Kv12.1

1

Fredericks GJ et al. Selenoprotein K and protein palmitoylation.
Antioxid. Redox Signal., 2015 Oct 1 , 23 (854-62).

2

Li X et al. Ether-à-go-go family voltage-gated K+ channels evolved in an ancestral metazoan and functionally diversified in a cnidarian-bilaterian ancestor.
J. Exp. Biol., 2015 Feb 15 , 218 (526-36).

3

Potet F et al. Intracellular calcium attenuates late current conducted by mutant human cardiac sodium channels.
Circ Arrhythm Electrophysiol, 2015 Aug , 8 (933-41).

4

Costantini TW et al. A Human-Specific α7-Nicotinic Acetylcholine Receptor Gene in Human Leukocytes: Identification, Regulation and the Consequences of CHRFAM7A Expression.
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5

Lesch A et al. Transient receptor potential melastatin-3 (TRPM3)-induced activation of AP-1 requires Ca2+ ions and the transcription factors c-Jun, ATF2, and ternary complex factor.
Mol. Pharmacol., 2015 Apr , 87 (617-28).

6

House CD et al. Voltage-gated Na+ Channel Activity Increases Colon Cancer Transcriptional Activity and Invasion Via Persistent MAPK Signaling.
Sci Rep, 2015 , 5 (11541).

7

Fredericks GJ et al. Stable expression and function of the inositol 1,4,5-triphosphate receptor requires palmitoylation by a DHHC6/selenoprotein K complex.
Proc. Natl. Acad. Sci. U.S.A., 2014 Nov 18 , 111 (16478-83).

8

Savio-Galimberti E et al. SCN10A/Nav1.8 modulation of peak and late sodium currents in patients with early onset atrial fibrillation.
Cardiovasc. Res., 2014 Nov 1 , 104 (355-63).

9

Lesch A et al. Activation and inhibition of transient receptor potential TRPM3-induced gene transcription.
Br. J. Pharmacol., 2014 May , 171 (2645-58).

10

Luna-Ramírez K et al. Structure, molecular modeling, and function of the novel potassium channel blocker urotoxin isolated from the venom of the Australian scorpion Urodacus yaschenkoi.
Mol. Pharmacol., 2014 Jul , 86 (28-41).

11

Lin TF et al. The subfamily-specific assembly of Eag and Erg K+ channels is determined by both the amino and the carboxyl recognition domains.
J. Biol. Chem., 2014 Aug 15 , 289 (22815-34).

12

Schlichter LC et al. Regulation of hERG and hEAG channels by Src and by SHP-1 tyrosine phosphatase via an ITIM region in the cyclic nucleotide binding domain.
PLoS ONE, 2014 , 9 (e90024).

13

Saber S et al. [Clinical polymorphisms and approaches of arrhythmias treatment in a family with δKPQ1505-1507 deletion in SCN5A gene].
Vestn. Akad. Med. Nauk SSSR, 2014 , (52-9).

14

Haitin Y et al. The structural mechanism of KCNH-channel regulation by the eag domain.
Nature, 2013 Sep 19 , 501 (444-8).

15

Gómez-Varela D et al. Lateral mobility of presynaptic α7-containing nicotinic receptors and its relevance for glutamate release.
J. Neurosci., 2013 Oct 23 , 33 (17062-71).

16

Kazmierczak M et al. External pH modulates EAG superfamily K+ channels through EAG-specific acidic residues in the voltage sensor.
J. Gen. Physiol., 2013 Jun , 141 (721-35).

17

Rasgado-Flores H et al. Effect of apical hyperosmotic sodium challenge and amiloride on sodium transport in human bronchial epithelial cells from cystic fibrosis donors.
Am. J. Physiol., Cell Physiol., 2013 Dec 1 , 305 (C1114-22).

18

Adaixo R et al. Structural properties of PAS domains from the KCNH potassium channels.
PLoS ONE, 2013 , 8 (e59265).

19

Ng CA et al. C-Terminal β9-Strand of the Cyclic Nucleotide-Binding Homology Domain Stabilizes Activated States of Kv11.1 Channels.
PLoS ONE, 2013 , 8 (e77032).

