 451 (415-20).

67

Benoist D et al. Systems approach to the study of stretch and arrhythmias in right ventricular failure induced in rats by monocrotaline.
Prog. Biophys. Mol. Biol., 2014 Aug , 115 (162-72).

68

Rinné S et al. A splice variant of the two-pore domain potassium channel TREK-1 with only one pore domain reduces the surface expression of full-length TREK-1 channels.
Pflugers Arch., 2014 Aug , 466 (1559-70).

69

Yang X et al. Functional study of TREK-1 potassium channels during rat heart development and cardiac ischemia using RNAi techniques.
J. Cardiovasc. Pharmacol., 2014 Aug , 64 (142-50).

70

Hund TJ et al. β(IV)-Spectrin regulates TREK-1 membrane targeting in the heart.
Cardiovasc. Res., 2014 Apr 1 , 102 (166-75).

71

Lu L et al. Electrophysiology and pharmacology of tandem domain potassium channel TREK-1 related BDNF synthesis in rat astrocytes.
Naunyn Schmiedebergs Arch. Pharmacol., 2014 Apr , 387 (303-12).

72

Noriega-Navarro R et al. Novel TASK channels inhibitors derived from dihydropyrrolo[2,1-a]isoquinoline.
Neuropharmacology, 2014 Apr , 79 (28-36).

73

Brand T et al. The cAMP-binding Popdc proteins have a redundant function in the heart.
Biochem. Soc. Trans., 2014 Apr , 42 (295-301).

74

Schneider ER et al. Temperature sensitivity of two-pore (K2P) potassium channels.
Curr Top Membr, 2014 , 74 (113-33).

75

Ali TY et al. The effect of pH and ion channel modulators on human placental arteries.
PLoS ONE, 2014 , 9 (e114405).

76

Roan E et al. The 2-pore domain potassium channel TREK-1 regulates stretch-induced detachment of alveolar epithelial cells.
PLoS ONE, 2014 , 9 (e89429).

77

Hwang EM et al. A disulphide-linked heterodimer of TWIK-1 and TREK-1 mediates passive conductance in astrocytes.
Nat Commun, 2014 , 5 (3227).

78

Berrier C et al. The purified mechanosensitive channel TREK-1 is directly sensitive to membrane tension.
J. Biol. Chem., 2013 Sep 20 , 288 (27307-14).

79

Heyman NS et al. TREK-1 currents in smooth muscle cells from pregnant human myometrium.
Am. J. Physiol., Cell Physiol., 2013 Sep 15 , 305 (C632-42).

80

Bittner S et al. Endothelial TWIK-related potassium channel-1 (TREK1) regulates immune-cell trafficking into the CNS.
Nat. Med., 2013 Sep , 19 (1161-5).

81

Innamaa A et al. Expression and effects of modulation of the K2P potassium channels TREK-1 (KCNK2) and TREK-2 (KCNK10) in the normal human ovary and epithelial ovarian cancer.
Clin Transl Oncol, 2013 Nov , 15 (910-8).

82

Pollema-Mays SL et al. Expression of background potassium channels in rat DRG is cell-specific and down-regulated in a neuropathic pain model.
Mol. Cell. Neurosci., 2013 Nov , 57 (1-9).

83

Ford KJ et al. A role for TREK1 in generating the slow afterhyperpolarization in developing starburst amacrine cells.
J. Neurophysiol., 2013 May , 109 (2250-9).

84

Schmidt C et al. Class I antiarrhythmic drugs inhibit human cardiac two-pore-domain K(+) (K2 ₂p) channels.
Eur. J. Pharmacol., 2013 Dec 5 , 721 (237-48).

85

Seyler C et al. Inhibition of cardiac two-pore-domain K(+) (K2P) channels by the antiarrhythmic drug vernakalant - Comparison with flecainide.
Eur. J. Pharmacol., 2013 Dec 27 , 724C (51-57).

86

Devilliers M et al. Activation of TREK-1 by morphine results in analgesia without adverse side effects.
Nat Commun, 2013 Dec 17 , 4 (2941).

87

Bagriantsev SN et al. A high-throughput functional screen identifies small molecule regulators of temperature- and mechano-sensitive K2P channels.
ACS Chem. Biol., 2013 Aug 16 , 8 (1841-51).

88

Enyeart JJ et al. Ca2+ and K+ channels of normal human adrenal zona fasciculata cells: properties and modulation by ACTH and AngII.
J. Gen. Physiol., 2013 Aug , 142 (137-55).

89

Ye DQ et al. [TREK1 potassium channels and depression].
Yao Xue Xue Bao, 2012 Nov , 47 (1403-8).

90

Wu X et al. Small RNA interference-mediated gene silencing of TREK-1 potassium channel in cultured astrocytes.
J. Huazhong Univ. Sci. Technol. Med. Sci., 2012 Dec , 32 (849-55).