Channelpedia

Kir2.2

377 literature references associated to Kir2.2

used / unused
Pubmed id

1

364912

2

364897

4

356702

Wu Y et al. Two inwardly rectifying potassium channels, Irk1 and Irk2, play redundant roles in Drosophila renal tubule function.
Am. J. Physiol. Regul. Integr. Comp. Physiol., 2015 Oct , 309 (R747-56).

5

365809

Hablitz LM et al. GIRK Channels Mediate the Nonphotic Effects of Exogenous Melatonin.
J. Neurosci., 2015 Nov 11 , 35 (14957-65).

7

357548

9

367729

DiFranco M et al. Inward rectifier potassium currents in mammalian skeletal muscle fibres.
J. Physiol. (Lond.), 2015 Mar 1 , 593 (1213-38).

10

363006

Tsantoulas C Emerging potassium channel targets for the treatment of pain.
Curr Opin Support Palliat Care, 2015 Jun , 9 (147-54).

11

357236

13

355803

14

349296

Masia R et al. The inward rectifier potassium channel Kir2.1 is expressed in mouse neutrophils from bone marrow and liver.
Am. J. Physiol., Cell Physiol., 2015 Feb 1 , 308 (C264-76).

15

361876

16

348673

22

366319

24

350981

Bagriantsev SN et al. Tethered protein display identifies a novel Kir3.2 (GIRK2) regulator from protein scaffold libraries.
ACS Chem Neurosci, 2014 Sep 17 , 5 (812-22).

27

364239

Gómez R et al. Structural basis of drugs that increase cardiac inward rectifier Kir2.1 currents.
Cardiovasc. Res., 2014 Nov 1 , 104 (337-46).

29

345290

Raphemot R et al. Direct activation of β-cell KATP channels with a novel xanthine derivative.
Mol. Pharmacol., 2014 Jun , 85 (858-65).

33

367747

Fürst O et al. Identification of a cholesterol-binding pocket in inward rectifier K(+) (Kir) channels.
Biophys. J., 2014 Dec 16 , 107 (2786-96).

35

359758

Xynogalos P et al. Class III antiarrhythmic drug dronedarone inhibits cardiac inwardly rectifying Kir2.1 channels through binding at residue E224.
Naunyn Schmiedebergs Arch. Pharmacol., 2014 Dec , 387 (1153-61).

36

351326

37

345071

Lalive AL et al. Firing modes of dopamine neurons drive bidirectional GIRK channel plasticity.
J. Neurosci., 2014 Apr 9 , 34 (5107-14).

38

354191

Noriega-Navarro R et al. Novel TASK channels inhibitors derived from dihydropyrrolo[2,1-a]isoquinoline.
Neuropharmacology, 2014 Apr , 79 (28-36).

39

349757

41

352688

Hartfield EM et al. Physiological characterisation of human iPS-derived dopaminergic neurons.
PLoS ONE, 2014 , 9 (e87388).

42

358466

Kumar M et al. Focus on Kir7.1: physiology and channelopathy.
Channels (Austin), 2014 , 8 (488-95).

46

367910

47

347177

Ramos-Hunter SJ et al. Discovery and SAR of a novel series of GIRK1/2 and GIRK1/4 activators.
Bioorg. Med. Chem. Lett., 2013 Sep 15 , 23 (5195-8).

48

347141

49

346806

50

341770

51

335774

53

335157

Whorton MR et al. X-ray structure of the mammalian GIRK2-βγ G-protein complex.
Nature, 2013 Jun 13 , 498 (190-7).

57

330429

58

340929

Aguado C et al. Differential maturation of GIRK2-expressing neurons in the mouse cerebellum.
J. Chem. Neuroanat., 2013 Jan , 47 (79-89).

60

354732

61

354967

62

347462

63

339969

Szuts V et al. Altered expression of genes for Kir ion channels in dilated cardiomyopathy.
Can. J. Physiol. Pharmacol., 2013 Aug , 91 (648-56).

66

331350

Dahal GR et al. An inwardly rectifying K+ channel is required for patterning.
Development, 2012 Oct , 139 (3653-64).

