Nav1.2
202 literature references associated to Nav1.2
1
Tao H
et al.
Molecular determinant for the tarantula toxin Jingzhaotoxin-I slowing the fast inactivation of voltage-gated sodium channels.
Toxicon,
2016
Mar
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2
Rogers M
et al.
Characterization of Endogenous Sodium Channels in the ND7-23 Neuroblastoma Cell Line: Implications for Use as a Heterologous Ion Channel Expression System Suitable for Automated Patch Clamp Screening.
Assay Drug Dev Technol,
2016
Mar
, 14 (109-30).
3
Arias HR
et al.
Positive allosteric modulators of α7 nicotinic acetylcholine receptors affect neither the function of other ligand- and voltage-gated ion channels and acetylcholinesterase, nor β-amyloid content.
Int. J. Biochem. Cell Biol.,
2016
Jul
, 76 (19-30).
4
Green BR
et al.
Structural Basis for the Inhibition of Voltage-gated Sodium Channels by Conotoxin μO§-GVIIJ.
J. Biol. Chem.,
2016
Jan
27
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5
Benned-Jensen T
et al.
Live Imaging of Kv7.2/7.3 Cell Surface Dynamics at the Axon Initial Segment: High Steady-State Stability and Calpain-Dependent Excitotoxic Downregulation Revealed.
J. Neurosci.,
2016
Feb
17
, 36 (2261-6).
6
Murenzi E
et al.
Evaluation of microtransplantation of rat brain neurolemma into Xenopus laevis oocytes as a technique to study the effect of neurotoxicants on endogenous voltage-sensitive ion channels.
Neurotoxicology,
2016
Apr
7
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7
Branch SY
et al.
Dopaminergic Neurons Exhibit an Age-Dependent Decline in Electrophysiological Parameters in the MitoPark Mouse Model of Parkinson's Disease.
J. Neurosci.,
2016
Apr
6
, 36 (4026-37).
8
Shcherbatko A
et al.
Engineering Highly Potent and Selective Microproteins Against Nav1.7 Sodium Channel for Treatment of Pain.
J. Biol. Chem.,
2016
Apr
22
, ().
9
Wildburger NC
et al.
Quantitative proteomics reveals protein-protein interactions with fibroblast growth factor 12 as a component of the voltage-gated sodium channel 1.2 (nav1.2) macromolecular complex in Mammalian brain.
Mol. Cell Proteomics,
2015
May
, 14 (1288-300).
10
Mishra S
et al.
Contribution of sodium channel neuronal isoform Nav1.1 to late sodium current in ventricular myocytes from failing hearts.
J. Physiol. (Lond.),
2015
Mar
15
, 593 (1409-27).
11
Gazina EV
et al.
'Neonatal' Nav1.2 reduces neuronal excitability and affects seizure susceptibility and behaviour.
Hum. Mol. Genet.,
2015
Mar
1
, 24 (1457-68).
12
Zhang MM
et al.
Probing the Redox States of Sodium Channel Cysteines at the Binding Site of μO§-Conotoxin GVIIJ.
Biochemistry,
2015
Jun
30
, 54 (3911-20).
13
Cai T
et al.
Mapping the interaction site for the tarantula toxin hainantoxin-IV (β-TRTX-Hn2a) in the voltage sensor module of domain II of voltage-gated sodium channels.
Peptides,
2015
Jun
, 68 (148-56).
14
Fukasawa T
et al.
A case of recurrent encephalopathy with SCN2A missense mutation.
Brain Dev.,
2015
Jun
, 37 (631-4).
15
Xu M
et al.
An Ankyrin-G N-terminal Gate and Protein Kinase CK2 Dually Regulate Binding of Voltage-gated Sodium and KCNQ2/3 Potassium Channels.
J. Biol. Chem.,
2015
Jul
3
, 290 (16619-32).
16
Pucca MB
et al.
Revealing the Function and the Structural Model of Ts4: Insights into the "Non-Toxic" Toxin from Tityus serrulatus Venom.
Toxins (Basel),
2015
Jul
, 7 (2534-50).
17
Chow CY
et al.
Three Peptide Modulators of the Human Voltage-Gated Sodium Channel 1.7, an Important Analgesic Target, from the Venom of an Australian Tarantula.
Toxins (Basel),
2015
Jul
, 7 (2494-513).
