Channelpedia

Kv7.1

2168 literature references associated to Kv7.1

used / unused
Pubmed id

1

364855

Lang CN et al. Transgenic rabbit models to investigate the cardiac ion channel disease long QT syndrome.
Prog. Biophys. Mol. Biol., 2016 May 19 , ().

2

364910

3

361767

Ali A et al. Heat shock protein 70 gene polymorphisms' influence on the electrophysiology of long QT syndrome.
J Interv Card Electrophysiol, 2016 Mar , 45 (119-30).

5

365194

Carbonell-Pascual B et al. Comparison between Hodgkin-Huxley and Markov formulations of cardiac ion channels.
J. Theor. Biol., 2016 Jun 21 , 399 (92-102).

6

364743

Yamaguchi Y et al. Latent pathogenicity of the G38S polymorphism of KCNE1 K(+) channel modulator.
Heart Vessels, 2016 Jun 2 , ().

8

364733

Wu W et al. Molecular Basis of Cardiac Delayed Rectifier Potassium Channel Function and Pharmacology.
Card Electrophysiol Clin, 2016 Jun , 8 (275-84).

12

361354

13

365657

Al-Hazza A et al. Upregulation of basolateral small conductance potassium channels (KCNQ1/KCNE3) in ulcerative colitis.
Biochem. Biophys. Res. Commun., 2016 Feb 5 , 470 (473-8).

15

365584

21

361408

Ichikawa M et al. Multigenerational Inheritance of Long QT Syndrome Type 2 in a Japanese Family.
Intern. Med., 2016 , 55 (259-62).

24

365104

Neverisky DL et al. Ion channel-transporter interactions.
Crit. Rev. Biochem. Mol. Biol., 2015 Jul-Aug , 51 (257-67).

25

367725

Neethling A et al. Filamin C: a novel component of the KCNE2 interactome during hypoxia.
Cardiovasc J Afr, 2015 Jan-Feb , 27 (4-11).

29

356343

El-Sherif N et al. Role of pharmacotherapy in cardiac ion channelopathies.
Pharmacol. Ther., 2015 Sep 12 , ().

31

368193

33

357342

Frea S et al. New echocardiographic insights in short QT syndrome: More than a channelopathy?
Heart Rhythm, 2015 Oct , 12 (2096-105).

34

366014

Andersen MN et al. Protein kinase A stimulates Kv7.1 surface expression by regulating Nedd4-2-dependent endocytic trafficking.
Am. J. Physiol., Cell Physiol., 2015 Nov 15 , 309 (C693-706).

36

366060

37

366065

Zoledziewska M et al. Height-reducing variants and selection for short stature in Sardinia.
Nat. Genet., 2015 Nov , 47 (1352-6).

38

362138

Powell KL et al. In response: LQT, HCN, and epilepsy model.
Epilepsia, 2015 Nov , 56 (1855-6).

39

362139

Kodirov SA LQT, HCN, and epilepsy model.
Epilepsia, 2015 Nov , 56 (1855).

40

362613

Vassilakopoulou V et al. Distinctive malfunctions of calmodulin mutations associated with heart RyR2-mediated arrhythmic disease.
Biochim. Biophys. Acta, 2015 Nov , 1850 (2168-76).

41

357700

Liin SI et al. Polyunsaturated fatty acid analogs act antiarrhythmically on the cardiac IKs channel.
Proc. Natl. Acad. Sci. U.S.A., 2015 May 5 , 112 (5714-9).

44

357738

Leren IS et al. Cardiac Mechanical Alterations and Genotype Specific Differences in Subjects With Long QT Syndrome.
JACC Cardiovasc Imaging, 2015 May , 8 (501-10).

45

362872

Jahangir A et al. Strain Echocardiography and LQTS Subtypes: Mechanical Alterations in an Electrical Disorder.
JACC Cardiovasc Imaging, 2015 May , 8 (511-3).

46

348613

47

355366

Perry MD et al. Getting to the heart of hERG K(+) channel gating.
J. Physiol. (Lond.), 2015 Mar 27 , ().

48

367434

Goodchild SJ et al. Sequence of gating charge movement and pore gating in HERG activation and deactivation pathways.
Biophys. J., 2015 Mar 24 , 108 (1435-47).

