Slo2

1

Budelli G et al. SLO2 Channels Are Inhibited By All Divalent Cations That Activate SLO1 K+ Channels.
J. Biol. Chem., 2016 Jan 28 , ().

2

Ferron L Fragile X mental retardation protein controls ion channel expression and activity.
J. Physiol. (Lond.), 2016 Feb 10 , ().

3

Bansal V et al. Na(+) -activated K(+) channels in rat supraoptic neurons.
J. Neuroendocrinol., 2016 Apr 19 , ().

4

Suzuki T et al. Hydrophobic interactions between the S5 segment and the pore helix stabilizes the closed state of Slo2.1 potassium channels.
Biochim. Biophys. Acta, 2016 Apr , 1858 (783-92).

5

Gururaj S et al. Slack sodium-activated potassium channel membrane expression requires p38 mitogen-activated protein kinase phosphorylation.
Neuropharmacology, 2016 Apr , 103 (279-89).

6

Huffman JE et al. Rare and low-frequency variants and their association with plasma levels of fibrinogen, FVII, FVIII, and vWF.
Blood, 2015 Sep 10 , 126 (e19-29).

7

Ohba C et al. De novo KCNT1 mutations in early-onset epileptic encephalopathy.
Epilepsia, 2015 Sep , 56 (e121-8).

8

Møller RS et al. Mutations in KCNT1 cause a spectrum of focal epilepsies.
Epilepsia, 2015 Sep , 56 (e114-20).

9

Hite RK et al. Cryo-electron microscopy structure of the Slo2.2 Na(+)-activated K(+) channel.
Nature, 2015 Oct 5 , ().

10

Thomson SJ et al. Identification of the Intracellular Na+ Sensor in Slo2.1 Potassium Channels.
J. Biol. Chem., 2015 Jun 5 , 290 (14528-35).

11

Boillot M et al. Genetic models of focal epilepsies.
J. Neurosci. Methods, 2015 Jun 11 , ().

12

Tomasello DL et al. Transcriptional Regulation of the Sodium-activated Potassium Channel SLICK (KCNT2) Promoter by Nuclear Factor-κB.
J. Biol. Chem., 2015 Jul 24 , 290 (18575-83).

13

Bausch AE et al. The sodium-activated potassium channel Slack is required for optimal cognitive flexibility in mice.
Learn. Mem., 2015 Jul , 22 (323-35).

14

Lu R et al. Slack channels expressed in sensory neurons control neuropathic pain in mice.
J. Neurosci., 2015 Jan 21 , 35 (1125-35).

15

Mikati MA et al. Quinidine in the treatment of KCNT1-positive epilepsies.
Ann. Neurol., 2015 Dec , 78 (995-9).

16

Rizzetto R et al. Late sodium current (INaL) in pancreatic β-cells.
Pflugers Arch., 2015 Aug , 467 (1757-68).

17

Bearden D et al. Targeted treatment of migrating partial seizures of infancy with quinidine.
Ann. Neurol., 2014 Sep , 76 (457-61).

18

Martin HC et al. Clinical whole-genome sequencing in severe early-onset epilepsy reveals new genes and improves molecular diagnosis.
Hum. Mol. Genet., 2014 Jun 15 , 23 (3200-11).

19

Jia S et al. Zebrafish Cacna1fa is required for cone photoreceptor function and synaptic ribbon formation.
Hum. Mol. Genet., 2014 Jun 1 , 23 (2981-94).

20

Brager DH et al. Channelopathies and Dendritic Dysfunction in Fragile X syndrome.
Brain Res. Bull., 2014 Jan 23 , ().

21

Vanderver A et al. Identification of a novel de novo p.Phe932Ile KCNT1 mutation in a patient with leukoencephalopathy and severe epilepsy.
Pediatr. Neurol., 2014 Jan , 50 (112-4).

22

Qu J et al. Gene-wide tagging study of the association between KCNT1 polymorphisms and the susceptibility and efficacy of genetic generalized epilepsy in Chinese population.
CNS Neurosci Ther, 2014 Feb , 20 (140-6).

23

De Filippo MR et al. Lack of pathogenic mutations in six patients with MMPSI.
Epilepsy Res., 2014 Feb , 108 (340-4).

24

Kim GE et al. Human slack potassium channel mutations increase positive cooperativity between individual channels.
Cell Rep, 2014 Dec 11 , 9 (1661-72).