67

326939

69

332116

Kulzer M et al. Inhibition of cardiac Kir2.1-2.3 channels by beta3 adrenoreceptor antagonist SR 59230A.
Biochem. Biophys. Res. Commun., 2012 Jul 27 , 424 (315-20).

72

325991

Best TK et al. Dysfunctional hippocampal inhibition in the Ts65Dn mouse model of Down syndrome.
Exp. Neurol., 2012 Feb , 233 (749-57).

73

336961

Wydeven N et al. Structural elements in the Girk1 subunit that potentiate G protein-gated potassium channel activity.
Proc. Natl. Acad. Sci. U.S.A., 2012 Dec 26 , 109 (21492-7).

75

339215

Reyes S et al. GIRK2 expression in dopamine neurons of the substantia nigra and ventral tegmental area.
J. Comp. Neurol., 2012 Aug 15 , 520 (2591-607).

79

321461

Lü Q et al. Identification of GIRK2-4 subunits in human esophageal smooth muscle cells.
Mol Med Report, 2011 Sep-Oct , 4 (941-5).

81

320841

85

317643

Dassau L et al. Kir2.6 regulates the surface expression of Kir2.x inward rectifier potassium channels.
J. Biol. Chem., 2011 Mar 18 , 286 (9526-41).

86

319590

Lazary J et al. Epistatic interaction of CREB1 and KCNJ6 on rumination and negative emotionality.
Eur Neuropsychopharmacol, 2011 Jan , 21 (63-70).

87

314035

Cheng WW et al. Dual-mode phospholipid regulation of human inward rectifying potassium channels.
Biophys. J., 2011 Feb 2 , 100 (620-8).

88

320372

89

326364

91

318262

93

140085

Vaidyanathan R et al. Regulation of cardiac inward rectifier potassium current (I(K1)) by synapse-associated protein-97.
J. Biol. Chem., 2010 Sep 3 , 285 (28000-9).

94

139583

Arora D et al. Altered neurotransmission in the mesolimbic reward system of Girk mice.
J. Neurochem., 2010 Sep 1 , 114 (1487-97).

95

140530

Nassirpour R et al. Morphine- and CaMKII-dependent enhancement of GIRK channel signaling in hippocampal neurons.
J. Neurosci., 2010 Oct 6 , 30 (13419-30).

97

314847

Panama BK et al. Functional consequences of Kir2.1/Kir2.2 subunit heteromerization.
Pflugers Arch., 2010 Oct , 460 (839-49).

101

140114

López-Izquierdo A et al. Thiopental inhibits function of different inward rectifying potassium channel isoforms by a similar mechanism.
Eur. J. Pharmacol., 2010 Jul 25 , 638 (33-41).

103

122420

105

140948

Caballero R et al. Flecainide increases Kir2.1 currents by interacting with cysteine 311, decreasing the polyamine-induced rectification.
Proc. Natl. Acad. Sci. U.S.A., 2010 Aug 31 , 107 (15631-6).

109

140613

Cramer NP et al. GABAB-GIRK2-mediated signaling in Down syndrome.
Adv. Pharmacol., 2010 , 58 (397-426).

110

131542

111

123236

113

8578

Aryal P et al. A discrete alcohol pocket involved in GIRK channel activation.
Nat. Neurosci., 2009 Jun 28 , ().

115

2254

Ureche ON et al. Differential modulation of cardiac potassium channels by Grb adaptor proteins.
Biochem. Biophys. Res. Commun., 2009 Jun 19 , 384 (28-31).

118

131606

120

2792

Chung HJ et al. G protein-activated inwardly rectifying potassium channels mediate depotentiation of long-term potentiation.
Proc. Natl. Acad. Sci. U.S.A., 2009 Jan 13 , 106 (635-40).

121

6230

Boyer SB et al. Regulation of Kir2.1 channels by the Rho-GTPase, Rac1.
J. Cell. Physiol., 2009 Feb , 218 (385-93).

