Nav1.6

1

Ali SR et al. Identification of Amino Acid Residues in Fibroblast Growth Factor 14 (FGF14) Required for Structure-Function Interactions with Voltage-gated Sodium Channel Nav1.6.
J. Biol. Chem., 2016 May 20 , 291 (11268-84).

2

Rogers M et al. Characterization of Endogenous Sodium Channels in the ND7-23 Neuroblastoma Cell Line: Implications for Use as a Heterologous Ion Channel Expression System Suitable for Automated Patch Clamp Screening.
Assay Drug Dev Technol, 2016 Mar , 14 (109-30).

3

Du Y et al. β1-Adrenergic blocker bisoprolol reverses down-regulated ion channels in sinoatrial node of heart failure rats.
J. Physiol. Biochem., 2016 Jun , 72 (293-302).

4

He B et al. Effects of the β1 auxiliary subunit on modification of Rat Na(v)1.6 sodium channels expressed in HEK293 cells by the pyrethroid insecticides tefluthrin and deltamethrin.
Toxicol. Appl. Pharmacol., 2016 Jan 15 , 291 (58-69).

5

Horvath GA et al. Secondary neurotransmitter deficiencies in epilepsy caused by voltage-gated sodium channelopathies: A potential treatment target?
Mol. Genet. Metab., 2016 Jan , 117 (42-8).

6

Makinson CD et al. An Scn1a epilepsy mutation in Scn8a alters seizure susceptibility and behavior.
Exp. Neurol., 2016 Jan , 275 Pt 1 (46-58).

7

Kim KX et al. Maturation of NaV and KV Channel Topographies in the Auditory Nerve Spike Initiator before and after Developmental Onset of Hearing Function.
J. Neurosci., 2016 Feb 17 , 36 (2111-8).

8

Murenzi E et al. Evaluation of microtransplantation of rat brain neurolemma into Xenopus laevis oocytes as a technique to study the effect of neurotoxicants on endogenous voltage-sensitive ion channels.
Neurotoxicology, 2016 Apr 7 , ().

9

Shcherbatko A et al. Engineering Highly Potent and Selective Microproteins Against Nav1.7 Sodium Channel for Treatment of Pain.
J. Biol. Chem., 2016 Apr 22 , ().

10

Alshammari MA et al. Improved Methods for Fluorescence Microscopy Detection of Macromolecules at the Axon Initial Segment.
Front Cell Neurosci, 2016 , 10 (5).

11

Remacle AG et al. Matrix Metalloproteinase (MMP) Proteolysis of the Extracellular Loop of Voltage-gated Sodium Channels and Potential Alterations in Pain Signaling.
J. Biol. Chem., 2015 Sep 18 , 290 (22939-44).

12

Olson HE et al. Mutations in epilepsy and intellectual disability genes in patients with features of Rett syndrome.
Am. J. Med. Genet. A, 2015 Sep , 167A (2017-25).

13

Berghuis B et al. Complex SCN8A DNA-abnormalities in an individual with therapy resistant absence epilepsy.
Epilepsy Res., 2015 Sep , 115 (141-4).

14

Liu C et al. Amyloid precursor protein enhances Nav1.6 sodium channel cell surface expression.
J. Biol. Chem., 2015 May 8 , 290 (12048-57).

15

Hamada MS et al. Myelin loss and axonal ion channel adaptations associated with gray matter neuronal hyperexcitability.
J. Neurosci., 2015 May 6 , 35 (7272-86).

16

Mercimek-Mahmutoglu S et al. Diagnostic yield of genetic testing in epileptic encephalopathy in childhood.
Epilepsia, 2015 May , 56 (707-16).

17

Blanchard MG et al. De novo gain-of-function and loss-of-function mutations of SCN8A in patients with intellectual disabilities and epilepsy.
J. Med. Genet., 2015 May , 52 (330-7).

18

Mishra S et al. Contribution of sodium channel neuronal isoform Nav1.1 to late sodium current in ventricular myocytes from failing hearts.
J. Physiol. (Lond.), 2015 Mar 15 , 593 (1409-27).

19

Gazina EV et al. 'Neonatal' Nav1.2 reduces neuronal excitability and affects seizure susceptibility and behaviour.
Hum. Mol. Genet., 2015 Mar 1 , 24 (1457-68).

20

Singh R et al. Early-onset movement disorder and epileptic encephalopathy due to de novo dominant SCN8A mutation.
Seizure, 2015 Mar , 26 (69-71).

21

Igci YZ et al. Expression profiling of SCN8A and NDUFC2 genes in colorectal carcinoma.
Exp. Oncol., 2015 Mar , 37 (77-80).

22

Kong W et al. SCN8A mutations in Chinese children with early onset epilepsy and intellectual disability.
Epilepsia, 2015 Mar , 56 (431-8).

23

Zhang MM et al. Probing the Redox States of Sodium Channel Cysteines at the Binding Site of μO§-Conotoxin GVIIJ.
Biochemistry, 2015 Jun 30 , 54 (3911-20).

24

Slowik D et al. Benchmarking the stability of human detergent-solubilised voltage-gated sodium channels for structural studies using eel as a reference.
Biochim. Biophys. Acta, 2015 Jul , 1848 (1545-51).

25

Pucca MB et al. Revealing the Function and the Structural Model of Ts4: Insights into the "Non-Toxic" Toxin from Tityus serrulatus Venom.
Toxins (Basel), 2015 Jul , 7 (2534-50).

26

Wang M et al. [Dynamic expressions of Nav1.2 and Nav1.6 in hippocampal CA3 region of epileptic rats].
Zhonghua Yi Xue Za Zhi, 2015 Jan 6 , 95 (61-5).

27

Fukuoka T et al. De novo expression of Nav1.7 in injured putative proprioceptive afferents: Multiple tetrodotoxin-sensitive sodium channels are retained in the rat dorsal root after spinal nerve ligation.
Neuroscience, 2015 Jan 22 , 284 (693-706).

28

Wagnon JL et al. Convulsive seizures and SUDEP in a mouse model of SCN8A epileptic encephalopathy.
Hum. Mol. Genet., 2015 Jan 15 , 24 (506-15).

29

Kirchhof P et al. First report on an inotropic peptide activating tetrodotoxin-sensitive, "neuronal" sodium currents in the heart.
Circ Heart Fail, 2015 Jan , 8 (79-88).

30

Sato T et al. Glial reaction in the spinal cord of the degenerating muscle mouse (Scn8a (dmu)).
Neurochem. Res., 2015 Jan , 40 (124-9).

31

Feng B et al. Experimental and computational evidence for an essential role of NaV1.6 in spike initiation at stretch-sensitive colorectal afferent endings.
J. Neurophysiol., 2015 Feb 4 , (jn.00717.2014).

32

Larsen J et al. The phenotypic spectrum of SCN8A encephalopathy.
Neurology, 2015 Feb 3 , 84 (480-9).

33

Teramoto N et al. Selective blocking effects of 4,9-anhydrotetrodotoxin, purified from a crude mixture of tetrodotoxin analogues, on NaV1.6 channels and its chemical aspects.
Mar Drugs, 2015 Feb , 13 (984-95).

34

Li N et al. Downregulation of the sodium channel Nav1.6 by potential transcriptomic deregulation may explain sensory deficits in critical illness neuropathy.
Life Sci., 2015 Dec 15 , 143 (231-6).

35

Huang X et al. Age-dependent alterations of voltage-gated Na(+) channel isoforms in rat sinoatrial node.
Mech. Ageing Dev., 2015 Dec , 152 (80-90).

36

Pucca MB et al. Electrophysiological characterization of the first Tityus serrulatus alpha-like toxin, Ts5: Evidence of a pro-inflammatory toxin on macrophages.
Biochimie, 2015 Aug , 115 (8-16).

37

Fung LW et al. SCN8A mutations in Chinese children with early onset epilepsy and intellectual disability.
Epilepsia, 2015 Aug , 56 (1319-20).

