ClC2

1

De Jesús-Pérez JJ et al. Gating the glutamate gate of CLC-2 chloride channel by pore occupancy.
J. Gen. Physiol., 2016 Jan , 147 (25-37).

2

Capdevila-Nortes X et al. Structural determinants of interaction, trafficking and function in the ClC-2/MLC1 subunit GlialCAM involved in leukodystrophy.
J. Physiol. (Lond.), 2015 Sep 15 , 593 (4165-80).

3

Barrallo-Gimeno A et al. Regulatory-auxiliary subunits of CLC chloride channel-transport proteins.
J. Physiol. (Lond.), 2015 Sep 15 , 593 (4111-27).

4

Hanagasi HA et al. Secondary paroxysmal kinesigenic dyskinesia associated with CLCN2 gene mutation.
Parkinsonism Relat. Disord., 2015 May , 21 (544-6).

5

de la Fuente-Ortega E et al. BASOLATERAL SORTING OF CHLORIDE CHANNEL 2 IS MEDIATED BY INTERACTIONS BETWEEN A DILEUCINE MOTIF AND THE CLATHRIN ADAPTOR AP-1.
Mol. Biol. Cell, 2015 Mar 4 , ().

6

Dubey M et al. Mice with megalencephalic leukoencephalopathy with cysts: a developmental angle.
Ann. Neurol., 2015 Jan , 77 (114-31).

7

Catalán MA et al. A fluid secretion pathway unmasked by acinar-specific Tmem16A gene ablation in the adult mouse salivary gland.
Proc. Natl. Acad. Sci. U.S.A., 2015 Feb 17 , 112 (2263-8).

8

Grant J et al. A Novel Mechanism of pH Buffering in C. elegans Glia: Bicarbonate Transport via the Voltage-Gated ClC Cl- Channel CLH-1.
J. Neurosci., 2015 Dec 16 , 35 (16377-97).

9

Pérez-Rius C et al. Identification and characterization of the zebrafish ClC-2 chloride channel orthologs.
Pflugers Arch., 2015 Aug , 467 (1769-81).

10

Wang YF et al. Molecular Physiology of an Extra-renal Cl(-) Uptake Mechanism for Body Fluid Cl(-) Homeostasis.
Int. J. Biol. Sci., 2015 , 11 (1190-203).

11

Imbrici P et al. ClC-1 chloride channels: state-of-the-art research and future challenges.
Front Cell Neurosci, 2015 , 9 (156).

12

Brignone MS et al. MLC1 protein: a likely link between leukodystrophies and brain channelopathies.
Front Cell Neurosci, 2015 , 9 (66).

13

Nikolaidou T et al. Congestive Heart Failure Leads to Prolongation of the PR Interval and Atrioventricular Junction Enlargement and Ion Channel Remodelling in the Rabbit.
PLoS ONE, 2015 , 10 (e0141452).

14

Zhao B et al. 4,4'-Diisothiocyanostilbene-2,2'-disulfonic Acid (DIDS) Ameliorates Ischemia-Hypoxia-Induced White Matter Damage in Neonatal Rats through Inhibition of the Voltage-Gated Chloride Channel ClC-2.
Int J Mol Sci, 2015 , 16 (10457-69).

15

Nighot MP et al. Genetic Ablation of the ClC-2 Cl- Channel Disrupts Mouse Gastric Parietal Cell Acid Secretion.
PLoS ONE, 2015 , 10 (e0138174).

16

Pan F et al. High glucose inhibits ClC-2 chloride channels and attenuates cell migration of rat keratinocytes.
Drug Des Devel Ther, 2015 , 9 (4779-91).

17

Di Bella D et al. Subclinical leukodystrophy and infertility in a man with a novel homozygous CLCN2 mutation.
Neurology, 2014 Sep 23 , 83 (1217-8).

18

Jeworutzki E et al. GlialCAM, a CLC-2 Cl(-) channel subunit, activates the slow gate of CLC chloride channels.
Biophys. J., 2014 Sep 2 , 107 (1105-16).

