HCN2

1

Hayashi K et al. Green apatites: hydride ions, electrons and their interconversion in the crystallographic channel.
Phys Chem Chem Phys, 2016 Mar 9 , 18 (8186-95).

2

Deberg HA et al. Structure and Energetics of Allosteric Regulation of HCN2 Ion Channels by Cyclic Nucleotides.
J. Biol. Chem., 2016 Jan 1 , 291 (371-81).

3

Bruzauskaite I et al. Relevance of HCN2-expressing human mesenchymal stem cells for the generation of biological pacemakers.
Stem Cell Res Ther, 2016 , 7 (67).

4

Huang X et al. Age-associated expression of HCN channel isoforms in rat sinoatrial node.
Exp. Biol. Med. (Maywood), 2015 Sep 3 , ().

5

Liu Y et al. Pulsed Radiofrequency Treatment Enhances Dorsal Root Ganglion Expression of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels in a Rat Model of Neuropathic Pain.
J. Mol. Neurosci., 2015 Sep , 57 (97-105).

6

Luo P et al. Long-lasting spatial learning and memory impairments caused by chronic cerebral hypoperfusion associate with a dynamic change of HCN1/HCN2 expression in hippocampal CA1 region.
Neurobiol Learn Mem, 2015 Sep , 123 (72-83).

7

Li YD et al. Altered expression of hyperpolarization-activated cyclic nucleotide-gated channels and microRNA-1 and -133 in patients with age-associated atrial fibrillation.
Mol Med Rep, 2015 Sep , 12 (3243-8).

8

Li N et al. Molecular Mapping of Sinoatrial Node HCN Channel Expression in the Human Heart.
Circ Arrhythm Electrophysiol, 2015 Oct , 8 (1219-27).

9

Hou B et al. Characteristics of hyperpolarization-activated cyclic nucleotide-gated channels in dorsal root ganglion neurons at different ages and sizes.
Neuroreport, 2015 Nov 11 , 26 (981-7).

10

O'Donnell AM et al. Decreased expression of hyperpolarisation-activated cyclic nucleotide-gated channel 3 in Hirschsprung's disease.
World J. Gastroenterol., 2015 May 14 , 21 (5635-40).

11

Challenor M et al. Prolonged glutamate excitotoxicity increases GluR1 immunoreactivity but decreases mRNA of GluR1 and associated regulatory proteins in dissociated rat retinae in vitro.
Biochimie, 2015 May , 112 (160-71).

12

Mattusch C et al. Impact of Hyperpolarization-activated, Cyclic Nucleotide-gated Cation Channel Type 2 for the Xenon-mediated Anesthetic Effect: Evidence from In Vitro and In Vivo Experiments.
Anesthesiology, 2015 May , 122 (1047-59).

13

Deberg HA et al. Structural Mechanism for the Regulation of HCN Ion Channels by the Accessory Protein TRIP8b.
Structure, 2015 Mar 4 , ().

14

Smith T et al. Increased Expression of HCN2 Channel Protein in L4 Dorsal Root Ganglion Neurons Following Axotomy of L5- and Inflammation of L4-Spinal Nerves in Rats.
Neuroscience, 2015 Mar 23 , ().

15

Zhou C et al. Hyperpolarization-activated cyclic nucleotide-gated channels may contribute to regional anesthetic effects of lidocaine.
Anesthesiology, 2015 Mar , 122 (606-18).

16

Oshita K et al. Ectopic automaticity induced in ventricular myocytes by transgenic overexpression of HCN2.
J. Mol. Cell. Cardiol., 2015 Mar , 80 (81-9).

17

Yu HD et al. Spironolactone Regulates HCN Protein Expression Through Micro-RNA-1 in Rats With Myocardial Infarction.
J. Cardiovasc. Pharmacol., 2015 Jun , 65 (587-92).

18

Yoshimoto R et al. Developmental increase in hyperpolarization-activated current regulates intrinsic firing properties in rat vestibular ganglion cells.
Neuroscience, 2015 Jan 22 , 284 (632-42).

19

Richards N et al. Contribution of hyperpolarization-activated channels to heat hypersensitivity and ongoing activity in the neuritis model.
Neuroscience, 2015 Jan 22 , 284 (87-98).

20

Zhou M et al. Imbalance of HCN1 and HCN2 expression in hippocampal CA1 area impairs spatial learning and memory in rats with chronic morphine exposure.
Prog. Neuropsychopharmacol. Biol. Psychiatry, 2015 Jan 2 , 56 (207-14).

21

Stoetzer C et al. Methadone is a local anaesthetic-like inhibitor of neuronal Na+ channels and blocks excitability of mouse peripheral nerves.
Br J Anaesth, 2015 Jan , 114 (110-20).

22

Li M et al. Effects of N-glycosylation on hyperpolarization-activated cyclic nucleotide-gated (HCN) channels.
Biochem. J., 2015 Feb 15 , 466 (77-84).

23

Pittoors F et al. HCN2 channels: a permanent open state and conductance changes.
J. Membr. Biol., 2015 Feb , 248 (67-81).

24

Galaz P et al. Advances in the pharmacology of lGICs auxiliary subunits.
Pharmacol. Res., 2015 Aug 7 , ().

25

Yang C et al. Decreased HCN2 expression in STN contributes to abnormal high-voltage spindles in the cortex and globus pallidus of freely moving rats.
Brain Res., 2015 Aug 27 , 1618 (17-28).

26

Djouhri L et al. Persistent hindlimb inflammation induces changes in activation properties of hyperpolarization-activated current (Ih) in rat C-fiber nociceptors in vivo.
Neuroscience, 2015 Aug 20 , 301 (121-33).

27

Cho YS et al. The expression of hyperpolarization-activated cyclic nucleotide-gated channel 1 (HCN1) and HCN2 in the rat trigeminal ganglion, sensory root, and dental pulp.
Neuroscience, 2015 Apr 16 , 291 (15-25).

28

Kopp-Scheinpflug C et al. Nitric oxide selectively suppresses IH currents mediated by HCN1-containing channels.
J. Physiol. (Lond.), 2015 Apr 1 , 593 (1685-700).

29

Günther A et al. Distinct expression patterns of HCN channels in HL-1 cardiomyocytes.
BMC Cell Biol., 2015 , 16 (18).

30

Seo H et al. Differential expression of hyperpolarization-activated cyclic nucleotide-gated channel subunits during hippocampal development in the mouse.
Mol Brain, 2015 , 8 (13).

31

Fürst O et al. Isoform dependent regulation of human HCN channels by cholesterol.
Sci Rep, 2015 , 5 (14270).

32

DiFrancesco JC et al. Dysfunctional HCN ion channels in neurological diseases.
Front Cell Neurosci, 2015 , 6 (174).

33

Baker EC et al. Functional Characterization of Cnidarian HCN Channels Points to an Early Evolution of Ih.
PLoS ONE, 2015 , 10 (e0142730).

34

Li H et al. Dual effects of amiodarone on pacemaker currents in hypertrophied ventricular myocytes isolated from spontaneously hypertensive rats.
Clin. Exp. Pharmacol. Physiol., 2014 Sep , 41 (698-707).

35

Kuppusamy M et al. A novel KCNJ5-insT149 somatic mutation close to, but outside, the selectivity filter causes resistant hypertension by loss of selectivity for potassium.
J. Clin. Endocrinol. Metab., 2014 Sep , 99 (E1765-73).

36

Saponaro A et al. Structural basis for the mutual antagonism of cAMP and TRIP8b in regulating HCN channel function.
Proc. Natl. Acad. Sci. U.S.A., 2014 Oct 7 , 111 (14577-82).

37

Yang YC et al. Dexmedetomidine produced analgesic effect via inhibition of HCN currents.
Eur. J. Pharmacol., 2014 Oct 5 , 740 (560-4).

38

Börger C et al. Resonance assignment of the ligand-free cyclic nucleotide-binding domain from the murine ion channel HCN2.
Biomol NMR Assign, 2014 Oct 17 , ().

39

Li CJ et al. Activation of GABAB receptors ameliorates cognitive impairment via restoring the balance of HCN1/HCN2 surface expression in the hippocampal CA1 area in rats with chronic cerebral hypoperfusion.
Mol. Neurobiol., 2014 Oct , 50 (704-20).

40

Sultana A et al. Deletion of olfactomedin 2 induces changes in the AMPA receptor complex and impairs visual, olfactory, and motor functions in mice.
Exp. Neurol., 2014 Nov , 261 (802-11).

41

Boudkkazi S et al. Cornichon2 dictates the time course of excitatory transmission at individual hippocampal synapses.
Neuron, 2014 May 21 , 82 (848-58).

42

Möller S et al. Cyclic nucleotide mapping of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels.
ACS Chem. Biol., 2014 May 16 , 9 (1128-37).

43

Gao W et al. State-dependent and site-directed photodynamic transformation of HCN2 channel by singlet oxygen.
J. Gen. Physiol., 2014 May , 143 (633-44).

44

Kodan A et al. Structural basis for gating mechanisms of a eukaryotic P-glycoprotein homolog.
Proc. Natl. Acad. Sci. U.S.A., 2014 Mar 18 , 111 (4049-54).

45

Klöckner U et al. Inhibition of cardiac pacemaker channel hHCN2 depends on intercalation of lipopolysaccharide into channel-containing membrane microdomains.
J. Physiol. (Lond.), 2014 Mar 15 , 592 (1199-211).

46

Wu T et al. [Neuropathic pain enhances expression of HCN2 channel in rat cerebrospinal fluid-contacting nucleus].
Sheng Li Xue Bao, 2014 Jun 25 , 66 (323-31).

47

Shields SD Conditional deletion of HCN2 from primary afferents uncovers the heterogeneity of inflammatory hypersensitivity.
Pain, 2014 Jun , 155 (1051-2).

48

Schnorr S et al. HCN2 channels account for mechanical (but not heat) hyperalgesia during long-standing inflammation.
Pain, 2014 Jun , 155 (1079-90).

49

Shah MM Cortical HCN channels: function, trafficking and plasticity.
J. Physiol. (Lond.), 2014 Jul 1 , 592 (2711-9).

50

Scheruebel S et al. I(f) blocking potency of ivabradine is preserved under elevated endotoxin levels in human atrial myocytes.
J. Mol. Cell. Cardiol., 2014 Jul , 72 (64-73).