25

Milligan CJ et al. KCNT1 gain of function in 2 epilepsy phenotypes is reversed by quinidine.
Ann. Neurol., 2014 Apr , 75 (581-90).

26

Liu P et al. SLO-2 potassium channel is an important regulator of neurotransmitter release in Caenorhabditis elegans.
Nat Commun, 2014 , 5 (5155).

27

Baulac S Genetics advances in autosomal dominant focal epilepsies: focus on DEPDC5.
Prog. Brain Res., 2014 , 213 (123-39).

28

Juang JM et al. Disease-targeted sequencing of ion channel genes identifies de novo mutations in patients with non-familial Brugada syndrome.
Sci Rep, 2014 , 4 (6733).

29

Tejada MA et al. Cell volume changes regulate slick (Slo2.1), but not slack (Slo2.2) K+ channels.
PLoS ONE, 2014 , 9 (e110833).

30

Fleming MR et al. Use of label-free optical biosensors to detect modulation of potassium channels by G-protein coupled receptors.
J Vis Exp, 2014 , (e51307).

31

Ishii A et al. A recurrent KCNT1 mutation in two sporadic cases with malignant migrating partial seizures in infancy.
Gene, 2013 Sep 10 , ().

32

Huang F et al. TMEM16C facilitates Na(+)-activated K+ currents in rat sensory neurons and regulates pain processing.
Nat. Neurosci., 2013 Sep , 16 (1284-90).

33

Gadotti VM et al. TMEM16C cuts pain no SLACK.
Nat. Neurosci., 2013 Sep , 16 (1165-6).

34

Lacaze E et al. De novo 15q13.3 microdeletion with cryptogenic West syndrome.
Am. J. Med. Genet. A, 2013 Oct , 161 (2582-7).

35

Garg P et al. Structural basis of ion permeation gating in Slo2.1 K+ channels.
J. Gen. Physiol., 2013 Nov , 142 (523-42).

36

Zhang Z et al. SLO-2 isoforms with unique Ca ( 2+) - and voltage-dependence characteristics confer sensitivity to hypoxia in C. elegans.
Channels (Austin), 2013 May 1 , 7 (194-205).

37

Cervantes B et al. Identity, expression and functional role of the sodium-activated potassium current in vestibular ganglion afferent neurons.
Neuroscience, 2013 Jun 14 , 240 (163-75).

38

Liu J et al. Distinct sensitivity of slo1 channel proteins to ethanol.
Mol. Pharmacol., 2013 Jan , 83 (235-44).

39

Dhamija R et al. Novel de novo SCN2A mutation in a child with migrating focal seizures of infancy.
Pediatr. Neurol., 2013 Dec , 49 (486-8).

40

Hayashi M et al. Molecular basis of potassium channels in pancreatic duct epithelial cells.
Channels (Austin), 2013 Aug 20 , 7 ().

41

Versari S et al. The challenging environment on board the International Space Station affects endothelial cell function by triggering oxidative stress through thioredoxin interacting protein overexpression: the ESA-SPHINX experiment.
FASEB J., 2013 Aug 2 , ().

42

Zhang Y et al. Regulation of neuronal excitability by interaction of fragile X mental retardation protein with slack potassium channels.
J. Neurosci., 2012 Oct 31 , 32 (15318-27).

43

Yan Y et al. Expression, purification and functional reconstitution of slack sodium-activated potassium channels.
J. Membr. Biol., 2012 Nov , 245 (667-74).

44

Garg P et al. Structure-activity relationship of fenamates as Slo2.1 channel activators.
Mol. Pharmacol., 2012 Nov , 82 (795-802).

45

Heron SE et al. Missense mutations in the sodium-gated potassium channel gene KCNT1 cause severe autosomal dominant nocturnal frontal lobe epilepsy.
Nat. Genet., 2012 Nov , 44 (1188-90).

46

Barcia G et al. De novo gain-of-function KCNT1 channel mutations cause malignant migrating partial seizures of infancy.
Nat. Genet., 2012 Nov , 44 (1255-9).

47

Igelström KM Is Slack an Intrinsic Seizure Terminator?
, 2012 May 29 , ().

48

Biton B et al. The antipsychotic drug loxapine is an opener of the sodium-activated potassium channel slack (Slo2.2).
J. Pharmacol. Exp. Ther., 2012 Mar , 340 (706-15).

