Channelpedia

Kv11

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Gene

The voltage-gated K+ channels of the EAG (ether-à-go-go) family consist of three subfamilies: eag, elk (eag-like) and erg (eag-related gene).


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Protein Isoforms

The erg subfamily consists of three members: erg1, erg2 (aka. Kv11.2) and erg3 [789], [790], [791]. These subunits may form homomultimeric channels, but they are also able to form heteromultimers within their subfamily [792].


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Function

Erg channels play critical roles in regulating the resting membrane potential [780], [781], action potential duration [782], spike frequency adaptation [797] and hormone secretion [797]. Due to a Per-Arnt-Sim domain in the N-terminus of erg channel subunits, even a role in O2-sensing has been discussed [783]. The different physiological roles of erg channels are enabled by their peculiar gating [325].


References

325

Wimmers S et al. Biophysical properties of heteromultimeric erg K+ channels.
Pflugers Arch., 2002 Dec , 445 (423-30).

780

Akbarali HI et al. Role of HERG-like K(+) currents in opossum esophageal circular smooth muscle.
Am. J. Physiol., 1999 Dec , 277 (C1284-90).

781

791

Warmke JW et al. A family of potassium channel genes related to eag in Drosophila and mammals.
Proc. Natl. Acad. Sci. U.S.A., 1994 Apr 12 , 91 (3438-42).

792

Wimmers S et al. Erg1, erg2 and erg3 K channel subunits are able to form heteromultimers.
Pflugers Arch., 2001 Jan , 441 (450-5).

797

Chiesa N et al. A novel role for HERG K+ channels: spike-frequency adaptation.
J. Physiol. (Lond.), 1997 Jun 1 , 501 ( Pt 2) (313-8).


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Credits

To cite this page: [Contributors] Channelpedia https://channelpedia.epfl.ch/wikipages/202/ , accessed on 2024 Dec 12



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