38

Kong W et al. In response: SCN8A mutations in Chinese children with early onset epilepsy and intellectual disability.
Epilepsia, 2015 Aug , 56 (1320).

39

Cardoso FC et al. Identification and Characterization of ProTx-III [μ-TRTX-Tp1a], a New Voltage-Gated Sodium Channel Inhibitor from Venom of the Tarantula Thrixopelma pruriens.
Mol. Pharmacol., 2015 Aug , 88 (291-303).

40

Xie W et al. Local knockdown of the NaV1.6 sodium channel reduces pain behaviors, sensory neuron excitability, and sympathetic sprouting in rat models of neuropathic pain.
Neuroscience, 2015 Apr 16 , 291 (317-30).

41

Wilson MJ et al. Α- and β-subunit composition of voltage-gated sodium channels investigated with μ-conotoxins and the recently discovered μO§-conotoxin GVIIJ.
J. Neurophysiol., 2015 Apr 1 , 113 (2289-301).

42

Chung G et al. Generation of resonance-dependent oscillation by mGluR-I activation switches single spiking to bursting in mesencephalic trigeminal sensory neurons.
Eur. J. Neurosci., 2015 Apr , 41 (998-1012).

43

Zhang C et al. 17β-Estradiol increases persistent Na(+) current and excitability of AVPV/PeN Kiss1 neurons in female mice.
Mol. Endocrinol., 2015 Apr , 29 (518-27).

44

Bao L Trafficking regulates the subcellular distribution of voltage-gated sodium channels in primary sensory neurons.
Mol Pain, 2015 , 11 (61).

45

Barbosa C et al. Navβ4 regulates fast resurgent sodium currents and excitability in sensory neurons.
Mol Pain, 2015 , 11 (60).

46

Pal D et al. Reduced Nav1.6 Sodium Channel Activity in Mice Increases In Vivo Sensitivity to Volatile Anesthetics.
PLoS ONE, 2015 , 10 (e0134960).

47

Akin EJ et al. Preferential targeting of Nav1.6 voltage-gated Na+ Channels to the axon initial segment during development.
PLoS ONE, 2015 , 10 (e0124397).

48

Patel RR et al. Human Nav1.6 Channels Generate Larger Resurgent Currents than Human Nav1.1 Channels, but the Navβ4 Peptide Does Not Protect Either Isoform from Use-Dependent Reduction.
PLoS ONE, 2015 , 10 (e0133485).

49

Poulet C et al. Late Sodium Current in Human Atrial Cardiomyocytes from Patients in Sinus Rhythm and Atrial Fibrillation.
PLoS ONE, 2015 , 10 (e0131432).

50

Chen W et al. Tumor necrosis factor-α enhances voltage-gated Na⁺ currents in primary culture of mouse cortical neurons.
J Neuroinflammation, 2015 , 12 (126).

51

Hsu WC et al. Identifying a kinase network regulating FGF14:Nav1.6 complex assembly using split-luciferase complementation.
PLoS ONE, 2015 , 10 (e0117246).

52

Horishita T et al. Neurosteroids allopregnanolone sulfate and pregnanolone sulfate have diverse effect on the α subunit of the neuronal voltage-gated sodium channels Nav1.2, Nav1.6, Nav1.7, and Nav1.8 expressed in xenopus oocytes.
Anesthesiology, 2014 Sep , 121 (620-31).

53

Zerem A et al. Paternal germline mosaicism of a SCN2A mutation results in Ohtahara syndrome in half siblings.
Eur. J. Paediatr. Neurol., 2014 Sep , 18 (567-71).

54

Estacion M et al. A novel de novo mutation of SCN8A (Nav1.6) with enhanced channel activation in a child with epileptic encephalopathy.
Neurobiol. Dis., 2014 Sep , 69 (117-23).

55

Deuis JR et al. Analgesic effects of clinically used compounds in novel mouse models of polyneuropathy induced by oxaliplatin and cisplatin.
Neuro-oncology, 2014 Oct , 16 (1324-32).

56

de Kovel CG et al. Characterization of a de novo SCN8A mutation in a patient with epileptic encephalopathy.
Epilepsy Res., 2014 Nov , 108 (1511-8).

57

McGlothlin JW et al. Parallel evolution of tetrodotoxin resistance in three voltage-gated sodium channel genes in the garter snake Thamnophis sirtalis.
Mol. Biol. Evol., 2014 Nov , 31 (2836-46).

58

Tan ZY et al. Tetrodotoxin-resistant sodium channels in sensory neurons generate slow resurgent currents that are enhanced by inflammatory mediators.
J. Neurosci., 2014 May 21 , 34 (7190-7).

59

Gilchrist J et al. Nav1.1 modulation by a novel triazole compound attenuates epileptic seizures in rodents.
ACS Chem. Biol., 2014 May 16 , 9 (1204-12).

60

Zhang YY et al. Characterization of functional ion channels in human cardiac c-kit+ progenitor cells.
Basic Res. Cardiol., 2014 May , 109 (407).

61

Thériault O et al. Modulation of peripheral Na(+) channels and neuronal firing by n-butyl-p-aminobenzoate.
Eur. J. Pharmacol., 2014 Mar 15 , 727 (158-66).

62

Black JA et al. Nav1.9 expression in magnocellular neurosecretory cells of supraoptic nucleus.
Exp. Neurol., 2014 Mar , 253 (174-9).

63

Okura D et al. The endocannabinoid anandamide inhibits voltage-gated sodium channels Nav1.2, Nav1.6, Nav1.7, and Nav1.8 in Xenopus oocytes.
Anesth. Analg., 2014 Mar , 118 (554-62).

64

Ohba C et al. Early onset epileptic encephalopathy caused by de novo SCN8A mutations.
Epilepsia, 2014 Jul , 55 (994-1000).

65

Oliva MK et al. Physiological and genetic analysis of multiple sodium channel variants in a model of genetic absence epilepsy.
Neurobiol. Dis., 2014 Jul , 67 (180-90).

66

Baroni D et al. Antisense-mediated post-transcriptional silencing of SCN1B gene modulates sodium channel functional expression.
Biol. Cell, 2014 Jan , 106 (13-29).

67

Sawyer NT et al. Scn8a voltage-gated sodium channel mutation alters seizure and anxiety responses to acute stress.
Psychoneuroendocrinology, 2014 Jan , 39 (225-36).

68

Jones JM et al. Modeling human epilepsy by TALEN targeting of mouse sodium channel Scn8a.
Genesis, 2014 Feb , 52 (141-8).

69

Vaher U et al. De novo SCN8A mutation identified by whole-exome sequencing in a boy with neonatal epileptic encephalopathy, multiple congenital anomalies, and movement disorders.
J. Child Neurol., 2014 Dec , 29 (NP202-6).

70

Makinson CD et al. Role of the hippocampus in Nav1.6 (Scn8a) mediated seizure resistance.
Neurobiol. Dis., 2014 Aug , 68 (16-25).

71

Bouafia A et al. Axonal expression of sodium channels and neuropathology of the plaques in multiple sclerosis.
Neuropathol. Appl. Neurobiol., 2014 Aug , 40 (579-90).

72

Brauner JM et al. Risperidone inhibits voltage-gated sodium channels.
Eur. J. Pharmacol., 2014 Apr 5 , 728 (100-6).

73

Zhao H et al. [Localization and expression pattern of MDM2 in axon initial segments of neuron in rodent brain].
Sheng Li Xue Bao, 2014 Apr 25 , 66 (107-17).

74

He B et al. Functional expression of Rat Nav1.6 voltage-gated sodium channels in HEK293 cells: modulation by the auxiliary β1 subunit.
PLoS ONE, 2014 , 9 (e85188).

75

Hsieh JY et al. Rapid development of Purkinje cell excitability, functional cerebellar circuit, and afferent sensory input to cerebellum in zebrafish.
Front Neural Circuits, 2014 , 8 (147).