20

Sabater L et al. Antibody repertoire in paraneoplastic cerebellar degeneration and small cell lung cancer.
PLoS ONE, 2013 , 8 (e60438).

21

Regus-Leidig H et al. Identification and immunocytochemical characterization of Piccolino, a novel Piccolo splice variant selectively expressed at sensory ribbon synapses of the eye and ear.
PLoS ONE, 2013 , 8 (e70373).

22

Zumhagen S et al. A heterozygous deletion mutation in the cardiac sodium channel gene SCN5A with loss- and gain-of-function characteristics manifests as isolated conduction disease, without signs of Brugada or long QT syndrome.
PLoS ONE, 2013 , 8 (e67963).

23

Frolov RV et al. Potassium channels in Drosophila: historical breakthroughs, significance, and perspectives.
J. Neurogenet., 2012 Sep , 26 (275-90).

24

Marques-Carvalho MJ et al. Structural, biochemical, and functional characterization of the cyclic nucleotide binding homology domain from the mouse EAG1 potassium channel.
J. Mol. Biol., 2012 Oct 12 , 423 (34-46).

25

Zhang Z et al. Upregulation of TRPM7 channels by angiotensin II triggers phenotypic switching of vascular smooth muscle cells of ascending aorta.
Circ. Res., 2012 Oct 12 , 111 (1137-46).

26

Wozniak MA et al. Adhesion regulates MAP kinase/ternary complex factor exchange to control a proliferative transcriptional switch.
Curr. Biol., 2012 Nov 6 , 22 (2017-26).

27

Brelidze TI et al. Structure of the carboxy-terminal region of a KCNH channel.
, 2012 Jan 9 , ().

28

Billings SE et al. ELKS1 and Ca(2+) channel subunit β4 interact and colocalize at cerebellar synapses.
Neuroreport, 2012 Jan 4 , 23 (49-54).

29

Ditting T et al. Norepinephrine reduces ω-conotoxin-sensitive Ca2+ currents in renal afferent neurons in rats.
Am. J. Physiol. Renal Physiol., 2012 Feb , 302 (F350-7).

30

Glaves JP et al. Distinct morphological and electrophysiological properties of an elk prion peptide.
Peptides, 2012 Dec 20 , ().

31

Nishimune H Active zones of mammalian neuromuscular junctions: formation, density, and aging.
Ann. N. Y. Acad. Sci., 2012 Dec , 1274 (24-32).

32

Maas C et al. Formation of Golgi-derived active zone precursor vesicles.
J. Neurosci., 2012 Aug 8 , 32 (11095-108).

33

Kiyonaka S et al. Physical and functional interaction of the active zone protein CAST/ERC2 and the β-subunit of the voltage-dependent Ca(2+) channel.
J. Biochem., 2012 Aug , 152 (149-59).

34

Wisniewska MB et al. Novel β-catenin target genes identified in thalamic neurons encode modulators of neuronal excitability.
BMC Genomics, 2012 , 13 (635).

35

Ponnusamy M et al. ERK pathway mediates P2X7 expression and cell death in renal interstitial fibroblasts exposed to necrotic renal epithelial cells.
Am. J. Physiol. Renal Physiol., 2011 Sep , 301 (F650-9).

36

Ben SB et al. Selenoprotein dSelK in Drosophila elevates release of Ca2+ from endoplasmic reticulum by upregulating expression of inositol 1,4,5-tris-phosphate receptor.
Biochemistry Mosc., 2011 Sep , 76 (1030-6).

37

Mayer SI et al. Signal transduction of pregnenolone sulfate in insulinoma cells: activation of Egr-1 expression involving TRPM3, voltage-gated calcium channels, ERK, and ternary complex factors.
J. Biol. Chem., 2011 Mar 25 , 286 (10084-96).

38

Cailotto F et al. Calcium input potentiates the transforming growth factor (TGF)-beta1-dependent signaling to promote the export of inorganic pyrophosphate by articular chondrocyte.
J. Biol. Chem., 2011 Jun 3 , 286 (19215-28).

