TRPM8

1

Touska F et al. Comprehensive thermal preference phenotyping in mice using a novel automated circular gradient assay.
Temperature (Austin), 2016 Jan-Mar , 3 (77-91).

2

McEntire DM et al. Pain transduction: a pharmacologic perspective.
Expert Rev Clin Pharmacol, 2016 May 23 , (1-12).

3

Ghosh D et al. Journey of a cold sensor - VAMP7-dependent transport of TRPM8.
Channels (Austin), 2016 May 2 , (1-3).

4

Khalil M et al. Transient receptor potential melastatin 8 ion channel in macrophages modulates colitis through a balance-shift in TNF-alpha and interleukin-10 production.
Mucosal Immunol, 2016 Mar 16 , ().

5

Everaerts W et al. TRPM8 antagonists to treat lower urinary tract symptoms: don't lose your cool just yet.
BJU Int., 2016 Mar , 117 (384-5).

6

Ciobanu AC et al. Glycolytic metabolite methylglyoxal inhibits cold and menthol activation of the transient receptor potential melastatin type 8 channel.
J. Neurosci. Res., 2016 Mar , 94 (282-94).

7

LeGay CM et al. Natural-Product-Derived Transient Receptor Potential Melastatin 8 (TRPM8) Channel Modulators.
Org. Lett., 2016 Jun 3 , 18 (2746-9).

8

Liu Z et al. TRPM8: a potential target for cancer treatment.
J. Cancer Res. Clin. Oncol., 2016 Jan 23 , ().

9

Rath P et al. Implications of Human Transient Receptor Potential Melastatin 8 (TRPM8) Channel Gating from Menthol Binding Studies of the Sensing Domain.
Biochemistry, 2016 Jan 12 , 55 (114-24).

10

Mistretta FA et al. DFL23448, A Novel Transient Receptor Potential Melastin 8-Selective Ion Channel Antagonist, Modifies Bladder Function and Reduces Bladder Overactivity in Awake Rats.
J. Pharmacol. Exp. Ther., 2016 Jan , 356 (200-11).

11

Tang M et al. Phosphoinositide interacting regulator of TRP (Pirt) enhances TRPM8 channel activity in vitro via increasing channel conductance.
Acta Pharmacol. Sin., 2016 Jan , 37 (98-104).

12

Ferreira LG et al. TRPing on the pore phenomenon: what do we know about transient receptor potential ion channel-related pore dilation up to now?
J. Bioenerg. Biomembr., 2016 Feb , 48 (1-12).

13

Chen S et al. TRP channel mediated neuronal activation and ablation in freely behaving zebrafish.
Nat. Methods, 2016 Feb , 13 (147-50).

14

Yudin Y et al. Phospholipase C δ4regulates cold sensitivity in mice.
J. Physiol. (Lond.), 2016 Apr 8 , ().

15

Ghosh D et al. VAMP7 regulates constitutive membrane incorporation of the cold-activated channel TRPM8.
Nat Commun, 2016 , 7 (10489).

16

Yee NS TRPM8 Ion Channels as Potential Cancer Biomarker and Target in Pancreatic Cancer.
Adv Protein Chem Struct Biol, 2016 , 104 (127-55).

17

da Silva Serra I et al. Characterization of cutaneous and articular sensory neurons.
Mol Pain, 2016 , 12 ().

18

Marshall-Gradisnik S et al. Natural killer cells and single nucleotide polymorphisms of specific ion channels and receptor genes in myalgic encephalomyelitis/chronic fatigue syndrome.
Appl Clin Genet, 2016 , 9 (39-47).

19

Liu SC et al. Identification of the cold receptor TRPM8 in the nasal mucosa.
Am J Rhinol Allergy, 2015 Jul-Aug , 29 (e112-6).

20

Shah AA et al. Pilot study to determine whether transient receptor potential melastatin type 8 (TRPM8) antibodies are detected in scleroderma.
Clin. Exp. Rheumatol., 2015 Jul-Aug , 33 (S123-6).