76

Zimmer T et al. Voltage-gated sodium channels in the mammalian heart.
Glob Cardiol Sci Pract, 2014 , 2014 (449-63).

77

[To the mechanisms of antiarrhythmic action of Allapinine].
Bioorg. Khim., 2013 Jan-Feb , 39 (105-16).

78

Qiao X et al. Expression of sodium channel α subunits 1.1, 1.2 and 1.6 in rat hippocampus after kainic acid-induced epilepsy.
Epilepsy Res., 2013 Sep , 106 (17-28).

79

Xiao M et al. FGF14 localization and organization of the axon initial segment.
Mol. Cell. Neurosci., 2013 Sep , 56 (393-403).

80

Deuis JR et al. An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Nav1.6 in peripheral pain pathways.
Pain, 2013 Sep , 154 (1749-57).

81

Zhu L et al. Two recombinant α-like scorpion toxins from Mesobuthus eupeus with differential affinity toward insect and mammalian Na(+) channels.
Biochimie, 2013 Sep , 95 (1732-40).

82

Black JA et al. Noncanonical roles of voltage-gated sodium channels.
Neuron, 2013 Oct 16 , 80 (280-91).

83

Sandalon S et al. Functional and structural evaluation of lamotrigine treatment in rat models of acute and chronic ocular hypertension.
Exp. Eye Res., 2013 Oct , 115 (47-56).

84

Abbasi S et al. Introducing treatment strategy for cerebellar ataxia in mutant med mice: Combination of acetazolamide and 4-Aminopyridine.
Comput Methods Programs Biomed, 2013 Nov 24 , ().

85

Westenbroek RE et al. Localization of sodium channel subtypes in mouse ventricular myocytes using quantitative immunocytochemistry.
J. Mol. Cell. Cardiol., 2013 Nov , 64 (69-78).

86

Hargus NJ et al. Evidence for a Role of Nav1.6 in Facilitating Increases in Neuronal Hyper-excitability During Epileptogenesis.
J. Neurophysiol., 2013 Jun 5 , ().

87

Driscoll HE et al. Pumilio-2 regulates translation of Nav1.6 to mediate homeostasis of membrane excitability.
J. Neurosci., 2013 Jun 5 , 33 (9644-54).

88

Shavkunov AS et al. The Fibroblast Growth Factor 14{middle dot}Voltage-gated Sodium Channel Complex Is a New Target of Glycogen Synthase Kinase 3 (GSK3).
J. Biol. Chem., 2013 Jul 5 , 288 (19370-85).

89

Xu X et al. Abnormal changes in voltage-gated sodium channels Na(V)1.1, Na(V)1.2, Na(V)1.3, Na(V)1.6 and in calmodulin/calmodulin-dependent protein kinase II, within the brains of spontaneously epileptic rats and tremor rats.
Brain Res. Bull., 2013 Jul , 96 (1-9).

90

Sun W et al. Aberrant sodium channel activity in the complex seizure disorder of Celf4 mutant mice.
J. Physiol. (Lond.), 2013 Jan 1 , 591 (241-55).

91

Stevens M et al. Block of a subset of sodium channels exacerbates experimental autoimmune encephalomyelitis.
J. Neuroimmunol., 2013 Aug 15 , 261 (21-8).

92

Kaufmann SG et al. Distribution and function of sodium channel subtypes in human atrial myocardium.
J. Mol. Cell. Cardiol., 2013 Aug , 61 (133-41).

93

Xie W et al. Knockdown of sodium channel NaV1.6 blocks mechanical pain and abnormal bursting activity of afferent neurons in inflamed sensory ganglia.
Pain, 2013 Aug , 154 (1170-80).

94

Mourão CB et al. Characterization of a novel peptide toxin from Acanthoscurria paulensis spider venom: a distinct cysteine assignment to the HWTX-II family.
Biochemistry, 2013 Apr 9 , 52 (2440-52).

95

Durek T et al. Chemical engineering and structural and pharmacological characterization of the α-scorpion toxin OD1.
ACS Chem. Biol., 2013 , 8 (1215-22).

96

Reddy Chichili VP et al. Structural basis for the modulation of the neuronal voltage-gated sodium channel NaV1.6 by calmodulin.
Sci Rep, 2013 , 3 (2435).

97

Black JA et al. NaV1.7: stress-induced changes in immunoreactivity within magnocellular neurosecretory neurons of the supraoptic nucleus.
Mol Pain, 2013 , 9 (39).

98

Zhou X et al. Modulation of mononuclear phagocyte inflammatory response by liposome-encapsulated voltage gated sodium channel inhibitor ameliorates myocardial ischemia/reperfusion injury in rats.
PLoS ONE, 2013 , 8 (e74390).

99

Zschüntzsch J et al. Heterologous expression of a glial Kir channel (KCNJ10) in a neuroblastoma spinal cord (NSC-34) cell line.
Physiol Res, 2013 , 62 (95-105).

100

Kennedy PG et al. Varicella-Zoster Viruses Associated with Post-Herpetic Neuralgia Induce Sodium Current Density Increases in the ND7-23 Nav-1.8 Neuroblastoma Cell Line.
PLoS ONE, 2013 , 8 (e51570).

101

Yu N et al. Spontaneous excitation patterns computed for axons with injury-like impairments of sodium channels and Na/K pumps.
PLoS Comput. Biol., 2012 Sep , 8 (e1002664).

102

Rivara M et al. Inhibition of NaV1.6 sodium channel currents by a novel series of 1,4-disubstituted-triazole derivatives obtained via copper-catalyzed click chemistry.
Bioorg. Med. Chem. Lett., 2012 Oct 15 , 22 (6401-4).

103

Teramoto N et al. Resurgent-like currents in mouse vas deferens myocytes are mediated by NaV1.6 voltage-gated sodium channels.
Pflugers Arch., 2012 Nov , 464 (493-502).

104

Oliva M et al. Sodium channels and the neurobiology of epilepsy.
Epilepsia, 2012 Nov , 53 (1849-59).

105

O'Brien JE et al. Interaction of voltage-gated sodium channel Nav1.6 (SCN8A) with microtubule-associated protein Map1b.
J. Biol. Chem., 2012 May 25 , 287 (18459-66).

106

Gasser A et al. An ankyrinG-binding motif is necessary and sufficient for targeting Nav1.6 sodium channels to axon initial segments and nodes of Ranvier.
J. Neurosci., 2012 May 23 , 32 (7232-43).

107

Veeramah KR et al. De novo pathogenic SCN8A mutation identified by whole-genome sequencing of a family quartet affected by infantile epileptic encephalopathy and SUDEP.
Am. J. Hum. Genet., 2012 Mar 9 , 90 (502-10).

108

Hodgdon KE et al. Dorsal root ganglia isolated from Nf1+/- mice exhibit increased levels of mRNA expression of voltage-dependent sodium channels.
Neuroscience, 2012 Mar 29 , 206 (237-44).

109

Schulte JS et al. CREB critically regulates action potential shape and duration in the adult mouse ventricle.
, 2012 Mar 16 , ().

110

Gehman LT et al. The splicing regulator Rbfox2 is required for both cerebellar development and mature motor function.
Genes Dev., 2012 Mar 1 , 26 (445-60).

111

McCavera SJ et al. Differential state-dependent modification of inactivation-deficient Nav1.6 sodium channels by the pyrethroid insecticides S-bioallethrin, tefluthrin and deltamethrin.
Neurotoxicology, 2012 Jun , 33 (384-90).

112

Liu P et al. Modulation of neuronal sodium channels by the sea anemone peptide BDS-I.
J. Neurophysiol., 2012 Jun , 107 (3155-67).

113

Fukuoka T et al. Re-evaluation of the phenotypic changes in L4 dorsal root ganglion neurons after L5 spinal nerve ligation.
Pain, 2012 Jan , 153 (68-79).

114

Noujaim SF et al. A null mutation of the neuronal sodium channel NaV1.6 disrupts action potential propagation and excitation-contraction coupling in the mouse heart.
FASEB J., 2012 Jan , 26 (63-72).