49

348493

Biliczki P et al. The interaction between delayed rectifier channel alpha-subunits does not involve hetero-tetramer formation.
Naunyn Schmiedebergs Arch. Pharmacol., 2015 Mar 20 , ().

50

348505

Steffensen AB et al. IKs Gain- and Loss-of-Function In Early-Onset Lone Atrial Fibrillation.
J. Cardiovasc. Electrophysiol., 2015 Mar 19 , ().

51

348537

52

364130

Laurentino S et al. Epigenetic germline mosaicism in infertile men.
Hum. Mol. Genet., 2015 Mar 1 , 24 (1295-304).

53

363988

Gómez-Úriz AM et al. Obesity and ischemic stroke modulate the methylation levels of KCNQ1 in white blood cells.
Hum. Mol. Genet., 2015 Mar 1 , 24 (1432-40).

59

359312

Yang L et al. Intravenous anesthetic propofol inhibits multiple human cardiac potassium channels.
Anesthesiology, 2015 Mar , 122 (571-84).

60

356913

61

367639

Liin SI et al. The KCNQ1 channel - remarkable flexibility in gating allows for functional versatility.
J. Physiol. (Lond.), 2015 Jun 15 , 593 (2605-15).

65

362680

Asahara S et al. Paternal allelic mutation at the Kcnq1 locus reduces pancreatic β-cell mass by epigenetic modification of Cdkn1c.
Proc. Natl. Acad. Sci. U.S.A., 2015 Jul 7 , 112 (8332-7).

66

356691

Stattin EL et al. Genetic screening in sudden cardiac death in the young can save future lives.
Int. J. Legal Med., 2015 Jul 31 , ().

67

357437

70

366724

Issa NP et al. QT interval prolongation in a patient with LQT2 on levetiracetam.
Seizure, 2015 Jul , 29 (134-6).

79

348938

Nakajo K et al. KCNQ1 channel modulation by KCNE proteins via the voltage-sensing domain.
J. Physiol. (Lond.), 2015 Jan 21 , ().

80

349283

Gayen S et al. Structural analysis of the S4-S5 linker of the human KCNQ1 potassium channel.
Biochem. Biophys. Res. Commun., 2015 Jan 2 , 456 (410-4).

81

350276

82

349712

Sedivy V et al. Role of Kv7 channels in responses of the pulmonary circulation to hypoxia.
Am. J. Physiol. Lung Cell Mol. Physiol., 2015 Jan 1 , 308 (L48-57).

84

348908

Xiong Q et al. Arrhythmogenic cardiomyopathy in a patient with a rare loss-of-function KCNQ1 mutation.
J Am Heart Assoc, 2015 Jan , 4 (e001526).

85

358461

Chen M et al. Pharmacogenomics of glinides.
Pharmacogenomics, 2015 Jan , 16 (45-60).

86

360806

Riuró H et al. Genetic analysis, in silico prediction, and family segregation in long QT syndrome.
Eur. J. Hum. Genet., 2015 Jan , 23 (79-85).

88

358542

Schultz BM et al. Enhancers compete with a long non-coding RNA for regulation of the Kcnq1 domain.
Nucleic Acids Res., 2015 Jan , 43 (745-59).

89

355797

90

358693

92

358837

95

363912

Lee S et al. Heterogeneity in Kv7 channel function in the cerebral and coronary circulation.
Microcirculation, 2015 Feb , 22 (109-21).

96

367769

Winbo A et al. Vestibular dysfunction is a clinical feature of the Jervell and Lange-Nielsen Syndrome.
Scand. Cardiovasc. J., 2015 Feb , 49 (7-13).

99

361639

100

361668

Peters CH et al. Triggers for arrhythmogenesis in the Brugada and long QT 3 syndromes.
Prog. Biophys. Mol. Biol., 2015 Dec 20 , ().

101

362081

103

356271

Qureshi SF et al. Mutational analysis of SCN5A gene in long QT syndrome.
Meta Gene, 2015 Dec , 6 (26-35).

105

362747

Wasano K et al. A novel frameshift mutation in KCNQ4 in a family with autosomal recessive non-syndromic hearing loss.
Biochem. Biophys. Res. Commun., 2015 Aug 7 , 463 (582-6).