39

Cui W et al. Bis(12)-hupyridone, a novel multifunctional dimer, promotes neuronal differentiation more potently than its monomeric natural analog huperzine A possibly through α7 nAChR.
Brain Res., 2011 Jul 15 , 1401 (10-7).

40

Ohtsuka T [Molecular mechanism at the presynaptic active zone].
Brain Nerve, 2011 Jul , 63 (641-8).

41

Jiang L et al. Glycine-induced cytoprotection is mediated by ERK1/2 and AKT in renal cells with ATP depletion.
Eur. J. Cell Biol., 2011 Apr , 90 (333-41).

42

Adaixo R et al. Crystallization and preliminary crystallographic characterization of the PAS domains of EAG and ELK potassium channels.
Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun., 2010 Sep 1 , 66 (1056-9).

43

Kajimoto K et al. HYPOTONIC SWELLING-INDUCED ACTIVATION OF PKN1 MEDIATES CELL SURVIVAL IN CARDIAC MYOCYTES.
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44

Moomaw AS et al. Cation Selectivity by the CorA Mg2+ Channel Requires a Fully Hydrated Cation.
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45

Müller I et al. Regulation of AP-1 activity in glucose-stimulated insulinoma cells.
J. Cell. Biochem., 2010 Aug 15 , 110 (1481-94).

46

Wang W et al. The role of ERK-1/2 in the N/OFQ-induced inhibition of delayed rectifier potassium currents.
Biochem. Biophys. Res. Commun., 2010 Apr 16 , 394 (1058-62).

47

Zhang X et al. Divalent cations slow activation of EAG family K+ channels through direct binding to S4.
Biophys. J., 2009 Jul 8 , 97 (110-20).

48

Koehl GE et al. Rapamycin inhibits oncogenic intestinal ion channels and neoplasia in APC(Min/+) mice.
Oncogene, 2009 Dec 7 , ().

49

Clancy SM et al. KCNE1 and KCNE3 beta-subunits regulate membrane surface expression of Kv12.2 K(+) channels in vitro and form a tripartite complex in vivo.
PLoS ONE, 2009 , 4 (e6330).

50

Usuki S et al. Topology and patch-clamp analysis of the sodium channel in relationship to the anti-lipid a antibody in campylobacteriosis.
J. Neurosci. Res., 2008 Nov 15 , 86 (3359-74).

51

Selimovic D et al. Taxol-induced mitochondrial stress in melanoma cells is mediated by activation of c-Jun N-terminal kinase (JNK) and p38 pathways via uncoupling protein 2.
Cell. Signal., 2008 Feb , 20 (311-22).

52

Stefano L et al. P2X(7) receptor stimulation upregulates Egr-1 biosynthesis involving a cytosolic Ca(2+) rise, transactivation of the EGF receptor and phosphorylation of ERK and Elk-1.
J. Cell. Physiol., 2007 Oct , 213 (36-44).

53

Lee J et al. L-type calcium channel blockade on haloperidol-induced c-Fos expression in the striatum.
Neuroscience, 2007 Nov 9 , 149 (602-16).

54

Kelkar DA et al. Modulation of gramicidin channel conformation and organization by hydrophobic mismatch in saturated phosphatidylcholine bilayers.
Biochim. Biophys. Acta, 2007 May , 1768 (1103-13).

55

Chen XH et al. [NR2B-pERK1/2-pElk-1 signaling contributes to the avoidance learning and memory of rats].
Zhongguo Ying Yong Sheng Li Xue Za Zhi, 2007 Feb , 23 (121-5).

56

Vadigepalli R et al. Epidermal growth factor receptor-induced circadian-time-dependent gene regulation in suprachiasmatic nucleus.
Neuroreport, 2006 Sep 18 , 17 (1437-41).

57

Boileau C et al. PD-0200347, an alpha2delta ligand of the voltage gated calcium channel, inhibits in vivo activation of the Erk1/2 pathway in osteoarthritic chondrocytes: a PKCalpha dependent effect.
Ann. Rheum. Dis., 2006 May , 65 (573-80).

