Kv1.2
643 literature references associated to Kv1.2
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Isolation, chemical and functional characterization of several new K(+)-channel blocking peptides from the venom of the scorpion Centruroides tecomanus.
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KV1 channels identified in rodent myelinated axons, linked to Cx29 in innermost myelin: Support for electrically-active myelin in mammalian saltatory conduction.
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Assembly of juxtaparanodes in myelinating DRG culture: Differential clustering of the Kv1/Caspr2 complex and scaffolding protein 4.1B.
Glia,
2016
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Developmental expression of Kv1 voltage-gated potassium channels in the avian hypothalamus.
Neurosci. Lett.,
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Effective pore size and radius of capture for K(+) ions in K-channels.
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Ion Concentration- and Voltage-Dependent Push and Pull Mechanisms of Potassium Channel Ion Conduction.
PLoS ONE,
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8
Ye F
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The Scorpion Toxin Analogue BmKTX-D33H as a Potential Kv1.3 Channel-Selective Immunomodulator for Autoimmune Diseases.
Toxins (Basel),
2016
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9
Wang X
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A single-point mutation enhances dual functionality of a scorpion toxin.
Comp. Biochem. Physiol. C Toxicol. Pharmacol.,
2015
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10
Jorgensen C
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In Silico Identification of PAP-1 Binding Sites in the Kv1.2 Potassium Channel.
Mol. Pharm.,
2015
Mar
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11
Ishida IG
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Voltage-dependent gating and gating charge measurements in the Kv1.2 potassium channel.
J. Gen. Physiol.,
2015
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12
Tsantoulas C
Emerging potassium channel targets for the treatment of pain.
Curr Opin Support Palliat Care,
2015
Jun
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13
Chang SC
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N-Terminally extended analogues of the K⁺ channel toxin from Stichodactyla helianthus as potent and selective blockers of the voltage-gated potassium channel Kv1.3.
FEBS J.,
2015
Jun
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14
Wu KW
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VEGF attenuated increase of outward delayed-rectifier potassium currents in hippocampal neurons induced by focal ischemia via PI3-K pathway.
Neuroscience,
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Jul
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15
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Porphyrin derivatives as potent and selective blockers of neuronal Kv1 channels.
Chem. Commun. (Camb.),
2015
Jan
21
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16
Wang X
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Mesomartoxin, a new K(v)1.2-selective scorpion toxin interacting with the channel selectivity filter.
Biochem. Pharmacol.,
2015
Jan
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17
Xiang F
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Plectasin, first animal toxin-like fungal defensin blocking potassium channels through recognizing channel pore region.
Toxins (Basel),
2015
Jan
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18
Baronas VA
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Use-dependent activation of neuronal kv1.2 channel complexes.
J. Neurosci.,
2015
Feb
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19
Konoki K
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Evaluation of gambierol and its analogs for their inhibition of human Kv1.2 and cytotoxicity.
Bioorg. Med. Chem. Lett.,
2015
Feb
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20
Wang YW
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Inhibitory effects of imperatorin on voltage-gated K(+) channels and ATP-sensitive K(+) channels.
Pharmacol Rep,
2015
Feb
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21
Pena SD
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Ataxia and myoclonic epilepsy due to a heterozygous new mutation in KCNA2: proposal for a new channelopathy.
Clin. Genet.,
2015
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22
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A novel pan-negative-gating modulator of KCa2/3 channels, fluoro-di-benzoate, RA-2, inhibits endothelium-derived hyperpolarization-type relaxation in coronary artery and produces bradycardia in vivo.
Mol. Pharmacol.,
2015
Feb
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23
Zhao R
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Designer and natural peptide toxin blockers of the KcsA potassium channel identified by phage display.
Proc. Natl. Acad. Sci. U.S.A.,
2015
Dec
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24
Kole MJ
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Selective Loss of Presynaptic Potassium Channel Clusters at the Cerebellar Basket Cell Terminal Pinceau in Adam11 Mutants Reveals Their Role in Ephaptic Control of Purkinje Cell Firing.