106

367031

107

362673

Yuan J et al. Potassium channel KCNJ15 is required for histamine-stimulated gastric acid secretion.
Am. J. Physiol., Cell Physiol., 2015 Aug 15 , 309 (C264-70).

109

362724

110

356608

Krönauer T et al. [Perioperative treatment of patients with long QT syndrome].
Anaesthesist, 2015 Aug , 64 (625-39).

111

361605

112

361893

Li G et al. RNA interference-based therapeutics for inherited long QT syndrome.
Exp Ther Med, 2015 Aug , 10 (395-400).

113

356637

Krönauer T et al. [Long QT syndrome : History, genetics, clinical symptoms, causes and therapy].
Anaesthesist, 2015 Aug , 64 (586-95).

114

362762

Winbo A et al. Third trimester fetal heart rate predicts phenotype and mutation burden in the type 1 long QT syndrome.
Circ Arrhythm Electrophysiol, 2015 Aug , 8 (806-14).

115

362758

Potet F et al. Intracellular calcium attenuates late current conducted by mutant human cardiac sodium channels.
Circ Arrhythm Electrophysiol, 2015 Aug , 8 (933-41).

117

366861

Lampert R Reassuring News for Genetically Tested, Appropriately Treated, Low-Risk LQTS Patients.
J. Cardiovasc. Electrophysiol., 2015 Aug , 26 (859-61).

118

366904

119

367187

Osterbur ML et al. An Interdomain KCNH2 Mutation Produces an Intermediate Long QT Syndrome.
Hum. Mutat., 2015 Aug , 36 (764-73).

120

367292

Zhang C et al. Identification of Low-Risk Adult Congenital LQTS Patients.
J. Cardiovasc. Electrophysiol., 2015 Aug , 26 (853-8).

121

357936

Christ T et al. LQT1-phenotypes in hiPSC: Are we measuring the right thing?
Proc. Natl. Acad. Sci. U.S.A., 2015 Apr 21 , 112 (E1968).

122

357937

Greber B et al. Reply to Christ et al.: LQT1 and JLNS phenotypes in hiPSC-derived cardiomyocytes are due to KCNQ1 mutations.
Proc. Natl. Acad. Sci. U.S.A., 2015 Apr 21 , 112 (E1969).

124

363038

133

366574

Itoh H et al. A Common Mutation of Long QT Syndrome Type 1 in Japan.
Circ. J., 2015 , 79 (2026-30).

134

366405

138

361781

Warsi J et al. Regulation of Voltage Gated K+ Channel KCNE1/KCNQ1 by the Janus Kinase JAK3.
Cell. Physiol. Biochem., 2015 , 37 (2476-85).

140

362224

Bellin M et al. Human iPS cell models of Jervell and Lange-Nielsen syndrome.
Rare Dis, 2015 , 3 (e1012978).

141

362816

147

356933

151

361471

Lazzerini PE et al. Long QT Syndrome: An Emerging Role for Inflammation and Immunity.
Front Cardiovasc Med, 2015 , 2 (26).

152

357281

Kılıç E et al. Jervell and Lange-Nielsen syndrome with homozygous missense mutation of the KCNQ1 gene.
Turk. J. Pediatr., 2014 Sep-Oct , 56 (542-5).

154

350741

Mirams GR et al. Prediction of Thorough QT study results using action potential simulations based on ion channel screens.
J Pharmacol Toxicol Methods, 2014 Nov-Dec , 70 (246-54).

155

353376

Hancox JC et al. In silico investigation of a KCNQ1 mutation associated with familial atrial fibrillation.
J Electrocardiol, 2014 Mar-Apr , 47 (158-65).

158

359589

Imaniastuti R et al. Computational prediction of proarrhythmogenic effect of the V241F KCNQ1 mutation in human atrium.
Prog. Biophys. Mol. Biol., 2014 Sep , 116 (70-5).

159

360518

160

355870

161

351144

van Hoeijen DA et al. Cardiac sodium channels and inherited electrophysiological disorders: an update on the pharmacotherapy.
Expert Opin Pharmacother, 2014 Sep , 15 (1875-87).

164

348716

165

350425

Singhal R et al. Colchicine suppresses atrial fibrillation in failing heart.
Int. J. Cardiol., 2014 Oct 20 , 176 (651-60).

166

350391

Olde Nordkamp LR et al. Syncope in genotype-negative long QT syndrome family members.
Am. J. Cardiol., 2014 Oct 15 , 114 (1223-8).