115

Shavkunov A et al. Bioluminescence Methodology for the Detection of Protein-Protein Interactions Within the Voltage-Gated Sodium Channel Macromolecular Complex.
, 2012 Feb 24 , ().

116

Ren YS et al. Sodium channel Nav1.6 is up-regulated in the dorsal root ganglia in a mouse model of type 2 diabetes.
Brain Res. Bull., 2012 Feb 10 , 87 (244-9).

117

O'Brien JE et al. Rbfox proteins regulate alternative splicing of neuronal sodium channel SCN8A.
Mol. Cell. Neurosci., 2012 Feb , 49 (120-6).

118

Sierra Bello O et al. In silico docking reveals possible Riluzole binding sites on Nav1.6 sodium channel: implications for amyotrophic lateral sclerosis therapy.
J. Theor. Biol., 2012 Dec 21 , 315 (53-63).

119

Ding H et al. Alterations of gene expression of sodium channels in dorsal root ganglion neurons of estrogen receptor knockout (ERKO) mice induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
Endocrine, 2012 Aug , 42 (118-24).

120

Boucher PA et al. Coupled left-shift of Nav channels: modeling the Na(+)-loading and dysfunctional excitability of damaged axons.
, 2012 Apr 5 , ().

121

Sittl R et al. Anticancer drug oxaliplatin induces acute cooling-aggravated neuropathy via sodium channel subtype Na(V)1.6-resurgent and persistent current.
Proc. Natl. Acad. Sci. U.S.A., 2012 Apr 24 , 109 (6704-9).

122

Huang CY et al. Co-expression of high-voltage-activated ion channels Kv3.4 and Cav1.2 in pioneer axons during pathfinding in the developing rat forebrain.
, 2012 Apr 2 , ().

123

Hu F et al. 17β-Estradiol regulates the gene expression of voltage-gated sodium channels: role of estrogen receptor α and estrogen receptor β.
Endocrine, 2012 Apr , 41 (274-80).

124

Smith BJ et al. Reduced Retinal Function in the Absence of Na(v)1.6.
PLoS ONE, 2012 , 7 (e31476).

125

Won YJ et al. Characterization of na(+) and ca(2+) channels in zebrafish dorsal root ganglion neurons.
PLoS ONE, 2012 , 7 (e42602).

126

Klinger AB et al. Sea-anemone toxin ATX-II elicits A-fiber-dependent pain and enhances resurgent and persistent sodium currents in large sensory neurons.
Mol Pain, 2012 , 8 (69).

127

Black JA et al. Sodium channels and microglial function.
, 2011 Oct 1 , ().

128

Byers MR et al. Odontoblasts in developing, mature and ageing rat teeth have multiple phenotypes that variably express all nine voltage-gated sodium channels.
Arch. Oral Biol., 2011 Nov , 56 (1199-220).

129

Hunanyan AS et al. Alterations of action potentials and the localization of Nav1.6 sodium channels in spared axons after hemisection injury of the spinal cord in adult rats.
J. Neurophysiol., 2011 Mar , 105 (1033-44).

130

Seidel KN et al. Expression of the voltage- and Ca2+-dependent BK potassium channel subunits BKβ1 and BKβ4 in rodent astrocytes.
Glia, 2011 Jun , 59 (893-902).

131

Nutini M et al. Increased expression of the beta3 subunit of voltage-gated Na+ channels in the spinal cord of the SOD1G93A mouse.
Mol. Cell. Neurosci., 2011 Jun , 47 (108-18).

132

Fukuoka T et al. Comparative study of voltage-gated sodium channel α-subunits in non-overlapping four neuronal populations in the rat dorsal root ganglion.
Neurosci. Res., 2011 Jun , 70 (164-71).

133

Zeng R et al. Differentiation of Human Bone Marrow Mesenchymal Stem Cells into Neuron-like Cells in Vitro.
, 2011 Jan 25 , ().

134

Widmark J et al. Differential evolution of voltage-gated sodium channels in tetrapods and teleost fishes.
Mol. Biol. Evol., 2011 Jan , 28 (859-71).

135

Sato T et al. Increase of CGRP expression in motor endplates within fore and hind limb muscles of the degenerating muscle mouse (Scn8a(dmu)).
Cell. Mol. Neurobiol., 2011 Jan , 31 (155-61).

136

Estrada G et al. Addition of positive charges at the C-terminal peptide region of CssII, a mammalian scorpion peptide toxin, improves its affinity for sodium channels Nav1.6.
Peptides, 2011 Jan , 32 (75-9).

137

Ho C et al. Single-cell analysis of sodium channel expression in dorsal root ganglion neurons.
Mol. Cell. Neurosci., 2011 Jan , 46 (159-66).

138

Sittl R et al. Sustained increase in the excitability of myelinated peripheral axons to depolarizing current is mediated by Nav1.6.
, 2011 Feb 2 , ().

139

Reimer MM et al. Rapid disruption of axon-glial integrity in response to mild cerebral hypoperfusion.
J. Neurosci., 2011 Dec 7 , 31 (18185-94).

140

Baroni D et al. Molecular differential expression of voltage-gated sodium channel α and β subunit mRNAs in five different mammalian cell lines.
J. Bioenerg. Biomembr., 2011 Dec , 43 (729-38).

141

Zhao J et al. Regulation of Nav1.6 and Nav1.8 peripheral nerve Na+ channels by auxiliary β-subunits.
J. Neurophysiol., 2011 Aug , 106 (608-19).

142

Tan J et al. Independent and joint modulation of rat Nav1.6 voltage-gated sodium channels by coexpression with the auxiliary β1 and β2 subunits.
Biochem. Biophys. Res. Commun., 2011 Apr 22 , 407 (788-92).

143

Ahn HS et al. Nav1.7 is the predominant sodium channel in rodent olfactory sensory neurons.
Mol Pain, 2011 , 7 (32).

144

He H et al. Molecular determination of selectivity of the site 3 modulator (BmK I) to sodium channels in the CNS: a clue to the importance of Nav1.6 in BmK I-induced neuronal hyperexcitability.
Biochem. J., 2010 Sep 28 , 431 (289-98).

145

Luo S et al. Pulpitis increases the proportion of atypical nodes of Ranvier in human dental pulp axons without a change in Nav1.6 sodium channel expression.
Neuroscience, 2010 Sep 15 , 169 (1881-7).

146

Fukuoka T et al. Laminae-specific distribution of alpha-subunits of voltage-gated sodium channels in the adult rat spinal cord.
Neuroscience, 2010 Sep 1 , 169 (994-1006).

147

Wright MA et al. In vivo evidence for transdifferentiation of peripheral neurons.
Development, 2010 Sep , 137 (3047-56).

148

Papale LA et al. Dysfunction of the Scn8a voltage-gated sodium channel alters sleep architecture, reduces diurnal corticosterone levels, and enhances spatial memory.
J. Biol. Chem., 2010 May 28 , 285 (16553-61).

149

Lorincz A et al. Molecular identity of dendritic voltage-gated sodium channels.
Science, 2010 May 14 , 328 (906-9).

150

Gazina EV et al. Differential expression of exon 5 splice variants of sodium channel alpha subunit mRNAs in the developing mouse brain.
Neuroscience, 2010 Mar 10 , 166 (195-200).

151

Black JA et al. Astrocytes within multiple sclerosis lesions upregulate sodium channel Nav1.5.
Brain, 2010 Mar , 133 (835-46).

152

Catterall WA et al. NaV1.1 channels and epilepsy.
J. Physiol. (Lond.), 2010 Jun 1 , 588 (1849-59).

153

Meisler MH et al. Sodium channel gene family: epilepsy mutations, gene interactions and modifier effects.
J. Physiol. (Lond.), 2010 Jun 1 , 588 (1841-8).

