TRPC4

1

Perrouin Verbe MA et al. Expression of store-operated channel components in prostate cancer: the prognostic paradox.
Hum. Pathol., 2016 Mar , 49 (77-82).

2

Gaunt HJ et al. Transient receptor potential canonical 4 and 5 proteins as targets in cancer therapeutics.
Eur. Biophys. J., 2016 Jun 11 , ().

3

Thakur DP et al. Critical roles of Gi/o proteins and phospholipase C-δ1 in the activation of receptor-operated TRPC4 channels.
Proc. Natl. Acad. Sci. U.S.A., 2016 Jan 26 , 113 (1092-7).

4

Marshall-Gradisnik S et al. Natural killer cells and single nucleotide polymorphisms of specific ion channels and receptor genes in myalgic encephalomyelitis/chronic fatigue syndrome.
Appl Clin Genet, 2016 , 9 (39-47).

5

Gopal S et al. Transmembrane proteoglycans control stretch-activated channels to set cytosolic calcium levels.
J. Cell Biol., 2015 Sep 28 , 210 (1199-211).

6

Camacho Londoño JE et al. A background Ca2+ entry pathway mediated by TRPC1/TRPC4 is critical for development of pathological cardiac remodelling.
Eur. Heart J., 2015 Sep 1 , 36 (2257-66).

7

Wei H et al. Regulation of neuropathic pain behavior by amygdaloid TRPC4/C5 channels.
Neurosci. Lett., 2015 Nov 3 , 608 (12-7).

8

Lin XH et al. Upregulation of TRPC1/6 may be involved in arterial remodeling in rat.
J. Surg. Res., 2015 May 1 , 195 (334-43).

9

De Clercq K et al. Functional expression of transient receptor potential channels in human endometrial stromal cells during the luteal phase of the menstrual cycle.
Hum. Reprod., 2015 Mar 27 , ().

10

Akbulut Y et al. (-)-Englerin A is a Potent and Selective Activator of TRPC4 and TRPC5 Calcium Channels.
Angew. Chem. Int. Ed. Engl., 2015 Mar 16 , 54 (3787-91).

11

Louhivuori LM et al. Transient receptor potential channels and their role in modulating radial glial-neuronal interaction: a signaling pathway involving mGluR5.
Stem Cells Dev., 2015 Mar 15 , 24 (701-13).

12

Kurahara LH et al. Intestinal myofibroblast TRPC6 channel may contribute to stenotic fibrosis in Crohn's disease.
Inflamm. Bowel Dis., 2015 Mar , 21 (496-506).

13

Myeong J et al. Close spatio-association of the transient receptor potential canonical 4 (TRPC4) channel with Gαi in TRPC4 activation process.
Am. J. Physiol., Cell Physiol., 2015 Jun 1 , 308 (C879-89).

14

Zhu Y et al. Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels.
Br. J. Pharmacol., 2015 Jul , 172 (3495-509).

15

Maier T et al. Discovery and pharmacological characterization of a novel potent inhibitor of diacylglycerol-sensitive TRPC cation channels.
Br. J. Pharmacol., 2015 Jul , 172 (3650-60).

16

Fu J et al. Canonical transient receptor potential 4 and its small molecule modulators.
Sci China Life Sci, 2015 Jan , 58 (39-47).

17

Isshiki M [Bone and Calcium Research Update 2015. Intracellular Ca2+ regulation in endothelial cells].
Clin Calcium, 2015 Jan , 25 (69-78).

18

Xu N et al. Sodium entry through endothelial store-operated calcium entry channels: regulation by Orai1.
Am. J. Physiol., Cell Physiol., 2015 Feb 15 , 308 (C277-88).

19

Song HB et al. Suppression of transient receptor potential canonical channel 4 inhibits vascular endothelial growth factor-induced retinal neovascularization.
Cell Calcium, 2015 Feb , 57 (101-8).

20

Zhang L et al. Novel role for TRPC4 in regulation of macroautophagy by a small molecule in vascular endothelial cells.
Biochim. Biophys. Acta, 2015 Feb , 1853 (377-87).