21

Feketa VV et al. Induction of therapeutic hypothermia by pharmacological modulation of temperature-sensitive TRP channels: theoretical framework and practical considerations.
Temperature (Austin), 2015 Apr-Jun , 2 (244-57).

22

Carrasquel-Ursulaez W et al. Biophysical analysis of thermosensitive TRP channels with a special focus on the cold receptor TRPM8.
Temperature (Austin), 2015 Apr-Jun , 2 (188-200).

23

Tatsumi E et al. Changes in transient receptor potential channels in the rat geniculate ganglion after chorda tympani nerve injury.
Neuroreport, 2015 Sep 30 , 26 (856-61).

24

Wei ZL et al. Identification of orally-bioavailable antagonists of the TRPV4 ion-channel.
Bioorg. Med. Chem. Lett., 2015 Sep 15 , 25 (4011-5).

25

Dai Y TRPs and pain.
Semin Immunopathol, 2015 Sep 15 , ().

26

Kim YS et al. Expression of vesicular glutamate transporters in transient receptor potential melastatin 8 (TRPM8)-positive dental afferents in the mouse.
Neuroscience, 2015 Sep 10 , 303 (378-88).

27

Sidaway P Urinary incontinence: TRPM8 influences bladder filling.
Nat Rev Urol, 2015 Sep , 12 (476).

28

De Petrocellis L et al. Inhibitory effect of positively charged triazine antagonists of prokineticin receptors on the transient receptor vanilloid type-1 (TRPV1) channel.
Pharmacol. Res., 2015 Sep , 99 (362-9).

29

Yajima T et al. Distribution of transient receptor potential melastatin-8-containing nerve fibers in rat oral and craniofacial structures.
Ann. Anat., 2015 Sep , 201 (1-5).

30

Billeter AT et al. TRPA1 mediates the effects of hypothermia on the monocyte inflammatory response.
Surgery, 2015 Sep , 158 (646-54).

31

Xu ZH et al. Action of thymol on spontaneous excitatory transmission in adult rat spinal substantia gelatinosa neurons.
Neurosci. Lett., 2015 Oct 8 , 606 (94-9).

32

Yu X et al. TRP channel functions in the gastrointestinal tract.
Semin Immunopathol, 2015 Oct 12 , ().

33

Patel R et al. Ionic Mechanisms of Spinal Neuronal Cold Hypersensitivity in Ciguatera.
Eur. J. Neurosci., 2015 Oct 10 , ().

34

Bidaux G et al. Functional and Modeling Studies of the Transmembrane Region of the TRPM8 Channel.
Biophys. J., 2015 Nov 3 , 109 (1840-51).

35

Naumov DE et al. Transient receptor potential melastatin 8 gene polymorphism is associated with cold-induced airway hyperresponsiveness in bronchial asthma.
Respirology, 2015 Nov , 20 (1192-7).

36

Tokuda M et al. Dentin and pulp sense cold stimulus.
Med. Hypotheses, 2015 May , 84 (442-4).

37

Qin DM et al. [Role of transient receptor potential melastatin 8 channels in migraine mechanism in rats].
Zhongguo Dang Dai Er Ke Za Zhi, 2015 May , 17 (515-9).

38

de Jong PR et al. TRPM8 on mucosal sensory nerves regulates colitogenic responses by innate immune cells via CGRP.
Mucosal Immunol, 2015 May , 8 (491-504).

39

Yu X et al. TRPM8 function and expression in vagal sensory neurons and afferent nerves innervating guinea pig esophagus.
Am. J. Physiol. Gastrointest. Liver Physiol., 2015 Mar 15 , 308 (G489-96).

40

Liu BY et al. Menthol suppresses laryngeal C-fiber hypersensitivity to cigarette smoke in a rat model of gastroesophageal reflux disease: the role of TRPM8.
J. Appl. Physiol., 2015 Mar 1 , 118 (635-45).

41

Sałat K et al. Antinociceptive activity of transient receptor potential channel TRPV1, TRPA1, and TRPM8 antagonists in neurogenic and neuropathic pain models in mice.
J Zhejiang Univ Sci B, 2015 Mar , 16 (167-78).

