Referenced in: none

Automatically associated channels: Cav1.2 , Cav2.1 , Cav2.2 , Cav3.1 , Kv11.1 , Kv8.2

Title: Two New Classes of T-Type Calcium Channel Inhibitors with New Chemical Scaffolds from Ganoderma cochlear.

Authors: Feng-Jiao Zhou, Yin Nian, Yongming Yan, Ye Gong, Qi Luo, Yu Zhang, Bo Hou, Zhi-Li Zuo, Shu-Mei Wang, He-Hai Jiang, Jian Yang, Yong-Xian Cheng

Journal, date & volume: Org. Lett., 2015 Jun 19 , 17, 3082-5

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/26024438

Abstract
T-type calcium channel (TTCC) inhibitors hold great potential for the treatment of a variety of neurological disorders. Cochlearoids A-E (1-5), five pairs of dimeric meroterpenoid enantiomers, and cochlearines A (6) and B (7), two pairs of enantiomeric hybrid metabolites, were isolated and characterized from Ganoderma cochlear. Biological evaluation found that compounds (+)-1, (-)-3, and (±)-6 significantly inhibited Cav3.1 TTCC and showed noticeable selectivity against Cav1.2, Cav2.1, Cav2.2, and Kv11.1 (hERG) channels.