168

350160

Sahu ID et al. Structural investigation of the transmembrane domain of KCNE1 in proteoliposomes.
Biochemistry, 2014 Oct 14 , 53 (6392-401).

169

359901

171

350384

172

350095

176

361046

Al-Aama JY et al. De novo mutation in the KCNQ1 gene causal to Jervell and Lange-Nielsen syndrome.
Clin. Genet., 2014 Nov , 86 (492-5).

177

344805

Hedley PL et al. MicroRNAs in cardiac arrhythmia: DNA sequence variation of MiR-1 and MiR-133A in long QT syndrome.
Scand. J. Clin. Lab. Invest., 2014 May 8 , ().

178

345349

Frolov RV et al. Celecoxib and ion channels: a story of unexpected discoveries.
Eur. J. Pharmacol., 2014 May 5 , 730 (61-71).

179

345087

180

352449

181

353199

Grunnet M et al. Kv7 channels as targets for anti-epileptic and psychiatric drug-development.
Eur. J. Pharmacol., 2014 Mar 5 , 726 (133-7).

183

346418

Wu J et al. A molecular mechanism for adrenergic-induced long QT syndrome.
J. Am. Coll. Cardiol., 2014 Mar 4 , 63 (819-27).

184

346419

Schwartz PJ et al. Sudden death by stress: how far under the nerves should we dig to find out why LQT1 patients die?
J. Am. Coll. Cardiol., 2014 Mar 4 , 63 (828-30).

186

345951

Brueggemann LI et al. KCNQ (Kv7) potassium channel activators as bronchodilators: combination with a β2-adrenergic agonist enhances relaxation of rat airways.
Am. J. Physiol. Lung Cell Mol. Physiol., 2014 Mar 15 , 306 (L476-86).

188

345042

Shimizu W [Current status and future perspective in inherited cardiac arrhythmias].
Nippon Rinsho, 2014 Mar , 72 (553-63).

191

354751

192

354728

194

344574

Jepps TA et al. Vasorelaxant effects of novel Kv7.4 channel enhancers ML213 and NS15370.
Br. J. Pharmacol., 2014 Jun 9 , ().

195

344422

197

352112

Currò D K+ channels as potential targets for the treatment of gastrointestinal motor disorders.
Eur. J. Pharmacol., 2014 Jun 15 , 733 (97-101).

198

345375

200

352177

201

352634

Glengarry JM et al. Long QT molecular autopsy in sudden infant death syndrome.
Arch. Dis. Child., 2014 Jul , 99 (635-40).

203

352314

Liu W et al. KCNE2 modulates cardiac L-type Ca(2+) channel.
J. Mol. Cell. Cardiol., 2014 Jul , 72 (208-18).

206

344698

Oliveras A et al. Functional assembly of kv7.1/kv7.5 channels with emerging properties on vascular muscle physiology.
Arterioscler. Thromb. Vasc. Biol., 2014 Jul , 34 (1522-30).

207

360908

Sakata S et al. Instability of KCNE1-D85N that causes long QT syndrome: stabilization by verapamil.
Pacing Clin Electrophysiol, 2014 Jul , 37 (853-63).

208

346047

209

346254

Brueggemann LI et al. Differential protein kinase C-dependent modulation of Kv7.4 and Kv7.5 subunits of vascular Kv7 channels.
J. Biol. Chem., 2014 Jan 24 , 289 (2099-111).

213

353190

214

345620

216

353765

217

354788

Zhang Y et al. The SCN5A mutation A1180V is associated with electrocardiographic features of LQT3.
Pediatr Cardiol, 2014 Feb , 35 (295-300).

220

349776

Schroder EA et al. Light phase-restricted feeding slows basal heart rate to exaggerate the type-3 long QT syndrome phenotype in mice.
Am. J. Physiol. Heart Circ. Physiol., 2014 Dec 15 , 307 (H1777-85).

222

349770

Aromolaran AS et al. LQT1 mutations in KCNQ1 C-terminus assembly domain suppress IKs using different mechanisms.
Cardiovasc. Res., 2014 Dec 1 , 104 (501-11).

