Channelpedia

Kv11

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Gene

The voltage-gated K+ channels of the EAG (ether-à-go-go) family consist of three subfamilies: eag, elk (eag-like) and erg (eag-related gene).

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Protein Isoforms

The erg subfamily consists of three members: erg1, erg2 (aka. Kv11.2) and erg3 [789], [790], [791]. These subunits may form homomultimeric channels, but they are also able to form heteromultimers within their subfamily [792].

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Function

Erg channels play critical roles in regulating the resting membrane potential [780], [781], action potential duration [782], spike frequency adaptation [797] and hormone secretion [797]. Due to a Per-Arnt-Sim domain in the N-terminus of erg channel subunits, even a role in O2-sensing has been discussed [783]. The different physiological roles of erg channels are enabled by their peculiar gating [325].

References

Wimmers S et al. Biophysical properties of heteromultimeric erg K+ channels.
Pflugers Arch., 2002 Dec , 445 (423-30).

Akbarali HI et al. Role of HERG-like K(+) currents in opossum esophageal circular smooth muscle.
Am. J. Physiol., 1999 Dec , 277 (C1284-90).

Bauer CK et al. A functional role of the erg-like inward-rectifying K+ current in prolactin secretion from rat lactotrophs.
Mol. Cell. Endocrinol., 1999 Feb 25 , 148 (37-45).

Sanguinetti MC et al. A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel.
Cell, 1995 Apr 21 , 81 (299-307).

Overholt JL et al. HERG-Like potassium current regulates the resting membrane potential in glomus cells of the rabbit carotid body.
J. Neurophysiol., 2000 Mar , 83 (1150-7).

Bauer CK et al. RERG is a molecular correlate of the inward-rectifying K current in clonal rat pituitary cells.
Recept. Channels, 1998 , 6 (19-29).

Shi W et al. Identification of two nervous system-specific members of the erg potassium channel gene family.
J. Neurosci., 1997 Dec 15 , 17 (9423-32).

Warmke JW et al. A family of potassium channel genes related to eag in Drosophila and mammals.
Proc. Natl. Acad. Sci. U.S.A., 1994 Apr 12 , 91 (3438-42).

Wimmers S et al. Erg1, erg2 and erg3 K channel subunits are able to form heteromultimers.
Pflugers Arch., 2001 Jan , 441 (450-5).

Chiesa N et al. A novel role for HERG K+ channels: spike-frequency adaptation.
J. Physiol. (Lond.), 1997 Jun 1 , 501 ( Pt 2) (313-8).

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Credits

To cite this page: [Contributors] Channelpedia https://channelpedia.epfl.ch/wikipages/202/ , accessed on 2024 Apr 25

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