51

Thon S et al. Avoiding the formation of vesicles by patch excision from Xenopus oocytes.
J. Neurosci. Methods, 2014 Jan 20 , ().

52

Calejo AI et al. Differences in the expression pattern of HCN isoforms among mammalian tissues: sources and implications.
Mol. Biol. Rep., 2014 Jan , 41 (297-307).

53

Gofman Y et al. Structure, dynamics and implied gating mechanism of a human cyclic nucleotide-gated channel.
PLoS Comput. Biol., 2014 Dec , 10 (e1003976).

54

Dufour MA et al. Somatodendritic ion channel expression in substantia nigra pars compacta dopaminergic neurons across postnatal development.
J. Neurosci. Res., 2014 Aug , 92 (981-99).

55

Powell KL et al. HCN channelopathy and cardiac electrophysiologic dysfunction in genetic and acquired rat epilepsy models.
Epilepsia, 2014 Apr , 55 (609-20).

56

Lenzini L et al. Lower expression of the TWIK-related acid-sensitive K+ channel 2 (TASK-2) gene is a hallmark of aldosterone-producing adenoma causing human primary aldosteronism.
J. Clin. Endocrinol. Metab., 2014 Apr , 99 (E674-82).

57

Horwitz GC et al. Mechanotransduction and hyperpolarization-activated currents contribute to spontaneous activity in mouse vestibular ganglion neurons.
J. Gen. Physiol., 2014 Apr , 143 (481-97).

58

Phillips AM et al. Spike-and-wave discharge mediated reduction in hippocampal HCN1 channel function associates with learning deficits in a genetic mouse model of epilepsy.
Neurobiol. Dis., 2014 Apr , 64 (30-5).

59

Lyashchenko AK et al. cAMP control of HCN2 channel Mg2+ block reveals loose coupling between the cyclic nucleotide-gating ring and the pore.
PLoS ONE, 2014 , 9 (e101236).

60

Li YD et al. Association between reversal in the expression of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel and age-related atrial fibrillation.
Med. Sci. Monit., 2014 , 20 (2292-7).

61

Sivagangabalan G et al. Regional ion channel gene expression heterogeneity and ventricular fibrillation dynamics in human hearts.
PLoS ONE, 2014 , 9 (e82179).

62

Williams TA et al. Somatic ATP1A1, ATP2B3, and KCNJ5 Mutations in Aldosterone-Producing Adenomas.
Hypertension, 2013 Sep 30 , ().

63

Zuo GF et al. Capsazepine concentration dependently inhibits currents in HEK 293 cells mediated by human hyperpolarization-activated cyclic nucleotide-gated 2 and 4 channels.
Exp. Biol. Med. (Maywood), 2013 Sep , 238 (1055-61).

64

Kim YH et al. Functional contributions of HCN channels in the primary auditory neurons of the mouse inner ear.
J. Gen. Physiol., 2013 Sep , 142 (207-23).

65

Nawathe PA et al. An LQTS6 MiRP1 mutation suppresses pacemaker current and is associated with sinus bradycardia.
J. Cardiovasc. Electrophysiol., 2013 Sep , 24 (1021-7).

66

Li Y et al. [Adipose tissue-derived adult stem cells transfected with the gene of hyperpolarization-activated cyclic nucleotide-gated ion channel 2 differentiated into pacemaker-like cells].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2013 Sep , 29 (901-4).

67

Zhang XY et al. Postsynaptic mechanisms underlying the excitatory action of histamine on medial vestibular nucleus neurons in rats.
Br. J. Pharmacol., 2013 Sep , 170 (156-69).

68

Carlson AE et al. Flavonoid regulation of HCN2 channels.
J. Biol. Chem., 2013 Oct 1 , ().

69

Thon S et al. Elementary functional properties of single HCN2 channels.
Biophys. J., 2013 Oct 1 , 105 (1581-9).

70

Zagidullin NSh et al. [Direct evidences of calcium traffic through pacemaker channel].
Ross Fiziol Zh Im I M Sechenova, 2013 Oct , 99 (1175-80).

71

Zagidullin NSh et al. [Direct evidences of calcium traffic through pacemaker channel].
Ross Fiziol Zh Im I M Sechenova, 2013 Oct , 99 (1175-80).

72

Monticone S et al. a Novel Y152C KCNJ5 mutation responsible for familial hyperaldosteronism type III.
J. Clin. Endocrinol. Metab., 2013 Nov , 98 (E1861-5).

73

Puljung MC et al. A secondary structural transition in the C-helix promotes gating of cyclic nucleotide-regulated ion channels.
J. Biol. Chem., 2013 May 3 , 288 (12944-56).

74

El Khoury N et al. Upregulation of the hyperpolarization-activated current increases pacemaker activity of the sinoatrial node and heart rate during pregnancy in mice.
Circulation, 2013 May 21 , 127 (2009-20).

75

Boink GJ et al. HCN2/SkM1 gene transfer into canine left bundle branch induces stable, autonomically responsive biological pacing at physiological heart rates.
J. Am. Coll. Cardiol., 2013 Mar 19 , 61 (1192-201).

76

Du L et al. The role of HCN channels within the periaqueductal gray in neuropathic pain.
Brain Res., 2013 Mar 15 , 1500 (36-44).

77

Rusznák Z et al. The hyperpolarization-activated non-specific cation current (In ) adjusts the membrane properties, excitability, and activity pattern of the giant cells in the rat dorsal cochlear nucleus.
Eur. J. Neurosci., 2013 Mar , 37 (876-90).

78

Morris GM et al. Characterisation of a Right Atrial Subsidiary Pacemaker and acceleration of the pacing rate by HCN over-expression.
Cardiovasc. Res., 2013 Jun 19 , ().

79

Tibbs GR et al. HCN1 channels as targets for anesthetic and nonanesthetic propofol analogs in the amelioration of mechanical and thermal hyperalgesia in a mouse model of neuropathic pain.
J. Pharmacol. Exp. Ther., 2013 Jun , 345 (363-73).

80

Cai Y et al. [Study on the effect of Klotho gene interferred by plasmid-mediated short hairpin RNA (shRNA) on sinoatrial node pacing channel gene].
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi, 2013 Jun , 30 (588-91).

81

Chowdhury S et al. Free-energy relationships in ion channels activated by voltage and ligand.
J. Gen. Physiol., 2013 Jan , 141 (11-28).

82

Cao-Ehlker X et al. Upregulation of hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) by specific interaction with K+ channel tetramerization-domain containing protein 3 (KCTD3).
J. Biol. Chem., 2013 Feb 4 , ().

83

Riesen SC et al. Myocardial expression of hyperpolarization-activated, cyclic nucleotide-gated proteins in healthy cats and cats with hypertrophic cardiomyopathy.
Schweiz. Arch. Tierheilkd., 2013 Feb , 155 (143-7).

84

Wilson CM et al. Phylogeny and effects of anoxia on hyperpolarization-activated cyclic nucleotide-gated channel gene expression in the heart of a primitive chordate, the Pacific hagfish (Eptatretus stoutii).
J. Exp. Biol., 2013 Dec 1 , 216 (4462-72).

85

Scavone A et al. Embryonic stem cell-derived CD166+ precursors develop into fully functional sinoatrial-like cells.
Circ. Res., 2013 Aug 2 , 113 (389-98).

86

Salem KA et al. Effects of exercise training on excitation-contraction coupling and related mRNA expression in hearts of Goto-Kakizaki type 2 diabetic rats.
Mol. Cell. Biochem., 2013 Aug , 380 (83-96).

87

Hatch RJ et al. Peripheral hyperpolarization-activated cyclic nucleotide-gated channels contribute to inflammation-induced hypersensitivity of the rat temporomandibular joint.
Eur J Pain, 2013 Aug , 17 (972-82).

88

Evans A et al. Postmortem review and genetic analysis in sudden infant death syndrome: an 11-year review.
Hum. Pathol., 2013 Apr 25 , ().

89

Dougherty KA et al. Differential expression of HCN subunits alters voltage-dependent gating of h-channels in CA1 pyramidal neurons from dorsal and ventral hippocampus.
J. Neurophysiol., 2013 Apr , 109 (1940-53).

90

Du L et al. Inhibition of HCN channels within the periaqueductal gray attenuates neuropathic pain in rats.
Behav. Neurosci., 2013 Apr , 127 (325-9).

91

Kuwabara Y et al. Increased Expression of HCN Channels in the Ventricular Myocardium Contributes to Enhanced Arrhythmicity in Mouse Failing Hearts.
J Am Heart Assoc, 2013 , 2 (e000150).

92

Ebadian AR et al. Hyperpolarization-activated cyclic nucleotide-gated 2 (HCN2) polymorphism is associated with chronic inflammatory periodontitis. A cross-sectional study.
J Basic Clin Physiol Pharmacol, 2013 , 24 (241-4).

93

Reetz O et al. Protein kinase C activation inhibits rat and human hyperpolarization activated cyclic nucleotide gated channel (HCN)1--mediated current in mammalian cells.
Cell. Physiol. Biochem., 2013 , 31 (532-41).

94

Nakamura Y et al. Novel HCN2 mutation contributes to febrile seizures by shifting the channel's kinetics in a temperature-dependent manner.
PLoS ONE, 2013 , 8 (e80376).

95

Yu L et al. [Endothelin-1 stimulates the expression of pacemaker channel I(f) in cardiomyocytes through a p38 MAPK-independent signaling pathway].
Nan Fang Yi Ke Da Xue Xue Bao, 2012 Sep , 32 (1274-9).

96

Oki K et al. The potassium channel, Kir3.4 participates in angiotensin II-stimulated aldosterone production by a human adrenocortical cell line.
Endocrinology, 2012 Sep , 153 (4328-35).

97

Gao LL et al. Expression and properties of hyperpolarization-activated current in rat dorsal root ganglion neurons with known sensory function.
J. Physiol. (Lond.), 2012 Oct 1 , 590 (4691-705).

98

Almanza A et al. Molecular identity, ontogeny, and cAMP modulation of the hyperpolarization-activated current in vestibular ganglion neurons.
J. Neurophysiol., 2012 Oct , 108 (2264-75).

