Kv1.3
744 literature references associated to Kv1.3
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Ubiquitin ligase Nedd4-2 modulates Kv1.3 current amplitude and ion channel protein targeting.
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Autocrine-Based Selection of Drugs that Target Ion Channels from Combinatorial Venom Peptide Libraries.
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Molecular basis for the toxin insensitivity of scorpion voltage-gated potassium channel MmKv1.
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Nanovesicle-targeted Kv1.3 knockdown in memory T cells suppresses CD40L expression and memory phenotype.
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Transcriptomic analysis of the ion channelome of human platelets and megakaryocytic cell lines.
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7DHC-induced changes of Kv1.3 operation contributes to modified T cell function in Smith-Lemli-Opitz syndrome.
Pflugers Arch.,
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Targeting Kv1.3 channels to reduce white matter pathology after traumatic brain injury.
Exp. Neurol.,
2016
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9
Olamendi-Portugal T
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Isolation, chemical and functional characterization of several new K(+)-channel blocking peptides from the venom of the scorpion Centruroides tecomanus.
Toxicon,
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Peimine, a main active ingredient of Fritillaria, exhibits anti-inflammatory and pain suppression properties at the cellular level.
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The anti-proliferative effect of cation channel blockers in T lymphocytes depends on the strength of mitogenic stimulation.
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Study of Small-Molecule-Membrane Protein Binding Kinetics with Nanodisc and Charge-Sensitive Optical Detection.
Anal. Chem.,
2016
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Developmental expression of Kv1 voltage-gated potassium channels in the avian hypothalamus.
Neurosci. Lett.,
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Kan XH
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Kv1.3 potassium channel mediates macrophage migration in atherosclerosis by regulating ERK activity.
Arch. Biochem. Biophys.,
2016
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15
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Immunosuppressive evidence of Tityus serrulatus toxins Ts6 and Ts15: insights of a novel K(+) channel pattern in T cells.
Immunology,
2016
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What do we not know about mitochondrial potassium channels?
Biochim. Biophys. Acta,
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Mitochondrial Ultrastructure and Glucose Signaling Pathways Attributed to the Kv1.3 Ion Channel.
Front Physiol,
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Zeng Z
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A Scorpion Defensin BmKDfsin4 Inhibits Hepatitis B Virus Replication in Vitro.
Toxins (Basel),
2016
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19
Ye F
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The Scorpion Toxin Analogue BmKTX-D33H as a Potential Kv1.3 Channel-Selective Immunomodulator for Autoimmune Diseases.
Toxins (Basel),
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Siddiqui TA
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Complex molecular and functional outcomes of single versus sequential cytokine stimulation of rat microglia.
J Neuroinflammation,
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Chen R
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Peptidomimetic Star Polymers for Targeting Biological Ion Channels.
PLoS ONE,
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22
Ohya S
Physiological Role of K(+) Channels in the Regulation of T Cell Function.
Yakugaku Zasshi,
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Caveolin interaction governs Kv1.3 lipid raft targeting.
Sci Rep,
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24
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Voltage-Gated Potassium Channels Kv1.3--Potentially New Molecular Target in Cancer Diagnostics and Therapy.
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25
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Molecular dynamics of Kv1.3 ion channel and structural basis of its inhibition by scorpion toxin-OSK1 derivatives.
Biophys. Chem.,
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A single-point mutation enhances dual functionality of a scorpion toxin.
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Pharmaceutical Optimization of Peptide Toxins for Ion Channel Targets: Potent, Selective, and Long-Lived Antagonists of Kv1.3.
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[Effect of Kv1.3 and KCa3.1 potassium ion channels on the proliferation and migration of monocytes/macrophages].
Sheng Li Xue Bao,
2015
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29
Xu H
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Characterization of the direct interaction between KcsA-Kv1.3 and its inhibitors.
Biochim. Biophys. Acta,
2015
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30
Kazama I
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Usefulness of targeting lymphocyte Kv1.3-channels in the treatment of respiratory diseases.
Inflamm. Res.,
2015
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31
Kazama I
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Chlorpromazine-induced changes in membrane micro-architecture inhibit thrombopoiesis in rat megakaryocytes.
Biochim. Biophys. Acta,
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Impact of aging on calcium influx and potassium channel characteristics of T lymphocytes.
Oncotarget,
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Toxins Targeting the Kv1.3 Channel: Potential Immunomodulators for Autoimmune Diseases.