223

360740

225

359035

226

350166

Li P et al. The human ether-a-go-go-related gene activator NS1643 enhances epilepsy-associated KCNQ channels.
J. Pharmacol. Exp. Ther., 2014 Dec , 351 (596-604).

227

350568

Salsbury G et al. Disruption of the potassium channel regulatory subunit KCNE2 causes iron-deficient anemia.
Exp. Hematol., 2014 Dec , 42 (1053-8.e1).

231

350080

232

353539

236

345469

Plant LD et al. Individual IKs channels at the surface of mammalian cells contain two KCNE1 accessory subunits.
Proc. Natl. Acad. Sci. U.S.A., 2014 Apr 8 , 111 (E1438-46).

240

345600

Chadha PS et al. Contribution of kv7.4/kv7.5 heteromers to intrinsic and calcitonin gene-related peptide-induced cerebral reactivity.
Arterioscler. Thromb. Vasc. Biol., 2014 Apr , 34 (887-93).

241

345339

Wang D et al. Cardiac channelopathy testing in 274 ethnically diverse sudden unexplained deaths.
Forensic Sci. Int., 2014 Apr , 237 (90-9).

244

353613

245

352135

Dvir M et al. Recent molecular insights from mutated IKS channels in cardiac arrhythmia.
Curr Opin Pharmacol, 2014 Apr , 15 (74-82).

246

344538

Tester DJ et al. GENETICS OF LONG QT SYNDROME.
Methodist Debakey Cardiovasc J, 2014 1 , 10 (29-33).

256

351742

Villafane J et al. Short QT syndrome manifesting with neonatal atrial fibrillation and bradycardia.
Cardiology, 2014 , 128 (236-40).

257

351715

259

351338

Miller D et al. Sodium channels, cardiac arrhythmia, and therapeutic strategy.
Adv. Pharmacol., 2014 , 70 (367-92).

261

355992

262

350460

Biernacka EK [Genetic arrhythmias and gender].
Prz. Lek., 2014 , 71 (139-41).

264

350355

Shimizu W Clinical and genetic diagnosis for inherited cardiac arrhythmias.
J Nippon Med Sch, 2014 , 81 (203-10).

265

353546

Zimmer T et al. Voltage-gated sodium channels in the mammalian heart.
Glob Cardiol Sci Pract, 2014 , 2014 (449-63).

266

353846

268

351925

270

352071

Antzelevitch C et al. The role of late I Na in development of cardiac arrhythmias.
Handb Exp Pharmacol, 2014 , 221 (137-68).

271

352810

274

364165

275

364459

276

359463

Mizusawa Y et al. Genetic and clinical advances in congenital long QT syndrome.
Circ. J., 2014 , 78 (2827-33).

281

358779

Strutz-Seebohm N et al. Klotho: a new trafficking modifier of Kv7.1/KCNE1 channels.
Channels (Austin), 2014 , 8 (285).

282

358679

283

360935

Almilaji A et al. Upregulation of KCNQ1/KCNE1 K+ channels by Klotho.
Channels (Austin), 2014 , 8 (222-9).

284

360981

Ertugrul I et al. Follow up of a family with asymptomatic compound long QT syndrome mutations.
Genet. Couns., 2014 , 25 (399-403).

286

364598

Qureshi SF et al. Novel mutations of KCNQ1 in Long QT syndrome.
Indian Heart J, 2013 Sep-Oct , 65 (552-60).

288

335375

Elkins RC et al. Variability in high-throughput ion-channel screening data and consequences for cardiac safety assessment.
J Pharmacol Toxicol Methods, 2013 Jul-Aug , 68 (112-22).

289

341293

Lang F et al. Serum and glucocorticoid inducible kinase, metabolic syndrome, inflammation, and tumor growth.
Hormones (Athens), 2013 Apr-Jun , 12 (160-71).

290

347792

Svalø J et al. Bladder contractility is modulated by Kv7 channels in pig detrusor.
Eur. J. Pharmacol., 2013 Sep 5 , 715 (312-20).

291

339515

Haugaa KH et al. Abnormal electroencephalograms in patients with long QT syndrome.
Heart Rhythm, 2013 Sep 27 , ().

292

339543

293

339578

294

342324

Haitin Y et al. The structural mechanism of KCNH-channel regulation by the eag domain.
Nature, 2013 Sep 19 , 501 (444-8).

