TRPA1

Description: transient receptor potential cation channel, subfamily A, member 1
Gene: Trpa1
Alias: TRPA1

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Gene

Species	NCBI gene ID	Chromosome	Position
Human	8989	8	68760
Mouse	277328	1	46218
Rat	312896	5	53244

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Transcript

Species	NCBI accession	Length (nt)
Human	NM_007332.3	5191
Mouse	NM_177781.5	4267
Rat	NM_207608.1	3378

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Protein Isoforms

Species	Uniprot ID	Length (aa)
Human	O75762	1119
Mouse	Q8BLA8	1125
Rat	Q6RI86	1125

Isoforms

Transcript

Length (nt)

Protein

Length (aa)

Variant

Isoform

Known

NM_007332.3

5191

NP_015628.2

1119

Predicted

XM_011517625.3

5291

XP_011515927.1

1119

transcript variant X2

isoform X2

XM_011517624.3

5131

XP_011515926.1

1144

transcript variant X1

isoform X1

XM_054361455.1

5131

XP_054217430.1

1144

transcript variant X1

isoform X1

XM_054361456.1

5156

XP_054217431.1

1119

transcript variant X3

isoform X2

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Post-Translational Modifications

PTM

Position

Type

Modified residue

394

4-hydroxyproline; by EGLN1; transient; in normoxia and hyperoxia

Modified residue

633

Cysteine sulfenic acid (-SOH); transient; in hyperoxia

Modified residue

856

Cysteine sulfenic acid (-SOH); transient; in hyperoxia

Glycosylation

747

N-linked (GlcNAc...) asparagine

Glycosylation

753

N-linked (GlcNAc...) asparagine

Disulfide bond

473

Alternate

Disulfide bond

203

Alternate

Disulfide bond

Alternate

Disulfide bond

Alternate

Disulfide bond

223

Alternate; transient; in hyperoxia; unknown whether inter- or intrachain

Modified residue

395

4-hydroxyproline; transient

Modified residue

634

Cysteine sulfenic acid (-SOH); transient; in hyperoxia

Modified residue

859

Cysteine sulfenic acid (-SOH); transient; in hyperoxia

Glycosylation

749

N-linked (GlcNAc...) asparagine

Glycosylation

755

N-linked (GlcNAc...) asparagine

Disulfide bond

473

Alternate

Disulfide bond

203

Alternate

Disulfide bond

Alternate

Disulfide bond

Alternate

Disulfide bond

225

Alternate; transient; in hyperoxia; unknown whether inter- or intrachain

Modified residue

395

4-hydroxyproline; transient

Modified residue

634

Cysteine sulfenic acid (-SOH); transient; in hyperoxia

Modified residue

859

Cysteine sulfenic acid (-SOH); transient; in hyperoxia

Glycosylation

749

N-linked (GlcNAc...) asparagine

Glycosylation

755

N-linked (GlcNAc...) asparagine

Disulfide bond

473

Alternate

Disulfide bond

203

Alternate

Disulfide bond

Alternate

Disulfide bond

Alternate

Disulfide bond

225

Alternate; transient; in hyperoxia; unknown whether inter- or intrachain

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Structure

TRPA1 predicted AlphaFold size

Species	Area (Å²)	Reference
Human	10269.18	source
Mouse	12961.01	source
Rat	12487.30	source

Methodology for AlphaFold size prediction and disclaimer are available here

References

344

da Costa DS et al. The involvement of the transient receptor potential A1 (TRPA1) in the maintenance of mechanical and cold hyperalgesia in persistent inflammation.
Pain, 2010 Mar , 148 (431-7).

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Credits

To cite this page: [Contributors] Channelpedia https://channelpedia.epfl.ch/wikipages/179/ , accessed on 2024 Nov 21

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