58

Barrett LE et al. Elk-1 associates with the mitochondrial permeability transition pore complex in neurons.
Proc. Natl. Acad. Sci. U.S.A., 2006 Mar 28 , 103 (5155-60).

59

Greenbaum L et al. Why do young women smoke? I. Direct and interactive effects of environment, psychological characteristics and nicotinic cholinergic receptor genes.
Mol. Psychiatry, 2006 Mar , 11 (312-22, 223).

60

Clarke CE et al. Effect of S5P alpha-helix charge mutants on inactivation of hERG K+ channels.
J. Physiol. (Lond.), 2006 Jun 1 , 573 (291-304).

61

Wellner RB et al. Further evidence for AQP8 expression in the myoepithelium of rat submandibular and parotid glands.
Pflugers Arch., 2006 Feb , 451 (642-5).

62

Kozinn J et al. Inhibition of glutamatergic activation of extracellular signal-regulated protein kinases in hippocampal neurons by the intravenous anesthetic propofol.
Anesthesiology, 2006 Dec , 105 (1182-91).

63

Matthews DB et al. Complex genetics of interactions of alcohol and CNS function and behavior.
Alcohol. Clin. Exp. Res., 2005 Sep , 29 (1706-19).

64

Brazier SP et al. Cloning of the human TASK-2 (KCNK5) promoter and its regulation by chronic hypoxia.
Biochem. Biophys. Res. Commun., 2005 Nov 4 , 336 (1251-8).

65

Mao L et al. The scaffold protein Homer1b/c links metabotropic glutamate receptor 5 to extracellular signal-regulated protein kinase cascades in neurons.
J. Neurosci., 2005 Mar 9 , 25 (2741-52).

66

Mordvintsev DY et al. A model for short alpha-neurotoxin bound to nicotinic acetylcholine receptor from Torpedo californica: comparison with long-chain alpha-neurotoxins and alpha-conotoxins.
Comput Biol Chem, 2005 Dec , 29 (398-411).

67

Yu CG et al. Activation of the ERK1/2 signaling cascade by excitotoxic spinal cord injury.
Brain Res. Mol. Brain Res., 2005 Aug 18 , 138 (244-55).

68

Oudard S et al. Homophilic anchorage of brain-hexokinase to mitochondria-porins revealed by specific-peptide antibody cross recognition.
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69

Yang L et al. A novel Ca2+-independent signaling pathway to extracellular signal-regulated protein kinase by coactivation of NMDA receptors and metabotropic glutamate receptor 5 in neurons.
J. Neurosci., 2004 Dec 1 , 24 (10846-57).

70

Arndt HD et al. Stereoselective synthesis of trans-threo-trans-oligopyrrolidines: potential agents for RNA cleavage.
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71

Cantin GT et al. Activation domain-mediator interactions promote transcription preinitiation complex assembly on promoter DNA.
Proc. Natl. Acad. Sci. U.S.A., 2003 Oct 14 , 100 (12003-8).

72

Mao L et al. Metabotropic glutamate receptor 5-regulated Elk-1 phosphorylation and immediate early gene expression in striatal neurons.
J. Neurochem., 2003 May , 85 (1006-17).

73

Gopalakrishnan M et al. Pharmacological characterization of a 1,4-dihydropyridine analogue, 9-(3,4-dichlorophenyl)-3,3,6,6-tetramethyl-3,4,6,7,9,10-hexahydro-1,8(2H,5H)-acridinedione (A-184209) as a novelK(ATP) channel inhibitor.
Br. J. Pharmacol., 2003 Jan , 138 (393-9).

74

Zou A et al. Distribution and functional properties of human KCNH8 (Elk1) potassium channels.
Am. J. Physiol., Cell Physiol., 2003 Dec , 285 (C1356-66).

75

Keller DI et al. A novel mutation in SCN5A, delQKP 1507-1509, causing long QT syndrome: role of Q1507 residue in sodium channel inactivation.
J. Mol. Cell. Cardiol., 2003 Dec , 35 (1513-21).

76

Coogan AN et al. Circadian and photic regulation of phosphorylation of ERK1/2 and Elk-1 in the suprachiasmatic nuclei of the Syrian hamster.
J. Neurosci., 2003 Apr 1 , 23 (3085-93).

