Nav1.2

1

Tao H et al. Molecular determinant for the tarantula toxin Jingzhaotoxin-I slowing the fast inactivation of voltage-gated sodium channels.
Toxicon, 2016 Mar 1 , 111 (13-21).

2

Rogers M et al. Characterization of Endogenous Sodium Channels in the ND7-23 Neuroblastoma Cell Line: Implications for Use as a Heterologous Ion Channel Expression System Suitable for Automated Patch Clamp Screening.
Assay Drug Dev Technol, 2016 Mar , 14 (109-30).

3

Arias HR et al. Positive allosteric modulators of α7 nicotinic acetylcholine receptors affect neither the function of other ligand- and voltage-gated ion channels and acetylcholinesterase, nor β-amyloid content.
Int. J. Biochem. Cell Biol., 2016 Jul , 76 (19-30).

4

Green BR et al. Structural Basis for the Inhibition of Voltage-gated Sodium Channels by Conotoxin μO§-GVIIJ.
J. Biol. Chem., 2016 Jan 27 , ().

5

Benned-Jensen T et al. Live Imaging of Kv7.2/7.3 Cell Surface Dynamics at the Axon Initial Segment: High Steady-State Stability and Calpain-Dependent Excitotoxic Downregulation Revealed.
J. Neurosci., 2016 Feb 17 , 36 (2261-6).

6

Murenzi E et al. Evaluation of microtransplantation of rat brain neurolemma into Xenopus laevis oocytes as a technique to study the effect of neurotoxicants on endogenous voltage-sensitive ion channels.
Neurotoxicology, 2016 Apr 7 , ().

7

Branch SY et al. Dopaminergic Neurons Exhibit an Age-Dependent Decline in Electrophysiological Parameters in the MitoPark Mouse Model of Parkinson's Disease.
J. Neurosci., 2016 Apr 6 , 36 (4026-37).

8

Shcherbatko A et al. Engineering Highly Potent and Selective Microproteins Against Nav1.7 Sodium Channel for Treatment of Pain.
J. Biol. Chem., 2016 Apr 22 , ().

9

Wildburger NC et al. Quantitative proteomics reveals protein-protein interactions with fibroblast growth factor 12 as a component of the voltage-gated sodium channel 1.2 (nav1.2) macromolecular complex in Mammalian brain.
Mol. Cell Proteomics, 2015 May , 14 (1288-300).

10

Mishra S et al. Contribution of sodium channel neuronal isoform Nav1.1 to late sodium current in ventricular myocytes from failing hearts.
J. Physiol. (Lond.), 2015 Mar 15 , 593 (1409-27).

11

Gazina EV et al. 'Neonatal' Nav1.2 reduces neuronal excitability and affects seizure susceptibility and behaviour.
Hum. Mol. Genet., 2015 Mar 1 , 24 (1457-68).

12

Zhang MM et al. Probing the Redox States of Sodium Channel Cysteines at the Binding Site of μO§-Conotoxin GVIIJ.
Biochemistry, 2015 Jun 30 , 54 (3911-20).

13

Cai T et al. Mapping the interaction site for the tarantula toxin hainantoxin-IV (β-TRTX-Hn2a) in the voltage sensor module of domain II of voltage-gated sodium channels.
Peptides, 2015 Jun , 68 (148-56).

14

Fukasawa T et al. A case of recurrent encephalopathy with SCN2A missense mutation.
Brain Dev., 2015 Jun , 37 (631-4).

15

Xu M et al. An Ankyrin-G N-terminal Gate and Protein Kinase CK2 Dually Regulate Binding of Voltage-gated Sodium and KCNQ2/3 Potassium Channels.
J. Biol. Chem., 2015 Jul 3 , 290 (16619-32).

16

Pucca MB et al. Revealing the Function and the Structural Model of Ts4: Insights into the "Non-Toxic" Toxin from Tityus serrulatus Venom.
Toxins (Basel), 2015 Jul , 7 (2534-50).

17

Chow CY et al. Three Peptide Modulators of the Human Voltage-Gated Sodium Channel 1.7, an Important Analgesic Target, from the Venom of an Australian Tarantula.
Toxins (Basel), 2015 Jul , 7 (2494-513).

18

Slowik D et al. Benchmarking the stability of human detergent-solubilised voltage-gated sodium channels for structural studies using eel as a reference.
Biochim. Biophys. Acta, 2015 Jul , 1848 (1545-51).

19

Wang M et al. [Dynamic expressions of Nav1.2 and Nav1.6 in hippocampal CA3 region of epileptic rats].
Zhonghua Yi Xue Za Zhi, 2015 Jan 6 , 95 (61-5).

20

Stoetzer C et al. Methadone is a local anaesthetic-like inhibitor of neuronal Na+ channels and blocks excitability of mouse peripheral nerves.
Br J Anaesth, 2015 Jan , 114 (110-20).

21

Kancherla AK et al. A Disulfide Stabilized β-Sandwich Defines the Structure of a New Cysteine Framework M-Superfamily Conotoxin.
ACS Chem. Biol., 2015 Aug 21 , 10 (1847-60).

22

Pucca MB et al. Electrophysiological characterization of the first Tityus serrulatus alpha-like toxin, Ts5: Evidence of a pro-inflammatory toxin on macrophages.
Biochimie, 2015 Aug , 115 (8-16).