21

Woo JS et al. Interaction between mitsugumin 29 and TRPC3 participates in regulating Ca(2+) transients in skeletal muscle.
Biochem. Biophys. Res. Commun., 2015 Aug 14 , 464 (133-9).

22

Carson C et al. Englerin A Agonizes the TRPC4/C5 Cation Channels to Inhibit Tumor Cell Line Proliferation.
PLoS ONE, 2015 , 10 (e0127498).

23

Nazıroğlu M et al. Psychiatric Disorders and TRP Channels: Focus on Psychotropic Drugs.
Curr Neuropharmacol, 2015 , 13 (248-57).

24

Yang LP et al. Acute Treatment with a Novel TRPC4/C5 Channel Inhibitor Produces Antidepressant and Anxiolytic-Like Effects in Mice.
PLoS ONE, 2015 , 10 (e0136255).

25

Wie J et al. The Roles of Rasd1 small G proteins and leptin in the activation of TRPC4 transient receptor potential channels.
Channels (Austin), 2015 , 9 (186-95).

26

Kang HJ et al. Selectivity and evolutionary divergence of metabotropic glutamate receptors for endogenous ligands and G proteins coupled to phospholipase C or TRP channels.
J. Biol. Chem., 2014 Oct 24 , 289 (29961-74).

27

Cooley N et al. The phosphatidylinositol(4,5)bisphosphate-binding sequence of transient receptor potential channel canonical 4α is critical for its contribution to cardiomyocyte hypertrophy.
Mol. Pharmacol., 2014 Oct , 86 (399-405).

28

Richter JM et al. Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5.
Mol. Pharmacol., 2014 Nov , 86 (514-21).

29

Kolaj M et al. Novel coupling between TRPC-like and KNa channels modulates low threshold spike-induced afterpotentials in rat thalamic midline neurons.
Neuropharmacology, 2014 Nov , 86 (88-96).

30

Riccio A et al. Decreased anxiety-like behavior and Gαq/11-dependent responses in the amygdala of mice lacking TRPC4 channels.
J. Neurosci., 2014 Mar 5 , 34 (3653-67).

31

Nedungadi TP et al. Differential regulation of TRPC4 in the vasopressin magnocellular system by water deprivation and hepatic cirrhosis in the rat.
Am. J. Physiol. Regul. Integr. Comp. Physiol., 2014 Mar 1 , 306 (R304-14).

32

Ulasli M et al. The effects of Nigella sativa (Ns), Anthemis hyalina (Ah) and Citrus sinensis (Cs) extracts on the replication of coronavirus and the expression of TRP genes family.
Mol. Biol. Rep., 2014 Mar , 41 (1703-11).

33

Zhao PY et al. TRP Channels Localize to Subdomains of the Apical Plasma Membrane in Human Fetal Retinal Pigment Epithelium.
Invest. Ophthalmol. Vis. Sci., 2014 Mar , 56 (1916-23).

34

Kim J et al. Isoform- and receptor-specific channel property of canonical transient receptor potential (TRPC)1/4 channels.
Pflugers Arch., 2014 Mar , 466 (491-504).

35

Tian J et al. Dual depolarization responses generated within the same lateral septal neurons by TRPC4-containing channels.
Pflugers Arch., 2014 Jul , 466 (1301-16).

36

Sepúlveda JC et al. Cell senescence abrogates the therapeutic potential of human mesenchymal stem cells in the lethal endotoxemia model.
Stem Cells, 2014 Jul , 32 (1865-77).

37

Sung HH et al. Increased expression of TRPC4 channels associated with erectile dysfunction in diabetes.
Andrology, 2014 Jul , 2 (550-8).

38

Westlund KN et al. A rat knockout model implicates TRPC4 in visceral pain sensation.
Neuroscience, 2014 Jan 3 , ().

39

Rønnekleiv OK et al. Kisspeptin and Gonadotropin-Releasing Hormone Neuronal Excitability: Molecular Mechanisms Driven by 17β-Estradiol.
Neuroendocrinology, 2014 Dec 8 , ().

40

Myeong J et al. Identification of a membrane-targeting domain of the transient receptor potential canonical (TRPC)4 channel unrelated to its formation of a tetrameric structure.
J. Biol. Chem., 2014 Dec 12 , 289 (34990-5002).