77

Ferrer I [Cell signaling in the epileptic hippocampus].
Rev Neurol, 2002 Mar 16-31 , 34 (544-50).

78

Taurin S et al. c-Fos expression in ouabain-treated vascular smooth muscle cells from rat aorta: evidence for an intracellular-sodium-mediated, calcium-independent mechanism.
J. Physiol. (Lond.), 2002 Sep 15 , 543 (835-47).

79

Pardo-López L et al. Mapping the receptor site for ergtoxin, a specific blocker of ERG channels.
FEBS Lett., 2002 Jan 2 , 510 (45-9).

80

Baxter DF et al. A novel membrane potential-sensitive fluorescent dye improves cell-based assays for ion channels.
, 2002 Feb , 7 (79-85).

81

Becchetti A et al. The functional properties of the human ether-à-go-go-like (HELK2) K+ channel.
Eur. J. Neurosci., 2002 Aug , 16 (415-28).

82

Yung Y et al. Altered regulation of ERK1b by MEK1 and PTP-SL and modified Elk1 phosphorylation by ERK1b are caused by abrogation of the regulatory C-terminal sequence of ERKs.
J. Biol. Chem., 2001 Sep 21 , 276 (35280-9).

83

Korolkova YV et al. An ERG channel inhibitor from the scorpion Buthus eupeus.
J. Biol. Chem., 2001 Mar 30 , 276 (9868-76).

84

Saganich MJ et al. Differential expression of genes encoding subthreshold-operating voltage-gated K+ channels in brain.
J. Neurosci., 2001 Jul 1 , 21 (4609-24).

85

Yamakura T et al. Differential effects of general anesthetics on G protein-coupled inwardly rectifying and other potassium channels.
Anesthesiology, 2001 Jul , 95 (144-53).

86

Chung KC et al. Intracellular calcium mobilization induces immediate early gene pip92 via Src and mitogen-activated protein kinase in immortalized hippocampal cells.
J. Biol. Chem., 2001 Jan 19 , 276 (2132-8).

87

Fukuda K et al. Hepatitis C virus core protein enhances the activation of the transcription factor, Elk1, in response to mitogenic stimuli.
Hepatology, 2001 Jan , 33 (159-65).

88

Wimmers S et al. Erg1, erg2 and erg3 K channel subunits are able to form heteromultimers.
Pflugers Arch., 2001 Jan , 441 (450-5).

89

Cheng JJ et al. Sequential activation of protein kinase C (PKC)-alpha and PKC-epsilon contributes to sustained Raf/ERK1/2 activation in endothelial cells under mechanical strain.
J. Biol. Chem., 2001 Aug 17 , 276 (31368-75).

90

Blaukat A et al. G protein-coupled receptor-mediated mitogen-activated protein kinase activation through cooperation of Galpha(q) and Galpha(i) signals.
Mol. Cell. Biol., 2000 Sep , 20 (6837-48).

91

Cammarota M et al. Learning-associated activation of nuclear MAPK, CREB and Elk-1, along with Fos production, in the rat hippocampus after a one-trial avoidance learning: abolition by NMDA receptor blockade.
Brain Res. Mol. Brain Res., 2000 Mar 10 , 76 (36-46).

92

Wulfsen I et al. Expression of mRNA for voltage-dependent and inward-rectifying K channels in GH3/B6 cells and rat pituitary.
J. Neuroendocrinol., 2000 Mar , 12 (263-72).

93

Pláteník J et al. Molecular mechanisms associated with long-term consolidation of the NMDA signals.
Life Sci., 2000 Jun 16 , 67 (335-64).

94

Valjent E et al. Involvement of the extracellular signal-regulated kinase cascade for cocaine-rewarding properties.
J. Neurosci., 2000 Dec 1 , 20 (8701-9).

95

Chung KC et al. Expression of immediate early gene pip92 during anisomycin-induced cell death is mediated by the JNK- and p38-dependent activation of Elk1.
Eur. J. Biochem., 2000 Aug , 267 (4676-84).