154

Low SE et al. Na(v)1.6a is required for normal activation of motor circuits normally excited by tactile stimulation.
Dev Neurobiol, 2010 Jun , 70 (508-22).

155

Mao Q et al. The up-regulation of voltage-gated sodium channel Nav1.6 expression following fluid percussion traumatic brain injury in rats.
Neurosurgery, 2010 Jun , 66 (1134-9; discussion 1139).

156

Chatelier A et al. Biophysical characterisation of the persistent sodium current of the Nav1.6 neuronal sodium channel: a single-channel analysis.
Pflugers Arch., 2010 Jun , 460 (77-86).

157

Moreno RL et al. Developmental regulation of subtype-specific motor neuron excitability.
Ann. N. Y. Acad. Sci., 2010 Jun , 1198 (201-7).

158

Ichikawa H et al. Increase of c-Fos and c-Jun expression in spinal and cranial motoneurons of the degenerating muscle mouse (Scn8a(dmu)).
Cell. Mol. Neurobiol., 2010 Jul , 30 (737-42).

159

Brackenbury WJ et al. Functional reciprocity between Na+ channel Nav1.6 and beta1 subunits in the coordinated regulation of excitability and neurite outgrowth.
Proc. Natl. Acad. Sci. U.S.A., 2010 Feb 2 , 107 (2283-8).

160

Osorio N et al. Persistent Nav1.6 current at axon initial segments tunes spike timing of cerebellar granule cells.
J. Physiol. (Lond.), 2010 Feb 15 , 588 (651-70).

161

Hawkins NA et al. Neuronal voltage-gated ion channels are genetic modifiers of generalized epilepsy with febrile seizures plus.
, 2010 Dec 13 , ().

162

Wang Y et al. Genetic polymorphisms in the SCN8A gene are associated with suicidal behavior in psychiatric disorders in the Chinese population.
World J. Biol. Psychiatry, 2010 Dec , 11 (956-63).

163

Gasser A et al. Two Nedd4-binding motifs underlie modulation of sodium channel Nav1.6 by p38 MAPK.
J. Biol. Chem., 2010 Aug 20 , 285 (26149-61).

164

Makoff A et al. High-density SNP screen of sodium channel genes by haplotype tagging and DNA pooling for association with idiopathic generalized epilepsy.
Epilepsia, 2010 Apr , 51 (694-8).

165

Zhu HL et al. Characterization of NaV1.6-mediated Na+ currents in smooth muscle cells isolated from mouse vas deferens.
J. Cell. Physiol., 2010 Apr , 223 (234-43).

166

Persson AK et al. Sodium-calcium exchanger and multiple sodium channel isoforms in intra-epidermal nerve terminals.
Mol Pain, 2010 , 6 (84).

167

Chen K et al. Cerebellum-related characteristics of Scn8a-mutant mice.
Cerebellum, 2009 Sep , 8 (192-201).

168

Bockhart V et al. Inhibitor kappaB Kinase beta deficiency in primary nociceptive neurons increases TRP channel sensitivity.
J. Neurosci., 2009 Oct 14 , 29 (12919-29).

169

Wang JA et al. Membrane trauma and Na+ leak from Nav1.6 channels.
Am. J. Physiol., Cell Physiol., 2009 Oct , 297 (C823-34).

170

Laezza F et al. FGF14 N-terminal splice variants differentially modulate Nav1.2 and Nav1.6-encoded sodium channels.
Mol. Cell. Neurosci., 2009 Oct , 42 (90-101).

171

Mackenzie FE et al. Analysis of the mouse mutant Cloth-ears shows a role for the voltage-gated sodium channel Scn8a in peripheral neural hearing loss.
Genes Brain Behav., 2009 Oct , 8 (699-713).

172

Wienecke J et al. Global gene expression analysis of rodent motor neurons following spinal cord injury associate molecular mechanisms with development of post-injury spasticity.
J. Neurophysiol., 2009 Nov 25 , ().

173

Chen Z et al. Long-term increasing co-localization of SCN8A and ankyrin-G in rat hippocampal cornu ammonis 1 after pilocarpine induced status epilepticus.
Brain Res., 2009 May 13 , 1270 (112-20).

174

Papale LA et al. Heterozygous mutations of the voltage-gated sodium channel SCN8A are associated with spike-wave discharges and absence epilepsy in mice.
Hum. Mol. Genet., 2009 May 1 , 18 (1633-41).

175

Sharkey LM et al. Evaluation of SCN8A as a candidate gene for autosomal dominant essential tremor.
Parkinsonism Relat. Disord., 2009 May , 15 (321-3).

176

Zhu HL et al. Actions of kurtoxin on tetrodotoxin-sensitive voltage-gated Na+ currents, NaV1.6, in murine vas deferens myocytes.
Naunyn Schmiedebergs Arch. Pharmacol., 2009 May , 379 (453-60).

177

Sharkey LM et al. The ataxia3 mutation in the N-terminal cytoplasmic domain of sodium channel Na(v)1.6 disrupts intracellular trafficking.
J. Neurosci., 2009 Mar 4 , 29 (2733-41).

178

Carrithers MD et al. Regulation of podosome formation in macrophages by a splice variant of the sodium channel SCN8A.
J. Biol. Chem., 2009 Mar 20 , 284 (8114-26).

179

Shakkottai VG et al. FGF14 regulates the intrinsic excitability of cerebellar Purkinje neurons.
Neurobiol. Dis., 2009 Jan , 33 (81-8).

180

Blumenfeld H et al. Role of hippocampal sodium channel Nav1.6 in kindling epileptogenesis.
Epilepsia, 2009 Jan , 50 (44-55).

181

Gunasekaran R et al. Exposure to cerebrospinal fluid of sporadic amyotrophic lateral sclerosis patients alters Nav1.6 and Kv1.6 channel expression in rat spinal motor neurons.
Brain Res., 2009 Feb 19 , 1255 (170-9).

182

Nakajima T et al. Eicosapentaenoic acid inhibits voltage-gated sodium channels and invasiveness in prostate cancer cells.
Br. J. Pharmacol., 2009 Feb , 156 (420-31).

183

Osorio N et al. Persistent Nav1.6 current at axon initial segments tunes spike timing of cerebellar granule cells.
, 2009 Dec 21 , ().

184

Black JA et al. Sodium channel activity modulates multiple functions in microglia.
Glia, 2009 Aug 1 , 57 (1072-81).

185

Xi Y et al. Increased late sodium currents are related to transcription of neuronal isoforms in a pressure-overload model.
Eur. J. Heart Fail., 2009 Aug , 11 (749-57).

186

Thakor DK et al. Increased peripheral nerve excitability and local NaV1.8 mRNA up-regulation in painful neuropathy.
, 2009 , 5 (14).

187

Vega AV et al. Reduced expression of Na(v)1.6 sodium channels and compensation by Na(v)1.2 channels in mice heterozygous for a null mutation in Scn8a.
Neurosci. Lett., 2008 Sep 5 , 442 (69-73).

188

Fukuoka T et al. Comparative study of the distribution of the alpha-subunits of voltage-gated sodium channels in normal and axotomized rat dorsal root ganglion neurons.
J. Comp. Neurol., 2008 Sep 10 , 510 (188-206).

189

Wu SH et al. Multiple regulatory elements mediating neuronal-specific expression of zebrafish sodium channel gene, scn8aa.
Dev. Dyn., 2008 Sep , 237 (2554-65).

190

Duflocq A et al. Nav1.1 is predominantly expressed in nodes of Ranvier and axon initial segments.
Mol. Cell. Neurosci., 2008 Oct , 39 (180-92).

191

Royeck M et al. Role of axonal NaV1.6 sodium channels in action potential initiation of CA1 pyramidal neurons.
J. Neurophysiol., 2008 Oct , 100 (2361-80).

192

Howell VM et al. A targeted deleterious allele of the splicing factor SCNM1 in the mouse.
Genetics, 2008 Nov , 180 (1419-27).