19

Domingue JC et al. HEK-293 cells expressing the cystic fibrosis transmembrane conductance regulator (CFTR): a model for studying regulation of Cl- transport.
Physiol Rep, 2014 Sep 1 , 2 ().

20

Cuppoletti J et al. Differentiation between human ClC-2 and CFTR Cl- channels with pharmacological agents.
Am. J. Physiol., Cell Physiol., 2014 Sep 1 , 307 (C479-92).

21

Warsi J et al. Downregulation of chloride channel ClC-2 by Janus kinase 3.
J. Membr. Biol., 2014 May , 247 (387-93).

22

Moreno-Galindo EG et al. The principal conductance in Giardia lamblia trophozoites possesses functional properties similar to the mammalian ClC-2 current.
Pflugers Arch., 2014 May , 466 (915-24).

23

Stölting G et al. ClC-1 and ClC-2 form hetero-dimeric channels with novel protopore functions.
Pflugers Arch., 2014 Mar 19 , ().

24

Arnedo T et al. Expanding the spectrum of megalencephalic leukoencephalopathy with subcortical cysts in two patients with GLIALCAM mutations.
Neurogenetics, 2014 Mar , 15 (41-8).

25

Hayashi S et al. Lubiprostone prevents nonsteroidal anti-inflammatory drug-induced small intestinal damage by suppressing the expression of inflammatory mediators via EP4 receptors.
J. Pharmacol. Exp. Ther., 2014 Jun , 349 (470-9).

26

Branicky R et al. The voltage-gated anion channels encoded by clh-3 regulate egg laying in C. elegans by modulating motor neuron excitability.
J. Neurosci., 2014 Jan 15 , 34 (764-75).

27

Okamoto Y et al. Pathological impact of hyperpolarization-activated chloride current peculiar to rat pulmonary vein cardiomyocytes.
J. Mol. Cell. Cardiol., 2014 Jan , 66 (53-62).

28

Sasaki S et al. Actin directly interacts with different membrane channel proteins and influences channel activities: AQP2 as a model.
Biochim. Biophys. Acta, 2014 Feb , 1838 (514-20).

29

Liang W et al. Swelling-activated Cl- currents and intracellular CLC-3 are involved in proliferation of human pulmonary artery smooth muscle cells.
J. Hypertens., 2014 Feb , 32 (318-30).

30

McCarthy NS et al. Two further blood pressure loci identified in ion channel genes with a gene-centric approach.
Circ Cardiovasc Genet, 2014 Dec , 7 (873-9).

31

Hoegg-Beiler MB et al. Disrupting MLC1 and GlialCAM and ClC-2 interactions in leukodystrophy entails glial chloride channel dysfunction.
Nat Commun, 2014 , 5 (3475).

32

Stölting G et al. CLC channel function and dysfunction in health and disease.
Front Physiol, 2014 , 5 (378).

33

Bi MM et al. Chloride channelopathies of ClC-2.
Int J Mol Sci, 2014 , 15 (218-49).

34

Warsi J et al. Regulation of ClC-2 activity by SPAK and OSR1.
Kidney Blood Press. Res., 2014 , 39 (378-87).

35

Wang HW et al. Effect of CLC-2 on the cytoskeleton in human trabecular meshwork cells.
Mol Med Rep, 2013 Oct , 8 (1099-105).

36

Stölting G et al. Regulation of ClC-2 gating by intracellular ATP.
Pflugers Arch., 2013 Oct , 465 (1423-37).

37

Capdevila-Nortes X et al. Insights into MLC pathogenesis: GlialCAM is an MLC1 chaperone required for proper activation of volume-regulated anion currents.
Hum. Mol. Genet., 2013 Nov 1 , 22 (4405-16).

38

Cuppoletti J et al. Methadone but not morphine inhibits lubiprostone-stimulated Cl- currents in T84 intestinal cells and recombinant human ClC-2, but not CFTR Cl- currents.
Cell Biochem. Biophys., 2013 May , 66 (53-63).