23

Cardoso FC et al. Identification and Characterization of ProTx-III [μ-TRTX-Tp1a], a New Voltage-Gated Sodium Channel Inhibitor from Venom of the Tarantula Thrixopelma pruriens.
Mol. Pharmacol., 2015 Aug , 88 (291-303).

24

Zúñiga-García V et al. Differential Expression of Ion Channels and Transporters During Hepatocellular Carcinoma Development.
Dig. Dis. Sci., 2015 Apr 5 , ().

25

Guo F et al. Low-Mg(2+) treatment increases sensitivity of voltage-gated Na(+) channels to Ca(2+)/calmodulin-mediated modulation in cultured hippocampal neurons.
Am. J. Physiol., Cell Physiol., 2015 Apr 15 , 308 (C594-605).

26

James TF et al. The Nav1.2 channel is regulated by GSK3.
Biochim. Biophys. Acta, 2015 Apr , 1850 (832-44).

27

Zhang C et al. 17β-Estradiol increases persistent Na(+) current and excitability of AVPV/PeN Kiss1 neurons in female mice.
Mol. Endocrinol., 2015 Apr , 29 (518-27).

28

Sun LH et al. MicroRNA-9 induces defective trafficking of Nav1.1 and Nav1.2 by targeting Navβ2 protein coding region in rat with chronic brain hypoperfusion.
Mol Neurodegener, 2015 , 10 (36).

29

Chen W et al. Tumor necrosis factor-α enhances voltage-gated Na⁺ currents in primary culture of mouse cortical neurons.
J Neuroinflammation, 2015 , 12 (126).

30

Horishita T et al. Neurosteroids allopregnanolone sulfate and pregnanolone sulfate have diverse effect on the α subunit of the neuronal voltage-gated sodium channels Nav1.2, Nav1.6, Nav1.7, and Nav1.8 expressed in xenopus oocytes.
Anesthesiology, 2014 Sep , 121 (620-31).

31

Li T et al. Action potential initiation in neocortical inhibitory interneurons.
PLoS Biol., 2014 Sep , 12 (e1001944).

32

Gur Barzilai M et al. The specificity of Av3 sea anemone toxin for arthropods is determined at linker DI/SS2-S6 in the pore module of target sodium channels.
Biochem. J., 2014 Oct 15 , 463 (271-7).

33

Green BR et al. Structure and function of μ-conotoxins, peptide-based sodium channel blockers with analgesic activity.
Future Med Chem, 2014 Oct , 6 (1677-98).

34

Foadi N et al. A combination of topical antiseptics for the treatment of sore throat blocks voltage-gated neuronal sodium channels.
Naunyn Schmiedebergs Arch. Pharmacol., 2014 Oct , 387 (991-1000).

35

Xu L et al. Functional characterization of two novel scorpion sodium channel toxins from Lychas mucronatus.
Toxicon, 2014 Nov , 90 (318-25).

36

Baek JH et al. Reciprocal Changes in Phosphorylation and Methylation of Mammalian Brain Sodium Channels in Response to Seizures.
J. Biol. Chem., 2014 May 30 , 289 (15363-15373).

37

Gilchrist J et al. Nav1.1 modulation by a novel triazole compound attenuates epileptic seizures in rodents.
ACS Chem. Biol., 2014 May 16 , 9 (1204-12).

38

Gui J et al. A tarantula-venom peptide antagonizes the TRPA1 nociceptor ion channel by binding to the S1-S4 gating domain.
Curr. Biol., 2014 Mar 3 , 24 (473-83).

39

Black JA et al. Nav1.9 expression in magnocellular neurosecretory cells of supraoptic nucleus.
Exp. Neurol., 2014 Mar , 253 (174-9).

40

Okura D et al. The endocannabinoid anandamide inhibits voltage-gated sodium channels Nav1.2, Nav1.6, Nav1.7, and Nav1.8 in Xenopus oocytes.
Anesth. Analg., 2014 Mar , 118 (554-62).

41

Coleman N et al. New Positive KCa Channel Gating Modulators with Selectivity for KCa3.1.
Mol. Pharmacol., 2014 Jun 23 , ().

42

Li HX et al. GATA-4 induces changes in electrophysiological properties of rat mesenchymal stem cells.
Biochim. Biophys. Acta, 2014 Jun , 1840 (2060-9).

43

Foadi N et al. Inhibition of voltage-gated Na⁺ channels by the synthetic cannabinoid ajulemic acid.
Anesth. Analg., 2014 Jun , 118 (1238-45).

44

Oliva MK et al. Physiological and genetic analysis of multiple sodium channel variants in a model of genetic absence epilepsy.
Neurobiol. Dis., 2014 Jul , 67 (180-90).

45

Lee JH et al. Metergoline inhibits the neuronal Nav1.2 voltage-dependent Na(+) channels expressed in Xenopus oocytes.
Acta Pharmacol. Sin., 2014 Jul , 35 (862-8).

46

Barry J et al. Ankyrin-G directly binds to kinesin-1 to transport voltage-gated Na+ channels into axons.
Dev. Cell, 2014 Jan 27 , 28 (117-31).

47

Gajewiak J et al. A disulfide tether stabilizes the block of sodium channels by the conotoxin μO§-GVIIJ.
Proc. Natl. Acad. Sci. U.S.A., 2014 Feb 18 , 111 (2758-63).