J. Neurosci.,
2015
Aug
12
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25
Smith KE
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Phosphoinositide Modulation of Heteromeric Kv1 Channels Adjusts Output of Spiral Ganglion Neurons from Hearing Mice.
J. Neurosci.,
2015
Aug
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26
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SjAPI-2 is the first member of a new neurotoxin family with Ascaris-type fold and KCNQ1 inhibitory activity.
Int. J. Biol. Macromol.,
2015
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27
Du Y
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Rotational Symmetry of Two Pyrethroid Receptor Sites in the Mosquito Sodium Channel.
Mol. Pharmacol.,
2015
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28
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Pore dimensions and the role of occupancy in unitary conductance of Shaker K channels.
J. Gen. Physiol.,
2015
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Drögemöller BI
Maintaining the balance: both gain- and loss-of-function KCNA2 mutants cause epileptic encephalopathy.
Clin. Genet.,
2015
Aug
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30
Steinmann ME
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A heteromeric potassium channel involved in the modulation of the plasma membrane potential is essential for the survival of African trypanosomes.
FASEB J.,
2015
Apr
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31
Lee JY
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The role of K⁺ conductances in regulating membrane excitability in human gastric corpus smooth muscle.
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32
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De novo loss- or gain-of-function mutations in KCNA2 cause epileptic encephalopathy.
Nat. Genet.,
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33
Guedon JM
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Current gene therapy using viral vectors for chronic pain.
Mol Pain,
2015
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34
ElFessi-Magouri R
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Characterization of Kbot21 Reveals Novel Side Chain Interactions of Scorpion Toxins Inhibiting Voltage-Gated Potassium Channels.
PLoS ONE,
2015
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35
Bartok A
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An engineered scorpion toxin analogue with improved Kv1.3 selectivity displays reduced conformational flexibility.
Sci Rep,
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36
Kesters D
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Structure of the SthK carboxy-terminal region reveals a gating mechanism for cyclic nucleotide-modulated ion channels.
PLoS ONE,
2015
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37
Bartok A
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Margatoxin is a non-selective inhibitor of human Kv1.3 K(+) channels.
Toxicon,
2014
Sep
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38
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Differential expression of the Kv1 voltage-gated potassium channel family in the rat nephron.
J. Mol. Histol.,
2014
Oct
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39
Chen R
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Mechanisms and energetics of potassium channel block by local anesthetics and antifungal agents.
Biochemistry,
2014
Nov
4
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40
Chater TE
Exciting endocytosis of Kv1.2--intrinsic plasticity in CA3.
J. Physiol. (Lond.),
2014
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41
Kasimova MA
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Voltage-gated ion channel modulation by lipids: insights from molecular dynamics simulations.
Biochim. Biophys. Acta,
2014
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42
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The Kvβ2 subunit of voltage-gated potassium channels is interacting with ProSAP2/Shank3 in the PSD.
Neuroscience,
2014
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43
Cerni FA
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Electrophysiological characterization of Ts6 and Ts7, K⁺ channel toxins isolated through an improved Tityus serrulatus venom purification procedure.
Toxins (Basel),
2014
Mar
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44
Li HX
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GATA-4 induces changes in electrophysiological properties of rat mesenchymal stem cells.
Biochim. Biophys. Acta,
2014
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45
Luna-Ramírez K
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Structure, molecular modeling, and function of the novel potassium channel blocker urotoxin isolated from the venom of the Australian scorpion Urodacus yaschenkoi.
Mol. Pharmacol.,
2014
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46
Sapay N
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Rebuilding a macromolecular membrane complex at the atomic scale: Case of the Kir6.2 potassium channel coupled to the muscarinic acetylcholine receptor m2.
Proteins,
2014
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47
Barry J
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Ankyrin-G directly binds to kinesin-1 to transport voltage-gated Na+ channels into axons.
Dev. Cell,
2014
Jan
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48
Kim I
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Coarse-grained simulations of the gating current in the voltage-activated Kv1.2 channel.
Proc. Natl. Acad. Sci. U.S.A.,
2014
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49
Çolakoğlu G
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Contactin-1 regulates myelination and nodal/paranodal domain organization in the central nervous system.