99

Yang S et al. The distribution of HCN2-positive cells in the gastrointestinal tract of mice.
J. Anat., 2012 Oct , 221 (303-10).

100

Benndorf K et al. Unraveling subunit cooperativity in homotetrameric HCN2 channels.
Biophys. J., 2012 Nov 7 , 103 (1860-9).

101

Wemhöner K et al. A leucine zipper motif essential for gating of hyperpolarization-activated channels.
J. Biol. Chem., 2012 Nov 23 , 287 (40150-60).

102

Ramakrishnan NA et al. HCN1 and HCN2 proteins are expressed in cochlear hair cells: HCN1 can form a ternary complex with protocadherin 15 CD3 and F-actin-binding filamin A or can interact with HCN2.
J. Biol. Chem., 2012 Nov 2 , 287 (37628-46).

103

Liao Z et al. Cellular context and multiple channel domains determine cAMP sensitivity of HCN4 channels: ligand-independent relief of autoinhibition in HCN4.
J. Gen. Physiol., 2012 Nov , 140 (557-66).

104

Oh YJ et al. Alterations in hyperpolarization-activated cyclic nucleotidegated cation channel (HCN) expression in the hippocampus following pilocarpine-induced status epilepticus.
BMB Rep, 2012 Nov , 45 (635-40).

105

Emery EC et al. HCN2 ion channels: an emerging role as the pacemakers of pain.
, 2012 May 19 , ().

106

Bankston JR et al. Structure and stoichiometry of an accessory subunit TRIP8b interaction with hyperpolarization-activated cyclic nucleotide-gated channels.
, 2012 May 1 , ().

107

Del Lungo M et al. Novel blockers of hyperpolarization-activated current with isoform selectivity in recombinant cells and native tissue.
Br. J. Pharmacol., 2012 May , 166 (602-16).

108

Surges R et al. Hyperpolarization-activated cation current Ih of dentate gyrus granule cells is upregulated in human and rat temporal lobe epilepsy.
Biochem. Biophys. Res. Commun., 2012 Mar 30 , 420 (156-60).

109

Brager DH et al. Impaired dendritic expression and plasticity of h-channels in the fmr1(-/y) mouse model of fragile X syndrome.
Cell Rep, 2012 Mar 29 , 1 (225-33).

110

Liu J et al. Angiotensin II induces protein overexpression of hyperpolarization-activated cyclic nucleotide-gated channels in primary cultured nodose neurons.
, 2012 Mar 24 , ().

111

Marcelin B et al. Dorsoventral Differences in Intrinsic Properties in Developing CA1 Pyramidal Cells.
, 2012 Mar 14 , 32 (3736-3747).

112

Suffredini S et al. Long-term treatment with ivabradine in post-myocardial infarcted rats counteracts f-channel overexpression.
Br. J. Pharmacol., 2012 Mar , 165 (1457-66).

113

Battefeld A et al. Distinct perinatal features of the hyperpolarization-activated non-selective cation current Ih in the rat cortical plate.
, 2012 Jun 13 , 7 (21).

114

Kryukova YN et al. Ca2+-activated adenylyl cyclase 1 introduces Ca2+-dependence to beta-adrenergic stimulation of HCN2 current.
J. Mol. Cell. Cardiol., 2012 Jun , 52 (1233-9).

115

Boink GJ et al. Ca(2+)-stimulated adenylyl cyclase AC1 generates efficient biological pacing as single gene therapy and in combination with HCN2.
Circulation, 2012 Jul 31 , 126 (528-36).

116

Wu S et al. Inner activation gate in S6 contributes to the state-dependent binding of cAMP in full-length HCN2 channel.
J. Gen. Physiol., 2012 Jul , 140 (29-39).

117

Xue L et al. Investigation of hyperpolarization-activated cyclic nucleotide-gated channels in interstitial cells of Cajal of human bladder.
Urology, 2012 Jul , 80 (224.e13-8).

118

Chow SS et al. Energetics of cyclic AMP binding to HCN channel C terminus reveal negative cooperativity.
J. Biol. Chem., 2012 Jan 2 , 287 (600-6).

119

Kretschmannova K et al. The expression and role of hyperpolarization-activated and cyclic nucleotide-gated channels in endocrine anterior pituitary cells.
Mol. Endocrinol., 2012 Jan , 26 (153-64).

120

Kanyshkova T et al. Differential regulation of HCN channel isoform expression in thalamic neurons of epileptic and non-epileptic rat strains.
Neurobiol. Dis., 2012 Jan , 45 (450-61).

121

Reid CA et al. HCN channelopathies: pathophysiology in genetic epilepsy and therapeutic implications.
Br. J. Pharmacol., 2012 Jan , 165 (49-56).

122

Yang J et al. Differentiation potential of human mesenchymal stem cells derived from adipose tissue and bone marrow to sinus node-like cells.
Mol Med Report, 2012 Jan , 5 (108-13).

123

Khurana S et al. An essential role for modulation of hyperpolarization-activated current in the development of binaural temporal precision.
J. Neurosci., 2012 Feb 22 , 32 (2814-23).

124

Kusch J et al. How subunits cooperate in cAMP-induced activation of homotetrameric HCN2 channels.
Nat. Chem. Biol., 2012 Feb , 8 (162-9).

125

Schild JH et al. Differential distribution of voltage-gated channels in myelinated and unmyelinated baroreceptor afferents.
Auton Neurosci, 2012 Dec 24 , 172 (4-12).

126

Schweikart K et al. The effects of jaspamide on human cardiomyocyte function and cardiac ion channel activity.
Toxicol In Vitro, 2012 Dec 20 , 27 (745-751).

127

Chen Y et al. Ethanol enhances human hyperpolarization-activated cyclic nucleotide-gated currents.
Alcohol. Clin. Exp. Res., 2012 Dec , 36 (2036-46).

128

Orio P et al. Role of Ih in the firing pattern of mammalian cold thermoreceptor endings.
J. Neurophysiol., 2012 Dec , 108 (3009-23).

129

Kim CS et al. Enhancement of dorsal hippocampal activity by knockdown of HCN1 channels leads to anxiolytic- and antidepressant-like behaviors.
Neuron, 2012 Aug 9 , 75 (503-16).

130

Zong X et al. Regulation of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel activity by cCMP.
J. Biol. Chem., 2012 Aug 3 , 287 (26506-12).

131

Angelo K et al. A biophysical signature of network affiliation and sensory processing in mitral cells.
Nature, 2012 Aug 16 , 488 (375-8).

132

Hofmann F et al. Ventricular HCN channels decrease the repolarization reserve in the hypertrophic heart.
Cardiovasc. Res., 2012 Aug 1 , 95 (317-26).

133

Monticone S et al. Effect of KCNJ5 mutations on gene expression in aldosterone-producing adenomas and adrenocortical cells.
J. Clin. Endocrinol. Metab., 2012 Aug , 97 (E1567-72).

134

Cingolani E et al. Biological pacemaker created by percutaneous gene delivery via venous catheters in a porcine model of complete heart block.
Heart Rhythm, 2012 Aug , 9 (1310-8).

135

Weng X et al. Chronic inflammatory pain is associated with increased excitability and hyperpolarization-activated current (Ih) in C- but not Aδ-nociceptors.
Pain, 2012 Apr , 153 (900-14).

136

Oki K et al. Potassium channel mutant KCNJ5 T158A expression in HAC-15 cells increases aldosterone synthesis.
Endocrinology, 2012 Apr , 153 (1774-82).

137

Ying SW et al. Targeted deletion of Kcne2 impairs HCN channel function in mouse thalamocortical circuits.
PLoS ONE, 2012 , 7 (e42756).

138

Della Santina L et al. Processing of retinal signals in normal and HCN deficient mice.
PLoS ONE, 2012 , 7 (e29812).

139

Acosta C et al. HCN1 and HCN2 in Rat DRG neurons: levels in nociceptors and non-nociceptors, NT3-dependence and influence of CFA-induced skin inflammation on HCN2 and NT3 expression.
PLoS ONE, 2012 , 7 (e50442).

140

Klueva J et al. Hyperpolarization-activated cation current contributes to spontaneous network activity in developing neocortical cultures.
Neurosignals, 2012 , 20 (35-47).

141

Benndorf K et al. Probability fluxes and transition paths in a Markovian model describing complex subunit cooperativity in HCN2 channels.
PLoS Comput. Biol., 2012 , 8 (e1002721).

142

Song T et al. Spironolactone diminishes spontaneous ventricular premature beats by reducing HCN4 protein expression in rats with myocardial infarction.
Mol Med Report, 2011 May-Jun , 4 (569-73).

143

Wei-qing H et al. Expression of hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN4) is increased in hypertrophic cardiomyopathy.
Cardiovasc. Pathol., 2011 Mar-Apr , 20 (110-3).

144

Emery EC et al. HCN2 ion channels play a central role in inflammatory and neuropathic pain.
Science, 2011 Sep 9 , 333 (1462-6).

145

Kraemer WP et al. Vibrational energies of LiH2(+) and LiD2(+) in the Ã1Σ+ electronic state.
J Phys Chem A, 2011 Oct 20 , 115 (11313-20).

146

Zhou Y et al. Ionic mechanisms underlying cardiac toxicity of the organochloride solvent trichloromethane.
, 2011 Oct 17 , ().

147

Poller WC et al. Lateral habenular neurons projecting to reward-processing monoaminergic nuclei express hyperpolarization-activated cyclic nucleotid-gated cation channels.
Neuroscience, 2011 Oct 13 , 193 (205-16).

148

Cho HJ et al. Postnatal maturation of the hyperpolarization-activated cation current, I(h), in trigeminal sensory neurons.
J. Neurophysiol., 2011 Oct , 106 (2045-56).

149

Carrisoza-Gaytán R et al. The hyperpolarization-activated cyclic nucleotide-gated HCN2 channel transports ammonium in the distal nephron.
Kidney Int., 2011 Oct , 80 (832-40).

150

DiFrancesco JC et al. Recessive loss-of-function mutation in the pacemaker HCN2 channel causing increased neuronal excitability in a patient with idiopathic generalized epilepsy.
J. Neurosci., 2011 Nov 30 , 31 (17327-37).

151

Horwitz GC et al. HCN Channels Expressed in the Inner Ear Are Necessary for Normal Balance Function.
J. Neurosci., 2011 Nov 16 , 31 (16814-25).