48

Magdaleno-Méndez A et al. Ghrelin increases growth hormone production and functional expression of NaV1.1 and Na V1.2 channels in pituitary somatotropes.
Endocrine, 2014 Aug 24 , ().

49

Park JH et al. Studies examining the relationship between the chemical structure of protoxin II and its activity on voltage gated sodium channels.
J. Med. Chem., 2014 Aug 14 , 57 (6623-31).

50

Makinson CD et al. Role of the hippocampus in Nav1.6 (Scn8a) mediated seizure resistance.
Neurobiol. Dis., 2014 Aug , 68 (16-25).

51

Bouafia A et al. Axonal expression of sodium channels and neuropathology of the plaques in multiple sclerosis.
Neuropathol. Appl. Neurobiol., 2014 Aug , 40 (579-90).

52

Wang C et al. Structural basis of diverse membrane target recognitions by ankyrins.
Elife, 2014 , 3 ().

53

Zimmer T et al. Voltage-gated sodium channels in the mammalian heart.
Glob Cardiol Sci Pract, 2014 , 2014 (449-63).

54

Wang ZJ et al. Resibufogenin and cinobufagin activate central neurons through an ouabain-like action.
PLoS ONE, 2014 , 9 (e113272).

55

Liu ZR et al. PKA phosphorylation reshapes the pharmacological kinetics of BmK AS, a unique site-4 sodium channel-specific modulator.
Sci Rep, 2014 , 4 (3721).

56

Abdelsayed M et al. Voltage-gated sodium channels: pharmaceutical targets via anticonvulsants to treat epileptic syndromes.
Channels (Austin), 2013 May-Jun , 7 (146-52).

57

Pérez-Medina C et al. Synthesis and evaluation of a 125I-labeled iminodihydroquinoline-derived tracer for imaging of voltage-gated sodium channels.
Bioorg. Med. Chem. Lett., 2013 Sep 15 , 23 (5170-3).

58

Qiao X et al. Expression of sodium channel α subunits 1.1, 1.2 and 1.6 in rat hippocampus after kainic acid-induced epilepsy.
Epilepsy Res., 2013 Sep , 106 (17-28).

59

Zhu L et al. Two recombinant α-like scorpion toxins from Mesobuthus eupeus with differential affinity toward insect and mammalian Na(+) channels.
Biochimie, 2013 Sep , 95 (1732-40).

60

Yang S et al. Discovery of a selective NaV1.7 inhibitor from centipede venom with analgesic efficacy exceeding morphine in rodent pain models.
Proc. Natl. Acad. Sci. U.S.A., 2013 Oct 22 , 110 (17534-9).

61

Westenbroek RE et al. Localization of sodium channel subtypes in mouse ventricular myocytes using quantitative immunocytochemistry.
J. Mol. Cell. Cardiol., 2013 Nov , 64 (69-78).

62

Kendel Y et al. Venomous secretions from marine snails of the Terebridae family target acetylcholine receptors.
Toxins (Basel), 2013 May , 5 (1043-50).

63

Minassian NA et al. Analysis of the structural and molecular basis of voltage-sensitive sodium channel inhibition by the spider toxin, Huwentoxin-IV (μ-TRTX-Hh2a).
J. Biol. Chem., 2013 Jun 12 , ().

64

Walewska A et al. Expanding chemical diversity of conotoxins: peptoid-peptide chimeras of the sodium channel blocker μ-KIIIA and its selenopeptide analogues.
Eur J Med Chem, 2013 Jul , 65 (144-50).

65

Xu X et al. Abnormal changes in voltage-gated sodium channels Na(V)1.1, Na(V)1.2, Na(V)1.3, Na(V)1.6 and in calmodulin/calmodulin-dependent protein kinase II, within the brains of spontaneously epileptic rats and tremor rats.
Brain Res. Bull., 2013 Jul , 96 (1-9).

66

Gilchrist J et al. Crystallographic insights into sodium-channel modulation by the β4 subunit.
Proc. Natl. Acad. Sci. U.S.A., 2013 Dec 17 , 110 (E5016-24).

67

Bradley E et al. The cardiac sodium current Na(v)1.5 is functionally expressed in rabbit bronchial smooth muscle cells.
Am. J. Physiol., Cell Physiol., 2013 Aug 15 , 305 (C427-35).

68

Stevens M et al. Block of a subset of sodium channels exacerbates experimental autoimmune encephalomyelitis.
J. Neuroimmunol., 2013 Aug 15 , 261 (21-8).

69

Kaufmann SG et al. Distribution and function of sodium channel subtypes in human atrial myocardium.
J. Mol. Cell. Cardiol., 2013 Aug , 61 (133-41).

70

Kamiński K et al. Synthesis and biological properties of new N-Mannich bases derived from 3-methyl-3-phenyl- and 3,3-dimethyl-succinimides. Part V.
Eur J Med Chem, 2013 Aug , 66 (12-21).

71

Mourão CB et al. Characterization of a novel peptide toxin from Acanthoscurria paulensis spider venom: a distinct cysteine assignment to the HWTX-II family.
Biochemistry, 2013 Apr 9 , 52 (2440-52).

72

Black JA et al. NaV1.7: stress-induced changes in immunoreactivity within magnocellular neurosecretory neurons of the supraoptic nucleus.
Mol Pain, 2013 , 9 (39).