18
Slowik D
et al.
Benchmarking the stability of human detergent-solubilised voltage-gated sodium channels for structural studies using eel as a reference.
Biochim. Biophys. Acta,
2015
Jul
, 1848 (1545-51).
19
Wang M
et al.
[Dynamic expressions of Nav1.2 and Nav1.6 in hippocampal CA3 region of epileptic rats].
Zhonghua Yi Xue Za Zhi,
2015
Jan
6
, 95 (61-5).
20
Stoetzer C
et al.
Methadone is a local anaesthetic-like inhibitor of neuronal Na+ channels and blocks excitability of mouse peripheral nerves.
Br J Anaesth,
2015
Jan
, 114 (110-20).
21
Kancherla AK
et al.
A Disulfide Stabilized β-Sandwich Defines the Structure of a New Cysteine Framework M-Superfamily Conotoxin.
ACS Chem. Biol.,
2015
Aug
21
, 10 (1847-60).
22
Pucca MB
et al.
Electrophysiological characterization of the first Tityus serrulatus alpha-like toxin, Ts5: Evidence of a pro-inflammatory toxin on macrophages.
Biochimie,
2015
Aug
, 115 (8-16).
23
Cardoso FC
et al.
Identification and Characterization of ProTx-III [μ-TRTX-Tp1a], a New Voltage-Gated Sodium Channel Inhibitor from Venom of the Tarantula Thrixopelma pruriens.
Mol. Pharmacol.,
2015
Aug
, 88 (291-303).
24
Zúñiga-García V
et al.
Differential Expression of Ion Channels and Transporters During Hepatocellular Carcinoma Development.
Dig. Dis. Sci.,
2015
Apr
5
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25
Guo F
et al.
Low-Mg(2+) treatment increases sensitivity of voltage-gated Na(+) channels to Ca(2+)/calmodulin-mediated modulation in cultured hippocampal neurons.
Am. J. Physiol., Cell Physiol.,
2015
Apr
15
, 308 (C594-605).
26
James TF
et al.
The Nav1.2 channel is regulated by GSK3.
Biochim. Biophys. Acta,
2015
Apr
, 1850 (832-44).
27
Zhang C
et al.
17β-Estradiol increases persistent Na(+) current and excitability of AVPV/PeN Kiss1 neurons in female mice.
Mol. Endocrinol.,
2015
Apr
, 29 (518-27).
28
Sun LH
et al.
MicroRNA-9 induces defective trafficking of Nav1.1 and Nav1.2 by targeting Navβ2 protein coding region in rat with chronic brain hypoperfusion.
Mol Neurodegener,
2015
, 10 (36).
29
Chen W
et al.
Tumor necrosis factor-α enhances voltage-gated Na⁺ currents in primary culture of mouse cortical neurons.
J Neuroinflammation,
2015
, 12 (126).
30
Horishita T
et al.
Neurosteroids allopregnanolone sulfate and pregnanolone sulfate have diverse effect on the α subunit of the neuronal voltage-gated sodium channels Nav1.2, Nav1.6, Nav1.7, and Nav1.8 expressed in xenopus oocytes.
Anesthesiology,
2014
Sep
, 121 (620-31).
31
Li T
et al.
Action potential initiation in neocortical inhibitory interneurons.
PLoS Biol.,
2014
Sep
, 12 (e1001944).
32
Gur Barzilai M
et al.
The specificity of Av3 sea anemone toxin for arthropods is determined at linker DI/SS2-S6 in the pore module of target sodium channels.
Biochem. J.,
2014
Oct
15
, 463 (271-7).
33
Green BR
et al.
Structure and function of μ-conotoxins, peptide-based sodium channel blockers with analgesic activity.
Future Med Chem,
2014
Oct
, 6 (1677-98).
34
Foadi N
et al.
A combination of topical antiseptics for the treatment of sore throat blocks voltage-gated neuronal sodium channels.
Naunyn Schmiedebergs Arch. Pharmacol.,
2014
Oct
, 387 (991-1000).
35
Xu L
et al.
Functional characterization of two novel scorpion sodium channel toxins from Lychas mucronatus.
Toxicon,
2014
Nov
, 90 (318-25).
36
Baek JH
et al.
Reciprocal Changes in Phosphorylation and Methylation of Mammalian Brain Sodium Channels in Response to Seizures.