42

Bidaux G et al. Epidermal TRPM8 channel isoform controls the balance between keratinocyte proliferation and differentiation in a cold-dependent manner.
Proc. Natl. Acad. Sci. U.S.A., 2015 Jun 30 , 112 (E3345-54).

43

De Petrocellis L et al. Structure-activity relationships of the prototypical TRPM8 agonist icilin.
Bioorg. Med. Chem. Lett., 2015 Jun 1 , 25 (2285-90).

44

Benemei S et al. TRP channels.
Curr Opin Pharmacol, 2015 Jun , 22 (18-23).

45

Ito H et al. Functional role of the transient receptor potential melastatin 8 (TRPM8) ion channel in the urinary bladder assessed by conscious cystometry and ex vivo measurements of single-unit mechanosensitive bladder afferent activities in the rat.
BJU Int., 2015 Jul 18 , ().

46

Asuthkar S et al. TRPM8 channel as a novel molecular target in androgen-regulated prostate cancer cells.
Oncotarget, 2015 Jul 10 , 6 (17221-36).

47

Kimball C et al. The Pore Loop Domain of TRPV1 Is Required for Its Activation by the Volatile Anesthetics Chloroform and Isoflurane.
Mol. Pharmacol., 2015 Jul , 88 (131-8).

48

Zhu Y et al. Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels.
Br. J. Pharmacol., 2015 Jul , 172 (3495-509).

49

Atala A Re: Ion Channel TRPM8 Promotes Hypoxic Growth of Prostate Cancer Cells via an O2-Independent and RACK1-Mediated Mechanism of HIF-1α Stabilization.
J. Urol., 2015 Jul , 194 (260).

50

Gkika D et al. TRP channel-associated factors are a novel protein family that regulates TRPM8 trafficking and activity.
J. Cell Biol., 2015 Jan 5 , 208 (89-107).

51

Asuthkar S et al. The TRPM8 protein is a testosterone receptor: I. Biochemical evidence for direct TRPM8-testosterone interactions.
J. Biol. Chem., 2015 Jan 30 , 290 (2659-69).

52

Asuthkar S et al. The TRPM8 protein is a testosterone receptor: II. Functional evidence for an ionotropic effect of testosterone on TRPM8.
J. Biol. Chem., 2015 Jan 30 , 290 (2670-88).

53

Palkar R et al. The molecular and cellular basis of thermosensation in mammals.
Curr. Opin. Neurobiol., 2015 Jan 23 , 34C (14-19).

54

Toro CA et al. Agonist-dependent modulation of cell surface expression of the cold receptor TRPM8.
J. Neurosci., 2015 Jan 14 , 35 (571-82).

55

Yrbas ML et al. Pharmacological mechanism underlying the antinociceptive activity of vanillic acid.
Pharmacol. Biochem. Behav., 2015 Feb 21 , 132 (88-95).

56

Fallon MT et al. Cancer treatment-related neuropathic pain: proof of concept study with menthol-a TRPM8 agonist.
Support Care Cancer, 2015 Feb 15 , ().

57

Khajavi N et al. Thyronamine induces TRPM8 channel activation in human conjunctival epithelial cells.
Cell. Signal., 2015 Feb , 27 (315-25).

58

Alptekin M et al. Gene expressions of TRP channels in glioblastoma multiforme and relation with survival.
Tumour Biol., 2015 Dec , 36 (9209-13).

59

Nozadze I et al. Role of thermo TRPA1 and TRPV1 channels in heat, cold, and mechanical nociception of rats.
Behav Pharmacol, 2015 Aug 13 , ().

60

Samour MS et al. Cav3.2-expressing low-threshold C fibres in human hairy skin contribute to cold allodynia--a non-TRPV1- and non-TRPM8-dependent phenomenon.
Pain, 2015 Aug , 156 (1566-75).

61

Andrews MD et al. Discovery of a Selective TRPM8 Antagonist with Clinical Efficacy in Cold-Related Pain.
ACS Med Chem Lett, 2015 Apr 9 , 6 (419-24).