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50
Kariev AM
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The open gate of the K(V)1.2 channel: quantum calculations show the key role of hydration.
Biophys. J.,
2014
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51
Fuchs JR
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Cerebellar secretin modulates eyeblink classical conditioning.
Learn. Mem.,
2014
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52
Lutz BM
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Noncoding RNAs: new players in chronic pain.
Anesthesiology,
2014
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53
Moore CL
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Protein kinase A-phosphorylated KV1 channels in PSD95 signaling complex contribute to the resting membrane potential and diameter of cerebral arteries.
Circ. Res.,
2014
Apr
11
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54
Galea CA
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Domain structure and function of matrix metalloprotease 23 (MMP23): role in potassium channel trafficking.
Cell. Mol. Life Sci.,
2014
Apr
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55
Li Z
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Exercise training reverses alterations in Kv and BKCa channel molecular expression in thoracic aorta smooth muscle cells from spontaneously hypertensive rats.
J. Vasc. Res.,
2014
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56
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Homology model and targeted mutagenesis identify critical residues for arachidonic acid inhibition of Kv4 channels.
Channels (Austin),
2013 Mar-Apr
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57
Fowler PW
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Detailed Examination of a Single Conduction Event in a Potassium Channel.
J Phys Chem Lett,
2013
Sep
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58
Li P
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The gating charge pathway of an epilepsy-associated potassium channel accommodates chemical ligands.
Cell Res.,
2013
Sep
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59
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Molecular dynamics simulations of membrane proteins under asymmetric ionic concentrations.
J. Gen. Physiol.,
2013
Oct
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60
Orts DJ
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BcsTx3 is a founder of a novel sea anemone toxin family of potassium channel blocker.
FEBS J.,
2013
Oct
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61
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5-HT2 receptors-mediated modulation of voltage-gated K+ channels and neurophysiopathological correlates.
Exp Brain Res,
2013
Oct
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62
Hyun JH
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Activity-dependent downregulation of D-type K+ channel subunit Kv1.2 in rat hippocampal CA3 pyramidal neurons.
J. Physiol. (Lond.),
2013
Nov
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63
Tarek M
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Omega Currents in Voltage-Gated Ion Channels: What Can We Learn from Uncovering the Voltage-Sensing Mechanism Using MD Simulations?
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2013
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64
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Atomic-level simulation of current-voltage relationships in single-file ion channels.
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2013
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65
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Venomous secretions from marine snails of the Terebridae family target acetylcholine receptors.
Toxins (Basel),
2013
May
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66
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Kv1.1 channels act as mechanical brake in the senses of touch and pain.
Neuron,
2013
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67
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Coumarsabin hastens C-type inactivation gating of voltage-gated K⁺ channels.
Eur. J. Pharmacol.,
2013
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68
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Intracellular trafficking of the KV1.3 potassium channel is regulated by the prodomain of a matrix metalloprotease.
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2013
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Expression and characterization of a novel scorpine-like peptide Ev37, from the scorpion Euscorpiops validus.
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2013
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70
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Biochemical and electrophysiological characterization of two sea anemone type 1 potassium toxins from a geographically distant population of Bunodosoma caissarum.
Mar Drugs,
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71
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Dynamic interaction between sigma-1 receptor and Kv1.2 shapes neuronal and behavioral responses to cocaine.
Cell,
2013
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72
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Voltage-gated K+ channels in adipogenic differentiation of bone marrow-derived human mesenchymal stem cells.
Acta Pharmacol. Sin.,
2013
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73
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Characterization of a ligand binding site in the human transient receptor potential ankyrin 1 pore.
Biophys. J.,
2013
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Conductance properties of the inwardly rectifying channel, Kir3.2: molecular and Brownian dynamics study.
Biochim. Biophys. Acta,
2013
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75
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An Allosteric Mechanism for Drug Block of the Human Cardiac Potassium Channel KCNQ1.
Mol. Pharmacol.,
2013
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Dynamic PIP2 interactions with voltage sensor elements contribute to KCNQ2 channel gating.