152

Tu E et al. GENETIC ANALYSIS OF HYPERPOLARISATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CATION (HCN) CHANNELS IN SUDDEN UNEXPECTED DEATH IN EPILEPSY (SUDEP) CASES.
, 2011 May 25 , ().

153

Lewis AS et al. Deletion of the Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel Auxiliary Subunit TRIP8b Impairs Hippocampal Ih Localization and Function and Promotes Antidepressant Behavior in Mice.
, 2011 May 18 , 31 (7424-7440).

154

Kefaloyianni E et al. Transcriptional Remodeling of Ion Channel Subunits by Flow Adaptation in Human Coronary Artery Endothelial Cells.
, 2011 Mar 9 , 48 (357-367).

155

Schünke S et al. Structural insights into conformational changes of a cyclic nucleotide-binding domain in solution from Mesorhizobium loti K1 channel.
, 2011 Mar 23 , ().

156

Ying SW et al. PIP2-mediated HCN3 channel gating is crucial for rhythmic burst firing in thalamic intergeniculate leaflet neurons.
J. Neurosci., 2011 Jul 13 , 31 (10412-23).

157

Kim YY et al. Cryopreservation of Human Embryonic Stem Cells Derived-Cardiomyocytes Induced by BMP2 in Serum-Free Condition.
, 2011 Jan 25 , ().

158

Matt L et al. HCN2 channels in local inhibitory interneurons constrain LTP in the hippocampal direct perforant path.
Cell. Mol. Life Sci., 2011 Jan , 68 (125-37).

159

Lolicato M et al. Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels.
J. Biol. Chem., 2011 Dec 30 , 286 (44811-20).

160

Herrmann S et al. Novel insights into the distribution of cardiac HCN channels: an expression study in the mouse heart.
J. Mol. Cell. Cardiol., 2011 Dec , 51 (997-1006).

161

Klöckner U et al. Differential reduction of HCN channel activity by various types of lipopolysaccharide.
J. Mol. Cell. Cardiol., 2011 Aug , 51 (226-35).

162

Peigneur S et al. A bifunctional sea anemone peptide with Kunitz type protease and potassium channel inhibiting properties.
, 2011 Apr 5 , ().

163

Zhang J et al. Differentiation induction of cardiac c-kit positive cells from rat heart into sinus node-like cells by 5-azacytidine.
Tissue Cell, 2011 Apr , 43 (67-74).

164

Hammelmann V et al. The cGMP-dependent protein kinase II Is an inhibitory modulator of the hyperpolarization-activated HCN2 channel.
PLoS ONE, 2011 , 6 (e17078).

165

Melchiorre M et al. Design, synthesis, and preliminary biological evaluation of new isoform-selective f-current blockers.
J. Med. Chem., 2010 Sep 23 , 53 (6773-7).

166

Norberg E et al. Critical role for hyperpolarization-activated cyclic nucleotide-gated channel 2 in the AIF-mediated apoptosis.
, 2010 Oct 29 , ().

167

Atherton JF et al. Selective participation of somatodendritic HCN channels in inhibitory but not excitatory synaptic integration in neurons of the subthalamic nucleus.
J. Neurosci., 2010 Nov 24 , 30 (16025-40).

168

Xu X et al. Structural basis for the cAMP-dependent gating in the human HCN4 channel.
J. Biol. Chem., 2010 Nov 19 , 285 (37082-91).

169

Chan CS et al. HCN channelopathy in external globus pallidus neurons in models of Parkinson's disease.
, 2010 Nov 14 , ().

170

Xia S et al. Dynamic changes in HCN2, HCN4, KCNE1, and KCNE2 expression in ventricular cells from acute myocardial infarction rat hearts.
Biochem. Biophys. Res. Commun., 2010 May 7 , 395 (330-5).

171

Ou Y et al. Expression of key ion channels in the rat cardiac conduction system by laser capture microdissection and qPCR.
, 2010 May 28 , ().

172

Yi E et al. Dendritic HCN channels shape excitatory postsynaptic potentials at the inner hair cell afferent synapse in the mammalian cochlea.
J. Neurophysiol., 2010 May , 103 (2532-43).

173

Hegle AP et al. Evolutionary emergence of N-glycosylation as a variable promoter of HCN channel surface expression.
Am. J. Physiol., Cell Physiol., 2010 May , 298 (C1066-76).

174

Lin YC et al. Inactivation of L-type calcium channel modulated by HCN2 channel.
Am. J. Physiol., Cell Physiol., 2010 May , 298 (C1029-37).

175

Gardarin A et al. Endoplasmic reticulum is a major target of cadmium toxicity in yeast.
Mol. Microbiol., 2010 May , 76 (1034-48).

176

Kusch J et al. Interdependence of receptor activation and ligand binding in HCN2 pacemaker channels.
Neuron, 2010 Jul 15 , 67 (75-85).

177

Baruscotti M et al. HCN-related channelopathies.
Pflugers Arch., 2010 Jul , 460 (405-15).

178

Tu H et al. Diabetes alters protein expression of hyperpolarization-activated cyclic nucleotide-gated channel subunits in rat nodose ganglion cells.
Neuroscience, 2010 Jan 13 , 165 (39-52).

179

Xiao YF et al. Hysteresis in human HCN4 channels: a crucial feature potentially affecting sinoatrial node pacemaking.
Sheng Li Xue Bao, 2010 Feb 25 , 62 (1-13).

180

Shlapakova IN et al. Biological pacemakers in canines exhibit positive chronotropic response to emotional arousal.
Heart Rhythm, 2010 Dec , 7 (1835-40).

181

Oh S et al. Remodeling of ion channel expression in patients with chronic atrial fibrillation and mitral valvular heart disease.
Korean J. Intern. Med., 2010 Dec , 25 (377-85).

182

Papp I et al. Plasticity of hyperpolarization-activated and cyclic nucleotid-gated cation channel subunit 2 expression in the spinal dorsal horn in inflammatory pain.
, 2010 Aug 19 , ().

183

Ma J et al. Use of rats mesenchymal stem cells modified with mHCN2 gene to create biologic pacemakers.
J. Huazhong Univ. Sci. Technol. Med. Sci., 2010 Aug , 30 (447-52).

184

Dibbens LM et al. Augmented currents of an HCN2 variant in patients with febrile seizure syndromes.
Ann. Neurol., 2010 Apr , 67 (542-6).

185

Horwitz GC et al. HCN channels are not required for mechanotransduction in sensory hair cells of the mouse inner ear.
PLoS ONE, 2010 , 5 (e8627).

186

Zhang J et al. Cardiac stem cells differentiate into sinus node-like cells.
Tohoku J. Exp. Med., 2010 , 222 (113-20).

187

Yu HG et al. Non-proteolytic HCN2 in the heart.
J. Biol. Chem., 2009 Sep 25 , 284 (le7; author reply le8).

188

Ye B et al. Proteolytic processing of HCN2 and co-assembly with HCN4 in the generation of cardiac pacemaker channels.
J. Biol. Chem., 2009 Sep 18 , 284 (25553-9).

189

Rozario AO et al. Voltage-dependent opening of HCN channels: Facilitation or inhibition by the phytoestrogen, genistein, is determined by the activation status of the cyclic nucleotide gating ring.
Biochim. Biophys. Acta, 2009 Sep , 1788 (1939-49).

190

Adams BE et al. Excitotoxic-mediated transcriptional decreases in HCN2 channel function increase network excitability in CA1.
Exp. Neurol., 2009 Sep , 219 (249-57).

191

Brelidze TI et al. Absence of direct cyclic nucleotide modulation of mEAG1 and hERG1 channels revealed with fluorescence and electrophysiological methods.
J. Biol. Chem., 2009 Oct 9 , 284 (27989-97).

192

Yeh J et al. Declines in levels of hyperpolarization-activated cation (HCN) channels in the rat ovary after cisplatin exposure.
Reprod Sci, 2009 Oct , 16 (986-94).

193

Zhang Y et al. Functional characterization of hyperpolarization-activated cyclic nucleotide-gated channels in rat pancreatic beta cells.
J. Endocrinol., 2009 Oct , 203 (45-53).

194

Gassanov N et al. Distinct regulation of cardiac I(f) current via thyroid receptors alpha1 and beta1.
Pflugers Arch., 2009 Oct , 458 (1061-8).

195

Valiunas V et al. Coupling an HCN2-expressing cell to a myocyte creates a two-cell pacing unit.
J. Physiol. (Lond.), 2009 Nov 1 , 587 (5211-26).

196

Soltysinska E et al. Transmural expression of ion channels and transporters in human nondiseased and end-stage failing hearts.
Pflugers Arch., 2009 Nov , 459 (11-23).

197

Schweizer PA et al. Transcription profiling of HCN-channel isotypes throughout mouse cardiac development.
Basic Res. Cardiol., 2009 May 7 , ().

198

Peters CJ et al. In situ co-distribution and functional interactions of SAP97 with sinoatrial isoforms of HCN channels.
J. Mol. Cell. Cardiol., 2009 May , 46 (636-43).

199

Zhang Q et al. Associated changes in HCN2 and HCN4 transcripts and I(f) pacemaker current in myocytes.
Biochim. Biophys. Acta, 2009 May , 1788 (1138-47).

200

Cheng L et al. Niflumic acid alters gating of HCN2 pacemaker channels by interaction with the outer region of S4 voltage sensing domains.
Mol. Pharmacol., 2009 May , 75 (1210-21).

201

Yeh YH et al. Funny current downregulation and sinus node dysfunction associated with atrial tachyarrhythmia: a molecular basis for tachycardia-bradycardia syndrome.
Circulation, 2009 Mar 31 , 119 (1576-85).

202

Marcelin B et al. h channel-dependent deficit of theta oscillation resonance and phase shift in temporal lobe epilepsy.
Neurobiol. Dis., 2009 Mar , 33 (436-47).

203

Chung WK et al. Absence epilepsy in apathetic, a spontaneous mutant mouse lacking the h channel subunit, HCN2.
Neurobiol. Dis., 2009 Mar , 33 (499-508).

204

Macri V et al. Alanine scanning of the S6 segment reveals a unique and cAMP-sensitive association between the pore and voltage-dependent opening in HCN channels.
J. Biol. Chem., 2009 Jun 5 , 284 (15659-67).