193

Blumenfeld H et al. Early treatment suppresses the development of spike-wave epilepsy in a rat model.
Epilepsia, 2008 Mar , 49 (400-9).

194

Chen YH et al. Knockdown of zebrafish Nav1.6 sodium channel impairs embryonic locomotor activities.
J. Biomed. Sci., 2008 Jan , 15 (69-78).

195

Wada A et al. Voltage-dependent Na(v)1.7 sodium channels: multiple roles in adrenal chromaffin cells and peripheral nervous system.
Acta Physiol (Oxf), 2008 Feb , 192 (221-31).

196

Lorincz A et al. Cell-type-dependent molecular composition of the axon initial segment.
J. Neurosci., 2008 Dec 31 , 28 (14329-40).

197

Wang Y et al. SCN8A as a novel candidate gene associated with bipolar disorder in the Han Chinese population.
Prog. Neuropsychopharmacol. Biol. Psychiatry, 2008 Dec 12 , 32 (1902-4).

198

Black JA et al. Multiple sodium channel isoforms and mitogen-activated protein kinases are present in painful human neuromas.
Ann. Neurol., 2008 Dec , 64 (644-53).

199

McKinney BC et al. Exaggerated emotional behavior in mice heterozygous null for the sodium channel Scn8a (Nav1.6).
Genes Brain Behav., 2008 Aug , 7 (629-38).

200

Zhu HL et al. Molecular and biophysical properties of voltage-gated Na+ channels in murine vas deferens.
Biophys. J., 2008 Apr 15 , 94 (3340-51).

201

Kaneko Y et al. Expression of Nav1.1 in rat retinal AII amacrine cells.
Neurosci. Lett., 2007 Sep 7 , 424 (83-8).

202

Buczek O et al. Structure and sodium channel activity of an excitatory I1-superfamily conotoxin.
Biochemistry, 2007 Sep 4 , 46 (9929-40).

203

Black JA et al. Sodium channel expression within chronic multiple sclerosis plaques.
J. Neuropathol. Exp. Neurol., 2007 Sep , 66 (828-37).

204

Drews VL et al. Identification of evolutionarily conserved, functional noncoding elements in the promoter region of the sodium channel gene SCN8A.
Mamm. Genome, 2007 Oct , 18 (723-31).

205

Seda M et al. Functional and molecular characterization of voltage-gated sodium channels in uteri from nonpregnant rats.
Biol. Reprod., 2007 Nov , 77 (855-63).

206

Fry M et al. Differentiated pattern of sodium channel expression in dissociated Purkinje neurons maintained in long-term culture.
J. Neurochem., 2007 May , 101 (737-48).

207

Martínez-Gómez A et al. Expression of IP3 receptor isoforms at the nodes of Ranvier in rat sciatic nerve.
Neuroreport, 2007 Mar 26 , 18 (447-50).

208

Carrithers MD et al. Expression of the voltage-gated sodium channel NaV1.5 in the macrophage late endosome regulates endosomal acidification.
J. Immunol., 2007 Jun 15 , 178 (7822-32).

209

Du Y et al. Downregulation of neuronal sodium channel subunits Nav1.1 and Nav1.6 in the sinoatrial node from volume-overloaded heart failure rat.
Pflugers Arch., 2007 Jun , 454 (451-9).

210

Huang X et al. [Expression and function of voltage-gated Na+ channel isoforms in rat sinoatrial node]
Nan Fang Yi Ke Da Xue Xue Bao, 2007 Jan , 27 (52-5).

211

Mercer JN et al. Nav1.6 sodium channels are critical to pacemaking and fast spiking in globus pallidus neurons.
J. Neurosci., 2007 Dec 5 , 27 (13552-66).

212

Martin MS et al. The voltage-gated sodium channel Scn8a is a genetic modifier of severe myoclonic epilepsy of infancy.
Hum. Mol. Genet., 2007 Dec 1 , 16 (2892-9).

213

Sun Y et al. Comparison of gamma-aminobutyrate receptors in the medial vestibular nucleus of control and Scn8a mutant mice.
Brain Res., 2007 Dec , 1186 (188-93).

214

Enomoto A et al. Sodium currents in mesencephalic trigeminal neurons from Nav1.6 null mice.
J. Neurophysiol., 2007 Aug , 98 (710-9).

215

Henry MA et al. Sodium channel Nav1.6 accumulates at the site of infraorbital nerve injury.
, 2007 , 8 (56).

216

Fein AJ et al. Cloning and expression of a zebrafish SCN1B ortholog and identification of a species-specific splice variant.
BMC Genomics, 2007 , 8 (226).

217

Shirahata E et al. Ankyrin-G regulates inactivation gating of the neuronal sodium channel, Nav1.6.
J. Neurophysiol., 2006 Sep , 96 (1347-57).

218

Pineda RH et al. Knockdown of Nav1.6a Na+ channels affects zebrafish motoneuron development.
Development, 2006 Oct , 133 (3827-36).

219

Black JA et al. Remyelination of dorsal column axons by endogenous Schwann cells restores the normal pattern of Nav1.6 and Kv1.2 at nodes of Ranvier.
Brain, 2006 May , 129 (1319-29).

220

Trudeau MM et al. Heterozygosity for a protein truncation mutation of sodium channel SCN8A in a patient with cerebellar atrophy, ataxia, and mental retardation.
J. Med. Genet., 2006 Jun , 43 (527-30).

221

Van Wart A et al. Impaired firing and cell-specific compensation in neurons lacking nav1.6 sodium channels.
J. Neurosci., 2006 Jul 5 , 26 (7172-80).

222

Schiavon E et al. Resurgent current and voltage sensor trapping enhanced activation by a beta-scorpion toxin solely in Nav1.6 channel. Significance in mice Purkinje neurons.
J. Biol. Chem., 2006 Jul 21 , 281 (20326-37).

223

Leipold E et al. Subtype specificity of scorpion beta-toxin Tz1 interaction with voltage-gated sodium channels is determined by the pore loop of domain 3.
Mol. Pharmacol., 2006 Jul , 70 (340-7).

224

de Ruiter MM et al. Voltage-gated sodium channels in cerebellar Purkinje cells of mormyrid fish.
J. Neurophysiol., 2006 Jul , 96 (378-90).

225

Musarella M et al. Expression of Nav1.6 sodium channels by Schwann cells at neuromuscular junctions: role in the motor endplate disease phenotype.
Glia, 2006 Jan 1 , 53 (13-23).

226

Sasaki M et al. Molecular reconstruction of nodes of Ranvier after remyelination by transplanted olfactory ensheathing cells in the demyelinated spinal cord.
J. Neurosci., 2006 Feb 8 , 26 (1803-12).

227

Meisler MH et al. Gene symbol: SCN8A. Disease: Ataxia. Accession #Hd0520.
Hum. Genet., 2006 Feb , 118 (776).

228

Van Wart A et al. Expression of sodium channels Nav1.2 and Nav1.6 during postnatal development of the retina.
Neurosci. Lett., 2006 Aug 7 , 403 (315-7).

229

Levin SI et al. Impaired motor function in mice with cell-specific knockout of sodium channel Scn8a (NaV1.6) in cerebellar purkinje neurons and granule cells.
J. Neurophysiol., 2006 Aug , 96 (785-93).

230

Bartoo AC et al. Expression of sodium channel Nav1.6 in cholinergic myenteric neurons of guinea pig proximal colon.
Cell Tissue Res., 2006 Aug , 325 (203-9).

231

Leão RN et al. Altered sodium currents in auditory neurons of congenitally deaf mice.
Eur. J. Neurosci., 2006 Aug , 24 (1137-46).

232

Woodruff-Pak DS et al. Inactivation of sodium channel Scn8A (Na-sub(v)1.6) in Purkinje neurons impairs learning in Morris water maze and delay but not trace eyeblink classical conditioning.
Behav. Neurosci., 2006 Apr , 120 (229-40).