295

339621

Cordeiro JM et al. Developmental changes in expression and biophysics of ion channels in the canine ventricle.
J. Mol. Cell. Cardiol., 2013 Sep 10 , 64C (79-89).

301

347947

Nawathe PA et al. An LQTS6 MiRP1 mutation suppresses pacemaker current and is associated with sinus bradycardia.
J. Cardiovasc. Electrophysiol., 2013 Sep , 24 (1021-7).

304

342168

Kimoto K et al. Characterization of a novel mutant KCNQ1 channel subunit lacking a large part of the C-terminal domain.
Biochem. Biophys. Res. Commun., 2013 Oct 18 , 440 (283-8).

307

346759

Meng J et al. Compound ICA-105574 prevents arrhythmias induced by cardiac delayed repolarization.
Eur. J. Pharmacol., 2013 Oct 15 , 718 (87-97).

309

342267

Campbell CM et al. Selective targeting of gain-of-function KCNQ1 mutations predisposing to atrial fibrillation.
Circ Arrhythm Electrophysiol, 2013 Oct , 6 (960-6).

310

339526

Andreasen L et al. Genetic Modifier of the QTc Interval Associated With Early-Onset Atrial Fibrillation.
Can J Cardiol, 2013 Oct , 29 (1234-40).

311

342295

Veerman CC et al. Slow delayed rectifier potassium current blockade contributes importantly to drug-induced long QT syndrome.
Circ Arrhythm Electrophysiol, 2013 Oct , 6 (1002-9).

313

339487

Giudicessi JR et al. Genotype- and Phenotype-Guided Management of Congenital Long QT Syndrome.
Curr Probl Cardiol, 2013 Oct , 38 (417-455).

314

347333

315

347813

316

346513

Lee YS et al. Long QT syndrome: a Korean single center study.
J. Korean Med. Sci., 2013 Oct , 28 (1454-60).

317

347994

Hummel YM et al. Ventricular dysfunction in a family with long QT syndrome type 3.
Europace, 2013 Oct , 15 (1516-21).

319

361099

321

341913

Li Y et al. Intracellular ATP binding is required to activate the slowly activating K+ channel I(Ks).
Proc. Natl. Acad. Sci. U.S.A., 2013 Nov 19 , 110 (18922-7).

322

342289

Stump MR et al. LQT2 nonsense mutations generate trafficking defective NH2-terminally truncated channels by the reinitiation of translation.
Am. J. Physiol. Heart Circ. Physiol., 2013 Nov 1 , 305 (H1397-404).

324

341612

Di Cori A et al. [Pro-arrhythmic effect of cardiac memory in a patient with long QT syndrome].
G Ital Cardiol (Rome), 2013 Nov , 14 (746-9).

327

346000

328

340210

329

335387

331

340904

334

347765

Aziz PF et al. Do LQTS gene single nucleotide polymorphisms alter QTc intervals at rest and during exercise stress testing?
Ann Noninvasive Electrocardiol, 2013 May , 18 (288-93).

336

343697

Bartos DC et al. A KCNQ1 mutation causes a high penetrance for familial atrial fibrillation.
J. Cardiovasc. Electrophysiol., 2013 May , 24 (562-9).

337

343784

339

336210

Werry D et al. Single-channel basis for the slow activation of the repolarizing cardiac potassium current, I(Ks).
Proc. Natl. Acad. Sci. U.S.A., 2013 Mar 12 , 110 (E996-1005).

341

336068

Babcock JJ et al. hERG channel function: beyond long QT.
Acta Pharmacol. Sin., 2013 Mar , 34 (329-35).

346

334939

Steinke K et al. Coxsackievirus B3 modulates cardiac ion channels.
FASEB J., 2013 Jun 27 , ().

350

343128

Heijman J et al. KCNQ1 autoantibodies: another way to regulate IKs.
Cardiovasc. Res., 2013 Jun 1 , 98 (329-31).

351

343358

Rapetti-Mauss R et al. Oestrogen promotes KCNQ1 potassium channel endocytosis and postendocytic trafficking in colonic epithelium.
J. Physiol. (Lond.), 2013 Jun 1 , 591 (2813-31).

355

335884

356

335911

Lang F et al. Therapeutic potential of serum and glucocorticoid inducible kinase inhibition.
Expert Opin Investig Drugs, 2013 Jun , 22 (701-14).