205

Zolles G et al. Association with the auxiliary subunit PEX5R/Trip8b controls responsiveness of HCN channels to cAMP and adrenergic stimulation.
Neuron, 2009 Jun 25 , 62 (814-25).

206

Kanyshkova T et al. Postnatal expression pattern of HCN channel isoforms in thalamic neurons: relationship to maturation of thalamocortical oscillations.
J. Neurosci., 2009 Jul 8 , 29 (8847-57).

207

Alig J et al. Control of heart rate by cAMP sensitivity of HCN channels.
Proc. Natl. Acad. Sci. U.S.A., 2009 Jul 21 , 106 (12189-94).

208

Taraska JW et al. Mapping the structure and conformational movements of proteins with transition metal ion FRET.
Nat. Methods, 2009 Jul , 6 (532-7).

209

Brandt MC et al. Effects of KCNE2 on HCN isoforms: distinct modulation of membrane expression and single channel properties.
Am. J. Physiol. Heart Circ. Physiol., 2009 Jul , 297 (H355-63).

210

Liang Q et al. Tanshinone IIA selectively enhances hyperpolarization-activated cyclic nucleotide-modulated (HCN) channel instantaneous current.
J. Pharmacol. Sci., 2009 Jul , 110 (381-8).

211

Chen X et al. Subunit-specific effects of isoflurane on neuronal Ih in HCN1 knockout mice.
J. Neurophysiol., 2009 Jan , 101 (129-40).

212

Lu Y et al. A single anti-microRNA antisense oligodeoxyribonucleotide (AMO) targeting multiple microRNAs offers an improved approach for microRNA interference.
Nucleic Acids Res., 2009 Feb , 37 (e24).

213

Kryukova Y et al. Age-dependent differences in the inhibition of HCN2 current in rat ventricular myocytes by the tyrosine kinase inhibitor erbstatin.
Pflugers Arch., 2009 Feb , 457 (821-30).

214

Cho HJ et al. Inflammation-induced increase in hyperpolarization-activated, cyclic nucleotide-gated channel protein in trigeminal ganglion neurons and the effect of buprenorphine.
Neuroscience, 2009 Aug 18 , 162 (453-61).

215

Zhao X et al. In vitro characterization of HCN channel kinetics and frequency dependence in myocytes predicts biological pacemaker functionality.
J. Physiol. (Lond.), 2009 Apr 1 , 587 (1513-25).

216

Nair AV et al. Movements of native C505 during channel gating in CNGA1 channels.
Eur. Biophys. J., 2009 Apr , 38 (465-78).

217

Lin H et al. Transcriptional control of pacemaker channel genes HCN2 and HCN4 by Sp1 and implications in re-expression of these genes in hypertrophied myocytes.
Cell. Physiol. Biochem., 2009 , 23 (317-26).

218

Li YL et al. Blunted excitability of aortic baroreceptor neurons in diabetic rats: involvement of hyperpolarization-activated channel.
Cardiovasc. Res., 2008 Sep 1 , 79 (715-21).

219

Nazzari H et al. Regulation of cell surface expression of functional pacemaker channels by a motif in the B-helix of the cyclic nucleotide-binding domain.
Am. J. Physiol., Cell Physiol., 2008 Sep , 295 (C642-52).

220

Budde T et al. Reciprocal modulation of I (h) and I (TASK) in thalamocortical relay neurons by halothane.
Pflugers Arch., 2008 Sep , 456 (1061-73).

221

Buniel M et al. Distribution of voltage-gated potassium and hyperpolarization-activated channels in sensory afferent fibers in the rat carotid body.
J. Comp. Neurol., 2008 Oct 1 , 510 (367-77).

222

Powell KL et al. Decreases in HCN mRNA expression in the hippocampus after kindling and status epilepticus in adult rats.
Epilepsia, 2008 Oct , 49 (1686-95).

223

Işler C et al. Prenatal expressions of hyperpolarization-activated cyclic-nucleotide-gated channel (HCN) genes in dysplastic hippocampi in rats.
, 2008 Oct , 18 (327-35).

224

Li HX et al. [The changes of funny currents in the ventricular myocytes of neonatal rats and adult rats].
Zhongguo Ying Yong Sheng Li Xue Za Zhi, 2008 Nov , 24 (411-5).

225

Craven KB et al. C-terminal movement during gating in cyclic nucleotide-modulated channels.
J. Biol. Chem., 2008 May 23 , 283 (14728-38).

226

Vitved T et al. [Mutations in the heart's pacemaker channels--a new cause of sick sinus node syndrome and long-QT syndrome]
Ugeskr. Laeg., 2008 Mar 10 , 170 (929-33).

227

Kouranova EV et al. Hyperpolarization-activated cyclic nucleotide-gated channel mRNA and protein expression in large versus small diameter dorsal root ganglion neurons: correlation with hyperpolarization-activated current gating.
Neuroscience, 2008 Jun 2 , 153 (1008-19).

228

Michels G et al. Direct evidence for calcium conductance of hyperpolarization-activated cyclic nucleotide-gated channels and human native If at physiological calcium concentrations.
Cardiovasc. Res., 2008 Jun 1 , 78 (466-75).

229

Luo X et al. Down-regulation of miR-1/miR-133 contributes to re-expression of pacemaker channel genes HCN2 and HCN4 in hypertrophic heart.
J. Biol. Chem., 2008 Jul 18 , 283 (20045-52).

230

Hardel N et al. Recycling endosomes supply cardiac pacemaker channels for regulated surface expression.
Cardiovasc. Res., 2008 Jul 1 , 79 (52-60).

231

Tang B et al. Mutation analysis of the hyperpolarization-activated cyclic nucleotide-gated channels HCN1 and HCN2 in idiopathic generalized epilepsy.
Neurobiol. Dis., 2008 Jan , 29 (59-70).

232

Qu Y et al. Hyperpolarization-activated cyclic nucleotide-modulated 'HCN' channels confer regular and faster rhythmicity to beating mouse embryonic stem cells.
J. Physiol. (Lond.), 2008 Feb 1 , 586 (701-16).

233

Stillitano F et al. Expression of the hyperpolarization-activated current, I(f), in cultured adult rat ventricular cardiomyocytes and its modulation by hypertrophic factors.
Pharmacol. Res., 2008 Feb , 57 (100-9).

234

Plotnikov AN et al. HCN212-channel biological pacemakers manifesting ventricular tachyarrhythmias are responsive to treatment with I(f) blockade.
, 2008 Feb , 5 (282-8).

235

Richichi C et al. Mechanisms of seizure-induced 'transcriptional channelopathy' of hyperpolarization-activated cyclic nucleotide gated (HCN) channels.
Neurobiol. Dis., 2008 Feb , 29 (297-305).

236

Momin A et al. Role of the hyperpolarization-activated current Ih in somatosensory neurons.
J. Physiol. (Lond.), 2008 Dec 15 , 586 (5911-29).

237

Dibattista M et al. Hyperpolarization-activated cyclic nucleotide-gated channels in mouse vomeronasal sensory neurons.
J. Neurophysiol., 2008 Aug , 100 (576-86).

238

Stillitano F et al. Molecular basis of funny current (If) in normal and failing human heart.
J. Mol. Cell. Cardiol., 2008 Aug , 45 (289-99).

239

Vemana S et al. Intracellular Mg2+ is a voltage-dependent pore blocker of HCN channels.
Am. J. Physiol., Cell Physiol., 2008 Aug , 295 (C557-65).

240

Bolívar JJ et al. A hyperpolarization-activated, cyclic nucleotide-gated, (Ih-like) cationic current and HCN gene expression in renal inner medullary collecting duct cells.
Am. J. Physiol., Cell Physiol., 2008 Apr , 294 (C893-906).

241

Zha Q et al. Activity-dependent heteromerization of the hyperpolarization-activated, cyclic-nucleotide gated (HCN) channels: role of N-linked glycosylation.
J. Neurochem., 2008 Apr , 105 (68-77).

242

Michels G et al. K+ channel regulator KCR1 suppresses heart rhythm by modulating the pacemaker current If.
PLoS ONE, 2008 , 3 (e1511).

243

Kondrats'kyĭ AP et al. [A hyperpolarization-activated current in rat menthol-sensitive sensory neurons]
, 2008 , 54 (16-22).

244

Wells JE et al. Hyperpolarization-activated channels in trigeminal ganglia innervating healthy and pulp-exposed teeth.
Int Endod J, 2007 Sep , 40 (715-21).

245

Cheng L et al. Molecular mapping of the binding site for a blocker of hyperpolarization-activated, cyclic nucleotide-modulated pacemaker channels.
J. Pharmacol. Exp. Ther., 2007 Sep , 322 (931-9).

246

Huang X et al. Age-related down-regulation of HCN channels in rat sinoatrial node.
Basic Res. Cardiol., 2007 Sep , 102 (429-35).

247

Pian P et al. Modulation of cyclic nucleotide-regulated HCN channels by PIP(2) and receptors coupled to phospholipase C.
Pflugers Arch., 2007 Oct , 455 (125-45).

248

Shin M et al. Activity-dependent regulation of h channel distribution in hippocampal CA1 pyramidal neurons.
J. Biol. Chem., 2007 Nov 9 , 282 (33168-80).

249

Muto T et al. Aldosterone modulates I(f) current through gene expression in cultured neonatal rat ventricular myocytes.
Am. J. Physiol. Heart Circ. Physiol., 2007 Nov , 293 (H2710-8).

250

Li HX et al. [Effects of amiodarone on funny current I(f) channel gene expression in neonatal rat ventricular myocytes]
, 2007 May , 35 (466-70).

251

Li C et al. [Electrophysiology of two human hyperpolarization activated cyclic nucleotide-gated potassium channels expressed in HEK293 cells]
Zhonghua Yi Xue Za Zhi, 2007 Mar 13 , 87 (706-9).

252

Lin W et al. Dual stretch responses of mHCN2 pacemaker channels: accelerated activation, accelerated deactivation.
Biophys. J., 2007 Mar 1 , 92 (1559-72).

253

Liu J et al. Organisation of the mouse sinoatrial node: structure and expression of HCN channels.
Cardiovasc. Res., 2007 Mar 1 , 73 (729-38).

