Kv10
The EAG family includes the eag (Kv10), erg (Kv11), and elk (Kv12) channel subfamilies, each sharing only ~20% amino acid identity to Kv1 channels in the voltage sensors. EAG family channels generally activate in a subthreshold voltage range with a relatively low apparent gating valence, but have highly variable gating kinetics [771], [772].
EAG channel family members, including both Kv10.1 and Kv10.2, are overexpressed in cancer and have been suggested as tumor markers as well as cancer therapeutic targets. Kv10.2 is natively expressed in the nervous system [1709]
References
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Evolution of the human ion channel set.
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Bannister JP
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Optical detection of rate-determining ion-modulated conformational changes of the ether-à-go-go K+ channel voltage sensor.
Proc. Natl. Acad. Sci. U.S.A.,
2005
Dec
20
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Yang Y
et al.
Multistate structural modeling and voltage-clamp analysis of epilepsy/autism mutation Kv10.2-R327H demonstrate the role of this residue in stabilizing the channel closed state.
J. Neurosci.,
2013
Oct
16
, 33 (16586-93).
Credits
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