K2P

1

Skarsfeldt MA et al. pH-dependent inhibition of K2P3.1 prolongs atrial refractoriness in whole hearts.
Pflugers Arch., 2016 Jan 5 , ().

2

Pisani DF et al. The K+ channel TASK1 modulates β-adrenergic response in brown adipose tissue through the mineralocorticoid receptor pathway.
FASEB J., 2016 Feb , 30 (909-22).

3

Antigny F et al. Potassium Channel Subfamily K Member 3 (KCNK3) Contributes to the Development of Pulmonary Arterial Hypertension.
Circulation, 2016 Apr 5 , 133 (1371-85).

4

Christensen AH et al. The two-pore domain potassium channel, TWIK-1, has a role in the regulation of heart rate and atrial size.
J. Mol. Cell. Cardiol., 2016 Apr 19 , 97 (24-35).

5

Sun H et al. A monoclonal antibody against KCNK9 K(+) channel extracellular domain inhibits tumour growth and metastasis.
Nat Commun, 2016 , 7 (10339).

6

Reed AP et al. Dominant-Negative Effect of a Missense Variant in the TASK-2 (KCNK5) K+ Channel Associated with Balkan Endemic Nephropathy.
PLoS ONE, 2016 , 11 (e0156456).

7

Yeon JT et al. KCNK1 inhibits osteoclastogenesis by blocking the Ca2+ oscillation and JNK-NFATc1 signaling axis.
J. Cell. Sci., 2015 Sep 15 , 128 (3411-9).

8

Chokshi RH et al. Breathing Stimulant Compounds Inhibit TASK-3 Potassium Channel Function Likely by Binding at a Common Site in the Channel Pore.
Mol. Pharmacol., 2015 Nov , 88 (926-34).

9

Göb E et al. The two-pore domain potassium channel KCNK5 deteriorates outcome in ischemic neurodegeneration.
Pflugers Arch., 2015 May , 467 (973-87).

10

Enyedi P et al. Properties, regulation, pharmacology, and functions of the K₂p channel, TRESK.
Pflugers Arch., 2015 May , 467 (945-58).

11

Dong YY et al. K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac.
Science, 2015 Mar 13 , 347 (1256-9).

12

Langford DJ et al. Variations in potassium channel genes are associated with distinct trajectories of persistent breast pain after breast cancer surgery.
Pain, 2015 Mar , 156 (371-80).

13

Baruteau AE et al. Inherited progressive cardiac conduction disorders.
Curr. Opin. Cardiol., 2015 Jan , 30 (33-9).

14

Congiu C et al. The role of the potassium channel gene KCNK2 in major depressive disorder.
Psychiatry Res, 2015 Feb 28 , 225 (489-92).

15

Guignabert C et al. New molecular targets of pulmonary vascular remodeling in pulmonary arterial hypertension: importance of endothelial communication.
Chest, 2015 Feb , 147 (529-37).

16

Gómez J et al. A Semiconductor Chip-Based Next Generation Sequencing Procedure for the Main Pulmonary Hypertension Genes.
Lung, 2015 Aug , 193 (571-4).

17

Farberov L et al. MicroRNA-mediated regulation of p21 and TASK1 cellular restriction factors enhances HIV-1 infection.
J. Cell. Sci., 2015 Apr 15 , 128 (1607-16).

18

Kubota K et al. Hydroxy-α sanshool induces colonic motor activity in rat proximal colon: a possible involvement of KCNK9.
Am. J. Physiol. Gastrointest. Liver Physiol., 2015 Apr 1 , 308 (G579-90).

19

Shinoda K et al. Genetic and functional characterization of clonally derived adult human brown adipocytes.
Nat. Med., 2015 Apr , 21 (389-94).

20

Bittner S et al. Murine K2P5.1 Deficiency Has No Impact on Autoimmune Neuroinflammation due to Compensatory K2P3.1- and KV1.3-Dependent Mechanisms.
Int J Mol Sci, 2015 , 16 (16880-96).