254

Brewster AL et al. Quantitative analysis and subcellular distribution of mRNA and protein expression of the hyperpolarization-activated cyclic nucleotide-gated channels throughout development in rat hippocampus.
Cereb. Cortex, 2007 Mar , 17 (702-12).

255

El-Kholy W et al. Hyperpolarization-activated cyclic nucleotide-gated channels in pancreatic beta-cells.
Mol. Endocrinol., 2007 Mar , 21 (753-64).

256

Yu X et al. Calcium influx through If channels in rat ventricular myocytes.
Am. J. Physiol., Cell Physiol., 2007 Mar , 292 (C1147-55).

257

Zhou L et al. Gating of HCN channels by cyclic nucleotides: residue contacts that underlie ligand binding, selectivity, and efficacy.
Structure, 2007 Jun , 15 (655-70).

258

Herrmann S et al. Pathophysiology of HCN channels.
Pflugers Arch., 2007 Jul , 454 (517-22).

259

Chen S et al. Voltage sensor movement and cAMP binding allosterically regulate an inherently voltage-independent closed-open transition in HCN channels.
J. Gen. Physiol., 2007 Feb , 129 (175-88).

260

Ying SW et al. Dendritic HCN2 channels constrain glutamate-driven excitability in reticular thalamic neurons.
J. Neurosci., 2007 Aug 8 , 27 (8719-32).

261

Whitaker GM et al. HCN2 and HCN4 isoforms self-assemble and co-assemble with equal preference to form functional pacemaker channels.
J. Biol. Chem., 2007 Aug 3 , 282 (22900-9).

262

Scott SP et al. Mapping ligand interactions with the hyperpolarization activated cyclic nucleotide modulated (HCN) ion channel binding domain using a soluble construct.
Biochemistry, 2007 Aug 21 , 46 (9417-31).

263

Lyashchenko AK et al. Propofol inhibits HCN1 pacemaker channels by selective association with the closed states of the membrane embedded channel core.
J. Physiol. (Lond.), 2007 Aug 15 , 583 (37-56).

264

Plotnikov AN et al. Xenografted adult human mesenchymal stem cells provide a platform for sustained biological pacemaker function in canine heart.
Circulation, 2007 Aug 14 , 116 (706-13).

265

Xiao J et al. Novel approaches for gene-specific interference via manipulating actions of microRNAs: examination on the pacemaker channel genes HCN2 and HCN4.
J. Cell. Physiol., 2007 Aug , 212 (285-92).

266

Fyk-Kolodziej B et al. Differential distribution of hyperpolarization-activated and cyclic nucleotide-gated channels in cone bipolar cells of the rat retina.
J. Comp. Neurol., 2007 Apr 20 , 501 (891-903).

267

Boyes J et al. Functional presynaptic HCN channels in the rat globus pallidus.
Eur. J. Neurosci., 2007 Apr , 25 (2081-92).

268

Zhou YF et al. Mesenchymal stem cells transfected with HCN2 genes by LentiV can be modified to be cardiac pacemaker cells.
Med. Hypotheses, 2007 , 69 (1093-7).

269

Varghese A et al. Endogenous channels in HEK cells and potential roles in HCN ionic current measurements.
Prog. Biophys. Mol. Biol., 2006 Jan-Apr , 90 (26-37).

270

Bucchi A et al. Wild-type and mutant HCN channels in a tandem biological-electronic cardiac pacemaker.
Circulation, 2006 Sep 5 , 114 (992-9).

271

Abbas SY et al. Compartmental distribution of hyperpolarization-activated cyclic-nucleotide-gated channel 2 and hyperpolarization-activated cyclic-nucleotide-gated channel 4 in thalamic reticular and thalamocortical relay neurons.
Neuroscience, 2006 Sep 15 , 141 (1811-25).

272

Elinder F et al. Mode shifts in the voltage gating of the mouse and human HCN2 and HCN4 channels.
J. Physiol. (Lond.), 2006 Sep 1 , 575 (417-31).

273

Papp I et al. Hyperpolarization-activated and cyclic nucleotide-gated cation channel subunit 2 ion channels modulate synaptic transmission from nociceptive primary afferents containing substance P to secondary sensory neurons in laminae I-IIo of the rodent spinal dorsa
Eur. J. Neurosci., 2006 Sep , 24 (1341-52).

274

Arroyo A et al. Hyperpolarization-activated cation channels are expressed in rat hypothalamic gonadotropin-releasing hormone (GnRH) neurons and immortalized GnRH neurons.
J. Soc. Gynecol. Investig., 2006 Sep , 13 (442-50).

275

Meuth SG et al. Membrane resting potential of thalamocortical relay neurons is shaped by the interaction among TASK3 and HCN2 channels.
J. Neurophysiol., 2006 Sep , 96 (1517-29).

276

Mistrik P et al. The enhancement of HCN channel instantaneous current facilitated by slow deactivation is regulated by intracellular chloride concentration.
Pflugers Arch., 2006 Sep , 452 (718-27).

277

Li HX et al. [Pacemaker current gene expression of rat mesenchymal stem cells and identification of mesenchymal stem cells expressing human pacemaker current gene (hHCN2)]
, 2006 Oct , 34 (917-21).

278

Nikolaev VO et al. Cyclic AMP imaging in adult cardiac myocytes reveals far-reaching beta1-adrenergic but locally confined beta2-adrenergic receptor-mediated signaling.
Circ. Res., 2006 Nov 10 , 99 (1084-91).

279

Leão KE et al. Hyperpolarization-activated currents are differentially expressed in mice brainstem auditory nuclei.
J. Physiol. (Lond.), 2006 Nov 1 , 576 (849-64).

280

Dekker JP et al. Cooperative gating between single HCN pacemaker channels.
J. Gen. Physiol., 2006 Nov , 128 (561-7).

281

Pian P et al. Regulation of gating and rundown of HCN hyperpolarization-activated channels by exogenous and endogenous PIP2.
J. Gen. Physiol., 2006 Nov , 128 (593-604).

282

Berrera M et al. cAMP Modulation of the cytoplasmic domain in the HCN2 channel investigated by molecular simulations.
Biophys. J., 2006 May 15 , 90 (3428-33).

283

Xu H et al. Glycosylation of the osmoresponsive transient receptor potential channel TRPV4 on Asn-651 influences membrane trafficking.
Am. J. Physiol. Renal Physiol., 2006 May , 290 (F1103-9).

284

Fernández-Velasco M et al. I K1 and I f in ventricular myocytes isolated from control and hypertrophied rat hearts.
Pflugers Arch., 2006 May , 452 (146-54).

285

Rateau Y et al. Expression of a functional hyperpolarization-activated current (Ih) in the mouse nucleus reticularis thalami.
J. Neurophysiol., 2006 May , 95 (3073-85).

286

Schridde U et al. Environmental manipulations early in development alter seizure activity, Ih and HCN1 protein expression later in life.
Eur. J. Neurosci., 2006 Jun , 23 (3346-58).

287

Poolos NP et al. Modulation of h-channels in hippocampal pyramidal neurons by p38 mitogen-activated protein kinase.
J. Neurosci., 2006 Jul 26 , 26 (7995-8003).

288

Aponte Y et al. Hyperpolarization-activated cation channels in fast-spiking interneurons of rat hippocampus.
J. Physiol. (Lond.), 2006 Jul 1 , 574 (229-43).

289

Surges R et al. Regulated expression of HCN channels and cAMP levels shape the properties of the h current in developing rat hippocampus.
Eur. J. Neurosci., 2006 Jul , 24 (94-104).

290

Kretschmannova K et al. Dependence of hyperpolarisation-activated cyclic nucleotide-gated channel activity on basal cyclic adenosine monophosphate production in spontaneously firing GH3 cells.
J. Neuroendocrinol., 2006 Jul , 18 (484-93).

291

Ying SW et al. Propofol block of I(h) contributes to the suppression of neuronal excitability and rhythmic burst firing in thalamocortical neurons.
Eur. J. Neurosci., 2006 Jan , 23 (465-80).

292

Proenza C et al. Distinct populations of HCN pacemaker channels produce voltage-dependent and voltage-independent currents.
J. Gen. Physiol., 2006 Feb , 127 (183-90).

293

Niu P et al. [Recombinant plasmid pIRES2-EGFP-HCN2 improved pacing function in canine model of sick sinus syndrome]
, 2006 Dec , 34 (1126-30).

294

Kuisle M et al. Functional stabilization of weakened thalamic pacemaker channel regulation in rat absence epilepsy.
J. Physiol. (Lond.), 2006 Aug 15 , 575 (83-100).

295

Shin M et al. Evaluation of HCN2 abnormalities as a cause of juvenile audiogenic seizures in Black Swiss mice.
Brain Res., 2006 Apr 14 , 1083 (14-20).

296

Brewster AL et al. Formation of heteromeric hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in the hippocampus is regulated by developmental seizures.
Neurobiol. Dis., 2005 Jun-Jul , 19 (200-7).

297

Yamada R et al. Hyperpolarization-activated cyclic nucleotide-gated cation channels regulate auditory coincidence detection in nucleus laminaris of the chick.
J. Neurosci., 2005 Sep 28 , 25 (8867-77).

298

Day M et al. Dendritic excitability of mouse frontal cortex pyramidal neurons is shaped by the interaction among HCN, Kir2, and Kleak channels.
J. Neurosci., 2005 Sep 21 , 25 (8776-87).

299

Calloe K et al. Hypoosmotic cell swelling as a novel mechanism for modulation of cloned HCN2 channels.
Biophys. J., 2005 Sep , 89 (2159-69).

300

Zong X et al. A novel mechanism of modulation of hyperpolarization-activated cyclic nucleotide-gated channels by Src kinase.
J. Biol. Chem., 2005 Oct 7 , 280 (34224-32).

301

Budde T et al. Impaired regulation of thalamic pacemaker channels through an imbalance of subunit expression in absence epilepsy.
J. Neurosci., 2005 Oct 26 , 25 (9871-82).

302

Bajorat R et al. Functional significance of HCN2/3-mediated I(h) in striatal cells at early developmental stages.
J. Neurosci. Res., 2005 Oct 15 , 82 (206-13).