62

Uvin P et al. Essential Role of Transient Receptor Potential M8 (TRPM8) in a Model of Acute Cold-induced Urinary Urgency.
Eur. Urol., 2015 Apr 2 , ().

63

Isman E et al. Effects of laser irradiation at different wavelengths (660, 810, 980, and 1064 nm) on transient receptor potential melastatin channels in an animal model of wound healing.
Lasers Med Sci, 2015 Apr 12 , ().

64

Tabur S et al. Role of the transient receptor potential (TRP) channel gene expressions and TRP melastatin (TRPM) channel gene polymorphisms in obesity-related metabolic syndrome.
Eur Rev Med Pharmacol Sci, 2015 Apr , 19 (1388-97).

65

Lehto SG et al. AMG2850, a potent and selective TRPM8 antagonist, is not effective in rat models of inflammatory mechanical hypersensitivity and neuropathic tactile allodynia.
Naunyn Schmiedebergs Arch. Pharmacol., 2015 Apr , 388 (465-76).

66

Son GY et al. Induction of IL-6 and IL-8 by activation of thermosensitive TRP channels in human PDL cells.
Arch. Oral Biol., 2015 Apr , 60 (526-32).

67

Shibukawa Y et al. Odontoblasts as sensory receptors: transient receptor potential channels, pannexin-1, and ionotropic ATP receptors mediate intercellular odontoblast-neuron signal transduction.
Pflugers Arch., 2015 Apr , 467 (843-63).

68

Quallo T et al. TRPM8 is a neuronal osmosensor that regulates eye blinking in mice.
Nat Commun, 2015 , 6 (7150).

69

Taylor-Clark TE et al. Thy1.2 YFP-16 transgenic mouse labels a subset of large-diameter sensory neurons that lack TRPV1 expression.
PLoS ONE, 2015 , 10 (e0119538).

70

Silva DF et al. TRPM8 Channel Activation Induced by Monoterpenoid Rotundifolone Underlies Mesenteric Artery Relaxation.
PLoS ONE, 2015 , 10 (e0143171).

71

Ren L et al. Function and postnatal changes of dural afferent fibers expressing TRPM8 channels.
Mol Pain, 2015 , 11 (37).

72

Olivares E et al. TRPM8-Dependent Dynamic Response in a Mathematical Model of Cold Thermoreceptor.
PLoS ONE, 2015 , 10 (e0139314).

73

Mueller-Tribbensee SM et al. Differential Contribution of TRPA1, TRPV4 and TRPM8 to Colonic Nociception in Mice.
PLoS ONE, 2015 , 10 (e0128242).

74

Belmonte C et al. What Causes Eye Pain?
Curr Ophthalmol Rep, 2015 , 3 (111-121).

75

Lötsch J et al. Multimodal distribution of human cold pain thresholds.
PLoS ONE, 2015 , 10 (e0125822).

76

Ha MA et al. Menthol attenuates respiratory irritation and elevates blood cotinine in cigarette smoke exposed mice.
PLoS ONE, 2015 , 10 (e0117128).

77

Majhi RK et al. Expression of temperature-sensitive ion channel TRPM8 in sperm cells correlates with vertebrate evolution.
PeerJ, 2015 , 3 (e1310).

78

Mancuso G et al. Phytochemicals from Ruta graveolens Activate TAS2R Bitter Taste Receptors and TRP Channels Involved in Gustation and Nociception.
Molecules, 2015 , 20 (18907-22).

79

Yee NS Roles of TRPM8 Ion Channels in Cancer: Proliferation, Survival, and Invasion.
Cancers (Basel), 2015 , 7 (2134-46).

80

Wang C et al. Wu-Tou Decoction Inhibits Chronic Inflammatory Pain in Mice: Participation of TRPV1 and TRPA1 Ion Channels.
Biomed Res Int, 2015 , 2015 (328707).

