TREK2

1

Jorgensen C et al. Lateral Fenestrations in K(+)-Channels Explored Using Molecular Dynamics Simulations.
Mol. Pharm., 2016 May 26 , ().

2

Veale EL et al. Aristolochic acid, a plant extract used in the treatment of pain and linked to Balkan endemic nephropathy, is a regulator of K2P channels.
Br. J. Pharmacol., 2016 May , 173 (1639-52).

3

Woo J et al. Inhibition of TREK-2 K(+) channels by PI(4,5)P2: an intrinsic mode of regulation by intracellular ATP via phosphatidylinositol kinase.
Pflugers Arch., 2016 Jun 9 , ().

4

McClenaghan C et al. Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states.
J. Gen. Physiol., 2016 Jun , 147 (497-505).

5

Lengyel M et al. Formation of Functional Heterodimers by TREK-1 and TREK-2 Two-pore Domain Potassium Channel Subunits.
J. Biol. Chem., 2016 Apr 28 , ().

6

Levitz J et al. Heterodimerization within the TREK channel subfamily produces a diverse family of highly regulated potassium channels.
Proc. Natl. Acad. Sci. U.S.A., 2016 Apr 12 , 113 (4194-9).

7

Kubanek J et al. Ultrasound modulates ion channel currents.
Sci Rep, 2016 , 6 (24170).

8

Brohawn SG How ion channels sense mechanical force: insights from mechanosensitive K2P channels TRAAK, TREK1, and TREK2.
Ann. N. Y. Acad. Sci., 2015 Sep , 1352 (20-32).

9

Mathie A et al. Two-pore domain potassium channels: potential therapeutic targets for the treatment of pain.
Pflugers Arch., 2015 May , 467 (931-43).

10

Dong YY et al. K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac.
Science, 2015 Mar 13 , 347 (1256-9).

11

Rivas-Ramírez P et al. Muscarinic modulation of TREK currents in mouse sympathetic superior cervical ganglion neurons.
Eur. J. Neurosci., 2015 Jul , 42 (1797-807).

12

Zhuo RG et al. Insights into the stimulatory mechanism of 2-aminoethoxydiphenyl borate on TREK-2 potassium channel.
Neuroscience, 2015 Aug 6 , 300 (85-93).

13

Zhuo RG et al. The isoforms generated by alternative translation initiation adopt similar conformation in the selectivity filter in TREK-2.
J. Physiol. Biochem., 2015 Aug 14 , ().

14

Braun G et al. Differential sensitivity of TREK-1, TREK-2 and TRAAK background potassium channels to the polycationic dye ruthenium red.
Br. J. Pharmacol., 2015 Apr , 172 (1728-38).

15

Rivera-Pagán AF et al. Up-regulation of TREK-2 potassium channels in cultured astrocytes requires de novo protein synthesis: relevance to localization of TREK-2 channels in astrocytes after transient cerebral ischemia.
PLoS ONE, 2015 , 10 (e0125195).

16

Comoglio Y et al. Phospholipase D2 specifically regulates TREK potassium channels via direct interaction and local production of phosphatidic acid.
Proc. Natl. Acad. Sci. U.S.A., 2014 Sep 16 , 111 (13547-52).

17

Xiao Z et al. Activation of neurotensin receptor 1 facilitates neuronal excitability and spatial learning and memory in the entorhinal cortex: beneficial actions in an Alzheimer's disease model.
J. Neurosci., 2014 May 14 , 34 (7027-42).

18

Zappia KJ et al. Cold hypersensitivity increases with age in mice with sickle cell disease.
Pain, 2014 Jun 3 , ().

19

Lei Q et al. Response of the human detrusor to stretch is regulated by TREK-1, a two-pore-domain (K2P) mechano-gated potassium channel.
J. Physiol. (Lond.), 2014 Jul 15 , 592 (3013-30).

20

Acosta C et al. TREK2 expressed selectively in IB4-binding C-fiber nociceptors hyperpolarizes their membrane potentials and limits spontaneous pain.
J. Neurosci., 2014 Jan 22 , 34 (1494-509).

21

Pereira V et al. Role of the TREK2 potassium channel in cold and warm thermosensation and in pain perception.
Pain, 2014 Dec , 155 (2534-44).

22

Seyler C et al. Vernakalant activates human cardiac K(2P)17.1 background K(+) channels.
Biochem. Biophys. Res. Commun., 2014 Aug 29 , 451 (415-20).

23

Nishizuka M et al. KCNK10, a tandem pore domain potassium channel, is a regulator of mitotic clonal expansion during the early stage of adipocyte differentiation.
Int J Mol Sci, 2014 , 15 (22743-56).

24

Schneider ER et al. Temperature sensitivity of two-pore (K2P) potassium channels.
Curr Top Membr, 2014 , 74 (113-33).

25

Pollema-Mays SL et al. Expression of background potassium channels in rat DRG is cell-specific and down-regulated in a neuropathic pain model.
Mol. Cell. Neurosci., 2013 Nov , 57 (1-9).

26

Innamaa A et al. Expression and effects of modulation of the K2P potassium channels TREK-1 (KCNK2) and TREK-2 (KCNK10) in the normal human ovary and epithelial ovarian cancer.
Clin Transl Oncol, 2013 Nov , 15 (910-8).