123

5862

125

131500

127

1521

Saenz del Burgo L et al. Distribution and neurochemical characterization of neurons expressing GIRK channels in the rat brain.
J. Comp. Neurol., 2008 Oct 20 , 510 (581-606).

128

4551

Park WS et al. Physiological role of inward rectifier K(+) channels in vascular smooth muscle cells.
Pflugers Arch., 2008 Oct , 457 (137-47).

131

150134

132

4633

Pravetoni M et al. Behavioral characterization of mice lacking GIRK/Kir3 channel subunits.
Genes Brain Behav., 2008 Jul , 7 (523-31).

134

11392

135

9469

137

3663

Cruz HG et al. Absence and rescue of morphine withdrawal in GIRK/Kir3 knock-out mice.
J. Neurosci., 2008 Apr 9 , 28 (4069-77).

138

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139

8034

140

8267

141

7840

143

18887

146

19134

Hassinen M et al. Cloning and expression of cardiac Kir2.1 and Kir2.2 channels in thermally acclimated rainbow trout.
Am. J. Physiol. Regul. Integr. Comp. Physiol., 2007 Jun , 292 (R2328-39).

147

16611

153

18765

154

18908

Panama BK et al. Heterogeneity of IK1 in the mouse heart.
Am. J. Physiol. Heart Circ. Physiol., 2007 Dec , 293 (H3558-67).

155

11575

157

5296

Steinecker B et al. The GIRK1 brain variant GIRK1d and its functional impact on heteromultimeric GIRK channels.
J. Recept. Signal Transduct. Res., 2007 , 27 (369-82).

159

16230

Grabe M et al. K+ channel selectivity depends on kinetic as well as thermodynamic factors.
Proc. Natl. Acad. Sci. U.S.A., 2006 Sep 26 , 103 (14361-6).

160

18589

Bichet D et al. Electrostatic interactions in the channel cavity as an important determinant of potassium channel selectivity.
Proc. Natl. Acad. Sci. U.S.A., 2006 Sep 26 , 103 (14355-60).

161

28210

Jantzi MC et al. Inward rectifying potassium channels facilitate cell-to-cell communication in hamster retractor muscle feed arteries.
Am. J. Physiol. Heart Circ. Physiol., 2006 Sep , 291 (H1319-28).

163

17684

166

14205

Kobayashi T et al. Inhibition of G protein-activated inwardly rectifying K+ channels by the antidepressant paroxetine.
J. Pharmacol. Sci., 2006 Nov , 102 (278-87).

167

25047

168

28127

Stasko MR et al. Hypothermic responses to 8-OH-DPAT in the Ts65Dn mouse model of Down syndrome.
Neuroreport, 2006 May 29 , 17 (837-41).

170

28952

Panama BK et al. Differential polyamine sensitivity in inwardly rectifying Kir2 potassium channels.
J. Physiol. (Lond.), 2006 Mar 1 , 571 (287-302).

171

23278

Kobayashi T et al. Inhibition of G protein-activated inwardly rectifying K+ channels by ifenprodil.
Neuropsychopharmacology, 2006 Mar , 31 (516-24).

173

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178

12282

182

28199

Kanjhan R et al. Tertiapin-Q blocks recombinant and native large conductance K+ channels in a use-dependent manner.
J. Pharmacol. Exp. Ther., 2005 Sep , 314 (1353-61).

184

20903

Fang Y et al. Functional expression of Kir2.x in human aortic endothelial cells: the dominant role of Kir2.2.
Am. J. Physiol., Cell Physiol., 2005 Nov , 289 (C1134-44).

185

21235

Fisher I et al. Prednisolone-induced changes in dystrophic skeletal muscle.
FASEB J., 2005 May , 19 (834-6).

188

22249

Cucullo L et al. Very low intensity alternating current decreases cell proliferation.
Glia, 2005 Jul , 51 (65-72).

190

30089

Collins A et al. Regulation of inward rectifier K+ channels by shift of intracellular pH dependence.
J. Cell. Physiol., 2005 Jan , 202 (76-86).