73

Davood A et al. Design, synthesis and protection against pentylenetetrazole-induced seizure of N-aryl derivatives of the phthalimide pharmacophore.
Med Chem, 2012 Sep , 8 (953-63).

74

Abe H et al. Gene regulation via excitation and BDNF is mediated by induction and phosphorylation of the Etv1 transcription factor in cerebellar granule cells.
Proc. Natl. Acad. Sci. U.S.A., 2012 May 29 , 109 (8734-9).

75

Hodgdon KE et al. Dorsal root ganglia isolated from Nf1+/- mice exhibit increased levels of mRNA expression of voltage-dependent sodium channels.
Neuroscience, 2012 Mar 29 , 206 (237-44).

76

Power KE et al. Modulation of voltage-gated sodium channels hyperpolarizes the voltage threshold for activation in spinal motoneurones.
Exp Brain Res, 2012 Mar , 217 (311-22).

77

Egri C et al. A thermoprotective role of the sodium channel β1 subunit is lost with the β1 (C121W) mutation.
Epilepsia, 2012 Mar , 53 (494-505).

78

Favreau P et al. A novel µ-conopeptide, CnIIIC, exerts potent and preferential inhibition of NaV1.2/1.4 channels and blocks neuronal nicotinic acetylcholine receptors.
Br. J. Pharmacol., 2012 Jul , 166 (1654-68).

79

Park JH et al. Cysteine racemization during the Fmoc solid phase peptide synthesis of the Nav1.7-selective peptide--protoxin II.
J. Pept. Sci., 2012 Jul , 18 (442-8).

80

Fu LY et al. Sensitivity of cloned muscle, heart and neuronal voltage-gated sodium channels to block by polyamines: A possible basis for modulation of excitability in vivo.
, 2012 Jan 1 , 6 ().

81

Huang CY et al. Co-expression of high-voltage-activated ion channels Kv3.4 and Cav1.2 in pioneer axons during pathfinding in the developing rat forebrain.
, 2012 Apr 2 , ().

82

Gao XF et al. Sigma-1 receptor agonists directly inhibit Nav1.2/1.4 channels.
PLoS ONE, 2012 , 7 (e49384).

83

Foadi N et al. Interaction of alfaxalone with the neuronal and the skeletal muscle sodium channel.
Pharmacology, 2012 , 89 (295-302).

84

Manno I et al. Environmental enrichment reduces spontaneous seizures in the Q54 transgenic mouse model of temporal lobe epilepsy.
Epilepsia, 2011 Sep , 52 (e113-7).

85

Abe H et al. The Etv1/Er81 transcription factor orchestrates activity-dependent gene regulation in the terminal maturation program of cerebellar granule cells.
Proc. Natl. Acad. Sci. U.S.A., 2011 Jul 26 , 108 (12497-502).

86

De Oliveira EO et al. Synthesis and evaluation of hermitamides A and B as human voltage-gated sodium channel blockers.
Bioorg. Med. Chem., 2011 Jul 15 , 19 (4322-9).

87

Ho C et al. Single-cell analysis of sodium channel expression in dorsal root ganglion neurons.
Mol. Cell. Neurosci., 2011 Jan , 46 (159-66).

88

Chen Z et al. ImKTx1, a new Kv1.3 channel blocker with a unique primary structure.
, 2011 Feb 9 , ().

89

Bosmans F et al. Palmitoylation influences the function and pharmacology of sodium channels.
Proc. Natl. Acad. Sci. U.S.A., 2011 Dec 13 , 108 (20213-8).

90

Baroni D et al. Molecular differential expression of voltage-gated sodium channel α and β subunit mRNAs in five different mammalian cell lines.
J. Bioenerg. Biomembr., 2011 Dec , 43 (729-38).

91

Liu Y et al. Validation of a patch clamp screening protocol that simultaneously measures compound activity in multiple states of the voltage-gated sodium channel Nav1.2.
Assay Drug Dev Technol, 2011 Dec , 9 (628-34).

92

Hildebrand ME et al. Identification of sodium channel isoforms that mediate action potential firing in lamina I/II spinal cord neurons.
Mol Pain, 2011 , 7 (67).

93

He H et al. Molecular determination of selectivity of the site 3 modulator (BmK I) to sodium channels in the CNS: a clue to the importance of Nav1.6 in BmK I-induced neuronal hyperexcitability.
Biochem. J., 2010 Sep 28 , 431 (289-98).

94

Fukuoka T et al. Laminae-specific distribution of alpha-subunits of voltage-gated sodium channels in the adult rat spinal cord.
Neuroscience, 2010 Sep 1 , 169 (994-1006).

95

Brachet A et al. Ankyrin G restricts ion channel diffusion at the axonal initial segment before the establishment of the diffusion barrier.
J. Cell Biol., 2010 Oct 18 , 191 (383-95).

96

Gao R et al. Expression of voltage-gated sodium channel alpha subunit in human ovarian cancer.
Oncol. Rep., 2010 May , 23 (1293-9).

97

Black JA et al. Astrocytes within multiple sclerosis lesions upregulate sodium channel Nav1.5.
Brain, 2010 Mar , 133 (835-46).

98

Berendt FJ et al. Multi-site Phosphorylation of Voltage-Gated Sodium Channel alpha Subunits from Rat Brain.
, 2010 Feb 5 , ().