39

Chen TT et al. Novel brain expression of ClC-1 chloride channels and enrichment of CLCN1 variants in epilepsy.
Neurology, 2013 Mar 19 , 80 (1078-85).

40

Schiffhauer ES et al. Dual activation of CFTR and CLCN2 by lubiprostone in murine nasal epithelia.
Am. J. Physiol. Lung Cell Mol. Physiol., 2013 Mar 1 , 304 (L324-31).

41

Depienne C et al. Brain white matter oedema due to ClC-2 chloride channel deficiency: an observational analytical study.
Lancet Neurol, 2013 Jul , 12 (659-68).

42

Lang F et al. Regulation of ion channels by the serum- and glucocorticoid-inducible kinase SGK1.
FASEB J., 2013 Jan , 27 (3-12).

43

Nighot P et al. Chloride channel ClC-2 is a key factor in the development of DSS-induced murine colitis.
Inflamm. Bowel Dis., 2013 Dec , 19 (2867-77).

44

Benfenati V et al. Photostimulation of Whole-Cell Conductance in Primary Rat Neocortical Astrocytes Mediated by Organic Semiconducting Thin Films.
Adv Healthc Mater, 2013 Aug 21 , ().

45

Ochoa-de la Paz LD et al. Characterization of an outward rectifying chloride current of Xenopus tropicalis oocytes.
Biochim. Biophys. Acta, 2013 Aug , 1828 (1743-53).

46

Duan DD Phenomics of cardiac chloride channels.
Compr Physiol, 2013 Apr , 3 (667-92).

47

Jonchere VV et al. Identification of uterine ion transporters for mineralisation precursors of the avian eggshell.
BMC Physiol., 2012 Sep 4 , 12 (10).

48

Norimatsu Y et al. Lubiprostone activates CFTR, but not ClC-2, via the prostaglandin receptor (EP(4)).
Biochem. Biophys. Res. Commun., 2012 Sep 28 , 426 (374-9).

49

Nighot M et al. Gastro protective properties of the novel prostone SPI-8811 against acid-injured porcine mucosa.
World J. Gastroenterol., 2012 Sep 14 , 18 (4684-92).

50

Sánchez-Rodríguez JE et al. Sequential interaction of chloride and proton ions with the fast gate steer the voltage-dependent gating in ClC-2 chloride channels.
J. Physiol. (Lond.), 2012 Sep 1 , 590 (4239-53).

51

van der Knaap MS et al. Megalencephalic leukoencephalopathy with subcortical cysts: chronic white matter oedema due to a defect in brain ion and water homoeostasis.
Lancet Neurol, 2012 Nov , 11 (973-85).

52

Jeworutzki E et al. GlialCAM, a Protein Defective in a Leukodystrophy, Serves as a ClC-2 Cl(-) Channel Auxiliary Subunit.
Neuron, 2012 Mar 8 , 73 (951-61).

53

Nandoskar P et al. Changes of chloride channels in the lacrimal glands of a rabbit model of Sjögren syndrome.
Cornea, 2012 Mar , 31 (273-9).

54

Nighot PK et al. Chloride channel ClC-2 modulates tight junction barrier function via intracellular trafficking of occludin.
Am. J. Physiol., Cell Physiol., 2012 Jan , 302 (C178-87).

55

Jakab RL et al. Lubiprostone Targets Prostanoid Signaling and Promotes Ion Transporter Trafficking, Mucus Exocytosis, and Contractility.
Dig. Dis. Sci., 2012 Aug 25 , ().

56

Benesova J et al. Distinct Expression/Function of Potassium and Chloride Channels Contributes to the Diverse Volume Regulation in Cortical Astrocytes of GFAP/EGFP Mice.
PLoS ONE, 2012 , 7 (e29725).

57

Hosseinzadeh Z et al. Downregulation of ClC-2 by JAK2.
Cell. Physiol. Biochem., 2012 , 29 (737-42).