J. Biol. Chem.,
2014
May
30
, 289 (15363-15373).
37
Gilchrist J
et al.
Nav1.1 modulation by a novel triazole compound attenuates epileptic seizures in rodents.
ACS Chem. Biol.,
2014
May
16
, 9 (1204-12).
38
Gui J
et al.
A tarantula-venom peptide antagonizes the TRPA1 nociceptor ion channel by binding to the S1-S4 gating domain.
Curr. Biol.,
2014
Mar
3
, 24 (473-83).
39
Black JA
et al.
Nav1.9 expression in magnocellular neurosecretory cells of supraoptic nucleus.
Exp. Neurol.,
2014
Mar
, 253 (174-9).
40
Okura D
et al.
The endocannabinoid anandamide inhibits voltage-gated sodium channels Nav1.2, Nav1.6, Nav1.7, and Nav1.8 in Xenopus oocytes.
Anesth. Analg.,
2014
Mar
, 118 (554-62).
41
Coleman N
et al.
New Positive KCa Channel Gating Modulators with Selectivity for KCa3.1.
Mol. Pharmacol.,
2014
Jun
23
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42
Li HX
et al.
GATA-4 induces changes in electrophysiological properties of rat mesenchymal stem cells.
Biochim. Biophys. Acta,
2014
Jun
, 1840 (2060-9).
43
Foadi N
et al.
Inhibition of voltage-gated Na⁺ channels by the synthetic cannabinoid ajulemic acid.
Anesth. Analg.,
2014
Jun
, 118 (1238-45).
44
Oliva MK
et al.
Physiological and genetic analysis of multiple sodium channel variants in a model of genetic absence epilepsy.
Neurobiol. Dis.,
2014
Jul
, 67 (180-90).
45
Lee JH
et al.
Metergoline inhibits the neuronal Nav1.2 voltage-dependent Na(+) channels expressed in Xenopus oocytes.
Acta Pharmacol. Sin.,
2014
Jul
, 35 (862-8).
46
Barry J
et al.
Ankyrin-G directly binds to kinesin-1 to transport voltage-gated Na+ channels into axons.
Dev. Cell,
2014
Jan
27
, 28 (117-31).
47
Gajewiak J
et al.
A disulfide tether stabilizes the block of sodium channels by the conotoxin μO§-GVIIJ.
Proc. Natl. Acad. Sci. U.S.A.,
2014
Feb
18
, 111 (2758-63).
48
Magdaleno-Méndez A
et al.
Ghrelin increases growth hormone production and functional expression of NaV1.1 and Na V1.2 channels in pituitary somatotropes.
Endocrine,
2014
Aug
24
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49
Park JH
et al.
Studies examining the relationship between the chemical structure of protoxin II and its activity on voltage gated sodium channels.
J. Med. Chem.,
2014
Aug
14
, 57 (6623-31).
50
Makinson CD
et al.
Role of the hippocampus in Nav1.6 (Scn8a) mediated seizure resistance.
Neurobiol. Dis.,
2014
Aug
, 68 (16-25).
51
Bouafia A
et al.
Axonal expression of sodium channels and neuropathology of the plaques in multiple sclerosis.
Neuropathol. Appl. Neurobiol.,
2014
Aug
, 40 (579-90).
52
Wang C
et al.
Structural basis of diverse membrane target recognitions by ankyrins.
Elife,
2014
, 3 ().
53
Zimmer T
et al.
Voltage-gated sodium channels in the mammalian heart.
Glob Cardiol Sci Pract,
2014
, 2014 (449-63).
54
Wang ZJ
et al.
Resibufogenin and cinobufagin activate central neurons through an ouabain-like action.
PLoS ONE,
2014
, 9 (e113272).
55
Liu ZR
et al.
PKA phosphorylation reshapes the pharmacological kinetics of BmK AS, a unique site-4 sodium channel-specific modulator.
Sci Rep,
2014
, 4 (3721).
56
Abdelsayed M
et al.
Voltage-gated sodium channels: pharmaceutical targets via anticonvulsants to treat epileptic syndromes.
Channels (Austin),
2013 May-Jun
, 7 (146-52).
57
Pérez-Medina C
et al.
Synthesis and evaluation of a 125I-labeled iminodihydroquinoline-derived tracer for imaging of voltage-gated sodium channels.