21

Cazals Y et al. KCNK5 channels mostly expressed in cochlear outer sulcus cells are indispensable for hearing.
Nat Commun, 2015 , 6 (8780).

22

Kim SH et al. Electrogenic transport and K(+) ion channel expression by the human endolymphatic sac epithelium.
Sci Rep, 2015 , 5 (18110).

23

Sánchez Delgado M et al. Screening individuals with intellectual disability, autism and Tourette's syndrome for KCNK9 mutations and aberrant DNA methylation within the 8q24 imprinted cluster.
Am. J. Med. Genet. B Neuropsychiatr. Genet., 2014 Sep , 165B (472-8).

24

Rhodin K et al. Chronic periodontitis genome-wide association studies: gene-centric and gene set enrichment analyses.
J. Dent. Res., 2014 Sep , 93 (882-90).

25

Bichet D et al. Silent but not dumb: how cellular trafficking and pore gating modulate expression of TWIK1 and THIK2.
Pflugers Arch., 2014 Oct 24 , ().

26

Perry JR et al. Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
Nature, 2014 Oct 2 , 514 (92-7).

27

He L et al. Association of variants in KCNK17 gene with ischemic stroke and cerebral hemorrhage in a Chinese population.
J Stroke Cerebrovasc Dis, 2014 Oct , 23 (2322-7).

28

Rainero I et al. KCNK18 (TRESK) genetic variants in Italian patients with migraine.
Headache, 2014 Oct , 54 (1515-22).

29

Ma L et al. The genetic basis of pulmonary arterial hypertension.
Hum. Genet., 2014 May , 133 (471-9).

30

Rahm AK et al. Functional characterization of zebrafish K2P18.1 (TRESK) two-pore-domain K+ channels.
Naunyn Schmiedebergs Arch. Pharmacol., 2014 Mar , 387 (291-300).

31

Zappia KJ et al. Cold hypersensitivity increases with age in mice with sickle cell disease.
Pain, 2014 Jun 3 , ().

32

Bruner JK et al. Identification of novel small molecule modulators of K2P18.1 two-pore potassium channel.
Eur. J. Pharmacol., 2014 Jun 24 , ().

33

Austin ED et al. The genetics of pulmonary arterial hypertension.
Circ. Res., 2014 Jun 20 , 115 (189-202).

34

Bittner S et al. TREK-king the blood-brain-barrier.
J Neuroimmune Pharmacol, 2014 Jun , 9 (293-301).

35

Friedrich C et al. Gain-of-function mutation in TASK-4 channels and severe cardiac conduction disorder.
EMBO Mol Med, 2014 Jul , 6 (937-51).

36

Hoggart CJ et al. Novel approach identifies SNPs in SLC2A10 and KCNK9 with evidence for parent-of-origin effect on body mass index.
PLoS Genet., 2014 Jul , 10 (e1004508).

37

Langford DJ et al. Variations in Potassium Channel Genes Are Associated With Breast Pain in Women Prior to Breast Cancer Surgery.
J. Neurogenet., 2014 Jan 7 , ().

38

Perathoner S et al. Bioelectric signaling regulates size in zebrafish fins.
PLoS Genet., 2014 Jan , 10 (e1004080).

39

Brohawn SG et al. Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel.
Nature, 2014 Dec 4 , 516 (126-30).

40

Pandit LM et al. TWIK-2 channel deficiency leads to pulmonary hypertension through a rho-kinase-mediated process.
Hypertension, 2014 Dec , 64 (1260-5).

41

Nagy D et al. Silencing the KCNK9 potassium channel (TASK-3) gene disturbs mitochondrial function, causes mitochondrial depolarization, and induces apoptosis of human melanoma cells.
Arch. Dermatol. Res., 2014 Dec , 306 (885-902).

42

Pereira V et al. Role of the TREK2 potassium channel in cold and warm thermosensation and in pain perception.
Pain, 2014 Dec , 155 (2534-44).