303

Stieber J et al. Functional expression of the human HCN3 channel.
J. Biol. Chem., 2005 Oct 14 , 280 (34635-43).

304

Cacheaux LP et al. Impairment of hyperpolarization-activated, cyclic nucleotide-gated channel function by the intravenous general anesthetic propofol.
J. Pharmacol. Exp. Ther., 2005 Nov , 315 (517-25).

305

Ma YN et al. [Association between familial febrile convulsions and HCN2 gene]
Zhonghua Yi Xue Za Zhi, 2005 Mar 16 , 85 (663-6).

306

Chen X et al. HCN subunit-specific and cAMP-modulated effects of anesthetics on neuronal pacemaker currents.
J. Neurosci., 2005 Jun 15 , 25 (5803-14).

307

Zicha S et al. Sinus node dysfunction and hyperpolarization-activated (HCN) channel subunit remodeling in a canine heart failure model.
Cardiovasc. Res., 2005 Jun 1 , 66 (472-81).

308

Mistrik P et al. The murine HCN3 gene encodes a hyperpolarization-activated cation channel with slow kinetics and unique response to cyclic nucleotides.
J. Biol. Chem., 2005 Jul 22 , 280 (27056-61).

309

Akhavan A et al. Identification of the cyclic-nucleotide-binding domain as a conserved determinant of ion-channel cell-surface localization.
J. Cell. Sci., 2005 Jul 1 , 118 (2803-12).

310

Qiu DL et al. Corticotrophin-releasing factor augments the I(H) in rat hypothalamic paraventricular nucleus parvocellular neurons in vitro.
J. Neurophysiol., 2005 Jul , 94 (226-34).

311

van Welie I et al. Low affinity block of native and cloned hyperpolarization-activated Ih channels by Ba2+ ions.
Eur. J. Pharmacol., 2005 Jan 10 , 507 (15-20).

312

Johnson JP et al. The carboxyl-terminal region of cyclic nucleotide-modulated channels is a gating ring, not a permeation path.
Proc. Natl. Acad. Sci. U.S.A., 2005 Feb 22 , 102 (2742-7).

313

Qiu DL et al. Neuromedin U receptor-2 mRNA and HCN channels mRNA expression in NMU-sensitive neurons in rat hypothalamic paraventricular nucleus.
Neurosci. Lett., 2005 Feb 1 , 374 (69-72).

314

Michels G et al. Single-channel properties support a potential contribution of hyperpolarization-activated cyclic nucleotide-gated channels and If to cardiac arrhythmias.
Circulation, 2005 Feb 1 , 111 (399-404).

315

Léoni AL et al. Chronic heart rate reduction remodels ion channel transcripts in the mouse sinoatrial node but not in the ventricle.
Physiol. Genomics, 2005 Dec 14 , 24 (4-12).

316

Chen X et al. Suppression of ih contributes to propofol-induced inhibition of mouse cortical pyramidal neurons.
J. Neurophysiol., 2005 Dec , 94 (3872-83).

317

Galindo BE et al. A new hyperpolarization-activated, cyclic nucleotide-gated channel from sea urchin sperm flagella.
Biochem. Biophys. Res. Commun., 2005 Aug 19 , 334 (96-101).

318

Azene EM et al. Non-equilibrium behavior of HCN channels: insights into the role of HCN channels in native and engineered pacemakers.
Cardiovasc. Res., 2005 Aug 1 , 67 (263-73).

319

Wahl-Schott C et al. An arginine residue in the pore region is a key determinant of chloride dependence in cardiac pacemaker channels.
J. Biol. Chem., 2005 Apr 8 , 280 (13694-700).

320

Shah MM et al. Seizure-induced plasticity of h channels in entorhinal cortical layer III pyramidal neurons.
Neuron, 2004 Oct 28 , 44 (495-508).

321

Gravante B et al. Interaction of the pacemaker channel HCN1 with filamin A.
J. Biol. Chem., 2004 Oct 15 , 279 (43847-53).

322

Qu J et al. MiRP1 modulates HCN2 channel expression and gating in cardiac myocytes.
J. Biol. Chem., 2004 Oct 15 , 279 (43497-502).

323

Rosen MR et al. Recreating the biological pacemaker.
, 2004 Oct , 280 (1046-52).

324

Chan CS et al. HCN2 and HCN1 channels govern the regularity of autonomous pacemaking and synaptic resetting in globus pallidus neurons.
J. Neurosci., 2004 Nov 3 , 24 (9921-32).

325

Wang Y et al. Anatomical, physiological and molecular properties of Martinotti cells in the somatosensory cortex of the juvenile rat.
J. Physiol. (Lond.), 2004 Nov 15 , 561 (65-90).

326

Vasilyev DV et al. Regulation of the hyperpolarization-activated cationic current Ih in mouse hippocampal pyramidal neurones by vitronectin, a component of extracellular matrix.
J. Physiol. (Lond.), 2004 Nov 1 , 560 (659-75).

327

Koizumi A et al. Inward rectifying currents stabilize the membrane potential in dendrites of mouse amacrine cells: patch-clamp recordings and single-cell RT-PCR.
Mol. Vis., 2004 May 13 , 10 (328-40).

328

Shin KS et al. Inactivation in HCN channels results from reclosure of the activation gate: desensitization to voltage.
Neuron, 2004 Mar 4 , 41 (737-44).

329

Doan TN et al. Differential distribution and function of hyperpolarization-activated channels in sensory neurons and mechanosensitive fibers.
J. Neurosci., 2004 Mar 31 , 24 (3335-43).

330

Antal M et al. Expression of hyperpolarization-activated and cyclic nucleotide-gated cation channel subunit 2 in axon terminals of peptidergic nociceptive primary sensory neurons in the superficial spinal dorsal horn of rats.
Eur. J. Neurosci., 2004 Mar , 19 (1336-42).

331

Strauss U et al. An impaired neocortical Ih is associated with enhanced excitability and absence epilepsy.
Eur. J. Neurosci., 2004 Jun , 19 (3048-58).

332

Kimura K et al. Hyperpolarization-activated, cyclic nucleotide-gated HCN2 cation channel forms a protein assembly with multiple neuronal scaffold proteins in distinct modes of protein-protein interaction.
Genes Cells, 2004 Jul , 9 (631-40).

333

Koch U et al. Distribution of HCN1 and HCN2 in rat auditory brainstem nuclei.
Eur. J. Neurosci., 2004 Jul , 20 (79-91).

334

Yu HG et al. Tyrosine kinase inhibition differentially regulates heterologously expressed HCN channels.
Pflugers Arch., 2004 Jan , 447 (392-400).

335

Stieber J et al. Pacemaker channels and sinus node arrhythmia.
Trends Cardiovasc. Med., 2004 Jan , 14 (23-8).

336

Plotnikov AN et al. Biological pacemaker implanted in canine left bundle branch provides ventricular escape rhythms that have physiologically acceptable rates.
Circulation, 2004 Feb 3 , 109 (506-12).

337

Heubach JF et al. Electrophysiological properties of human mesenchymal stem cells.
J. Physiol. (Lond.), 2004 Feb 1 , 554 (659-72).

338

Craven KB et al. Salt bridges and gating in the COOH-terminal region of HCN2 and CNGA1 channels.
J. Gen. Physiol., 2004 Dec , 124 (663-77).

339

Notomi T et al. Immunohistochemical localization of Ih channel subunits, HCN1-4, in the rat brain.
J. Comp. Neurol., 2004 Apr 5 , 471 (241-76).

340

Decher N et al. Voltage-dependent gating of hyperpolarization-activated, cyclic nucleotide-gated pacemaker channels: molecular coupling between the S4-S5 and C-linkers.
J. Biol. Chem., 2004 Apr 2 , 279 (13859-65).

341

Macri V et al. Structural elements of instantaneous and slow gating in hyperpolarization-activated cyclic nucleotide-gated channels.
J. Biol. Chem., 2004 Apr 16 , 279 (16832-46).

342

Potapova I et al. Human mesenchymal stem cells as a gene delivery system to create cardiac pacemakers.
Circ. Res., 2004 Apr 16 , 94 (952-9).

343

Jiang M et al. KCNE2 protein is expressed in ventricles of different species, and changes in its expression contribute to electrical remodeling in diseased hearts.
Circulation, 2004 Apr 13 , 109 (1783-8).

344

Xiao J et al. Molecular and functional analysis of hyperpolarisation-activated nucleotide-gated (HCN) channels in the enteric nervous system.
Neuroscience, 2004 , 129 (603-14).

345

Stieber J et al. Molecular basis for the different activation kinetics of the pacemaker channels HCN2 and HCN4.
J. Biol. Chem., 2003 Sep 5 , 278 (33672-80).

346

Zagotta WN et al. Structural basis for modulation and agonist specificity of HCN pacemaker channels.
Nature, 2003 Sep 11 , 425 (200-5).

347

Decher N et al. KCNE2 modulates current amplitudes and activation kinetics of HCN4: influence of KCNE family members on HCN4 currents.
Pflugers Arch., 2003 Sep , 446 (633-40).

348

Much B et al. Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels.
J. Biol. Chem., 2003 Oct 31 , 278 (43781-6).

349

Pál B et al. HCN channels contribute to the intrinsic activity of cochlear pyramidal cells.
Cell. Mol. Life Sci., 2003 Oct , 60 (2189-99).

350

Qu J et al. Expression and function of a biological pacemaker in canine heart.
Circulation, 2003 Mar 4 , 107 (1106-9).

351

Azene EM et al. Molecular basis of the effect of potassium on heterologously expressed pacemaker (HCN) channels.
J. Physiol. (Lond.), 2003 Mar 1 , 547 (349-56).

352

Bender RA et al. Enhanced expression of a specific hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN) in surviving dentate gyrus granule cells of human and experimental epileptic hippocampus.
J. Neurosci., 2003 Jul 30 , 23 (6826-36).

353

Er F et al. Dominant-negative suppression of HCN channels markedly reduces the native pacemaker current I(f) and undermines spontaneous beating of neonatal cardiomyocytes.
Circulation, 2003 Jan 28 , 107 (485-9).

354

Ludwig A et al. Absence epilepsy and sinus dysrhythmia in mice lacking the pacemaker channel HCN2.
EMBO J., 2003 Jan 15 , 22 (216-24).