81

Morgan K et al. Genetic variants affecting human TRPA1 or TRPM8 structure can be classified in vitro as 'well expressed', 'poorly expressed' or 'salvageable'.
Biosci. Rep., 2015 , 35 ().

82

Carson C et al. Englerin A Agonizes the TRPC4/C5 Cation Channels to Inhibit Tumor Cell Line Proliferation.
PLoS ONE, 2015 , 10 (e0127498).

83

Kozyreva TV et al. [Respiratory system response to cooling in subjects with single nucleotide polymorphism rs11562975 in gene of thermosensitive TRPM8 ion channel].
Fiziol Cheloveka, 2014 Mar-Apr , 40 (94-8).

84

Dusmez D et al. Effect of verapamil and lidocaine on TRPM and NaV1.9 gene expressions in renal ischemia-reperfusion.
Transplant. Proc., 2014 Jan-Feb , 46 (33-9).

85

Kupisz K et al. Menthol-induced action potentials in Conocephalum conicum as a result of unspecific interactions between menthol and the lipid phase of the plasma membrane.
Physiol Plant, 2014 Sep 25 , ().

86

Morenilla-Palao C et al. Ion channel profile of TRPM8 cold receptors reveals a role of TASK-3 potassium channels in thermosensation.
Cell Rep, 2014 Sep 11 , 8 (1571-82).

87

Bron R et al. Piezo2 expression in corneal afferent neurons.
J. Comp. Neurol., 2014 Sep 1 , 522 (2967-79).

88

Liu J et al. TRPM8 promotes aggressiveness of breast cancer cells by regulating EMT via activating AKT/GSK-3β pathway.
Tumour Biol., 2014 Sep , 35 (8969-77).

89

Straub RH TRPV1, TRPA1, and TRPM8 channels in inflammation, energy redirection, and water retention: role in chronic inflammatory diseases with an evolutionary perspective.
J. Mol. Med., 2014 Sep , 92 (925-37).

90

Egbuniwe O et al. TRPA1 and TRPV4 activation in human odontoblasts stimulates ATP release.
J. Dent. Res., 2014 Sep , 93 (911-7).

91

Gardiner JC et al. The role of TRPM8 in the Guinea-pig bladder-cooling reflex investigated using a novel TRPM8 antagonist.
Eur. J. Pharmacol., 2014 Oct 5 , 740 (398-409).

92

Taberner FJ et al. The region adjacent to the C-end of the inner gate in transient receptor potential melastatin 8 (TRPM8) channels plays a central role in allosteric channel activation.
J. Biol. Chem., 2014 Oct 10 , 289 (28579-94).

93

Wan HY et al. [Effect of traditional Chinese medicines with different properties on thermoregulation and temperature-sensitive transient receptor potentialion channel protein of rats with yeast-induced fever].
Zhongguo Zhong Yao Za Zhi, 2014 Oct , 39 (3813-8).

94

Patel R et al. Anti-hyperalgesic effects of a novel TRPM8 agonist in neuropathic rats: a comparison with topical menthol.
Pain, 2014 Oct , 155 (2097-107).

95

Potapova TA et al. Associations of cold receptor TRPM8 gene single nucleotide polymorphism with blood lipids and anthropometric parameters in Russian population.
Bull. Exp. Biol. Med., 2014 Oct , 157 (757-61).

96

Olsen RV et al. Somatosensory and vasomotor manifestations of individual and combined stimulation of TRPM8 and TRPA1 using topical L-menthol and trans-cinnamaldehyde in healthy volunteers.
Eur J Pain, 2014 Oct , 18 (1333-42).

97

Brenner DS et al. A dynamic set point for thermal adaptation requires phospholipase C-mediated regulation of TRPM8 in vivo.
Pain, 2014 Oct , 155 (2124-33).

98

Hegarty DM et al. Capsaicin-responsive corneal afferents do not contain TRPV1 at their central terminals in trigeminal nucleus caudalis in rats.
J. Chem. Neuroanat., 2014 Nov , 61-62 (1-12).

99

Xiao N et al. Over-expression of TRPM8 is associated with poor prognosis in urothelial carcinoma of bladder.
Tumour Biol., 2014 Nov , 35 (11499-504).