58

Lembo AJ et al. Long-term safety and effectiveness of lubiprostone, a chloride channel (ClC-2) activator, in patients with chronic idiopathic constipation.
Dig. Dis. Sci., 2011 Sep , 56 (2639-45).

59

Catalán MA et al. Severe Defects in Absorptive Ion Transport in Distal Colons of Mice that Lack ClC-2 Channels.
, 2011 Nov 9 , ().

60

Ratté S et al. ClC-2 channels regulate neuronal excitability, not intracellular chloride levels.
J. Neurosci., 2011 Nov 2 , 31 (15838-43).

61

Zhang H et al. Characterisation of Cl(-) transporter and channels in experimentally induced myopic chick eyes.
Clin Exp Optom, 2011 Nov , 94 (528-35).

62

Deisz RA et al. Components of neuronal chloride transport in rat and human neocortex.
J. Physiol. (Lond.), 2011 Mar 15 , 589 (1317-47).

63

Ge YX et al. ClC-2 contributes to tonic inhibition mediated by α5 subunit-containing GABA(A) receptor in experimental temporal lobe epilepsy.
Neuroscience, 2011 Jul 14 , 186 (120-7).

64

Cuthbert AW Lubiprostone targets prostanoid EP₄ receptors in ovine airways.
Br. J. Pharmacol., 2011 Jan , 162 (508-20).

65

Ao M et al. Lubiprostone activates Cl- secretion via cAMP signaling and increases membrane CFTR in the human colon carcinoma cell line, T84.
Dig. Dis. Sci., 2011 Feb , 56 (339-51).

66

Vieira AC et al. Ionic components of electric current at rat corneal wounds.
PLoS ONE, 2011 , 6 (e17411).

67

Földy C et al. Regulation of fast-spiking basket cell synapses by the chloride channel ClC-2.
Nat. Neurosci., 2010 Sep , 13 (1047-9).

68

Gradogna A et al. A regulatory calcium-binding site at the subunit interface of CLC-K kidney chloride channels.
J. Gen. Physiol., 2010 Sep , 136 (311-23).

69

Lui VC et al. Invasion of Human Glioma Cells Is Regulated by Multiple Chloride Channels Including ClC-3.
Anticancer Res., 2010 Nov , 30 (4515-24).

70

Inagaki A et al. Functional characterization of a ClC-2-like Cl(-) conductance in surface epithelial cells of rat rectal colon.
J. Membr. Biol., 2010 May , 235 (27-41).

71

Kim KX et al. Inward-rectifier chloride currents in Reissner's membrane epithelial cells.
, 2010 Mar 9 , ().

72

Rinke I et al. ClC-2 voltage-gated channels constitute part of the background conductance and assist chloride extrusion.
J. Neurosci., 2010 Mar 31 , 30 (4776-86).

73

O'Brien CE et al. Use of the chloride channel activator lubiprostone for constipation in adults with cystic fibrosis: a case series.
Ann Pharmacother, 2010 Mar , 44 (577-81).

74

Wood JD Enteric nervous system: sensory physiology, diarrhea and constipation.
Curr. Opin. Gastroenterol., 2010 Mar , 26 (102-8).

75

Lang F et al. Significance of SGK1 in the regulation of neuronal function.
, 2010 Jun 7 , ().

76

Klausen TK et al. Monovalent Ions Control Proliferation of Ehrlich Lettre Ascites cells.
, 2010 Jun 30 , ().

77

Cao L et al. Chloride channels and transporters in human corneal epithelium.
Exp. Eye Res., 2010 Jun , 90 (771-9).

78

Ding C et al. Duct system of the rabbit lacrimal gland: structural characteristics and role in lacrimal secretion.
Invest. Ophthalmol. Vis. Sci., 2010 Jun , 51 (2960-7).

79

Edwards MM et al. Photoreceptor degeneration, azoospermia, leukoencephalopathy, and abnormal RPE cell function in mice expressing an early stop mutation in CLCN2.
Invest. Ophthalmol. Vis. Sci., 2010 Jun , 51 (3264-72).