99

Osorio N et al. Persistent Nav1.6 current at axon initial segments tunes spike timing of cerebellar granule cells.
J. Physiol. (Lond.), 2010 Feb 15 , 588 (651-70).

100

Cheng HW et al. Pharmacological modulation of brain Nav1.2 and cardiac Nav1.5 subtypes by the local anesthetic ropivacaine.
Neurosci Bull, 2010 Aug , 26 (289-96).

101

Lenkey N et al. Classification of drugs based on properties of sodium channel inhibition: a comparative automated patch-clamp study.
PLoS ONE, 2010 , 5 (e15568).

102

Cao Z et al. Antillatoxin is a sodium channel activator that displays unique efficacy in heterologously expressed rNav1.2, rNav1.4 and rNav1.5 α subunits.
BMC Neurosci, 2010 , 11 (154).

103

Zhang MM et al. Synergistic and antagonistic interactions between tetrodotoxin and mu-conotoxin in blocking voltage-gated sodium channels.
Channels (Austin), 2009 Jan-Feb , 3 (32-8).

104

Abbas N et al. Full characterization of three toxins from the Androctonus amoreuxi scorpion venom.
Toxicon, 2009 Sep 15 , 54 (460-70).

105

Laezza F et al. FGF14 N-terminal splice variants differentially modulate Nav1.2 and Nav1.6-encoded sodium channels.
Mol. Cell. Neurosci., 2009 Oct , 42 (90-101).

106

Fantini M et al. 2,4(5)-diarylimidazoles as inhibitors of hNaV1.2 sodium channels: pharmacological evaluation and structure-property relationships.
Bioorg. Med. Chem., 2009 May 15 , 17 (3642-8).

107

Miloushev VZ et al. Solution structure of the NaV1.2 C-terminal EF-hand domain.
J. Biol. Chem., 2009 Mar 6 , 284 (6446-54).

108

Zhu MM et al. The alpha-like scorpion toxin BmK I enhances membrane excitability via persistent sodium current by preventing slow inactivation and deactivation of rNav1.2a expressed in Xenopus Oocytes.
Toxicol In Vitro, 2009 Jun , 23 (561-8).

109

Tan J et al. Human and rat Nav1.3 voltage-gated sodium channels differ in inactivation properties and sensitivity to the pyrethroid insecticide tefluthrin.
Neurotoxicology, 2009 Jan , 30 (81-9).

110

Huth T et al. Non-proteolytic effect of beta-site APP-cleaving enzyme 1 (BACE1) on sodium channel function.
Neurobiol. Dis., 2009 Feb , 33 (282-9).

111

Osorio N et al. Persistent Nav1.6 current at axon initial segments tunes spike timing of cerebellar granule cells.
, 2009 Dec 21 , ().

112

Zhu MM et al. U-shaped dose-dependent effects of BmK AS, a unique scorpion polypeptide toxin, on voltage-gated sodium channels.
Br. J. Pharmacol., 2009 Dec , 158 (1895-903).

113

Black JA et al. Sodium channel activity modulates multiple functions in microglia.
Glia, 2009 Aug 1 , 57 (1072-81).

114

Misra SN et al. Impaired NaV1.2 function and reduced cell surface expression in benign familial neonatal-infantile seizures.
Epilepsia, 2008 Sep , 49 (1535-45).

115

Xiao Y et al. Tarantula huwentoxin-IV inhibits neuronal sodium channels by binding to receptor site 4 and trapping the domain ii voltage sensor in the closed configuration.
J. Biol. Chem., 2008 Oct 3 , 283 (27300-13).

116

Duflocq A et al. Nav1.1 is predominantly expressed in nodes of Ranvier and axon initial segments.
Mol. Cell. Neurosci., 2008 Oct , 39 (180-92).

117

Huth T et al. Four-mode gating model of fast inactivation of sodium channel Nav1.2a.
Pflugers Arch., 2008 Oct , 457 (103-19).

118

Lee JH et al. Modifications of aliphatic side chain of 20(S)-ginsenoside RG3 cause an enhancement or loss of brain Na+ channel current inhibitions.
Biol. Pharm. Bull., 2008 Mar , 31 (480-6).

119

Theoharis NT et al. The neuronal voltage-dependent sodium channel type II IQ motif lowers the calcium affinity of the C-domain of calmodulin.
Biochemistry, 2008 Jan 8 , 47 (112-23).

120

Kort ME et al. Discovery and biological evaluation of 5-aryl-2-furfuramides, potent and selective blockers of the Nav1.8 sodium channel with efficacy in models of neuropathic and inflammatory pain.
J. Med. Chem., 2008 Feb 14 , 51 (407-16).

121

Black JA et al. Multiple sodium channel isoforms and mitogen-activated protein kinases are present in painful human neuromas.
Ann. Neurol., 2008 Dec , 64 (644-53).

122

Lee JH et al. Involvement of batrachotoxin binding sites in ginsenoside-mediated voltage-gated Na+ channel regulation.
Brain Res., 2008 Apr 8 , 1203 (61-7).

123

Tan M et al. Effects of BmK AS on Nav1.2 expressed in Xenopus laevis oocytes.
Cell Biol. Toxicol., 2008 Apr , 24 (143-9).

124

Kaneko Y et al. Expression of Nav1.1 in rat retinal AII amacrine cells.
Neurosci. Lett., 2007 Sep 7 , 424 (83-8).

