Channelpedia

PubMed 8825650


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Cav2.1 , Cav2.2



Title: Chromosomal localization of the human genes for alpha 1A, alpha 1B, and alpha 1E voltage-dependent Ca2+ channel subunits.

Authors: S Diriong, P Lory, M E Williams, S B Ellis, M M Harpold, S Taviaux

Journal, date & volume: Genomics, 1995 Dec 10 , 30, 605-9

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/8825650


Abstract
The alpha 1 subunit genes encoding voltage-dependent Ca2+ channels are members of a gene family. We have used human brain cDNA probes to localize the neuronal isoform genes CACNL1A4 (alpha 1A), CACNL1A5 (alpha 1B), and CACNL1A6 (alpha 1E) to 19p13, 9q34, and 1q25-q31, respectively, using fluorescence in situ hybridization on human chromosomes. These genes are particularly interesting gene candidates in the pathogenesis of neuronal disorders. Although genetic disorders have been linked to loci 9q34 and 19p13, no genetic disease related to Ca2+ signaling defects has yet been linked to these loci.