80

McCoy ES et al. Water permeability through aquaporin-4 is regulated by protein kinase C and becomes rate-limiting for glioma invasion.
Neuroscience, 2010 Jul 28 , 168 (971-81).

81

Sánchez-Rodríguez JE et al. Permeant anions contribute to voltage dependence of ClC-2 chloride channel by interacting with the protopore gate.
J. Physiol. (Lond.), 2010 Jul 15 , 588 (2545-56).

82

Fei G et al. Lubiprostone reverses the inhibitory action of morphine on intestinal secretion in guinea pig and mouse.
J. Pharmacol. Exp. Ther., 2010 Jul , 334 (333-40).

83

Galanopoulou AS Mutations affecting GABAergic signaling in seizures and epilepsy.
Pflugers Arch., 2010 Jul , 460 (505-23).

84

Niemeyer MI et al. No evidence for a role of CLCN2 variants in idiopathic generalized epilepsy.
Nat. Genet., 2010 Jan , 42 (3).

85

Bove PF et al. Human alveolar type II cells secrete and absorb liquid in response to local nucleotide signaling.
, 2010 Aug 27 , ().

86

Nighot PK et al. ClC-2 regulates mucosal barrier function associated with structural changes to the villus and epithelial tight junction.
Am. J. Physiol. Gastrointest. Liver Physiol., 2010 Aug , 299 (G449-56).

87

Cortez MA et al. Disruption of ClC-2 expression is associated with progressive neurodegeneration in aging mice.
Neuroscience, 2010 Apr 28 , 167 (154-62).

88

Scheper GC et al. Analysis of CLCN2 as candidate gene for megalencephalic leukoencephalopathy with subcortical cysts.
Genet Test Mol Biomarkers, 2010 Apr , 14 (255-7).

89

Ornellas Ddos S et al. Thyroid hormone beta receptor mutation causes renal dysfunction and impairment of ClC-2 chloride channel expression in mouse kidney.
Cell. Physiol. Biochem., 2010 , 26 (227-34).

90

De Lisle RC et al. Lubiprostone ameliorates the cystic fibrosis mouse intestinal phenotype.
BMC Gastroenterol, 2010 , 10 (107).

91

Thompson CH et al. Isolation and characterization of a high affinity peptide inhibitor of ClC-2 chloride channels.
J. Biol. Chem., 2009 Sep 18 , 284 (26051-62).

92

Kleefuss-Lie A et al. CLCN2 variants in idiopathic generalized epilepsy.
Nat. Genet., 2009 Sep , 41 (954-5).

93

Bijvelds MJ et al. Activation of intestinal Cl- secretion by lubiprostone requires the cystic fibrosis transmembrane conductance regulator.
Gastroenterology, 2009 Sep , 137 (976-85).

94

Ringman Uggla A et al. Expression of chloride channels in trachea-occluded hyperplastic lungs and nitrofen-induced hypoplastic lungs in rats.
Pediatr. Surg. Int., 2009 Sep , 25 (799-806).

95

Johnson M et al. Characteristics of Cl- uptake in rat alveolar type I cells.
Am. J. Physiol. Lung Cell Mol. Physiol., 2009 Nov , 297 (L816-27).

96

Duan D Phenomics of cardiac chloride channels: the systematic study of chloride channel function in the heart.
J. Physiol. (Lond.), 2009 May 15 , 587 (2163-77).

97

Joo NS et al. Lubiprostone stimulates secretion from tracheal submucosal glands of sheep, pigs, and humans.
Am. J. Physiol. Lung Cell Mol. Physiol., 2009 May , 296 (L811-24).

98

Saint-Martin C et al. Two novel CLCN2 mutations accelerating chloride channel deactivation are associated with idiopathic generalized epilepsy.
Hum. Mutat., 2009 Mar , 30 (397-405).

99

Yoshise Y et al. Functional and molecular characterizations of chloride channels in rat pleural mesothelial cells.
Eur. J. Pharmacol., 2009 Jul 1 , 614 (22-9).