Toxins (Basel),
2015
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34
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Nuclear Localization and Functional Characteristics of Voltage-gated Potassium Channel, Kv1.3.
J. Biol. Chem.,
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35
Chang SC
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N-Terminally extended analogues of the K⁺ channel toxin from Stichodactyla helianthus as potent and selective blockers of the voltage-gated potassium channel Kv1.3.
FEBS J.,
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36
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Psora-4, a Kv1.3 Blocker, Enhances Differentiation and Maturation in Neural Progenitor Cells.
CNS Neurosci Ther,
2015
Jul
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37
Kazama I
Roles of lymphocyte Kv1.3-channels in gut mucosal immune system: Novel therapeutic implications for inflammatory bowel disease.
Med. Hypotheses,
2015
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Targeting a mitochondrial potassium channel to fight cancer.
Cell Calcium,
2015
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40
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Potassium currents inhibition by gambierol analogs prevents human T lymphocyte activation.
Arch. Toxicol.,
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41
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Mesomartoxin, a new K(v)1.2-selective scorpion toxin interacting with the channel selectivity filter.
Biochem. Pharmacol.,
2015
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42
Kazama I
Physiological significance of delayed rectifier K(+) channels (Kv1.3) expressed in T lymphocytes and their pathological significance in chronic kidney disease.
J Physiol Sci,
2015
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43
Pennington MW
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Development of highly selective Kv1.3-blocking peptides based on the sea anemone peptide ShK.
Mar Drugs,
2015
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44
Xiang F
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Plectasin, first animal toxin-like fungal defensin blocking potassium channels through recognizing channel pore region.
Toxins (Basel),
2015
Jan
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45
Yang W
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Endogenous animal toxin-like human β-defensin 2 inhibits own K(+) channels through interaction with channel extracellular pore region.
Cell. Mol. Life Sci.,
2015
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46
Zhao R
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Designer and natural peptide toxin blockers of the KcsA potassium channel identified by phage display.
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47
Silver K
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Inhibition of Kv channel expression by NSAIDs depolarizes membrane potential and inhibits cell migration by disrupting calpain signaling.
Biochem. Pharmacol.,
2015
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48
Frolov RV
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Evidence of more ion channels inhibited by celecoxib: KV1.3 and L-type Ca (2+) channels.
BMC Res Notes,
2015
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49
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Antigenic Stimulation of Kv1.3-Deficient Th Cells Gives Rise to a Population of Foxp3-Independent T Cells with Suppressive Properties.
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2015
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SjAPI-2 is the first member of a new neurotoxin family with Ascaris-type fold and KCNQ1 inhibitory activity.
Int. J. Biol. Macromol.,
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51
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Differential Expression of Ion Channels and Transporters During Hepatocellular Carcinoma Development.
Dig. Dis. Sci.,
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Expression and function of a CP339,818-sensitive K⁺ current in a subpopulation of putative nociceptive neurons from adult mouse trigeminal ganglia.
J. Neurophysiol.,
2015
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53
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Up-regulation of Kv1.3 channels by janus kinase 2.
J. Membr. Biol.,
2015
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Different solvent fractions of Acanthopanax senticosus harms exert antioxidant and anti-inflammatory activities and inhibit the human Kv1.3 channel.
J Med Food,
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55
Bittner S
et al.
Murine K2P5.1 Deficiency Has No Impact on Autoimmune Neuroinflammation due to Compensatory K2P3.1- and KV1.3-Dependent Mechanisms.
Int J Mol Sci,
2015
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56
Meredith FL
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Kv1 channels and neural processing in vestibular calyx afferents.
Front Syst Neurosci,
2015
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57
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Evidence of more ion channels inhibited by celecoxib: KV1.3 and L-type Ca(2+) channels.
BMC Res Notes,
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58
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An engineered scorpion toxin analogue with improved Kv1.3 selectivity displays reduced conformational flexibility.
Sci Rep,
2015
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59
Rangaraju S
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Potassium channel Kv1.3 is highly expressed by microglia in human Alzheimer's disease.
J. Alzheimers Dis.,
2015
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60
Charolidi N
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Microglial Kv1.3 Channels and P2Y12 Receptors Differentially Regulate Cytokine and Chemokine Release from Brain Slices of Young Adult and Aged Mice.
PLoS ONE,
2015
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61
Chen Z
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Toxin acidic residue evolutionary function-guided design of de novo peptide drugs for the immunotherapeutic target, the Kv1.3 channel.