Bioorg. Med. Chem. Lett.,
2013
Sep
15
, 23 (5170-3).
58
Qiao X
et al.
Expression of sodium channel α subunits 1.1, 1.2 and 1.6 in rat hippocampus after kainic acid-induced epilepsy.
Epilepsy Res.,
2013
Sep
, 106 (17-28).
59
Zhu L
et al.
Two recombinant α-like scorpion toxins from Mesobuthus eupeus with differential affinity toward insect and mammalian Na(+) channels.
Biochimie,
2013
Sep
, 95 (1732-40).
60
Yang S
et al.
Discovery of a selective NaV1.7 inhibitor from centipede venom with analgesic efficacy exceeding morphine in rodent pain models.
Proc. Natl. Acad. Sci. U.S.A.,
2013
Oct
22
, 110 (17534-9).
61
Westenbroek RE
et al.
Localization of sodium channel subtypes in mouse ventricular myocytes using quantitative immunocytochemistry.
J. Mol. Cell. Cardiol.,
2013
Nov
, 64 (69-78).
62
Kendel Y
et al.
Venomous secretions from marine snails of the Terebridae family target acetylcholine receptors.
Toxins (Basel),
2013
May
, 5 (1043-50).
63
Minassian NA
et al.
Analysis of the structural and molecular basis of voltage-sensitive sodium channel inhibition by the spider toxin, Huwentoxin-IV (μ-TRTX-Hh2a).
J. Biol. Chem.,
2013
Jun
12
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64
Walewska A
et al.
Expanding chemical diversity of conotoxins: peptoid-peptide chimeras of the sodium channel blocker μ-KIIIA and its selenopeptide analogues.
Eur J Med Chem,
2013
Jul
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65
66
Gilchrist J
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Crystallographic insights into sodium-channel modulation by the β4 subunit.
Proc. Natl. Acad. Sci. U.S.A.,
2013
Dec
17
, 110 (E5016-24).
67
Bradley E
et al.
The cardiac sodium current Na(v)1.5 is functionally expressed in rabbit bronchial smooth muscle cells.
Am. J. Physiol., Cell Physiol.,
2013
Aug
15
, 305 (C427-35).
68
Stevens M
et al.
Block of a subset of sodium channels exacerbates experimental autoimmune encephalomyelitis.
J. Neuroimmunol.,
2013
Aug
15
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69
Kaufmann SG
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Distribution and function of sodium channel subtypes in human atrial myocardium.
J. Mol. Cell. Cardiol.,
2013
Aug
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70
Kamiński K
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Synthesis and biological properties of new N-Mannich bases derived from 3-methyl-3-phenyl- and 3,3-dimethyl-succinimides. Part V.
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2013
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71
Mourão CB
et al.
Characterization of a novel peptide toxin from Acanthoscurria paulensis spider venom: a distinct cysteine assignment to the HWTX-II family.
Biochemistry,
2013
Apr
9
, 52 (2440-52).
72
Black JA
et al.
NaV1.7: stress-induced changes in immunoreactivity within magnocellular neurosecretory neurons of the supraoptic nucleus.
Mol Pain,
2013
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73
Davood A
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Design, synthesis and protection against pentylenetetrazole-induced seizure of N-aryl derivatives of the phthalimide pharmacophore.
Med Chem,
2012
Sep
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74
Abe H
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Gene regulation via excitation and BDNF is mediated by induction and phosphorylation of the Etv1 transcription factor in cerebellar granule cells.
Proc. Natl. Acad. Sci. U.S.A.,
2012
May
29
, 109 (8734-9).
75
Hodgdon KE
et al.
Dorsal root ganglia isolated from Nf1+/- mice exhibit increased levels of mRNA expression of voltage-dependent sodium channels.
Neuroscience,
2012
Mar
29
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76
Power KE
et al.
Modulation of voltage-gated sodium channels hyperpolarizes the voltage threshold for activation in spinal motoneurones.
Exp Brain Res,
2012
Mar
, 217 (311-22).
77
Egri C
et al.
A thermoprotective role of the sodium channel β1 subunit is lost with the β1 (C121W) mutation.
Epilepsia,
2012
Mar
, 53 (494-505).
78
Favreau P
et al.
A novel µ-conopeptide, CnIIIC, exerts potent and preferential inhibition of NaV1.2/1.4 channels and blocks neuronal nicotinic acetylcholine receptors.
