Kv11
The voltage-gated K+ channels of the EAG (ether-à-go-go) family consist of three subfamilies: eag, elk (eag-like) and erg (eag-related gene).
The erg subfamily consists of three members: erg1, erg2 (aka. Kv11.2) and erg3 [789], [790], [791]. These subunits may form homomultimeric channels, but they are also able to form heteromultimers within their subfamily [792].
Erg channels play critical roles in regulating the resting membrane potential [780], [781], action potential duration [782], spike frequency adaptation [797] and hormone secretion [797]. Due to a Per-Arnt-Sim domain in the N-terminus of erg channel subunits, even a role in O2-sensing has been discussed [783]. The different physiological roles of erg channels are enabled by their peculiar gating [325].
References
Wimmers S
et al.
Biophysical properties of heteromultimeric erg K+ channels.
Pflugers Arch.,
2002
Dec
, 445 (423-30).
Akbarali HI
et al.
Role of HERG-like K(+) currents in opossum esophageal circular smooth muscle.
Am. J. Physiol.,
1999
Dec
, 277 (C1284-90).
Bauer CK
et al.
A functional role of the erg-like inward-rectifying K+ current in prolactin secretion from rat lactotrophs.
Mol. Cell. Endocrinol.,
1999
Feb
25
, 148 (37-45).
Sanguinetti MC
et al.
A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel.
Cell,
1995
Apr
21
, 81 (299-307).
Overholt JL
et al.
HERG-Like potassium current regulates the resting membrane potential in glomus cells of the rabbit carotid body.
J. Neurophysiol.,
2000
Mar
, 83 (1150-7).
Bauer CK
et al.
RERG is a molecular correlate of the inward-rectifying K current in clonal rat pituitary cells.
Recept. Channels,
1998
, 6 (19-29).
Shi W
et al.
Identification of two nervous system-specific members of the erg potassium channel gene family.
J. Neurosci.,
1997
Dec
15
, 17 (9423-32).
Warmke JW
et al.
A family of potassium channel genes related to eag in Drosophila and mammals.
Proc. Natl. Acad. Sci. U.S.A.,
1994
Apr
12
, 91 (3438-42).
Wimmers S
et al.
Erg1, erg2 and erg3 K channel subunits are able to form heteromultimers.
Pflugers Arch.,
2001
Jan
, 441 (450-5).
Chiesa N
et al.
A novel role for HERG K+ channels: spike-frequency adaptation.
J. Physiol. (Lond.),
1997
Jun
1
, 501 ( Pt 2) (313-8).
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