100

Huang ZM et al. Functional role of CLC-2 chloride inward rectifier channels in cardiac sinoatrial nodal pacemaker cells.
J. Mol. Cell. Cardiol., 2009 Jul , 47 (121-32).

101

Nighot PK et al. ClC-2 is required for rapid restoration of epithelial tight junctions in ischemic-injured murine jejunum.
Exp. Cell Res., 2009 Jan 1 , 315 (110-8).

102

Hohberger B et al. Cereblon is expressed in the retina and binds to voltage-gated chloride channels.
FEBS Lett., 2009 Feb 18 , 583 (633-7).

103

Cornejo I et al. Rapid recycling of ClC-2 chloride channels between plasma membrane and endosomes: role of a tyrosine endocytosis motif in surface retrieval.
J. Cell. Physiol., 2009 Dec , 221 (650-7).

104

Jesse NM et al. Expression of ENaC subunits, chloride channels, and aquaporins in ovine fetal lung: ontogeny of expression and effects of altered fetal cortisol concentrations.
Am. J. Physiol. Regul. Integr. Comp. Physiol., 2009 Aug , 297 (R453-61).

105

Combi R et al. Clinical and genetic familial study of a large cohort of Italian children with idiopathic epilepsy.
Brain Res. Bull., 2009 Apr 29 , 79 (89-96).

106

Klaus F et al. PIKfyve-dependent regulation of the Cl- channel ClC-2.
Biochem. Biophys. Res. Commun., 2009 Apr 10 , 381 (407-11).

107

Pusch M et al. It's the proton also in ClC-2.
J. Physiol. (Lond.), 2009 Apr 1 , 587 (1379-80).

108

Niemeyer MI et al. Voltage-dependent and -independent titration of specific residues accounts for complex gating of a ClC chloride channel by extracellular protons.
J. Physiol. (Lond.), 2009 Apr 1 , 587 (1387-400).

109

Huber SM et al. Organic osmolyte channels in malaria-infected erythrocytes.
Biochem. Biophys. Res. Commun., 2008 Nov 21 , 376 (514-8).

110

Arreola J et al. Gating and trafficking of ClC-2 chloride channel without cystathionine beta-synthase domains.
J. Physiol. (Lond.), 2008 Nov 15 , 586 (5289).

111

Garcia-Olivares J et al. Gating of human ClC-2 chloride channels and regulation by carboxy-terminal domains.
J. Physiol. (Lond.), 2008 Nov 15 , 586 (5325-36).

112

Romanenko VG et al. Clcn2 encodes the hyperpolarization-activated chloride channel in the ducts of mouse salivary glands.
Am. J. Physiol. Gastrointest. Liver Physiol., 2008 Nov , 295 (G1058-67).

113

MacDonald KD et al. Lubiprostone activates non-CFTR-dependent respiratory epithelial chloride secretion in cystic fibrosis mice.
Am. J. Physiol. Lung Cell Mol. Physiol., 2008 Nov , 295 (L933-40).

114

Miyakawa H et al. A chloride ion channel in Halocynthia roretzi hemocytes is associated with PO activity but not pigmentation during the contact reaction.
Zool. Sci., 2008 Nov , 25 (1130-8).

115

Bassil AK et al. Activation of prostaglandin EP receptors by lubiprostone in rat and human stomach and colon.
Br. J. Pharmacol., 2008 May , 154 (126-35).

116

Graves AR et al. The Cl-/H+ antiporter ClC-7 is the primary chloride permeation pathway in lysosomes.
Nature, 2008 Jun 5 , 453 (788-92).

117

Dhani SU et al. ATP depletion inhibits the endocytosis of ClC-2.
J. Cell. Physiol., 2008 Jan , 214 (273-80).

118

Bao HF et al. A synthetic prostone activates apical chloride channels in A6 epithelial cells.
Am. J. Physiol. Gastrointest. Liver Physiol., 2008 Aug , 295 (G234-51).