125

Black JA et al. Sodium channel expression within chronic multiple sclerosis plaques.
J. Neuropathol. Exp. Neurol., 2007 Sep , 66 (828-37).

126

Seda M et al. Functional and molecular characterization of voltage-gated sodium channels in uteri from nonpregnant rats.
Biol. Reprod., 2007 Nov , 77 (855-63).

127

Fry M et al. Differentiated pattern of sodium channel expression in dissociated Purkinje neurons maintained in long-term culture.
J. Neurochem., 2007 May , 101 (737-48).

128

Lee JH et al. Effects of dextrorotatory morphinans on brain Na+ channels expressed in Xenopus oocytes.
Eur. J. Pharmacol., 2007 Jun 14 , 564 (7-17).

129

Du Y et al. Downregulation of neuronal sodium channel subunits Nav1.1 and Nav1.6 in the sinoatrial node from volume-overloaded heart failure rat.
Pflugers Arch., 2007 Jun , 454 (451-9).

130

Xu R et al. A childhood epilepsy mutation reveals a role for developmentally regulated splicing of a sodium channel.
Mol. Cell. Neurosci., 2007 Jun , 35 (292-301).

131

Ouyang W et al. Isoform-selective effects of isoflurane on voltage-gated Na+ channels.
Anesthesiology, 2007 Jul , 107 (91-8).

132

Bosmans F et al. Differential effects of five 'classical' scorpion beta-toxins on rNav1.2a and DmNav1 provide clues on species-selectivity.
Toxicol. Appl. Pharmacol., 2007 Jan 1 , 218 (45-51).

133

Huang X et al. [Expression and function of voltage-gated Na+ channel isoforms in rat sinoatrial node]
Nan Fang Yi Ke Da Xue Xue Bao, 2007 Jan , 27 (52-5).

134

Corzo G et al. Solution structure and alanine scan of a spider toxin that affects the activation of mammalian voltage-gated sodium channels.
J. Biol. Chem., 2007 Feb 16 , 282 (4643-52).

135

Watkins JA et al. Concentration-dependent accumulation of [3H]-deltamethrin in sodium channel Nav1.2/beta1 expressing Xenopus laevis oocytes.
Toxicol In Vitro, 2007 Dec , 21 (1672-7).

136

Xu R et al. Generalized epilepsy with febrile seizures plus-associated sodium channel beta1 subunit mutations severely reduce beta subunit-mediated modulation of sodium channel function.
Neuroscience, 2007 Aug 10 , 148 (164-74).

137

Johnson D et al. Isoform-specific effects of the beta2 subunit on voltage-gated sodium channel gating.
J. Biol. Chem., 2006 Sep 8 , 281 (25875-81).

138

Chai ZF et al. Chinese-scorpion (Buthus martensi Karsch) toxin BmK alphaIV, a novel modulator of sodium channels: from genomic organization to functional analysis.
Biochem. J., 2006 Nov 1 , 399 (445-53).

139

Diniz MR et al. Functional expression and purification of recombinant Tx1, a sodium channel blocker neurotoxin from the venom of the Brazilian "armed" spider, Phoneutria nigriventer.
Protein Expr. Purif., 2006 Nov , 50 (18-24).

140

Weiser T Comparison of the effects of four Na+ channel analgesics on TTX-resistant Na+ currents in rat sensory neurons and recombinant Nav1.2 channels.
Neurosci. Lett., 2006 Mar 13 , 395 (179-84).

141

Li GR et al. Ion channels in mesenchymal stem cells from rat bone marrow.
Stem Cells, 2006 Jun , 24 (1519-28).

142

de Ruiter MM et al. Voltage-gated sodium channels in cerebellar Purkinje cells of mormyrid fish.
J. Neurophysiol., 2006 Jul , 96 (378-90).

143

Leipold E et al. Subtype specificity of scorpion beta-toxin Tz1 interaction with voltage-gated sodium channels is determined by the pore loop of domain 3.
Mol. Pharmacol., 2006 Jul , 70 (340-7).

144

Musarella M et al. Expression of Nav1.6 sodium channels by Schwann cells at neuromuscular junctions: role in the motor endplate disease phenotype.
Glia, 2006 Jan 1 , 53 (13-23).

145

Benjamin ER et al. State-dependent compound inhibition of Nav1.2 sodium channels using the FLIPR Vm dye: on-target and off-target effects of diverse pharmacological agents.
, 2006 Feb , 11 (29-39).

146

Hudgens DP et al. Discovery of diphenyl amine based sodium channel blockers, effective against hNav1.2.
Bioorg. Med. Chem., 2006 Dec 15 , 14 (8366-78).

147

Van Wart A et al. Expression of sodium channels Nav1.2 and Nav1.6 during postnatal development of the retina.
Neurosci. Lett., 2006 Aug 7 , 403 (315-7).

148

Jarnot M et al. Immunolocalization of NaV1.2 channel subtypes in rat and cat brain and spinal cord with high affinity antibodies.
Brain Res., 2006 Aug 30 , 1107 (1-12).

149

Majumdar S et al. G-protein activation modulates pseudo-periodic oscillation of Na channel.
Biochem. Biophys. Res. Commun., 2006 Aug 25 , 347 (444-51).