43

Girerd B et al. KCNK3: new gene target for pulmonary hypertension?
Expert Rev Respir Med, 2014 Aug , 8 (385-7).

44

Enyedi P et al. Tubulin binds to the cytoplasmic loop of TRESK background K⁺ channel in vitro.
PLoS ONE, 2014 , 9 (e97854).

45

Sehgal SA et al. Pharmacoinformatics elucidation of potential drug targets against migraine to target ion channel protein KCNK18.
Drug Des Devel Ther, 2014 , 8 (571-81).

46

Schneider ER et al. Temperature sensitivity of two-pore (K2P) potassium channels.
Curr Top Membr, 2014 , 74 (113-33).

47

Aryal P et al. A hydrophobic barrier deep within the inner pore of the TWIK-1 K2P potassium channel.
Nat Commun, 2014 , 5 (4377).

48

Wilke BU et al. Diacylglycerol mediates regulation of TASK potassium channels by Gq-coupled receptors.
Nat Commun, 2014 , 5 (5540).

49

Nishizuka M et al. KCNK10, a tandem pore domain potassium channel, is a regulator of mitotic clonal expansion during the early stage of adipocyte differentiation.
Int J Mol Sci, 2014 , 15 (22743-56).

50

Toncheva D et al. NGS nominated CELA1, HSPG2, and KCNK5 as candidate genes for predisposition to Balkan endemic nephropathy.
Biomed Res Int, 2014 , 2014 (920723).

51

Bittner S et al. Endothelial TWIK-related potassium channel-1 (TREK1) regulates immune-cell trafficking into the CNS.
Nat. Med., 2013 Sep , 19 (1161-5).

52

Maher BH et al. Analysis of 3 common polymorphisms in the KCNK18 gene in an Australian Migraine case-control cohort.
Gene, 2013 Oct 10 , 528 (343-6).

53

Austin ED et al. Heritable forms of pulmonary arterial hypertension.
Semin Respir Crit Care Med, 2013 Oct , 34 (568-80).

54

Innamaa A et al. Expression and effects of modulation of the K2P potassium channels TREK-1 (KCNK2) and TREK-2 (KCNK10) in the normal human ovary and epithelial ovarian cancer.
Clin Transl Oncol, 2013 Nov , 15 (910-8).

55

Ford KJ et al. A role for TREK1 in generating the slow afterhyperpolarization in developing starburst amacrine cells.
J. Neurophysiol., 2013 May , 109 (2250-9).

56

Liang B et al. Genetic variation in the two-pore domain potassium channel, TASK-1, may contribute to an atrial substrate for arrhythmogenesis.
J. Mol. Cell. Cardiol., 2013 Dec 27 , 67C (69-76).

57

Turner PJ et al. Oxygen and mitochondrial inhibitors modulate both monomeric and heteromeric TASK-1 and TASK-3 channels in mouse carotid body type-1 cells.
J. Physiol. (Lond.), 2013 Dec 1 , 591 (5977-98).

58

Bagriantsev SN et al. A high-throughput functional screen identifies small molecule regulators of temperature- and mechano-sensitive K2P channels.
ACS Chem. Biol., 2013 Aug 16 , 8 (1841-51).

59

Enyeart JJ et al. Ca2+ and K+ channels of normal human adrenal zona fasciculata cells: properties and modulation by ACTH and AngII.
J. Gen. Physiol., 2013 Aug , 142 (137-55).

60

Salem KA et al. Effects of exercise training on excitation-contraction coupling and related mRNA expression in hearts of Goto-Kakizaki type 2 diabetic rats.
Mol. Cell. Biochem., 2013 Aug , 380 (83-96).

61

Kirkegaard SS et al. KCNK5 is functionally down-regulated upon long-term hypotonicity in Ehrlich ascites tumor cells.
Cell. Physiol. Biochem., 2013 , 32 (1238-46).