41

Makarewich CA et al. Transient receptor potential channels contribute to pathological structural and functional remodeling after myocardial infarction.
Circ. Res., 2014 Aug 29 , 115 (567-80).

42

Zimmermann J et al. Trans-activation response (TAR) RNA-binding protein 2 is a novel modulator of transient receptor potential canonical 4 (TRPC4) protein.
J. Biol. Chem., 2014 Apr 4 , 289 (9766-80).

43

Ronco V et al. Differential deregulation of astrocytic calcium signalling by amyloid-β, TNFα, IL-1β and LPS.
Cell Calcium, 2014 Apr , 55 (219-29).

44

Freichel M et al. TRPC4- and TRPC4-containing channels.
Handb Exp Pharmacol, 2014 , 222 (85-128).

45

Meng K et al. Calcium sensing receptor modulates extracellular calcium entry and proliferation via TRPC3/6 channels in cultured human mesangial cells.
PLoS ONE, 2014 , 9 (e98777).

46

Dragoni S et al. Enhanced expression of Stim, Orai, and TRPC transcripts and proteins in endothelial progenitor cells isolated from patients with primary myelofibrosis.
PLoS ONE, 2014 , 9 (e91099).

47

Zholos AV TRPC5.
Handb Exp Pharmacol, 2014 , 222 (129-56).

48

Zufall F TRPs in olfaction.
Handb Exp Pharmacol, 2014 , 223 (917-33).

49

Zhang L et al. GIRK-like and TRPC-like conductances mediate thyrotropin-releasing hormone-induced increases in excitability in thalamic paraventricular nucleus neurons.
Neuropharmacology, 2013 Sep , 72 (106-15).

50

Li W et al. Transient alterations of the blood-brain barrier tight junction and receptor potential channel gene expression by chlorpyrifos.
J Appl Toxicol, 2013 Oct , 33 (1187-91).

51

Jeon JP et al. Activation of TRPC4β by Gαi subunit increases Ca(2+) selectivity and controls neurite morphogenesis in cultured hippocampal neuron.
Cell Calcium, 2013 Oct , 54 (307-19).

52

Zhang Y et al. Bone morphogenetic protein 2 decreases TRPC expression, store-operated Ca(2+) entry, and basal [Ca(2+)]i in rat distal pulmonary arterial smooth muscle cells.
Am. J. Physiol., Cell Physiol., 2013 May 1 , 304 (C833-43).

53

Bon RS et al. In pursuit of small molecule chemistry for calcium-permeable non-selective TRPC channels - mirage or pot of gold?
Br. J. Pharmacol., 2013 Jun 14 , ().

54

Antigny F et al. During post-natal human myogenesis, normal myotube size requires TRPC1- and TRPC4-mediated Ca²⁺ entry.
J. Cell. Sci., 2013 Jun 1 , 126 (2525-33).

55

Beck A et al. Conserved Gating Elements in TRPC4 and TRPC5 Channels.
J. Biol. Chem., 2013 Jul 5 , 288 (19471-83).

56

Kim H et al. An essential role of PI(4,5)P₂ for maintaining the activity of the transient receptor potential canonical (TRPC)4β.
Pflugers Arch., 2013 Jul , 465 (1011-21).

57

Bosch MA et al. mRNA Expression of Ion Channels in GnRH Neurons: Subtype-Specific Regulation by 17β-Estradiol.
Mol. Cell. Endocrinol., 2013 Jan 7 , ().

58

Yang Y et al. Wakayama symposium: dependence of corneal epithelial homeostasis on transient receptor potential function.
Ocul Surf, 2013 Jan , 11 (8-11).

59

Zeng B et al. TRPC channels and their splice variants are essential for promoting human ovarian cancer cell proliferation and tumorigenesis.
Curr Cancer Drug Targets, 2013 Jan , 13 (103-16).

60

Green EK et al. Replication of bipolar disorder susceptibility alleles and identification of two novel genome-wide significant associations in a new bipolar disorder case-control sample.
Mol. Psychiatry, 2013 Dec , 18 (1302-7).

61

Alzoubi A et al. TRPC4 inactivation confers a survival benefit in severe pulmonary arterial hypertension.
Am. J. Pathol., 2013 Dec , 183 (1779-88).