355

Le Bouter S et al. Microarray analysis reveals complex remodeling of cardiac ion channel expression with altered thyroid status: relation to cellular and integrated electrophysiology.
Circ. Res., 2003 Feb 7 , 92 (234-42).

356

Ulens C et al. Regulation of hyperpolarization-activated HCN channels by cAMP through a gating switch in binding domain symmetry.
Neuron, 2003 Dec 4 , 40 (959-70).

357

Fernández-Velasco M et al. Regional distribution of hyperpolarization-activated current (If) and hyperpolarization-activated cyclic nucleotide-gated channel mRNA expression in ventricular cells from control and hypertrophied rat hearts.
J. Physiol. (Lond.), 2003 Dec 1 , 553 (395-405).

358

Cho WJ et al. Hyperpolarization-activated, cyclic AMP-gated, HCN1-like cation channel: the primary, full-length HCN isoform expressed in a saccular hair-cell layer.
Neuroscience, 2003 , 118 (525-34).

359

Macri V et al. Separable gating mechanisms in a Mammalian pacemaker channel.
J. Biol. Chem., 2002 Sep 27 , 277 (35939-46).

360

Vasilyev DV et al. Postnatal development of the hyperpolarization-activated excitatory current Ih in mouse hippocampal pyramidal neurons.
J. Neurosci., 2002 Oct 15 , 22 (8992-9004).

361

Sartiani L et al. Functional expression of the hyperpolarization-activated, non-selective cation current I(f) in immortalized HL-1 cardiomyocytes.
J. Physiol. (Lond.), 2002 Nov 15 , 545 (81-92).

362

Tran N et al. A conserved domain in the NH2 terminus important for assembly and functional expression of pacemaker channels.
J. Biol. Chem., 2002 Nov 15 , 277 (43588-92).

363

Han W et al. Comparison of ion-channel subunit expression in canine cardiac Purkinje fibers and ventricular muscle.
Circ. Res., 2002 Nov 1 , 91 (790-7).

364

Bonilla M et al. Essential role of calcineurin in response to endoplasmic reticulum stress.
EMBO J., 2002 May 15 , 21 (2343-53).

365

Xue T et al. Dominant-negative suppression of HCN1- and HCN2-encoded pacemaker currents by an engineered HCN1 construct: insights into structure-function relationships and multimerization.
Circ. Res., 2002 Jun 28 , 90 (1267-73).

366

Brewster A et al. Developmental febrile seizures modulate hippocampal gene expression of hyperpolarization-activated channels in an isoform- and cell-specific manner.
J. Neurosci., 2002 Jun 1 , 22 (4591-9).

367

Hiramatsu M et al. Ion channel remodeling in cardiac hypertrophy is prevented by blood pressure reduction without affecting heart weight increase in rats with abdominal aortic banding.
J. Cardiovasc. Pharmacol., 2002 Jun , 39 (866-74).

368

Proenza C et al. Pacemaker channels produce an instantaneous current.
J. Biol. Chem., 2002 Feb 15 , 277 (5101-9).

369

Hammond L et al. Alteration of branch site consensus sequence and enhanced pre-mRNA splicing of an NMDAR1 intron not associated with schizophrenia.
Am. J. Med. Genet., 2002 Aug 8 , 114 (631-6).

370

Proenza C et al. Different roles for the cyclic nucleotide binding domain and amino terminus in assembly and expression of hyperpolarization-activated, cyclic nucleotide-gated channels.
J. Biol. Chem., 2002 Aug 16 , 277 (29634-42).

371

Qu J et al. Functional comparison of HCN isoforms expressed in ventricular and HEK 293 cells.
Pflugers Arch., 2002 Aug , 444 (597-601).

372

Greenwood IA et al. Characteristics of hyperpolarization-activated cation currents in portal vein smooth muscle cells.
Am. J. Physiol., Cell Physiol., 2002 Apr , 282 (C744-53).

373

Sauviat MP et al. [Cardiotoxicity of lindane, a gamma isomer of hexachlorocyclohexane]
J. Soc. Biol., 2002 , 196 (339-48).

374

Chen J et al. The S4-S5 linker couples voltage sensing and activation of pacemaker channels.
Proc. Natl. Acad. Sci. U.S.A., 2001 Sep 25 , 98 (11277-82).

375

Wang J et al. Regulation of hyperpolarization-activated HCN channel gating and cAMP modulation due to interactions of COOH terminus and core transmembrane regions.
J. Gen. Physiol., 2001 Sep , 118 (237-50).

376

Ulens C et al. Gi- and Gs-coupled receptors up-regulate the cAMP cascade to modulate HCN2, but not HCN1 pacemaker channels.
Pflugers Arch., 2001 Sep , 442 (928-42).

377

Chen S et al. Properties of hyperpolarization-activated pacemaker current defined by coassembly of HCN1 and HCN2 subunits and basal modulation by cyclic nucleotide.
J. Gen. Physiol., 2001 May , 117 (491-504).

378

Zong X et al. A single histidine residue determines the pH sensitivity of the pacemaker channel HCN2.
J. Biol. Chem., 2001 Mar 2 , 276 (6313-9).

379

Ulens C et al. Functional heteromerization of HCN1 and HCN2 pacemaker channels.
J. Biol. Chem., 2001 Mar 2 , 276 (6069-72).

380

Yasui K et al. I(f) current and spontaneous activity in mouse embryonic ventricular myocytes.
Circ. Res., 2001 Mar 16 , 88 (536-42).

381

Moosmang S et al. Cellular expression and functional characterization of four hyperpolarization-activated pacemaker channels in cardiac and neuronal tissues.
Eur. J. Biochem., 2001 Mar , 268 (1646-52).

382

Wainger BJ et al. Molecular mechanism of cAMP modulation of HCN pacemaker channels.
Nature, 2001 Jun 14 , 411 (805-10).

383

Altomare C et al. Integrated allosteric model of voltage gating of HCN channels.
J. Gen. Physiol., 2001 Jun , 117 (519-32).

384

Qu J et al. HCN2 overexpression in newborn and adult ventricular myocytes: distinct effects on gating and excitability.
Circ. Res., 2001 Jul 6 , 89 (E8-14).

385

Pachucki J et al. Type 2 iodothyronin deiodinase transgene expression in the mouse heart causes cardiac-specific thyrotoxicosis.
Endocrinology, 2001 Jan , 142 (13-20).

386

Gloss B et al. Cardiac ion channel expression and contractile function in mice with deletion of thyroid hormone receptor alpha or beta.
Endocrinology, 2001 Feb , 142 (544-50).

387

Brãuer AU et al. Molecular and functional analysis of hyperpolarization-activated pacemaker channels in the hippocampus after entorhinal cortex lesion.
FASEB J., 2001 Dec , 15 (2689-701).

388

Cuttle MF et al. Modulation of a presynaptic hyperpolarization-activated cationic current (I(h)) at an excitatory synaptic terminal in the rat auditory brainstem.
J. Physiol. (Lond.), 2001 Aug 1 , 534 (733-44).

389

Graf EM et al. The hyperpolarization-activated current If in ventricular myocytes of non-transgenic and beta2-adrenoceptor overexpressing mice.
Naunyn Schmiedebergs Arch. Pharmacol., 2001 Aug , 364 (131-9).

390

Monteggia LM et al. Cloning and localization of the hyperpolarization-activated cyclic nucleotide-gated channel family in rat brain.
Brain Res. Mol. Brain Res., 2000 Sep 30 , 81 (129-39).

391

Chen J et al. Functional roles of charged residues in the putative voltage sensor of the HCN2 pacemaker channel.
J. Biol. Chem., 2000 Nov 17 , 275 (36465-71).

392

Moroni A et al. Kinetic and ionic properties of the human HCN2 pacemaker channel.
Pflugers Arch., 2000 Mar , 439 (618-26).

393

Santoro B et al. Molecular and functional heterogeneity of hyperpolarization-activated pacemaker channels in the mouse CNS.
J. Neurosci., 2000 Jul 15 , 20 (5264-75).

394

Gögelein H et al. Inhibition of IKs channels by HMR 1556.
Naunyn Schmiedebergs Arch. Pharmacol., 2000 Dec , 362 (480-8).

395

Vaca L et al. Mutations in the S4 domain of a pacemaker channel alter its voltage dependence.
FEBS Lett., 2000 Aug 11 , 479 (35-40).

396

Franz O et al. Single-cell mRNA expression of HCN1 correlates with a fast gating phenotype of hyperpolarization-activated cyclic nucleotide-gated ion channels (Ih) in central neurons.
Eur. J. Neurosci., 2000 Aug , 12 (2685-93).

397

Tian L et al. Characterization of hyperpolarization-activated cation currents in mouse anterior pituitary, AtT20 D16:16 corticotropes.
Endocrinology, 2000 Aug , 141 (2930-7).

398

Moosmang S et al. Differential distribution of four hyperpolarization-activated cation channels in mouse brain.
Biol. Chem., 1999 Jul-Aug , 380 (975-80).

399

Vaccari T et al. The human gene coding for HCN2, a pacemaker channel of the heart.
Biochim. Biophys. Acta, 1999 Sep 3 , 1446 (419-25).

400

Pachucki J et al. Thyroid hormone regulates hyperpolarization-activated cyclic nucleotide-gated channel (HCN2) mRNA in the rat heart.
Circ. Res., 1999 Sep 17 , 85 (498-503).

401

Gründer S et al. Identification of a highly conserved sequence at the N-terminus of the epithelial Na+ channel alpha subunit involved in gating.
Pflugers Arch., 1999 Oct , 438 (709-15).

402

Ludwig A et al. Two pacemaker channels from human heart with profoundly different activation kinetics.
EMBO J., 1999 May 4 , 18 (2323-9).

403

Shi W et al. Distribution and prevalence of hyperpolarization-activated cation channel (HCN) mRNA expression in cardiac tissues.
Circ. Res., 1999 Jul 9 , 85 (e1-6).

404

Ishii TM et al. Molecular characterization of the hyperpolarization-activated cation channel in rabbit heart sinoatrial node.
J. Biol. Chem., 1999 Apr 30 , 274 (12835-9).

405

Ludwig A et al. A family of hyperpolarization-activated mammalian cation channels.
Nature, 1998 Jun 11 , 393 (587-91).