100

Winchester WJ et al. Inhibition of TRPM8 channels reduces pain in the cold pressor test in humans.
J. Pharmacol. Exp. Ther., 2014 Nov , 351 (259-69).

101

Teliban A et al. Responses of intact and injured sural nerve fibers to cooling and menthol.
J. Neurophysiol., 2014 May , 111 (2071-83).

102

Demir T et al. Evaluation of TRPM (transient receptor potential melastatin) genes expressions in myocardial ischemia and reperfusion.
Mol. Biol. Rep., 2014 May , 41 (2845-9).

103

Van Gerven L et al. Capsaicin treatment reduces nasal hyperreactivity and transient receptor potential cation channel subfamily V, receptor 1 (TRPV1) overexpression in patients with idiopathic rhinitis.
J. Allergy Clin. Immunol., 2014 May , 133 (1332-9, 1339.e1-3).

104

Feketa VV et al. Transient receptor potential melastatin 8 channel inhibition potentiates the hypothermic response to transient receptor potential vanilloid 1 activation in the conscious mouse.
Crit. Care Med., 2014 May , 42 (e355-63).

105

Franken J et al. TRP channels in lower urinary tract dysfunction.
Br. J. Pharmacol., 2014 May , 171 (2537-51).

106

Rossato M et al. Human white adipocytes express the cold receptor TRPM8 which activation induces UCP1 expression, mitochondrial activation and heat production.
Mol. Cell. Endocrinol., 2014 Mar 5 , 383 (137-46).

107

de Oliveira C et al. Transient receptor potential channel ankyrin-1 is not a cold sensor for autonomic thermoregulation in rodents.
J. Neurosci., 2014 Mar 26 , 34 (4445-52).

108

Ulasli M et al. The effects of Nigella sativa (Ns), Anthemis hyalina (Ah) and Citrus sinensis (Cs) extracts on the replication of coronavirus and the expression of TRP genes family.
Mol. Biol. Rep., 2014 Mar , 41 (1703-11).

109

Zappia KJ et al. Cold hypersensitivity increases with age in mice with sickle cell disease.
Pain, 2014 Jun 3 , ().

110

Chen GY et al. [Decreased amplitude of [Ca²⁺]i elevation induced by menthol in pulmonary arterial smooth muscle cells of pulmonary hypertensive rats].
Sheng Li Xue Bao, 2014 Jun 25 , 66 (267-75).

111

Pertusa MI et al. Bidirectional Modulation of Thermal and Chemical Sensitivity of TRPM8 Channels by the Initial Region of the N-Terminal Domain.
J. Biol. Chem., 2014 Jun 10 , ().

112

Sun J et al. Activation of cold-sensing transient receptor potential melastatin subtype 8 antagonizes vasoconstriction and hypertension through attenuating RhoA/Rho kinase pathway.
Hypertension, 2014 Jun , 63 (1354-63).

113

Nocchi L et al. Induction of oxidative stress causes functional alterations in mouse urothelium via a TRPM8-mediated mechanism: implications for aging.
Aging Cell, 2014 Jun , 13 (540-50).

114

Lau BK et al. Menthol enhances phasic and tonic GABAA receptor-mediated currents in midbrain periaqueductal grey neurons.
Br. J. Pharmacol., 2014 Jun , 171 (2803-13).

115

Deruyver Y et al. Transient receptor potential channel modulators as pharmacological treatments for lower urinary tract symptoms (LUTS): myth or reality?
BJU Int., 2014 Jul 25 , ().

116

Cucu D et al. Characterization of functional transient receptor potential melastatin 8 channels in human pancreatic ductal adenocarcinoma cells.
Pancreas, 2014 Jul , 43 (795-800).

117

Teichert RW et al. Using constellation pharmacology to define comprehensively a somatosensory neuronal subclass.
Proc. Natl. Acad. Sci. U.S.A., 2014 Jan 27 , ().