49

de los Angeles Tejada M et al. PIP₂ modulation of Slick and Slack K⁺ channels.
Biochem. Biophys. Res. Commun., 2012 Jul 27 , 424 (208-13).

50

Hayashi M et al. An intermediate-conductance Ca2+-activated K+ channel is important for secretion in pancreatic duct cells.
Am. J. Physiol., Cell Physiol., 2012 Jul 15 , 303 (C151-9).

51

Li X et al. Extracellular chloride regulation of Kv2.1, contributor to the major outward Kv current in mammalian outer hair cells.
Am. J. Physiol., Cell Physiol., 2012 Jan , 302 (C296-306).

52

Dinardo MM et al. Splicing of the rSlo gene affects the molecular composition and drug response of Ca2+-activated K+ channels in skeletal muscle.
PLoS ONE, 2012 , 7 (e40235).

53

Poulsen AN et al. Neuronal fast activating and meningeal silent modulatory BK channel splice variants cloned from rat.
Pflugers Arch., 2011 Jan , 461 (65-75).

54

Wojtovich AP et al. SLO-2 is cytoprotective and contributes to mitochondrial potassium transport.
PLoS ONE, 2011 , 6 (e28287).

55

Nuwer MO et al. PKA-Induced Internalization of Slack KNa Channels Produces Dorsal Root Ganglion Neuron Hyperexcitability.
J. Neurosci., 2010 Oct 20 , 30 (14165-72).

56

Jayasinghe ID et al. A new twist in cardiac muscle: dislocated and helicoid arrangements of myofibrillar z-disks in mammalian ventricular myocytes.
J. Mol. Cell. Cardiol., 2010 May , 48 (964-71).

57

Dai L et al. Activation of Slo2.1 channels by niflumic acid.
J. Gen. Physiol., 2010 Mar , 135 (275-95).

58

Zhang Z et al. The RCK2 domain uses a coordination site present in Kir channels to confer sodium sensitivity to Slo2.2 channels.
J. Neurosci., 2010 Jun 2 , 30 (7554-62).

59

Lu S et al. The slack sodium-activated potassium channel provides a major outward current in olfactory neurons of Kv1.3-/- super-smeller mice.
J. Neurophysiol., 2010 Jun , 103 (3311-9).

60

Brown MR et al. Fragile X mental retardation protein controls gating of the sodium-activated potassium channel Slack.
Nat. Neurosci., 2010 Jul , 13 (819-21).

61

Nuwer MO et al. cAMP-dependent kinase does not modulate the Slack sodium-activated potassium channel.
Neuropharmacology, 2009 Sep , 57 (219-26).

62

Budelli G et al. Na+-activated K+ channels express a large delayed outward current in neurons during normal physiology.
Nat. Neurosci., 2009 Jun , 12 (745-50).

63

Chen H et al. The N-terminal domain of Slack determines the formation and trafficking of Slick/Slack heteromeric sodium-activated potassium channels.
J. Neurosci., 2009 Apr 29 , 29 (5654-65).

64

Tamsett TJ et al. NAD+ activates KNa channels in dorsal root ganglion neurons.
J. Neurosci., 2009 Apr 22 , 29 (5127-34).

65

Fleming MR et al. Use of optical biosensors to detect modulation of Slack potassium channels by G protein-coupled receptors.
J. Recept. Signal Transduct. Res., 2009 , 29 (173-81).

66

Brown MR et al. Amino-termini isoforms of the Slack K+ channel, regulated by alternative promoters, differentially modulate rhythmic firing and adaptation.
J. Physiol. (Lond.), 2008 Nov 1 , 586 (5161-79).

67

Ruffin VA et al. The sodium-activated potassium channel Slack is modulated by hypercapnia and acidosis.
Neuroscience, 2008 Jan 24 , 151 (410-8).

68

Gao SB et al. Slack and Slick KNa channels are required for the depolarizing afterpotential of acutely isolated, medium diameter rat dorsal root ganglion neurons.
Acta Pharmacol. Sin., 2008 Aug , 29 (899-905).

69

Wallén P et al. Sodium-dependent potassium channels of a Slack-like subtype contribute to the slow afterhyperpolarization in lamprey spinal neurons.
J. Physiol. (Lond.), 2007 Nov 15 , 585 (75-90).

70

Yang B et al. Slack and Slick K(Na) channels regulate the accuracy of timing of auditory neurons.
J. Neurosci., 2007 Mar 7 , 27 (2617-27).

