Channelpedia

Kv10

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Gene

The EAG family includes the eag (Kv10), erg (Kv11), and elk (Kv12) channel subfamilies, each sharing only ~20% amino acid identity to Kv1 channels in the voltage sensors. EAG family channels generally activate in a subthreshold voltage range with a relatively low apparent gating valence, but have highly variable gating kinetics [771], [772].


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Function

EAG channel family members, including both Kv10.1 and Kv10.2, are overexpressed in cancer and have been suggested as tumor markers as well as cancer therapeutic targets. Kv10.2 is natively expressed in the nervous system [1709]


References

771

Jegla TJ et al. Evolution of the human ion channel set.
Comb. Chem. High Throughput Screen., 2009 Jan , 12 (2-23).

772

Bannister JP et al. Optical detection of rate-determining ion-modulated conformational changes of the ether-à-go-go K+ channel voltage sensor.
Proc. Natl. Acad. Sci. U.S.A., 2005 Dec 20 , 102 (18718-23).


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Credits

To cite this page: [Contributors] Channelpedia https://channelpedia.epfl.ch/wikipages/201/ , accessed on 2024 Dec 02



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