Sci Rep,
2015
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62
Kazama I
Roles of lymphocyte kv1.3-channels in the pathogenesis of renal diseases and novel therapeutic implications of targeting the channels.
Mediators Inflamm.,
2015
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63
Bartok A
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Margatoxin is a non-selective inhibitor of human Kv1.3 K(+) channels.
Toxicon,
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Computational approaches for designing potent and selective analogs of peptide toxins as novel therapeutics.
Future Med Chem,
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Differential expression of the Kv1 voltage-gated potassium channel family in the rat nephron.
J. Mol. Histol.,
2014
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66
Hansen LK
The role of T cell potassium channels, KV1.3 and KCa3.1, in the inflammatory cascade in ulcerative colitis.
Dan Med J,
2014
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67
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Expression of T-cell KV1.3 potassium channel correlates with pro-inflammatory cytokines and disease activity in ulcerative colitis.
J Crohns Colitis,
2014
Nov
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68
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Determinants of pore folding in potassium channel biogenesis.
Proc. Natl. Acad. Sci. U.S.A.,
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69
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Ion channels and anti-cancer immunity.
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Electrophysiological characterization of Ts6 and Ts7, K⁺ channel toxins isolated through an improved Tityus serrulatus venom purification procedure.
Toxins (Basel),
2014
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New Positive KCa Channel Gating Modulators with Selectivity for KCa3.1.
Mol. Pharmacol.,
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Kv1.3 channel-blocking immunomodulatory peptides from parasitic worms: implications for autoimmune diseases.
FASEB J.,
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Targeting the Ion Channel Kv1.3 with Scorpion Venom Peptides Engineered for Potency, Selectivity, and Half-life.
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74
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Structure, molecular modeling, and function of the novel potassium channel blocker urotoxin isolated from the venom of the Australian scorpion Urodacus yaschenkoi.
Mol. Pharmacol.,
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75
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Different calcium influx characteristics upon Kv1.3 and IKCa1 potassium channel inhibition in T helper subsets.
Cytometry A,
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76
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Free energy simulations of binding of HsTx1 toxin to Kv1 potassium channels: the basis of Kv1.3/Kv1.1 selectivity.
J Phys Chem B,
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77
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Vietnamese Heterometrus laoticus scorpion venom: evidence for analgesic and anti-inflammatory activity and isolation of new polypeptide toxin acting on Kv1.3 potassium channel.
Toxicon,
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78
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Kv1.3 inhibitors have differential effects on glucose uptake and AMPK activity in skeletal muscle cell lines and mouse ex vivo skeletal muscle.
J Physiol Sci,
2014
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79
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Kv1.3 potassium channel-blocking toxin Ctri9577, novel gating modifier of Kv4.3 potassium channel from the scorpion toxin family.
Biochem. Biophys. Res. Commun.,
2014
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80
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Soluble prokaryotic expression and purification of crotamine using an N-terminal maltose-binding protein tag.
Toxicon,
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81
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K+ channels expression in hypertension after arterial injury, and effect of selective Kv1.3 blockade with PAP-1 on intimal hyperplasia formation.
Cardiovasc Drugs Ther,
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82
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Kv1.3 in psoriatic disease: PAP-1, a small molecule inhibitor of Kv1.3 is effective in the SCID mouse psoriasis--xenograft model.
J. Autoimmun.,
2014
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83
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Down-regulation of K⁺ channels by human parvovirus B19 capsid protein VP1.
Biochem. Biophys. Res. Commun.,
2014
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84
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Somatodendritic ion channel expression in substantia nigra pars compacta dopaminergic neurons across postnatal development.
J. Neurosci. Res.,
2014
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85
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HMG-CoA reductase inhibitors pravastatin, lovastatin and simvastatin suppress delayed rectifier K(+)-channel currents in murine thymocytes.
Pharmacol Rep,
2014
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The Kv1.3 potassium channel is localized to the cis-Golgi and Kv1.6 is localized to the endoplasmic reticulum in rat astrocytes.
FEBS J.,
2014
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87
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Unusual binding mode of scorpion toxin BmKTX onto potassium channels relies on its distribution of acidic residues.
Biochem. Biophys. Res. Commun.,
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88
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Domain structure and function of matrix metalloprotease 23 (MMP23): role in potassium channel trafficking.
Cell. Mol. Life Sci.,
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Recombinant expression and functional characterization of martentoxin: a selective inhibitor for BK channel (α + β4).