119

Li H et al. Possible role of transforming growth factor beta and interleukin-4 in the up-regulation of CLC-2 and CLC-3 in chronic rhinosinusitis.
, 2007 Jul-Aug , 21 (389-94).

120

Lucarini N et al. Genetic polymorphisms and idiopathic generalized epilepsies.
Pediatr. Neurol., 2007 Sep , 37 (157-64).

121

Itani OA et al. Basolateral chloride current in human airway epithelia.
Am. J. Physiol. Lung Cell Mol. Physiol., 2007 Oct , 293 (L991-9).

122

Ducharme G et al. Small-conductance Cl- channels contribute to volume regulation and phagocytosis in microglia.
Eur. J. Neurosci., 2007 Oct , 26 (2119-30).

123

Bouyer G et al. Toward a unifying model of malaria-induced channel activity.
Proc. Natl. Acad. Sci. U.S.A., 2007 Jun 26 , 104 (11044-9).

124

Baglole CJ et al. Alpha1-adrenoceptors down-regulate ClC-2 chloride channels in epithelial cells from the acutely denervated jejunum.
Eur. J. Pharmacol., 2007 Jun 22 , 565 (202-6).

125

Blanz J et al. Leukoencephalopathy upon disruption of the chloride channel ClC-2.
J. Neurosci., 2007 Jun 13 , 27 (6581-9).

126

Qu C et al. Identification of ClC-2 and CIC-K2 chloride channels in cultured rat type IV spiral ligament fibrocytes.
J. Assoc. Res. Otolaryngol., 2007 Jun , 8 (205-19).

127

Everett K et al. Linkage and mutational analysis of CLCN2 in childhood absence epilepsy.
Epilepsy Res., 2007 Jul , 75 (145-53).

128

Rose U et al. Properties and possible function of a hyperpolarisation-activated chloride current in Drosophila.
J. Exp. Biol., 2007 Jul , 210 (2489-500).

129

Hinzpeter A et al. Membrane cholesterol content modulates ClC-2 gating and sensitivity to oxidative stress.
J. Biol. Chem., 2007 Jan 26 , 282 (2423-32).

130

Cheng G et al. Involvement of chloride channels in IGF-I-induced proliferation of porcine arterial smooth muscle cells.
Cardiovasc. Res., 2007 Jan 1 , 73 (198-207).

131

Bertelli M et al. Quantification of chloride channel 2 (CLCN2) gene isoforms in normal versus lesion- and epilepsy-associated brain tissue.
Biochim. Biophys. Acta, 2007 Jan , 1772 (15-20).

132

Crowell MD et al. Activation of type-2 chloride channels: a novel therapeutic target for the treatment of chronic constipation.
, 2007 Jan , 8 (66-70).

133

Moeser AJ et al. Recovery of mucosal barrier function in ischemic porcine ileum and colon is stimulated by a novel agonist of the ClC-2 chloride channel, lubiprostone.
Am. J. Physiol. Gastrointest. Liver Physiol., 2007 Feb , 292 (G647-56).

134

MacVinish LJ et al. Chloride transporting capability of Calu-3 epithelia following persistent knockdown of the cystic fibrosis transmembrane conductance regulator, CFTR.
Br. J. Pharmacol., 2007 Apr , 150 (1055-65).

135

Lacy BE et al. Lubiprostone: a chloride channel activator.
J. Clin. Gastroenterol., 2007 Apr , 41 (345-51).

136

Zifarelli G et al. CLC chloride channels and transporters: a biophysical and physiological perspective.
Rev. Physiol. Biochem. Pharmacol., 2007 , 158 (23-76).

137

Paul J et al. Alterations in the cytoplasmic domain of CLCN2 result in altered gating kinetics.
Cell. Physiol. Biochem., 2007 , 20 (441-54).

138

Flores CA et al. Two splice variants derived from a Drosophila melanogaster candidate ClC gene generate ClC-2-type Cl- channels.
Mol. Membr. Biol., 2006 Mar-Apr , 23 (149-56).