62

Li X et al. BMP4 increases canonical transient receptor potential protein expression by activating p38 MAPK and ERK1/2 signaling pathways in pulmonary arterial smooth muscle cells.
Am. J. Respir. Cell Mol. Biol., 2013 Aug , 49 (212-20).

63

Zhang C et al. Kisspeptin activation of TRPC4 channels in female GnRH neurons requires PIP2 depletion and cSrc kinase activation.
Endocrinology, 2013 Aug , 154 (2772-83).

64

Parrau D et al. Store-operated channels in the pulmonary circulation of high- and low-altitude neonatal lambs.
Am. J. Physiol. Lung Cell Mol. Physiol., 2013 Apr 15 , 304 (L540-8).

65

Cheng KT et al. Contribution and regulation of TRPC channels in store-operated Ca2+ entry.
Curr Top Membr, 2013 , 71 (149-79).

66

Vandewauw I et al. Systematic and quantitative mRNA expression analysis of TRP channel genes at the single trigeminal and dorsal root ganglion level in mouse.
BMC Neurosci, 2013 , 14 (21).

67

Bishnoi M et al. Expression of multiple Transient Receptor Potential channel genes in murine 3T3-L1 cell lines and adipose tissue.
Pharmacol Rep, 2013 , 65 (751-5).

68

Boudes M et al. Crucial role of TRPC1 and TRPC4 in cystitis-induced neuronal sprouting and bladder overactivity.
PLoS ONE, 2013 , 8 (e69550).

69

Jiang HN et al. Involvement of TRPC channels in lung cancer cell differentiation and the correlation analysis in human non-small cell lung cancer.
PLoS ONE, 2013 , 8 (e67637).

70

Eisinger BE et al. Large scale expression changes of genes related to neuronal signaling and developmental processes found in lateral septum of postpartum outbred mice.
PLoS ONE, 2013 , 8 (e63824).

71

Kim H et al. The roles of G proteins in the activation of TRPC4 and TRPC5 transient receptor potential channels.
Channels (Austin), 2012 Sep-Oct , 6 (333-43).

72

Lee JE et al. Mass spectrometric analysis of novel phosphorylation sites in the TRPC4β channel.
Rapid Commun. Mass Spectrom., 2012 Sep 15 , 26 (1965-70).

73

Schindl R et al. Canonical transient receptor potential (TRPC) 1 acts as a negative regulator for vanilloid TRPV6-mediated Ca2+ influx.
J. Biol. Chem., 2012 Oct 12 , 287 (35612-20).

74

Cioffi DL et al. Orai1 determines calcium selectivity of an endogenous TRPC heterotetramer channel.
Circ. Res., 2012 May 25 , 110 (1435-44).

75

Jeon JP et al. Selective Gαi subunits as novel direct activators of transient receptor potential canonical (TRPC)4 and TRPC5 channels.
J. Biol. Chem., 2012 May 18 , 287 (17029-39).

76

Phelan KD et al. Heteromeric canonical transient receptor potential 1 and 4 channels play a critical role in epileptiform burst firing and seizure-induced neurodegeneration.
Mol. Pharmacol., 2012 Mar , 81 (384-92).

77

Balbuena P et al. Malathion/oxon and lead acetate increase gene expression and protein levels of transient receptor potential canonical channel subunits TRPC1 and TRPC4 in rat endothelial cells of the blood-brain barrier.
Int. J. Toxicol., 2012 Jun , 31 (238-49).

78

Kučka M et al. Dependence of spontaneous electrical activity and basal prolactin release on nonselective cation channels in pituitary lactotrophs.
Physiol Res, 2012 Jul 20 , 61 (267-75).

79

Jiang H et al. Effect of non-steroidal anti-inflammatory drugs and new fenamate analogues on TRPC4 and TRPC5 channels.
, 2012 Jan 20 , ().

80

Xu SZ et al. Activation of TRPC cationic channels by mercurial compounds confers the cytotoxicity of mercury exposure.
Toxicol. Sci., 2012 Jan , 125 (56-68).