150

Liu Y et al. Inhibition of the rat brain sodium channel Nav1.2 after prolonged exposure to gabapentin.
Epilepsy Res., 2006 Aug , 70 (263-8).

151

Zhao P et al. Sodium channel expression in the ventral posterolateral nucleus of the thalamus after peripheral nerve injury.
, 2006 , 2 (27).

152

Ebensperger G et al. Fetal brain hypometabolism during prolonged hypoxaemia in the llama.
J. Physiol. (Lond.), 2005 Sep 15 , 567 (963-75).

153

Ye X et al. Structural basis for the voltage-gated Na+ channel selectivity of the scorpion alpha-like toxin BmK M1.
J. Mol. Biol., 2005 Nov 4 , 353 (788-803).

154

Ptak K et al. Sodium currents in medullary neurons isolated from the pre-Bötzinger complex region.
J. Neurosci., 2005 May 25 , 25 (5159-70).

155

Rush AM et al. Electrophysiological properties of two axonal sodium channels, Nav1.2 and Nav1.6, expressed in mouse spinal sensory neurones.
J. Physiol. (Lond.), 2005 May 1 , 564 (803-15).

156

Srairi-Abid N et al. A new type of scorpion Na+-channel-toxin-like polypeptide active on K+ channels.
Biochem. J., 2005 Jun 1 , 388 (455-64).

157

Hossain WA et al. Where is the spike generator of the cochlear nerve? Voltage-gated sodium channels in the mouse cochlea.
J. Neurosci., 2005 Jul 20 , 25 (6857-68).

158

Rush AM et al. Contactin regulates the current density and axonal expression of tetrodotoxin-resistant but not tetrodotoxin-sensitive sodium channels in DRG neurons.
Eur. J. Neurosci., 2005 Jul , 22 (39-49).

159

Thimmapaya R et al. Distribution and functional characterization of human Nav1.3 splice variants.
Eur. J. Neurosci., 2005 Jul , 22 (1-9).

160

Kim JH et al. A role for the carbohydrate portion of ginsenoside Rg3 in Na+ channel inhibition.
Mol. Cells, 2005 Feb 28 , 19 (137-42).

161

Osorio N et al. Differential targeting and functional specialization of sodium channels in cultured cerebellar granule cells.
J. Physiol. (Lond.), 2005 Dec 15 , 569 (801-16).

162

Liu LH et al. Molecular basis of the mammalian potency of the scorpion alpha-like toxin, BmK M1.
FASEB J., 2005 Apr , 19 (594-6).

163

Mechaly I et al. Molecular diversity of voltage-gated sodium channel alpha subunits expressed in neuronal and non-neuronal excitable cells.
Neuroscience, 2005 , 130 (389-96).

164

Kim J et al. Calmodulin mediates Ca2+ sensitivity of sodium channels.
J. Biol. Chem., 2004 Oct 22 , 279 (45004-12).

165

Craner MJ et al. Molecular changes in neurons in multiple sclerosis: altered axonal expression of Nav1.2 and Nav1.6 sodium channels and Na+/Ca2+ exchanger.
Proc. Natl. Acad. Sci. U.S.A., 2004 May 25 , 101 (8168-73).

166

Suzuki A et al. Paranodal axoglial junction is required for the maintenance of the Nav1.6-type sodium channel in the node of Ranvier in the optic nerves but not in peripheral nerve fibers in the sulfatide-deficient mice.
Glia, 2004 May , 46 (274-83).

167

Klein JP et al. Dysregulation of sodium channel expression in cortical neurons in a rodent model of absence epilepsy.
Brain Res., 2004 Mar 12 , 1000 (102-9).

168

Padmashri R et al. Functional characterization of the pentapeptide QYNAD on rNav1.2 channels and its NMR structure.
Pflugers Arch., 2004 Mar , 447 (895-907).

169

Leipold E et al. Combinatorial interaction of scorpion toxins Lqh-2, Lqh-3, and LqhalphaIT with sodium channel receptor sites-3.
Mol. Pharmacol., 2004 Mar , 65 (685-91).

170

Vennekamp J et al. Kv1.3-blocking 5-phenylalkoxypsoralens: a new class of immunomodulators.
Mol. Pharmacol., 2004 Jun , 65 (1364-74).

171

Majumdar S et al. Induction of pseudo-periodic oscillation in voltage-gated sodium channel properties is dependent on the duration of prolonged depolarization.
Eur. J. Neurosci., 2004 Jul , 20 (127-43).

172

Grieco TM et al. Production of resurgent current in NaV1.6-null Purkinje neurons by slowing sodium channel inactivation with beta-pompilidotoxin.
J. Neurosci., 2004 Jan 7 , 24 (35-42).

173

Belyaev ND et al. Distinct RE-1 silencing transcription factor-containing complexes interact with different target genes.
J. Biol. Chem., 2004 Jan 2 , 279 (556-61).

174

Barbier J et al. A delta-conotoxin from Conus ermineus venom inhibits inactivation in vertebrate neuronal Na+ channels but not in skeletal and cardiac muscles.
J. Biol. Chem., 2004 Feb 6 , 279 (4680-5).

175

Zhou W et al. Use-dependent potentiation of the Nav1.6 sodium channel.
Biophys. J., 2004 Dec , 87 (3862-72).

176

McNulty MM et al. State-dependent mibefradil block of Na+ channels.
Mol. Pharmacol., 2004 Dec , 66 (1652-61).