233

Zhao P et al. Sodium channel expression in the ventral posterolateral nucleus of the thalamus after peripheral nerve injury.
, 2006 , 2 (27).

234

Ebensperger G et al. Fetal brain hypometabolism during prolonged hypoxaemia in the llama.
J. Physiol. (Lond.), 2005 Sep 15 , 567 (963-75).

235

Saleh S et al. Electrophysiological and molecular identification of voltage-gated sodium channels in murine vascular myocytes.
J. Physiol. (Lond.), 2005 Oct 1 , 568 (155-69).

236

Ptak K et al. Sodium currents in medullary neurons isolated from the pre-Bötzinger complex region.
J. Neurosci., 2005 May 25 , 25 (5159-70).

237

Côté PD et al. Physiological maturation of photoreceptors depends on the voltage-gated sodium channel NaV1.6 (Scn8a).
J. Neurosci., 2005 May 18 , 25 (5046-50).

238

Rush AM et al. Electrophysiological properties of two axonal sodium channels, Nav1.2 and Nav1.6, expressed in mouse spinal sensory neurones.
J. Physiol. (Lond.), 2005 May 1 , 564 (803-15).

239

Pineda RH et al. Developmental, molecular, and genetic dissection of INa in vivo in embryonic zebrafish sensory neurons.
J. Neurophysiol., 2005 Jun , 93 (3582-93).

240

Gao Y et al. Linkage mapping of the SCN8A gene to chicken linkage group E22C19W28.
Anim. Genet., 2005 Jun , 36 (284).

241

Hossain WA et al. Where is the spike generator of the cochlear nerve? Voltage-gated sodium channels in the mouse cochlea.
J. Neurosci., 2005 Jul 20 , 25 (6857-68).

242

Wittmack EK et al. Voltage-gated sodium channel Nav1.6 is modulated by p38 mitogen-activated protein kinase.
J. Neurosci., 2005 Jul 13 , 25 (6621-30).

243

Rush AM et al. Contactin regulates the current density and axonal expression of tetrodotoxin-resistant but not tetrodotoxin-sensitive sodium channels in DRG neurons.
Eur. J. Neurosci., 2005 Jul , 22 (39-49).

244

Craner MJ et al. Sodium channels contribute to microglia/macrophage activation and function in EAE and MS.
Glia, 2005 Jan 15 , 49 (220-9).

245

Devaux JJ et al. Altered ion channels in an animal model of Charcot-Marie-Tooth disease type IA.
J. Neurosci., 2005 Feb 9 , 25 (1470-80).

246

Wasserman D et al. Suicide attempt and basic mechanisms in neural conduction: relationships to the SCN8A and VAMP4 genes.
Am. J. Med. Genet. B Neuropsychiatr. Genet., 2005 Feb 5 , 133B (116-9).

247

Drews VL et al. Multiple transcripts of sodium channel SCN8A (Na(V)1.6) with alternative 5'- and 3'-untranslated regions and initial characterization of the SCN8A promoter.
Genomics, 2005 Feb , 85 (245-57).

248

Osorio N et al. Differential targeting and functional specialization of sodium channels in cultured cerebellar granule cells.
J. Physiol. (Lond.), 2005 Dec 15 , 569 (801-16).

249

Meisler MH et al. Sodium channel mutations in epilepsy and other neurological disorders.
J. Clin. Invest., 2005 Aug , 115 (2010-7).

250

Cummins TR et al. Nav1.6 channels generate resurgent sodium currents in spinal sensory neurons.
FEBS Lett., 2005 Apr 11 , 579 (2166-70).

251

Mechaly I et al. Molecular diversity of voltage-gated sodium channel alpha subunits expressed in neuronal and non-neuronal excitable cells.
Neuroscience, 2005 , 130 (389-96).

252

Lei M et al. Requirement of neuronal- and cardiac-type sodium channels for murine sinoatrial node pacemaking.
J. Physiol. (Lond.), 2004 Sep 15 , 559 (835-48).

253

Meisler MH et al. Allelic mutations of the sodium channel SCN8A reveal multiple cellular and physiological functions.
Genetica, 2004 Sep , 122 (37-45).

254

Raymond CK et al. Expression of alternatively spliced sodium channel alpha-subunit genes. Unique splicing patterns are observed in dorsal root ganglia.
J. Biol. Chem., 2004 Oct 29 , 279 (46234-41).

255

Craner MJ et al. Molecular changes in neurons in multiple sclerosis: altered axonal expression of Nav1.2 and Nav1.6 sodium channels and Na+/Ca2+ exchanger.
Proc. Natl. Acad. Sci. U.S.A., 2004 May 25 , 101 (8168-73).

256

Suzuki A et al. Paranodal axoglial junction is required for the maintenance of the Nav1.6-type sodium channel in the node of Ranvier in the optic nerves but not in peripheral nerve fibers in the sulfatide-deficient mice.
Glia, 2004 May , 46 (274-83).

257

Buchner DA et al. Three ENU-induced neurological mutations in the pore loop of sodium channel Scn8a (Na(v)1.6) and a genetically linked retinal mutation, rd13.
Mamm. Genome, 2004 May , 15 (344-51).

258

Klein JP et al. Dysregulation of sodium channel expression in cortical neurons in a rodent model of absence epilepsy.
Brain Res., 2004 Mar 12 , 1000 (102-9).

259

Leipold E et al. Combinatorial interaction of scorpion toxins Lqh-2, Lqh-3, and LqhalphaIT with sodium channel receptor sites-3.
Mol. Pharmacol., 2004 Mar , 65 (685-91).

260

Wittmack EK et al. Fibroblast growth factor homologous factor 2B: association with Nav1.6 and selective colocalization at nodes of Ranvier of dorsal root axons.
J. Neurosci., 2004 Jul 28 , 24 (6765-75).

261

Grieco TM et al. Production of resurgent current in NaV1.6-null Purkinje neurons by slowing sodium channel inactivation with beta-pompilidotoxin.
J. Neurosci., 2004 Jan 7 , 24 (35-42).

262

Barbier J et al. A delta-conotoxin from Conus ermineus venom inhibits inactivation in vertebrate neuronal Na+ channels but not in skeletal and cardiac muscles.
J. Biol. Chem., 2004 Feb 6 , 279 (4680-5).

263

Craner MJ et al. Co-localization of sodium channel Nav1.6 and the sodium-calcium exchanger at sites of axonal injury in the spinal cord in EAE.
Brain, 2004 Feb , 127 (294-303).

264

Zhou W et al. Use-dependent potentiation of the Nav1.6 sodium channel.
Biophys. J., 2004 Dec , 87 (3862-72).

265

Oliveira JS et al. Binding specificity of sea anemone toxins to Nav 1.1-1.6 sodium channels: unexpected contributions from differences in the IV/S3-S4 outer loop.
J. Biol. Chem., 2004 Aug 6 , 279 (33323-35).

266

Levin SI et al. Floxed allele for conditional inactivation of the voltage-gated sodium channel Scn8a (NaV1.6).
Genesis, 2004 Aug , 39 (234-9).

267

Do MT et al. Sodium currents in subthalamic nucleus neurons from Nav1.6-null mice.
J. Neurophysiol., 2004 Aug , 92 (726-33).

268

Colbert CM Is resurgent Na+ current an alpha-subunit-specific property? Maybe not. Focus on "Sodium currents in subthalamic nucleus neurons from Nav1.6-null mice".
J. Neurophysiol., 2004 Aug , 92 (672).

269

Herzog RI et al. Distinct repriming and closed-state inactivation kinetics of Nav1.6 and Nav1.7 sodium channels in mouse spinal sensory neurons.
J. Physiol. (Lond.), 2003 Sep 15 , 551 (741-50).

270

Herzog RI et al. Calmodulin binds to the C terminus of sodium channels Nav1.4 and Nav1.6 and differentially modulates their functional properties.
J. Neurosci., 2003 Sep 10 , 23 (8261-70).