Br. J. Pharmacol.,
2012
Jul
, 166 (1654-68).
79
Park JH
et al.
Cysteine racemization during the Fmoc solid phase peptide synthesis of the Nav1.7-selective peptide--protoxin II.
J. Pept. Sci.,
2012
Jul
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80
81
Huang CY
et al.
Co-expression of high-voltage-activated ion channels Kv3.4 and Cav1.2 in pioneer axons during pathfinding in the developing rat forebrain.
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2012
Apr
2
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82
Gao XF
et al.
Sigma-1 receptor agonists directly inhibit Nav1.2/1.4 channels.
PLoS ONE,
2012
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83
Foadi N
et al.
Interaction of alfaxalone with the neuronal and the skeletal muscle sodium channel.
Pharmacology,
2012
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84
Manno I
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Environmental enrichment reduces spontaneous seizures in the Q54 transgenic mouse model of temporal lobe epilepsy.
Epilepsia,
2011
Sep
, 52 (e113-7).
85
Abe H
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The Etv1/Er81 transcription factor orchestrates activity-dependent gene regulation in the terminal maturation program of cerebellar granule cells.
Proc. Natl. Acad. Sci. U.S.A.,
2011
Jul
26
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86
De Oliveira EO
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Synthesis and evaluation of hermitamides A and B as human voltage-gated sodium channel blockers.
Bioorg. Med. Chem.,
2011
Jul
15
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87
Ho C
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Single-cell analysis of sodium channel expression in dorsal root ganglion neurons.
Mol. Cell. Neurosci.,
2011
Jan
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88
Chen Z
et al.
ImKTx1, a new Kv1.3 channel blocker with a unique primary structure.
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2011
Feb
9
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89
Bosmans F
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Palmitoylation influences the function and pharmacology of sodium channels.
Proc. Natl. Acad. Sci. U.S.A.,
2011
Dec
13
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90
Baroni D
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Molecular differential expression of voltage-gated sodium channel α and β subunit mRNAs in five different mammalian cell lines.
J. Bioenerg. Biomembr.,
2011
Dec
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91
Liu Y
et al.
Validation of a patch clamp screening protocol that simultaneously measures compound activity in multiple states of the voltage-gated sodium channel Nav1.2.
Assay Drug Dev Technol,
2011
Dec
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92
Hildebrand ME
et al.
Identification of sodium channel isoforms that mediate action potential firing in lamina I/II spinal cord neurons.
Mol Pain,
2011
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93
He H
et al.
Molecular determination of selectivity of the site 3 modulator (BmK I) to sodium channels in the CNS: a clue to the importance of Nav1.6 in BmK I-induced neuronal hyperexcitability.
Biochem. J.,
2010
Sep
28
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94
Fukuoka T
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Laminae-specific distribution of alpha-subunits of voltage-gated sodium channels in the adult rat spinal cord.
Neuroscience,
2010
Sep
1
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95
Brachet A
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Ankyrin G restricts ion channel diffusion at the axonal initial segment before the establishment of the diffusion barrier.
J. Cell Biol.,
2010
Oct
18
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96
Gao R
et al.
Expression of voltage-gated sodium channel alpha subunit in human ovarian cancer.
Oncol. Rep.,
2010
May
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97
Black JA
et al.
Astrocytes within multiple sclerosis lesions upregulate sodium channel Nav1.5.
Brain,
2010
Mar
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98
Berendt FJ
et al.
Multi-site Phosphorylation of Voltage-Gated Sodium Channel alpha Subunits from Rat Brain.
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2010
Feb
5
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99
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Persistent Nav1.6 current at axon initial segments tunes spike timing of cerebellar granule cells.
J. Physiol. (Lond.),
2010
Feb
15
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100
Cheng HW
et al.
Pharmacological modulation of brain Nav1.2 and cardiac Nav1.5 subtypes by the local anesthetic ropivacaine.
Neurosci Bull,
2010
Aug
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101
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Classification of drugs based on properties of sodium channel inhibition: a comparative automated patch-clamp study.
PLoS ONE,
2010
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102
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Antillatoxin is a sodium channel activator that displays unique efficacy in heterologously expressed rNav1.2, rNav1.4 and rNav1.5 α subunits.
BMC Neurosci,
2010
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103
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Synergistic and antagonistic interactions between tetrodotoxin and mu-conotoxin in blocking voltage-gated sodium channels.