193

25457

Koyrakh L et al. Molecular and cellular diversity of neuronal G-protein-gated potassium channels.
J. Neurosci., 2005 Dec 7 , 25 (11468-78).

196

20386

Koike-Tani M et al. Signal transduction pathway for the substance P-induced inhibition of rat Kir3 (GIRK) channel.
J. Physiol. (Lond.), 2005 Apr 15 , 564 (489-500).

203

32939

204

39773

Kobayashi T et al. Inhibition of G protein-activated inwardly rectifying K+ channels by various antidepressant drugs.
Neuropsychopharmacology, 2004 Oct , 29 (1841-51).

208

37065

Pil J et al. Synthesis and electrophysiological characterization of cyclic morphiceptin analogues.
Biochem. Pharmacol., 2004 May 15 , 67 (1887-95).

209

36255

Bichet D et al. Evolving potassium channels by means of yeast selection reveals structural elements important for selectivity.
Proc. Natl. Acad. Sci. U.S.A., 2004 Mar 30 , 101 (4441-6).

210

38427

216

30979

Romanenko VG et al. Cholesterol sensitivity and lipid raft targeting of Kir2.1 channels.
Biophys. J., 2004 Dec , 87 (3850-61).

219

39224

222

32774

224

36222

Zhao Q et al. Interaction of G protein beta subunit with inward rectifier K(+) channel Kir3.
Mol. Pharmacol., 2003 Nov , 64 (1085-91).

225

40159

Pil J et al. Serine 329 of the mu-opioid receptor interacts differently with agonists.
J. Pharmacol. Exp. Ther., 2003 Mar , 304 (924-30).

226

44514

Kobayashi T et al. Inhibition of G protein-activated inwardly rectifying K+ channels by fluoxetine (Prozac).
Br. J. Pharmacol., 2003 Mar , 138 (1119-28).

227

42807

Karkanis T et al. Plasticity of KIR channels in human smooth muscle cells from internal thoracic artery.
Am. J. Physiol. Heart Circ. Physiol., 2003 Jun , 284 (H2325-34).

230

46886

Blednov YA et al. A pervasive mechanism for analgesia: activation of GIRK2 channels.
Proc. Natl. Acad. Sci. U.S.A., 2003 Jan 7 , 100 (277-82).

231

43426

232

45377

Prüss H et al. Kir2 potassium channels in rat striatum are strategically localized to control basal ganglia function.
Brain Res. Mol. Brain Res., 2003 Feb 20 , 110 (203-19).

234

40429

236

40269

237

44611

239

32076

Thiery E et al. Chromosome 21 KIR channels in brain development.
J. Neural Transm. Suppl., 2003 , (105-15).

241

41690

245

40900

Preisig-Müller R et al. Heteromerization of Kir2.x potassium channels contributes to the phenotype of Andersen's syndrome.
Proc. Natl. Acad. Sci. U.S.A., 2002 May 28 , 99 (7774-9).

246

47233

Suda S et al. Potassium channel mRNAs with AU-rich elements and brain-specific expression.
Biochem. Biophys. Res. Commun., 2002 Mar 15 , 291 (1265-71).

248

43334

249

47844

250

47874

251

45774

Harkins AB et al. Cell death in weaver mouse cerebellum.
Cerebellum, 2002 Jul , 1 (201-6).

252

40857

Kobayashi T et al. Functional characterization of an endogenous Xenopus oocyte adenosine receptor.
Br. J. Pharmacol., 2002 Jan , 135 (313-22).

253

46460

Bachmann A et al. Inhibition of cardiac potassium currents by pentobarbital.
Naunyn Schmiedebergs Arch. Pharmacol., 2002 Jan , 365 (29-37).

254

49079

Wickman K et al. Structural characterization of the mouse Girk genes.
Gene, 2002 Feb 6 , 284 (241-50).

255

49647

Blednov YA et al. Hyperactivity and dopamine D1 receptor activation in mice lacking girk2 channels.
Psychopharmacology (Berl.), 2002 Feb , 159 (370-8).