118

Gohlke BO et al. SuperPain--a resource on pain-relieving compounds targeting ion channels.
Nucleic Acids Res., 2014 Jan 1 , 42 (D1107-12).

119

Abdullah H et al. Rhinovirus upregulates transient receptor potential channels in a human neuronal cell line: implications for respiratory virus-induced cough reflex sensitivity.
Thorax, 2014 Jan , 69 (46-54).

120

Li MC et al. The pathophysiological mechanisms underlying mucus hypersecretion induced by cold temperatures in cigarette smoke-exposed rats.
Int. J. Mol. Med., 2014 Jan , 33 (83-90).

121

Terada Y et al. Activation and inhibition of thermosensitive TRP channels by voacangine, an alkaloid present in Voacanga africana, an African tree.
J. Nat. Prod., 2014 Feb 28 , 77 (285-97).

122

Zhu S et al. Involvement of transient receptor potential melastatin-8 (TRPM8) in menthol-induced calcium entry, reactive oxygen species production and cell death in rheumatoid arthritis rat synovial fibroblasts.
Eur. J. Pharmacol., 2014 Feb 15 , 725 (1-9).

123

Du GJ et al. The combination of TRPM8 and TRPA1 expression causes an invasive phenotype in lung cancer.
Tumour Biol., 2014 Feb , 35 (1251-61).

124

Devesa I et al. Neurotrophins, endocannabinoids and thermo-transient receptor potential: a threesome in pain signalling.
Eur. J. Neurosci., 2014 Feb , 39 (353-62).

125

Raddatz N et al. Temperature and voltage coupling to channel opening in transient receptor potential melastatin 8 (TRPM8).
J. Biol. Chem., 2014 Dec 19 , 289 (35438-54).

126

Yamaguchi S et al. Negatively charged amino acids near and in transient receptor potential (TRP) domain of TRPM4 channel are one determinant of its Ca2+ sensitivity.
J. Biol. Chem., 2014 Dec 19 , 289 (35265-82).

127

Amato A et al. Involvement of cholinergic nicotinic receptors in the menthol-induced gastric relaxation.
Eur. J. Pharmacol., 2014 Dec 15 , 745 (129-34).

128

Ortar G et al. Effect of acyclic monoterpene alcohols and their derivatives on TRP channels.
Bioorg. Med. Chem. Lett., 2014 Dec 1 , 24 (5507-11).

129

Ohmi M et al. Identification of a novel 2-pyridyl-benzensulfonamide derivative, RQ-00203078, as a selective and orally active TRPM8 antagonist.
Bioorg. Med. Chem. Lett., 2014 Dec 1 , 24 (5364-8).

130

Yu S et al. Ion channel TRPM8 promotes hypoxic growth of prostate cancer cells via an O2 -independent and RACK1-mediated mechanism of HIF-1α stabilization.
J. Pathol., 2014 Dec , 234 (514-25).

131

Borrelli F et al. Colon carcinogenesis is inhibited by the TRPM8 antagonist cannabigerol, a Cannabis-derived non-psychotropic cannabinoid.
Carcinogenesis, 2014 Dec , 35 (2787-97).

132

Terada Y et al. Identification of Indole Alkaloid Structural Units Important for Stimulus-Selective TRPM8 Inhibition: SAR Study of Naturally Occurring Iboga Derivatives.
J. Nat. Prod., 2014 Aug 22 , 77 (1831-8).

133

Suzuki H et al. The NADPH oxidase inhibitor diphenyleneiodonium activates the human TRPA1 nociceptor.
Am. J. Physiol., Cell Physiol., 2014 Aug 15 , 307 (C384-94).

134

Hosoya T et al. TRPM8 has a key role in experimental colitis-induced visceral hyperalgesia in mice.
Neurogastroenterol. Motil., 2014 Aug , 26 (1112-21).

135

Hagenacker T et al. Icilin reduces voltage-gated calcium channel currents in naïve and injured DRG neurons in the rat spinal nerve ligation model.
Brain Res., 2014 Apr 4 , 1557 (171-9).

