Channelpedia

PubMed 9748855


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Cav2.1



Title: [Familial hemiplegic migraine]

Authors: L L Thomsen, J Olesen, M B Russell

Journal, date & volume: Ugeskr. Laeg., 1998 Sep 7 , 160, 5325-9

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/9748855


Abstract
Familial hemiplegic migraine (FHM) is a rare subtype of migraine with aura. It is inherited as an autosomal dominant trait. A gene for FHM has been assigned to chromosome 19. This gene codes for a brain-specific calcium channel, and is responsible for FHM in 55% of the FHM families. Other FHM families have been linked to two different locations on chromosome 1. These locations contain possible candidate genes coding for calcium-and potassium channels. Thus FHM is a genetically heterogenous ion channel disorder, which is caused by at least three different genes. About 29% of the FHM families also have cerebellar ataxia, these families have all been linked to chromosome 19. The identification of the genes for FHM may be a key to the identification of the gene/genes for migraine with and without aura.