271

Buchner DA et al. High-resolution mapping of the sodium channel modifier Scnm1 on mouse chromosome 3 and identification of a 1.3-kb recombination hot spot.
Genomics, 2003 Oct , 82 (452-9).

272

Chabbert C et al. Voltage-gated Na+ channel activation induces both action potentials in utricular hair cells and brain-derived neurotrophic factor release in the rat utricle during a restricted period of development.
J. Physiol. (Lond.), 2003 Nov 15 , 553 (113-23).

273

Rasband MN et al. Paranodal transverse bands are required for maintenance but not initiation of Nav1.6 sodium channel clustering in CNS optic nerve axons.
Glia, 2003 Nov , 44 (173-82).

274

Khaliq ZM et al. The contribution of resurgent sodium current to high-frequency firing in Purkinje neurons: an experimental and modeling study.
J. Neurosci., 2003 Jun 15 , 23 (4899-912).

275

Craner MJ et al. Abnormal sodium channel distribution in optic nerve axons in a model of inflammatory demyelination.
Brain, 2003 Jul , 126 (1552-61).

276

Hamann M et al. Motor disturbances in mice with deficiency of the sodium channel gene Scn8a show features of human dystonia.
Exp. Neurol., 2003 Dec , 184 (830-8).

277

Rios JC et al. Paranodal interactions regulate expression of sodium channel subtypes and provide a diffusion barrier for the node of Ranvier.
J. Neurosci., 2003 Aug 6 , 23 (7001-11).

278

Vega AV et al. L-type calcium channel activation up-regulates the mRNAs for two different sodium channel alpha subunits (Nav1.2 and Nav1.3) in rat pituitary GH3 cells.
Brain Res. Mol. Brain Res., 2003 Aug 19 , 116 (115-25).

279

Rasband MN et al. Dysregulation of axonal sodium channel isoforms after adult-onset chronic demyelination.
J. Neurosci. Res., 2003 Aug 15 , 73 (465-70).

280

Buchner DA et al. SCNM1, a putative RNA splicing factor that modifies disease severity in mice.
Science, 2003 Aug 15 , 301 (967-9).

281

Schaller KL et al. Expression and distribution of voltage-gated sodium channels in the cerebellum.
Cerebellum, 2003 , 2 (2-9).

282

Koay G et al. Behavioral audiograms of homozygous med(J) mutant mice with sodium channel deficiency and unaffected controls.
Hear. Res., 2002 Sep , 171 (111-118).

283

Kearney JA et al. Molecular and pathological effects of a modifier gene on deficiency of the sodium channel Scn8a (Na(v)1.6).
Hum. Mol. Genet., 2002 Oct 15 , 11 (2765-75).

284

Alessandri-Haber N et al. Molecular determinants of emerging excitability in rat embryonic motoneurons.
J. Physiol. (Lond.), 2002 May 15 , 541 (25-39).

285

Meisler MH et al. Mutations of voltage-gated sodium channels in movement disorders and epilepsy.
Novartis Found. Symp., 2002 , 241 (72-81; discussion 82-6, 226-32).

286

Jenkins SM et al. Ankyrin-G coordinates assembly of the spectrin-based membrane skeleton, voltage-gated sodium channels, and L1 CAMs at Purkinje neuron initial segments.
J. Cell Biol., 2001 Nov 26 , 155 (739-46).

287

Reid E et al. The spastic paraplegia SPG10 locus: narrowing of critical region and exclusion of sodium channel gene SCN8A as a candidate.
J. Med. Genet., 2001 Jan , 38 (65-7).

288

De Repentigny Y et al. Pathological and genetic analysis of the degenerating muscle (dmu) mouse: a new allele of Scn8a.
Hum. Mol. Genet., 2001 Aug 15 , 10 (1819-27).

289

Shah BS et al. Developmental expression of the novel voltage-gated sodium channel auxiliary subunit beta3, in rat CNS.
J. Physiol. (Lond.), 2001 Aug 1 , 534 (763-76).

290

Maurice N et al. D1/D5 dopamine receptor activation differentially modulates rapidly inactivating and persistent sodium currents in prefrontal cortex pyramidal neurons.
J. Neurosci., 2001 Apr 1 , 21 (2268-77).

291

Meisler MH et al. Sodium channels and neurological disease: insights from Scn8a mutations in the mouse.
, 2001 Apr , 7 (136-45).

292

Tzoumaka E et al. Differential distribution of the tetrodotoxin-sensitive rPN4/NaCh6/Scn8a sodium channel in the nervous system.
J. Neurosci. Res., 2000 Apr 1 , 60 (37-44).

293

Smith MR et al. A mutation that causes ataxia shifts the voltage-dependence of the Scn8a sodium channel.
Neuroreport, 1999 Sep 29 , 10 (3027-31).

294

Chen K et al. Reduced spontaneous activity in the dorsal cochlear nucleus of Scn8a mutant mice.
Brain Res., 1999 Nov 13 , 847 (85-9).

295

Sprunger LK et al. Dystonia associated with mutation of the neuronal sodium channel Scn8a and identification of the modifier locus Scnm1 on mouse chromosome 3.
Hum. Mol. Genet., 1999 Mar , 8 (471-9).

296

Traub O et al. Shear stress-mediated extracellular signal-regulated kinase activation is regulated by sodium in endothelial cells. Potential role for a voltage-dependent sodium channel.
J. Biol. Chem., 1999 Jul 16 , 274 (20144-50).

297

Pan F et al. The absence of resurgent sodium current in mouse spinal neurons.
Brain Res., 1999 Dec 4 , 849 (162-8).

298

Dietrich PS et al. Functional analysis of a voltage-gated sodium channel and its splice variant from rat dorsal root ganglia.
J. Neurochem., 1998 Jun , 70 (2262-72).

299

García KD et al. The sodium channel Scn8a is the major contributor to the postnatal developmental increase of sodium current density in spinal motoneurons.
J. Neurosci., 1998 Jul 15 , 18 (5234-9).

300

Plummer NW et al. Exon organization, coding sequence, physical mapping, and polymorphic intragenic markers for the human neuronal sodium channel gene SCN8A.
Genomics, 1998 Dec 1 , 54 (287-96).

301

Smith MR et al. Functional analysis of the mouse Scn8a sodium channel.
J. Neurosci., 1998 Aug 15 , 18 (6093-102).

302

Plummer NW et al. Alternative splicing of the sodium channel SCN8A predicts a truncated two-domain protein in fetal brain and non-neuronal cells.
J. Biol. Chem., 1997 Sep 19 , 272 (24008-15).

303

Raman IM et al. Altered subthreshold sodium currents and disrupted firing patterns in Purkinje neurons of Scn8a mutant mice.
Neuron, 1997 Oct , 19 (881-91).

304

Vega-Saenz de Miera EC et al. Molecular characterization of the sodium channel subunits expressed in mammalian cerebellar Purkinje cells.
Proc. Natl. Acad. Sci. U.S.A., 1997 Jun 24 , 94 (7059-64).

305

Meisler MH et al. Ion channel mutations in mouse models of inherited neurological disease.
Ann. Med., 1997 Dec , 29 (569-74).

306

Kohrman DC et al. A missense mutation in the sodium channel Scn8a is responsible for cerebellar ataxia in the mouse mutant jolting.
J. Neurosci., 1996 Oct 1 , 16 (5993-9).

307

Porter JD et al. The neuronal voltage-gated sodium channel, Scn8a, is essential for postnatal maturation of spinal, but not oculomotor, motor units.
Exp. Neurol., 1996 Jun , 139 (328-34).

308

Kohrman DC et al. Mutation detection in the med and medJ alleles of the sodium channel Scn8a. Unusual splicing due to a minor class AT-AC intron.
J. Biol. Chem., 1996 Jul 19 , 271 (17576-81).

309

Burgess DL et al. Mutation of a new sodium channel gene, Scn8a, in the mouse mutant 'motor endplate disease'.
Nat. Genet., 1995 Aug , 10 (461-5).