Toxins (Basel),
2014
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90
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Blockade of Kv1.3 channels ameliorates radiation-induced brain injury.
Neuro-oncology,
2014
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91
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Acacetin blocks kv1.3 channels and inhibits human T cell activation.
Cell. Physiol. Biochem.,
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92
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Binding modes of two scorpion toxins to the voltage-gated potassium channel kv1.3 revealed from molecular dynamics.
Toxins (Basel),
2014
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93
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Kv1.3 lymphocyte potassium channel inhibition as a potential novel therapeutic target in acute ischemic stroke.
CNS Neurol Disord Drug Targets,
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94
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Effect of methamphetamine on the microglial damage: role of potassium channel Kv1.3.
PLoS ONE,
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Effects of voltage-gated K+ channel on cell proliferation in multiple myeloma.
ScientificWorldJournal,
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96
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Regulation of the voltage gated K channel Kv1.3 by recombinant human klotho protein.
Kidney Blood Press. Res.,
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Benidipine suppresses in situ proliferation of leukocytes and slows the progression of renal fibrosis in rat kidneys with advanced chronic renal failure.
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NMDA-receptor antagonists block B-cell function but foster IL-10 production in BCR/CD40-activated B cells.
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Hetlaxin, a new toxin from the Heterometrus laoticus scorpion venom, interacts with voltage-gated potassium channel Kv1.3.
Dokl. Biochem. Biophys.,
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100
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Functionalized liposomes loaded with siRNAs targeting ion channels in effector memory T cells as a potential therapy for autoimmunity.
Biomaterials,
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101
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The role of PSD-95 in the rearrangement of Kv1.3 channels to the immunological synapse.
Pflugers Arch.,
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102
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Curcumin serves as a human kv1.3 blocker to inhibit effector memory T lymphocyte activities.
Phytother Res,
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103
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Shaker-related potassium channels in the central medial nucleus of the thalamus are important molecular targets for arousal suppression by volatile general anesthetics.
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104
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Tuning voltage-gated channel activity and cellular excitability with a sphingomyelinase.
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BcsTx3 is a founder of a novel sea anemone toxin family of potassium channel blocker.
FEBS J.,
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Emerging role for the voltage-dependent K+ channel Kv1.5 in B-lymphocyte physiology: expression associated with human lymphoma malignancy.
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Expression of Kv1.3 potassium channels regulates density of cortical interneurons.
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Correlation between potassium channel expression and sensitivity to drug-induced cell death in tumor cell lines.
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Glucose sensitivity of mouse olfactory bulb neurons is conveyed by a voltage-gated potassium channel.
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Venomous secretions from marine snails of the Terebridae family target acetylcholine receptors.
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Targeting potassium channels Kv1.3 and KC a 3.1: routes to selective immunomodulators in autoimmune disorder treatment?
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Targeting the Kv1.3 potassium channel for immunosuppression in vascularized composite allotransplantation - a pilot study.
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Structural determinants of specific lipid binding to potassium channels.
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CMYA5: a new potential substrate of Kcna3 in human heart.
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The effects of Kv1.3 and IKCa1 potassium channel inhibition on calcium influx of human peripheral T lymphocytes in rheumatoid arthritis.
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Analysis by flow cytometry of calcium influx kinetics in peripheral lymphocytes of patients with rheumatoid arthritis.
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Fluorescent system based on bacterial expression of hybrid KcsA channels designed for Kv1.3 ligand screening and study.
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Selective Kv1.3 channel blocker as therapeutic for obesity and insulin resistance.
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Differential effects of clarithromycin and azithromycin on delayed rectifier K(+)-channel currents in murine thymocytes.
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18β-Glycyrrhetinic acid potently inhibits Kv1.3 potassium channels and T cell activation in human Jurkat T cells.
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Designing a C84 fullerene as a specific voltage-gated sodium channel blocker.
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Increased proliferation of human bladder smooth muscle cells is mediated by physiological cyclic stretch via the PI3K‑SGK1‑Kv1.3 pathway.
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Regulation of ion channels by the serum- and glucocorticoid-inducible kinase SGK1.
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Analysis of the K+ current in human CD4+ T lymphocytes in hypercholesterolemic state.
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Specific Kv1.3 blockade modulates key cholesterol-metabolism-associated molecules in human macrophages exposed to ox-LDL.
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Voltage-gated K+ channels in adipogenic differentiation of bone marrow-derived human mesenchymal stem cells.
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Amiodarone inhibits tissue factor expression in monocytic THP-1 cells.
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