257

48439

Wickenden AD Potassium channels as anti-epileptic drug targets.
Neuropharmacology, 2002 Dec , 43 (1055-60).

258

46096

259

41869

Ozaki M et al. Degeneration of pontine mossy fibres during cerebellar development in weaver mutant mice.
Eur. J. Neurosci., 2002 Aug , 16 (565-74).

260

58511

Blednov YA et al. GIRK2 deficient mice. Evidence for hyperactivity and reduced anxiety.
Physiol. Behav., 2001 Sep 1-15 , 74 (109-17).

262

58883

Mascia MP et al. Does acetaldehyde mediate ethanol action in the central nervous system?
Alcohol. Clin. Exp. Res., 2001 Nov , 25 (1570-5).

263

52426

Zhou W et al. Mechanism underlying bupivacaine inhibition of G protein-gated inwardly rectifying K+ channels.
Proc. Natl. Acad. Sci. U.S.A., 2001 May 22 , 98 (6482-7).

264

51779

Salvador C et al. Functional properties of a truncated recombinant GIRK5 potassium channel.
Biochim. Biophys. Acta, 2001 May 2 , 1512 (135-47).

265

57358

Liu Y et al. Direct activation of an inwardly rectifying potassium channel by arachidonic acid.
Mol. Pharmacol., 2001 May , 59 (1061-8).

266

54530

Leonoudakis D et al. Inward rectifier potassium channel Kir2.2 is associated with synapse-associated protein SAP97.
J. Cell. Sci., 2001 Mar , 114 (987-98).

267

58256

272

54906

274

58632

276

57838

Medina I et al. A switch mechanism for G beta gamma activation of I(KACh).
J. Biol. Chem., 2000 Sep 22 , 275 (29709-16).

278

59538

Mark MD et al. G-protein mediated gating of inward-rectifier K+ channels.
Eur. J. Biochem., 2000 Oct , 267 (5830-6).

281

65486

Hou P et al. Impermeability of the GIRK2 weaver channel to divalent cations.
Am. J. Physiol., Cell Physiol., 2000 May , 278 (C1038-46).

282

135018

Kuryshev YA et al. KChAP as a chaperone for specific K(+) channels.
Am. J. Physiol., Cell Physiol., 2000 May , 278 (C931-41).

283

62615

287

54547

288

50206

Wickman K et al. Brain localization and behavioral impact of the G-protein-gated K+ channel subunit GIRK4.
J. Neurosci., 2000 Aug 1 , 20 (5608-15).

289

64321

Liesi P et al. Involvement of GIRK2 in postnatal development of the weaver cerebellum.
J. Neurosci. Res., 2000 Apr 15 , 60 (164-73).

290

61780

Harkins AB et al. Evidence of elevated intracellular calcium levels in weaver homozygote mice.
J. Physiol. (Lond.), 2000 Apr 15 , 524 Pt 2 (447-55).

291

62271

Wang H et al. Direct block of inward rectifier potassium channels by nicotine.
Toxicol. Appl. Pharmacol., 2000 Apr 1 , 164 (97-101).

293

68260

Jensen P et al. Rescue of cerebellar granule cells from death in weaver NR1 double mutants.
J. Neurosci., 1999 Sep 15 , 19 (7991-8).

295

68625

296

135132

Ho IH et al. Molecular mechanism for sodium-dependent activation of G protein-gated K+ channels.
J. Physiol. (Lond.), 1999 Nov 1 , 520 Pt 3 (645-51).

297

63084

299

64981

Ho IH et al. Molecular determinants for sodium-dependent activation of G protein-gated K+ channels.
J. Biol. Chem., 1999 Mar 26 , 274 (8639-48).

300

67530

Fernández-Fernández JM et al. Selective activation of heterologously expressed G protein-gated K+ channels by M2 muscarinic receptors in rat sympathetic neurones.
J. Physiol. (Lond.), 1999 Mar 15 , 515 ( Pt 3) (631-7).

301

65631

Bradley KK et al. Kir2.1 encodes the inward rectifier potassium channel in rat arterial smooth muscle cells.
J. Physiol. (Lond.), 1999 Mar 15 , 515 ( Pt 3) (639-51).