177

Weiser T A novel toxicity-based assay for the identification of modulators of voltage-gated Na+ channels.
J. Neurosci. Methods, 2004 Aug 15 , 137 (79-85).

178

McEwen DP et al. Sodium channel beta1 subunit-mediated modulation of Nav1.2 currents and cell surface density is dependent on interactions with contactin and ankyrin.
J. Biol. Chem., 2004 Apr 16 , 279 (16044-9).

179

Sudarslal S et al. Sodium channel modulating activity in a delta-conotoxin from an Indian marine snail.
FEBS Lett., 2003 Oct 9 , 553 (209-12).

180

Garrido JJ et al. Dynamic compartmentalization of the voltage-gated sodium channels in axons.
Biol. Cell, 2003 Oct , 95 (437-45).

181

Chabbert C et al. Voltage-gated Na+ channel activation induces both action potentials in utricular hair cells and brain-derived neurotrophic factor release in the rat utricle during a restricted period of development.
J. Physiol. (Lond.), 2003 Nov 15 , 553 (113-23).

182

Anderson JD et al. Voltage-gated sodium channel blockers as cytostatic inhibitors of the androgen-independent prostate cancer cell line PC-3.
Mol. Cancer Ther., 2003 Nov , 2 (1149-54).

183

Rasband MN et al. Paranodal transverse bands are required for maintenance but not initiation of Nav1.6 sodium channel clustering in CNS optic nerve axons.
Glia, 2003 Nov , 44 (173-82).

184

Moran O et al. Tonic and phasic guanidinium toxin-block of skeletal muscle Na channels expressed in Mammalian cells.
Biophys. J., 2003 May , 84 (2999-3006).

185

Garrido JJ et al. A targeting motif involved in sodium channel clustering at the axonal initial segment.
Science, 2003 Jun 27 , 300 (2091-4).

186

Craner MJ et al. Abnormal sodium channel distribution in optic nerve axons in a model of inflammatory demyelination.
Brain, 2003 Jul , 126 (1552-61).

187

Qin N et al. Molecular cloning and functional expression of the human sodium channel beta1B subunit, a novel splicing variant of the beta1 subunit.
Eur. J. Biochem., 2003 Dec , 270 (4762-70).

188

Rios JC et al. Paranodal interactions regulate expression of sodium channel subtypes and provide a diffusion barrier for the node of Ranvier.
J. Neurosci., 2003 Aug 6 , 23 (7001-11).

189

Yu FH et al. Sodium channel beta4, a new disulfide-linked auxiliary subunit with similarity to beta2.
J. Neurosci., 2003 Aug 20 , 23 (7577-85).

190

Vega AV et al. L-type calcium channel activation up-regulates the mRNAs for two different sodium channel alpha subunits (Nav1.2 and Nav1.3) in rat pituitary GH3 cells.
Brain Res. Mol. Brain Res., 2003 Aug 19 , 116 (115-25).

191

Rasband MN et al. Dysregulation of axonal sodium channel isoforms after adult-onset chronic demyelination.
J. Neurosci. Res., 2003 Aug 15 , 73 (465-70).

192

Schaller KL et al. Expression and distribution of voltage-gated sodium channels in the cerebellum.
Cerebellum, 2003 , 2 (2-9).

193

Battaglioli E et al. REST repression of neuronal genes requires components of the hSWI.SNF complex.
J. Biol. Chem., 2002 Oct 25 , 277 (41038-45).

194

Armisén R et al. Repressor element-1 silencing transcription/neuron-restrictive silencer factor is required for neural sodium channel expression during development of Xenopus.
J. Neurosci., 2002 Oct 1 , 22 (8347-51).

195

Sun YM et al. Roles of disulfide bridges in scorpion toxin BmK M1 analyzed by mutagenesis.
J. Pept. Res., 2002 Nov , 60 (247-56).

196

Alessandri-Haber N et al. Molecular determinants of emerging excitability in rat embryonic motoneurons.
J. Physiol. (Lond.), 2002 May 15 , 541 (25-39).

197

Bouzidi M et al. Interaction of the Nav1.2a subunit of the voltage-dependent sodium channel with nodal ankyrinG. In vitro mapping of the interacting domains and association in synaptosomes.
J. Biol. Chem., 2002 Aug 9 , 277 (28996-9004).

198

Chen H et al. Differential sensitivity of sodium channels from the central and peripheral nervous system to the scorpion toxins Lqh-2 and Lqh-3.
Eur. J. Neurosci., 2002 Aug , 16 (767-70).

199

Hamon A et al. Characterization of scorpion alpha-like toxin group using two new toxins from the scorpion Leiurus quinquestriatus hebraeus.
Eur. J. Biochem., 2002 Aug , 269 (3920-33).

200

Ballas N et al. Regulation of neuronal traits by a novel transcriptional complex.
Neuron, 2001 Aug 16 , 31 (353-65).

201

Shah BS et al. Developmental expression of the novel voltage-gated sodium channel auxiliary subunit beta3, in rat CNS.
J. Physiol. (Lond.), 2001 Aug 1 , 534 (763-76).

202

Baulac S et al. A second locus for familial generalized epilepsy with febrile seizures plus maps to chromosome 2q21-q33.
Am. J. Hum. Genet., 1999 Oct , 65 (1078-85).