96

Choe ES et al. N-Methyl-D-aspartate receptors and p38 mitogen-activated protein kinase are required for cAMP-dependent cyclase response element binding protein and Elk-1 phosphorylation in the striatum.
Neuroscience, 2000 , 101 (607-17).

97

Wu W et al. Activation of the EGF receptor signaling pathway in human airway epithelial cells exposed to metals.
Am. J. Physiol., 1999 Nov , 277 (L924-31).

98

Li Q et al. Activation of the 9E3/cCAF chemokine by phorbol esters occurs via multiple signal transduction pathways that converge to MEK1/ERK2 and activate the Elk1 transcription factor.
J. Biol. Chem., 1999 May 28 , 274 (15454-65).

99

Tian J et al. Stimulation of Elk1 transcriptional activity by mitogen-activated protein kinases is negatively regulated by protein phosphatase 2B (calcineurin).
J. Biol. Chem., 1999 May 21 , 274 (15173-80).

100

Zhao C et al. Gab2, a new pleckstrin homology domain-containing adapter protein, acts to uncouple signaling from ERK kinase to Elk-1.
J. Biol. Chem., 1999 Jul 9 , 274 (19649-54).

101

Meves H et al. Separation of M-like current and ERG current in NG108-15 cells.
Br. J. Pharmacol., 1999 Jul , 127 (1213-23).

102

Yamauchi T et al. Structural organization of the human Elk1 gene and its processed pseudogene Elk2.
DNA Res., 1999 Feb 26 , 6 (21-7).

103

Dhulipala PD et al. Cloning and characterization of the promoters of the maxiK channel alpha and beta subunits.
Biochim. Biophys. Acta, 1999 Feb 16 , 1444 (254-62).

104

Sharif TR et al. A high throughput system for the evaluation of protein kinase C inhibitors based on Elk1 transcriptional activation in human astrocytoma cells.
Int. J. Oncol., 1999 Feb , 14 (327-35).

105

Kansha M et al. Dibucaine and tetracaine inhibit the activation of mitogen-activated protein kinase mediated by L-type calcium channels in PC12 cells.
Anesthesiology, 1999 Dec , 91 (1798-806).

106

Miyake A et al. New ether-à-go-go K(+) channel family members localized in human telencephalon.
J. Biol. Chem., 1999 Aug 27 , 274 (25018-25).

107

Ganetzky B et al. The eag family of K+ channels in Drosophila and mammals.
Ann. N. Y. Acad. Sci., 1999 Apr 30 , 868 (356-69).

108

Chang MS et al. Positive and negative regulatory elements in the upstream region of the rat Cu/Zn-superoxide dismutase gene.
Biochem. J., 1999 Apr 15 , 339 ( Pt 2) (335-41).

109

Trudeau MC et al. Functional analysis of a mouse brain Elk-type K+ channel.
J. Neurosci., 1999 Apr 15 , 19 (2906-18).

110

Shi W et al. Cloning of a mammalian elk potassium channel gene and EAG mRNA distribution in rat sympathetic ganglia.
J. Physiol. (Lond.), 1998 Sep 15 , 511 ( Pt 3) (675-82).

111

Engeland B et al. Cloning and functional expression of rat ether-à-go-go-like K+ channel genes.
J. Physiol. (Lond.), 1998 Dec 15 , 513 ( Pt 3) (647-54).

112

Querfurth HW et al. Expression of ryanodine receptors in human embryonic kidney (HEK293) cells.
Biochem. J., 1998 Aug 15 , 334 ( Pt 1) (79-86).

113

Titus SA et al. The Drosophila erg K+ channel polypeptide is encoded by the seizure locus.
J. Neurosci., 1997 Feb 1 , 17 (875-81).

114

Johnson CM et al. Calcium controls gene expression via three distinct pathways that can function independently of the Ras/mitogen-activated protein kinases (ERKs) signaling cascade.
J. Neurosci., 1997 Aug 15 , 17 (6189-202).

115

Xia Z et al. Calcium influx via the NMDA receptor induces immediate early gene transcription by a MAP kinase/ERK-dependent mechanism.
J. Neurosci., 1996 Sep 1 , 16 (5425-36).