Proc. Natl. Acad. Sci. U.S.A.,
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77
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Hyperexcitability of bladder afferent neurons associated with reduction of Kv1.4 α-subunit in rats with spinal cord injury.
J. Urol.,
2013
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78
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The Large Conductance, Calcium-activated K(+) (BK) Channel is regulated by Cysteine String Protein.
Sci Rep,
2013
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79
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Pharmacological characteristics of Kv1.1- and Kv1.2-containing channels are influenced by the stoichiometry and positioning of their α subunits.
Biochem. J.,
2013
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A long noncoding RNA contributes to neuropathic pain by silencing Kcna2 in primary afferent neurons.
Nat. Neurosci.,
2013
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81
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Fine-tuning of voltage sensitivity of the Kv1.2 potassium channel by interhelix loop dynamics.
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82
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Ion concentration-dependent ion conduction mechanism of a voltage-sensitive potassium channel.
PLoS ONE,
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83
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Chukrasones A and B: potential Kv1.2 potassium channel blockers with new skeletons from Chukrasia tabularis.
Org. Lett.,
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84
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Interaction of C70 fullerene with the Kv1.2 potassium channel.
Phys Chem Chem Phys,
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Glioma big potassium channel expression in human cancers and possible T cell epitopes for their immunotherapy.
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2012
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86
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Modeling of open, closed, and open-inactivated states of the hERG1 channel: structural mechanisms of the state-dependent drug binding.
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Myelination of rodent hippocampal neurons in culture.
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Novel activation of voltage-gated K(+) channels by sevoflurane.
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Basis for allosteric open-state stabilization of voltage-gated potassium channels by intracellular cations.
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Molecular mechanism for depolarization-induced modulation of Kv channel closure.
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91
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Identification of a new specific Kv1.3 channel blocker, Ctri9577, from the scorpion Chaerilus tricostatus.
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Altered distribution of juxtaparanodal kv1.2 subunits mediates peripheral nerve hyperexcitability in type 2 diabetes mellitus.
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Increased Kv1 channel expression may contribute to decreased sIPSC frequency following chronic inhibition of NR2B-containing NMDAR.
Neuropsychopharmacology,
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94
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Engineering a potent and specific blocker of voltage-gated potassium channel Kv1.3, a target for autoimmune diseases.
Biochemistry,
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Identification of Selective Inhibitors of the Potassium Channel Kv1.1-1.2((3)) by High-Throughput Virtual Screening and Automated Patch Clamp.
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2012
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96
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Single cell analysis of voltage-gated potassium channels that determines neuronal types of rat hypothalamic paraventricular nucleus neurons.
Neuroscience,
2012
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97
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Multi-faceted modulation of K+ channels by protein tyrosine phosphatase epsilon tunes neuronal excitability.
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98
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Experimental validation of in silico predicted KCNA1, KCNA2, KCNA6 and KCNQ2 genes for association studies of peripheral nerve hyperexcitability syndrome in Jack Russell Terriers.
Neuromuscul. Disord.,
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Kv1.1 and Kv1.2: Similar channels, different seizure models.
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Comparison of the effects of DC031050, a class III antiarrhythmic agent, on hERG channel and three neuronal potassium channels.
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Cellular mechanisms and behavioral consequences of Kv1.2 regulation in the rat cerebellum.
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Developmental changes in the expression of Κv1 potassium channels in rat vestibular ganglion cells.
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Rigid Body Brownian Dynamics as a Tool for Studying Ion Channel Blockers.
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Kv1.2 potassium channel inhibitors from Chukrasia tabularis.
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Realistic simulation of the activation of voltage-gated ion channels.
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BKCa and KV channels limit conducted vasomotor responses in rat mesenteric terminal arterioles.
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Endocytic regulation of voltage-dependent potassium channels in the heart.
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K+ channel alterations in the progression of experimental autoimmune encephalomyelitis.
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Tracking a complete voltage-sensor cycle with metal-ion bridges.
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rKv1.2 overexpression in the central medial thalamic area decreases caffeine-induced arousal.
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