Cav3.2

Description: calcium channel, voltage-dependent, T type, alpha 1H subunit
Gene: Cacna1h
Alias: cacna1h, cav3.2, ca3.2, Ca(v)3.2

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Introduction

Cav3.2 is a T type, low voltage activated (LVA) calcium channel found in neurons and many other tissues. It is also known as a1H.

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Gene

GeneID: 257648 Cacna1b calcium channel, voltage-dependent, N type, alpha 1B subunit [ Rattus norvegicus ]

Species	NCBI gene ID	Chromosome	Position
Human	8912	16	68662
Mouse	58226	17	62049
Rat	114862	10	58100

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Transcript

Species	NCBI accession	Length (nt)
Human	NM_021098.3	8219
Mouse	NM_021415.4	8240
Rat	NM_153814.2	7871

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Protein Isoforms

Species	Uniprot ID	Length (aa)
Human	O95180	2353
Mouse	O88427	2365
Rat	Q9EQ60	2359

Isoforms

Transcript

Length (nt)

Protein

Length (aa)

Variant

Isoform

Known

NM_021098.3

8219

NP_066921.2

2353

transcript variant 1

isoform a

NM_001005407.2

8201

NP_001005407.1

2347

transcript variant 2

isoform b

Predicted

XR_002957850.2

4325

transcript variant X13

XM_047434836.1

8412

XP_047290792.1

2092

transcript variant X7

isoform X7

XM_006720963.4

8234

XP_006721026.1

2358

transcript variant X1

isoform X1

XM_005255652.5

8201

XP_005255709.1

2347

transcript variant X2

isoform X2

XM_006720964.4

8186

XP_006721027.1

2342

transcript variant X4

isoform X4

XM_006720965.4

8168

XP_006721028.1

2336

transcript variant X5

isoform X5

XM_017023819.2

8195

XP_016879308.1

2345

transcript variant X3

isoform X3

XM_017023820.2

5590

XP_016879309.1

1691

transcript variant X8

isoform X8

XM_017023821.2

5501

XP_016879310.1

1691

transcript variant X9

isoform X8

XM_006720967.4

5362

XP_006721030.1

1618

transcript variant X10

isoform X9

XM_006720968.4

5344

XP_006721031.1

1612

transcript variant X11

isoform X10

XM_011522727.4

4569

XP_011521029.1

1283

transcript variant X12

isoform X11

XM_011522724.3

7394

XP_011521026.1

2176

transcript variant X6

isoform X6

XR_008484746.1

4325

transcript variant X13

XM_054314268.1

8412

XP_054170243.1

2092

transcript variant X7

isoform X7

XM_054314262.1

8234

XP_054170237.1

2358

transcript variant X1

isoform X1

XM_054314263.1

8201

XP_054170238.1

2347

transcript variant X2

isoform X2

XM_054314265.1

8186

XP_054170240.1

2342

transcript variant X4

isoform X4

XM_054314266.1

8168

XP_054170241.1

2336

transcript variant X5

isoform X5

XM_054314264.1

8195

XP_054170239.1

2345

transcript variant X3

isoform X3

XM_054314269.1

5590

XP_054170244.1

1691

transcript variant X8

isoform X8

XM_054314270.1

5501

XP_054170245.1

1691

transcript variant X9

isoform X8

XM_054314271.1

5362

XP_054170246.1

1618

transcript variant X10

isoform X9

XM_054314272.1

5344

XP_054170247.1

1612

transcript variant X11

isoform X10

XM_054314273.1

4569

XP_054170248.1

1283

transcript variant X12

isoform X11

XM_054314267.1

7394

XP_054170242.1

2176

transcript variant X6

isoform X6

Known

NM_001163691.1

8187

NP_001157163.1

2007

transcript variant 2

isoform 2

NM_021415.4

8240

NP_067390.4

2359

transcript variant 1

isoform 1

Predicted

XR_385353.4

10719

transcript variant X4

XR_385352.4

10737

transcript variant X3

XM_006524734.4

10799

XP_006524797.1

2365

transcript variant X2

isoform X2

XM_006524733.4

10805

XP_006524796.1

2367

transcript variant X1

isoform X1

XM_011246555.3

7721

XP_011244857.1

1577

transcript variant X5

isoform X3

Known

NM_153814.2

7871

NP_722521.1

2359

Predicted

XM_017596953.2

8011

XP_017452442.1

2359

transcript variant X4

isoform X4

XM_008767534.3

8026

XP_008765756.2

2364

transcript variant X3

isoform X3

XM_017596952.2

8029

XP_017452441.1

2365

transcript variant X2

isoform X2

XM_008767532.3

8044

XP_008765754.2

2370

transcript variant X1

isoform X1

XM_017596954.2

6801

XP_017452443.1

1961

transcript variant X5

isoform X5

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Post-Translational Modifications

PTM

Position

Type

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Structure

Cav3.2 predicted AlphaFold size

Species	Area (Å²)	Reference
Human	12995.63	source
Mouse	9552.46	source
Rat	10573.16	source

Methodology for AlphaFold size prediction and disclaimer are available here

References

103

Traboulsie A et al. Subunit-specific modulation of T-type calcium channels by zinc.
J. Physiol. (Lond.), 2007 Jan 1 , 578 (159-71).

108

Vitko I et al. Functional characterization and neuronal modeling of the effects of childhood absence epilepsy variants of CACNA1H, a T-type calcium channel.
J. Neurosci., 2005 May 11 , 25 (4844-55).

109

Ohkubo T et al. Identification and electrophysiological characteristics of isoforms of T-type calcium channel Ca(v)3.2 expressed in pregnant human uterus.
Cell. Physiol. Biochem., 2005 , 16 (245-54).

110

Kaku T et al. The gating and conductance properties of Cav3.2 low-voltage-activated T-type calcium channels.
Jpn. J. Physiol., 2003 Jun , 53 (165-72).

111

Autret L et al. The involvement of Cav3.2/alpha1H T-type calcium channels in excitability of mouse embryonic primary vestibular neurones.
J. Physiol. (Lond.), 2005 Aug 15 , 567 (67-78).

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Credits

Contributors: Rajnish Ranjan, Michael Schartner

To cite this page: [Contributors] Channelpedia https://channelpedia.epfl.ch/wikipages/86/ , accessed on 2024 Apr 16

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