Channelpedia

PubMed 11796946


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Cav2.1



Title: Episodic vertigo: central nervous system causes.

Authors: Robert W Baloh

Journal, date & volume: Curr. Opin. Neurol., 2002 Feb , 15, 17-21

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/11796946


Abstract
Episodic ataxia type 2 is a prototypical episodic vertigo and ataxia syndrome that is caused by mutations in the calcium channel gene CACNA1A. Recent discoveries regarding the molecular mechanisms that underlie this syndrome provide a model for understanding the more common familial episodic vertigo syndromes, particularly those associated with migraine. Vertigo due to cerebrovascular disease can be of peripheral or central origin, and can mimic more benign peripheral vestibular disorders. Small infarcts in the cerebellum and lateral medulla can present with vertigo without other localizing symptoms.