TRPML1

Gene: Mcoln1
Alias: TRPML1, Mcoln1, mucolipin, TRP, cation, channel, 1

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Gene

Species	NCBI gene ID	Chromosome	Position
Human	57192	19	11385
Mouse	94178	8	14774
Rat	288371	12	13911

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Transcript

Species	NCBI accession	Length (nt)
Human	NM_020533.3	2084
Mouse	NM_053177.1	2039
Rat	NM_001105903.1	2070

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Protein Isoforms

Species	Uniprot ID	Length (aa)
Human	Q9GZU1	580
Mouse	Q99J21	580
Rat	D3ZRF9	605

Isoforms

Transcript

Length (nt)

Protein

Length (aa)

Variant

Isoform

Known

NM_001105903.1

2070

NP_001099373.1

580

Predicted

XR_005491605.1

1384

transcript variant X11

XR_005491602.1

2137

transcript variant X6

XR_005491604.1

2011

transcript variant X9

XR_005491603.1

1468

transcript variant X7

XM_039089143.1

1980

XP_038945071.1

551

transcript variant X5

isoform X5

XM_006248754.4

2185

XP_006248816.1

620

transcript variant X1

isoform X1

XM_006248755.4

2138

XP_006248817.1

605

transcript variant X2

isoform X2

XM_006248756.4

2107

XP_006248818.1

595

transcript variant X4

isoform X4

XM_039089142.1

2105

XP_038945070.1

604

transcript variant X3

isoform X3

XM_039089144.1

1458

XP_038945072.1

380

transcript variant X8

isoform X6

XM_039089145.1

1251

XP_038945073.1

311

transcript variant X10

isoform X7

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Post-Translational Modifications

PTM

Position

Type

Modified residue

Phosphoserine

Modified residue

557

Phosphoserine; by PAK

Modified residue

559

Phosphoserine; by PAK

Glycosylation

230

N-linked (GlcNAc...) asparagine

Disulfide bond

Modified residue

Phosphoserine

Modified residue

557

Phosphoserine

Modified residue

559

Phosphoserine; by PAK

Glycosylation

220

N-linked (GlcNAc...) asparagine

Glycosylation

230

N-linked (GlcNAc...) asparagine

Disulfide bond

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Structure

TRPML1 predicted AlphaFold size

Species	Area (Å²)	Reference
Human	4900.18	source
Mouse	5097.62	source
Rat	4141.71	source

Methodology for AlphaFold size prediction and disclaimer are available here

References

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Credits

To cite this page: [Contributors] Channelpedia https://channelpedia.epfl.ch/wikipages/185/ , accessed on 2024 Dec 21

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