139

Kwak SE et al. Differential paired-pulse responses between the CA1 region and the dentate gyrus are related to altered CLC-2 immunoreactivity in the pilocarpine-induced rat epilepsy model.
Brain Res., 2006 Oct 18 , 1115 (162-8).

140

Comes N et al. Identification and functional characterization of ClC-2 chloride channels in trabecular meshwork cells.
Exp. Eye Res., 2006 Oct , 83 (877-89).

141

Stogmann E et al. Mutations in the CLCN2 gene are a rare cause of idiopathic generalized epilepsy syndromes.
Neurogenetics, 2006 Nov , 7 (265-8).

142

Abdullaev IF et al. Pharmacological comparison of swelling-activated excitatory amino acid release and Cl- currents in cultured rat astrocytes.
J. Physiol. (Lond.), 2006 May 1 , 572 (677-89).

143

Camilleri M et al. Effect of a selective chloride channel activator, lubiprostone, on gastrointestinal transit, gastric sensory, and motor functions in healthy volunteers.
Am. J. Physiol. Gastrointest. Liver Physiol., 2006 May , 290 (G942-7).

144

Coppola G et al. Mutational scanning of potassium, sodium and chloride ion channels in malignant migrating partial seizures in infancy.
Brain Dev., 2006 Mar , 28 (76-9).

145

Ramjeesingh M et al. Evaluation of the membrane-spanning domain of ClC-2.
Biochem. J., 2006 Jun 15 , 396 (449-60).

146

Vij N et al. Regulation of the ClC-2 lung epithelial chloride channel by glycosylation of SP1.
Am. J. Respir. Cell Mol. Biol., 2006 Jun , 34 (754-9).

147

Yang XY et al. [siRNA-mediated silencing of ClC-2 gene inhibits proliferation of human U-87 glioma cells]
Ai Zheng, 2006 Jul , 25 (805-10).

148

Cid LP et al. ClC-2 channels get new partners. Focus on "association between Hsp90 and the ClC-2 chloride channel upregulates channel function".
Am. J. Physiol., Cell Physiol., 2006 Jan , 290 (C42-4).

149

Nakamura A et al. Molecular cloning, functional expression and subcellular localization of two putative vacuolar voltage-gated chloride channels in rice (Oryza sativa L.).
Plant Cell Physiol., 2006 Jan , 47 (32-42).

150

Hinzpeter A et al. Association between Hsp90 and the ClC-2 chloride channel upregulates channel function.
Am. J. Physiol., Cell Physiol., 2006 Jan , 290 (C45-56).

151

Uwaifo O et al. Acidic pH hyperpolarizes nasal potential difference.
Pediatr. Pulmonol., 2006 Feb , 41 (151-7).

152

Yusef YR et al. Removal of gating in voltage-dependent ClC-2 chloride channel by point mutations affecting the pore and C-terminus CBS-2 domain.
J. Physiol. (Lond.), 2006 Apr 1 , 572 (173-81).

153

Duta V et al. Regulation of basolateral Cl(-) channels in airway epithelial cells: the role of nitric oxide.
J. Membr. Biol., 2006 , 213 (165-74).

154

Flis K et al. The functioning of mammalian ClC-2 chloride channel in Saccharomyces cerevisiae cells requires an increased level of Kha1p.
Biochem. J., 2005 Sep 15 , 390 (655-64).

155

Peña-Münzenmayer G et al. Basolateral localization of native ClC-2 chloride channels in absorptive intestinal epithelial cells and basolateral sorting encoded by a CBS-2 domain di-leucine motif.
J. Cell. Sci., 2005 Sep 15 , 118 (4243-52).

156

Ugarte G et al. Putative ClC-2 chloride channel mediates inward rectification in Drosophila retinal photoreceptors.
J. Membr. Biol., 2005 Oct , 207 (151-60).

157

Yeung CH et al. Chloride channels in physiological volume regulation of human spermatozoa.
Biol. Reprod., 2005 Nov , 73 (1057-63).

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