71

Nanou E et al. A postsynaptic negative feedback mediated by coupling between AMPA receptors and Na+-activated K+ channels in spinal cord neurones.
Eur. J. Neurosci., 2007 Jan , 25 (445-50).

72

Berg AP et al. TrpC3/C7 and Slo2.1 are molecular targets for metabotropic glutamate receptor signaling in rat striatal cholinergic interneurons.
J. Neurosci., 2007 Aug 15 , 27 (8845-56).

73

Yang B et al. Pharmacological activation and inhibition of Slack (Slo2.2) channels.
Neuropharmacology, 2006 Sep , 51 (896-906).

74

Santi CM et al. Opposite regulation of Slick and Slack K+ channels by neuromodulators.
J. Neurosci., 2006 May 10 , 26 (5059-68).

75

Paulais M et al. A Na+- and Cl- -activated K+ channel in the thick ascending limb of mouse kidney.
J. Gen. Physiol., 2006 Feb , 127 (205-15).

76

Sugino K et al. Electrical properties and fusion dynamics of in vitro membrane vesicles derived from separate parts of the contractile vacuole complex of Paramecium multimicronucleatum.
J. Exp. Biol., 2005 Oct , 208 (3957-69).

77

Bhattacharjee A et al. Localization of the Na+-activated K+ channel Slick in the rat central nervous system.
J. Comp. Neurol., 2005 Mar 28 , 484 (80-92).

78

Kaczmarek LK et al. Regulation of the timing of MNTB neurons by short-term and long-term modulation of potassium channels.
Hear. Res., 2005 Aug , 206 (133-45).

79

Bhattacharjee A et al. For K+ channels, Na+ is the new Ca2+.
Trends Neurosci., 2005 Aug , 28 (422-8).

80

Zhang L et al. Direct binding of estradiol enhances Slack (sequence like a calcium-activated potassium channel) channels' activity.
Neuroscience, 2005 , 131 (275-82).

81

Uchino S et al. Slo2 sodium-activated K+ channels bind to the PDZ domain of PSD-95.
Biochem. Biophys. Res. Commun., 2003 Oct 31 , 310 (1140-7).

82

Yuan A et al. The sodium-activated potassium channel is encoded by a member of the Slo gene family.
Neuron, 2003 Mar 6 , 37 (765-73).

83

Dryer SE Molecular identification of the Na+-activated K+ channel.
Neuron, 2003 Mar 6 , 37 (727-8).

84

Wang SX et al. The cytoplasmic tail of large conductance, voltage- and Ca2+-activated K+ (MaxiK) channel is necessary for its cell surface expression.
J. Biol. Chem., 2003 Jan 24 , 278 (2713-22).

85

Bhattacharjee A et al. Slick (Slo2.1), a rapidly-gating sodium-activated potassium channel inhibited by ATP.
J. Neurosci., 2003 Dec 17 , 23 (11681-91).

86

Ji G et al. Stretch-induced calcium release in smooth muscle.
J. Gen. Physiol., 2002 Jun , 119 (533-44).

87

Bhattacharjee A et al. Localization of the Slack potassium channel in the rat central nervous system.
J. Comp. Neurol., 2002 Dec 16 , 454 (241-54).

88

Hamill OP et al. Molecular basis of mechanotransduction in living cells.
Physiol. Rev., 2001 Apr , 81 (685-740).

89

Ha TS et al. Functional characteristics of two BKCa channel variants differentially expressed in rat brain tissues.
Eur. J. Biochem., 2000 Feb , 267 (910-8).

90

Kunze WA et al. Contractile activity in intestinal muscle evokes action potential discharge in guinea-pig myenteric neurons.
J. Physiol. (Lond.), 1999 Jun 1 , 517 ( Pt 2) (547-61).

91

Joiner WJ et al. Formation of intermediate-conductance calcium-activated potassium channels by interaction of Slack and Slo subunits.
Nat. Neurosci., 1998 Oct , 1 (462-9).

92

Morita T et al. Cloning and characterization of maxi K+ channel alpha-subunit in rabbit kidney.
Am. J. Physiol., 1997 Oct , 273 (F615-24).

93

Kent RL et al. Load responsiveness of protein synthesis in adult mammalian myocardium: role of cardiac deformation linked to sodium influx.
Circ. Res., 1989 Jan , 64 (74-85).