303

68213

304

61150

Ulens C et al. The dual modulation of GIRK1/GIRK2 channels by opioid receptor ligands.
Eur. J. Pharmacol., 1999 Dec 3 , 385 (239-45).

306

67889

Lewohl JM et al. G-protein-coupled inwardly rectifying potassium channels are targets of alcohol action.
Nat. Neurosci., 1999 Dec , 2 (1084-90).

307

66385

Kobayashi T et al. Ethanol opens G-protein-activated inwardly rectifying K+ channels.
Nat. Neurosci., 1999 Dec , 2 (1091-7).

309

66085

Stonehouse AH et al. Characterisation of Kir2.0 proteins in the rat cerebellum and hippocampus by polyclonal antibodies.
Histochem. Cell Biol., 1999 Dec , 112 (457-65).

311

69613

313

67206

Womack M et al. Elevated intracellular calcium levels in cerebellar granule neurons of weaver mice.
Neuroreport, 1998 Oct 26 , 9 (3391-5).

314

64141

316

73952

317

70797

Nakamura TY et al. Inhibition of rat ventricular IK1 with antisense oligonucleotides targeted to Kir2.1 mRNA.
Am. J. Physiol., 1998 Mar , 274 (H892-900).

318

71347

319

72640

Raab-Graham KF et al. Tetrameric subunit structure of the native brain inwardly rectifying potassium channel Kir 2.2.
J. Biol. Chem., 1998 Jul 31 , 273 (19699-707).

323

65901

Kuzhikandathil EV et al. Human dopamine D3 and D2L receptors couple to inward rectifier potassium channels in mammalian cell lines.
Mol. Cell. Neurosci., 1998 Dec , 12 (390-402).

329

78093

332

70750

334

71366

340

71019

Bjerregaard A et al. Weaver mutant mouse cerebellar granule cells respond normally to chronic depolarization.
Int. J. Dev. Neurosci., 1997 Apr , 15 (155-62).

341

73625

Karschin C et al. Ontogeny of gene expression of Kir channel subunits in the rat.
Mol. Cell. Neurosci., 1997 , 10 (131-48).

342

77387

344

135579

Surmeier DJ et al. The weaver mutation of GIRK2 results in a loss of inwardly rectifying K+ current in cerebellar granule cells.
Proc. Natl. Acad. Sci. U.S.A., 1996 Oct 1 , 93 (11191-5).

345

72773

346

71338

348

89182

Namba N et al. Kir2.2v: a possible negative regulator of the inwardly rectifying K+ channel Kir2.2.
FEBS Lett., 1996 May 20 , 386 (211-4).

349

84879

Yamashita T et al. Competition between Mg2+ and spermine for a cloned IRK2 channel expressed in a human cell line.
J. Physiol. (Lond.), 1996 May 15 , 493 ( Pt 1) (143-56).

351

72354

Navarro B et al. Nonselective and G betagamma-insensitive weaver K+ channels.
Science, 1996 Jun 28 , 272 (1950-3).

353

89356

356

82905

360

77579

Silverman SK et al. A regenerative link in the ionic fluxes through the weaver potassium channel underlies the pathophysiology of the mutation.
Proc. Natl. Acad. Sci. U.S.A., 1996 Dec 24 , 93 (15429-34).

361

79162

Cohen NA et al. Inhibition of an inward rectifier potassium channel (Kir2.3) by G-protein betagamma subunits.
J. Biol. Chem., 1996 Dec 13 , 271 (32301-5).

362

70902

368

86887

Bredt DS et al. Cloning and expression of two brain-specific inwardly rectifying potassium channels.
Proc. Natl. Acad. Sci. U.S.A., 1995 Jul 18 , 92 (6753-7).

369

80274

370

83595

Lesage F et al. Molecular properties of neuronal G-protein-activated inwardly rectifying K+ channels.
J. Biol. Chem., 1995 Dec 1 , 270 (28660-7).

371

87709

376

82954