81

Liu XR et al. Enhanced store-operated Ca²+ entry and TRPC channel expression in pulmonary arteries of monocrotaline-induced pulmonary hypertensive rats.
Am. J. Physiol., Cell Physiol., 2012 Jan , 302 (C77-87).

82

Antigny F et al. Transient receptor potential canonical channels are required for in vitro endothelial tube formation.
J. Biol. Chem., 2012 Feb 17 , 287 (5917-27).

83

Stroh O et al. NMDA receptor-dependent synaptic activation of TRPC channels in olfactory bulb granule cells.
J. Neurosci., 2012 Apr 25 , 32 (5737-46).

84

Sundivakkam PC et al. The Ca(2+) sensor stromal interaction molecule 1 (STIM1) is necessary and sufficient for the store-operated Ca(2+) entry function of transient receptor potential canonical (TRPC) 1 and 4 channels in endothelial cells.
Mol. Pharmacol., 2012 Apr , 81 (510-26).

85

Miller M et al. Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels.
J. Biol. Chem., 2011 Sep 23 , 286 (33436-46).

86

Tai C et al. Plasma membrane insertion of TRPC5 channels contributes to the cholinergic plateau potential in hippocampal CA1 pyramidal neurons.
Hippocampus, 2011 Sep , 21 (958-67).

87

Sung TS et al. Molecular determinants of PKA-dependent inhibition of TRPC5 channel.
Am. J. Physiol., Cell Physiol., 2011 Oct , 301 (C823-32).

88

Holzer P Transient receptor potential (TRP) channels as drug targets for diseases of the digestive system.
, 2011 Mar 17 , ().

89

Park KS et al. Identification and functional characterization of ion channels in CD34(+) hematopoietic stem cells from human peripheral blood.
, 2011 Jun 1 , ().

90

Sousa CT et al. Sildenafil decreases rat tracheal hyperresponsiveness to carbachol and changes canonical transient receptor potential gene expression after antigen challenge.
Braz. J. Med. Biol. Res., 2011 Jun , 44 (562-72).

91

Suzuki Y et al. Involvement of TRP channels in the signal transduction of bradykinin in human osteoblasts.
Biochem. Biophys. Res. Commun., 2011 Jul 1 , 410 (317-21).

92

Holzer P TRP channels in the digestive system.
Curr Pharm Biotechnol, 2011 Jan 1 , 12 (24-34).

93

Zhang DX et al. Transient receptor potential channel activation and endothelium-dependent dilation in the systemic circulation.
J. Cardiovasc. Pharmacol., 2011 Feb , 57 (133-9).

94

Gilliam JC et al. TRP channel gene expression in the mouse retina.
Vision Res., 2011 Dec 8 , 51 (2440-52).

95

Jung C et al. A gain-of-function SNP in TRPC4 cation channel protects against myocardial infarction.
Cardiovasc. Res., 2011 Aug 1 , 91 (465-71).

96

Tomic M et al. Role of nonselective cation channels in spontaneous and protein kinase A-stimulated calcium signaling in pituitary cells.
Am. J. Physiol. Endocrinol. Metab., 2011 Aug , 301 (E370-9).

97

Zhang Z et al. TRPC channels underlie cholinergic plateau potentials and persistent activity in entorhinal cortex.
Hippocampus, 2011 Apr , 21 (386-97).

98

Leuner K et al. Reduced TRPC channel expression in psoriatic keratinocytes is associated with impaired differentiation and enhanced proliferation.
PLoS ONE, 2011 , 6 (e14716).

99

Cheng KT et al. Contribution of TRPC1 and Orai1 to Ca(2+) entry activated by store depletion.
Adv. Exp. Med. Biol., 2011 , 704 (435-49).

100

Sánchez-Hernández Y et al. Store-operated Ca(2+) entry is expressed in human endothelial progenitor cells.
Stem Cells Dev., 2010 Dec , 19 (1967-81).

101

Kojima A et al. Ca2+ paradox injury mediated through TRPC channels in mouse ventricular myocytes.
Br. J. Pharmacol., 2010 Dec , 161 (1734-50).

102

Cvetkovic-Lopes V et al. Rat hypocretin/orexin neurons are maintained in a depolarized state by TRPC channels.
PLoS ONE, 2010 , 5 (e15673).