136

Kong X et al. Rheum palmatum L. and Coptis chinensis Franch., exert antipyretic effect on yeast-induced pyrexia rats involving regulation of TRPV1 and TRPM8 expression.
J Ethnopharmacol, 2014 Apr 11 , 153 (160-8).

137

Horne DB et al. Optimization of potency and pharmacokinetic properties of tetrahydroisoquinoline transient receptor potential melastatin 8 (TRPM8) antagonists.
J. Med. Chem., 2014 Apr 10 , 57 (2989-3004).

138

Patel R et al. Novel TRPM8 antagonist attenuates cold hypersensitivity after peripheral nerve injury in rats.
J. Pharmacol. Exp. Ther., 2014 Apr , 349 (47-55).

139

Soya M et al. Plasma membrane stretch activates transient receptor potential vanilloid and ankyrin channels in Merkel cells from hamster buccal mucosa.
Cell Calcium, 2014 Apr , 55 (208-18).

140

Fan X et al. Replication of migraine GWAS susceptibility loci in Chinese Han population.
Headache, 2014 Apr , 54 (709-15).

141

Lakomá J et al. Pain related channels are differentially expressed in neuronal and non-neuronal cells of glabrous skin of fabry knockout male mice.
PLoS ONE, 2014 , 9 (e108641).

142

Pezzoli M et al. Dampened neural activity and abolition of epileptic-like activity in cortical slices by active ingredients of spices.
Sci Rep, 2014 , 4 (6825).

143

Koh WU et al. Perineural pretreatment of bee venom attenuated the development of allodynia in the spinal nerve ligation injured neuropathic pain model; an experimental study.
BMC Complement Altern Med, 2014 , 14 (431).

144

Zhai C et al. Identification of natural compound carnosol as a novel TRPA1 receptor agonist.
Molecules, 2014 , 19 (18733-46).

145

Fresno N et al. Adamantyl analogues of paracetamol as potent analgesic drugs via inhibition of TRPA1.
PLoS ONE, 2014 , 9 (e113841).

146

Mergler S et al. Temperature-sensitive transient receptor potential channels in corneal tissue layers and cells.
Ophthalmic Res., 2014 , 52 (151-9).

147

Miller S et al. Antibodies to the extracellular pore loop of TRPM8 act as antagonists of channel activation.
PLoS ONE, 2014 , 9 (e107151).

148

Morgan K et al. Human TRPM8 and TRPA1 pain channels, including a gene variant with increased sensitivity to agonists (TRPA1 R797T), exhibit differential regulation by SRC-tyrosine kinase inhibitor.
Biosci. Rep., 2014 , 34 ().

149

Ramos-Filho AC et al. Menthol inhibits detrusor contractility independently of TRPM8 activation.
PLoS ONE, 2014 , 9 (e111616).

150

Baez D et al. Gating of thermally activated channels.
Curr Top Membr, 2014 , 74 (51-87).

151

Cohen MR et al. Structure of thermally activated TRP channels.
Curr Top Membr, 2014 , 74 (181-211).

152

Madrid R et al. Intimacies and physiological role of the polymodal cold-sensitive ion channel TRPM8.
Curr Top Membr, 2014 , 74 (293-324).

153

Ren AJ et al. ZBTB20 regulates nociception and pain sensation by modulating TRP channel expression in nociceptive sensory neurons.
Nat Commun, 2014 , 5 (4984).

154

McCoy ES et al. Enhanced behavioral responses to cold stimuli following CGRPα sensory neuron ablation are dependent on TRPM8.
Mol Pain, 2014 , 10 (69).

155

Roper SD TRPs in taste and chemesthesis.
Handb Exp Pharmacol, 2014 , 223 (827-71).

156

Anderson EM et al. The effects of a co-application of menthol and capsaicin on nociceptive behaviors of the rat on the operant orofacial pain assessment device.
PLoS ONE, 2014 , 9 (e89137).

157

Kijpornyongpan T et al. Dose-dependent cytotoxic effects of menthol on human malignant melanoma A-375 cells: correlation with TRPM8 transcript expression.
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