Channels (Austin),
2009 Jan-Feb
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104
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Full characterization of three toxins from the Androctonus amoreuxi scorpion venom.
Toxicon,
2009
Sep
15
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105
Laezza F
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FGF14 N-terminal splice variants differentially modulate Nav1.2 and Nav1.6-encoded sodium channels.
Mol. Cell. Neurosci.,
2009
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106
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2,4(5)-diarylimidazoles as inhibitors of hNaV1.2 sodium channels: pharmacological evaluation and structure-property relationships.
Bioorg. Med. Chem.,
2009
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107
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Solution structure of the NaV1.2 C-terminal EF-hand domain.
J. Biol. Chem.,
2009
Mar
6
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108
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The alpha-like scorpion toxin BmK I enhances membrane excitability via persistent sodium current by preventing slow inactivation and deactivation of rNav1.2a expressed in Xenopus Oocytes.
Toxicol In Vitro,
2009
Jun
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109
Tan J
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Human and rat Nav1.3 voltage-gated sodium channels differ in inactivation properties and sensitivity to the pyrethroid insecticide tefluthrin.
Neurotoxicology,
2009
Jan
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110
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et al.
Non-proteolytic effect of beta-site APP-cleaving enzyme 1 (BACE1) on sodium channel function.
Neurobiol. Dis.,
2009
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111
Osorio N
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Persistent Nav1.6 current at axon initial segments tunes spike timing of cerebellar granule cells.
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2009
Dec
21
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112
Zhu MM
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U-shaped dose-dependent effects of BmK AS, a unique scorpion polypeptide toxin, on voltage-gated sodium channels.
Br. J. Pharmacol.,
2009
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113
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Sodium channel activity modulates multiple functions in microglia.
Glia,
2009
Aug
1
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114
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Impaired NaV1.2 function and reduced cell surface expression in benign familial neonatal-infantile seizures.
Epilepsia,
2008
Sep
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115
Xiao Y
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Tarantula huwentoxin-IV inhibits neuronal sodium channels by binding to receptor site 4 and trapping the domain ii voltage sensor in the closed configuration.
J. Biol. Chem.,
2008
Oct
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116
Duflocq A
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Nav1.1 is predominantly expressed in nodes of Ranvier and axon initial segments.
Mol. Cell. Neurosci.,
2008
Oct
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117
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Four-mode gating model of fast inactivation of sodium channel Nav1.2a.
Pflugers Arch.,
2008
Oct
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118
Lee JH
et al.
Modifications of aliphatic side chain of 20(S)-ginsenoside RG3 cause an enhancement or loss of brain Na+ channel current inhibitions.
Biol. Pharm. Bull.,
2008
Mar
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119
Theoharis NT
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The neuronal voltage-dependent sodium channel type II IQ motif lowers the calcium affinity of the C-domain of calmodulin.
Biochemistry,
2008
Jan
8
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120
Kort ME
et al.
Discovery and biological evaluation of 5-aryl-2-furfuramides, potent and selective blockers of the Nav1.8 sodium channel with efficacy in models of neuropathic and inflammatory pain.
J. Med. Chem.,
2008
Feb
14
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121
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Multiple sodium channel isoforms and mitogen-activated protein kinases are present in painful human neuromas.
Ann. Neurol.,
2008
Dec
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122
Lee JH
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Involvement of batrachotoxin binding sites in ginsenoside-mediated voltage-gated Na+ channel regulation.
Brain Res.,
2008
Apr
8
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123
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Effects of BmK AS on Nav1.2 expressed in Xenopus laevis oocytes.
Cell Biol. Toxicol.,
2008
Apr
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124
Kaneko Y
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Expression of Nav1.1 in rat retinal AII amacrine cells.
Neurosci. Lett.,
2007
Sep
7
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125
Black JA
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Sodium channel expression within chronic multiple sclerosis plaques.
J. Neuropathol. Exp. Neurol.,
2007
Sep
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126
Seda M
et al.
Functional and molecular characterization of voltage-gated sodium channels in uteri from nonpregnant rats.
Biol. Reprod.,
2007
Nov
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127
Fry M
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Differentiated pattern of sodium channel expression in dissociated Purkinje neurons maintained in long-term culture.
J. Neurochem.,
2007
May
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128
Lee JH
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