357

336021

359

342663

Brelidze TI et al. Structure of the C-terminal region of an ERG channel and functional implications.
Proc. Natl. Acad. Sci. U.S.A., 2013 Jul 9 , 110 (11648-53).

360

335120

Amin AS et al. Long QT syndrome: beyond the causal mutation.
J. Physiol. (Lond.), 2013 Jul 22 , ().

361

334799

362

334839

Zaydman MA et al. Kv7.1 ion channels require a lipid to couple voltage sensing to pore opening.
Proc. Natl. Acad. Sci. U.S.A., 2013 Jul 16 , ().

364

335463

Takanari H et al. Efficient and specific cardiac IK1 inhibition by a new pentamidine analogue.
Cardiovasc. Res., 2013 Jul 1 , 99 (203-14).

366

335594

369

347948

371

337289

Nguyen N et al. Independent trafficking of the KCNQ1 K+ channel and H+-K+-ATPase in gastric parietal cells from mice.
Am. J. Physiol. Gastrointest. Liver Physiol., 2013 Jan 15 , 304 (G157-66).

373

343040

Feng MJ et al. [KCNQ1 mutation in patients with lone atrial fibrillation].
Zhonghua Xin Xue Guan Bing Za Zhi, 2013 Jan , 41 (8-12).

379

330413

380

330425

Abbott GW KCNE genetics and pharmacogenomics in cardiac arrhythmias: much ado about nothing?
Expert Rev Clin Pharmacol, 2013 Jan , 6 (49-60).

382

331114

383

336355

384

336489

385

330611

Yang T et al. An Allosteric Mechanism for Drug Block of the Human Cardiac Potassium Channel KCNQ1.
Mol. Pharmacol., 2013 Feb , 83 (481-9).

386

336774

Melnick M et al. An in vitro mouse model of congenital cytomegalovirus-induced pathogenesis of the inner ear cochlea.
Birth Defects Res. Part A Clin. Mol. Teratol., 2013 Feb , 97 (69-78).

388

337187

389

338236

Ware JS et al. Next generation diagnostics in inherited arrhythmia syndromes : a comparison of two approaches.
J Cardiovasc Transl Res, 2013 Feb , 6 (94-103).

391

353493

Nguyen HL et al. Andersen-Tawil syndrome: clinical and molecular aspects.
Int. J. Cardiol., 2013 Dec 5 , 170 (1-16).

393

353804

Seebohm G A complex partnership: KCNQ1 and KCNE1.
Biophys. J., 2013 Dec 3 , 105 (2437-8).

395

346366

397

342161

Khanamiri S et al. Contribution of Kv7 channels to basal coronary flow and active response to ischemia.
Hypertension, 2013 Dec , 62 (1090-7).

400

339438

401

339740

Than BL et al. The role of KCNQ1 in mouse and human gastrointestinal cancers.
Oncogene, 2013 Aug 26 , ().

402

339774

Hayashi M et al. Molecular basis of potassium channels in pancreatic duct epithelial cells.
Channels (Austin), 2013 Aug 20 , 7 ().

405

348087

Cheng J et al. Caveolin-3 suppresses late sodium current by inhibiting nNOS-dependent S-nitrosylation of SCN5A.
J. Mol. Cell. Cardiol., 2013 Aug , 61 (102-10).

407

347569

411

342466

412

343573

414

335640

Crotti L et al. Long QT syndrome-associated mutations in intrauterine fetal death.
JAMA, 2013 Apr 10 , 309 (1473-82).

415

336450

Hu RM et al. Digenic inheritance novel mutations in SCN5a and SNTA1 increase late I(Na) contributing to LQT syndrome.
Am. J. Physiol. Heart Circ. Physiol., 2013 Apr 1 , 304 (H994-H1001).

419

343414

Netchine I et al. Epigenetic anomalies in childhood growth disorders.
Nestle Nutr Inst Workshop Ser, 2013 , 71 (65-73).

420

347110

423

334900

424

335952

425

334905

428

341891

431

339847

Moric-Janiszewska E et al. Quantitative PCR as an Alternative in the Diagnosis of Long-QT Syndrome.
Biomed Res Int, 2013 , 2013 (418604).

437

355052

439

354543

Ferrer T et al. Tamoxifen inhibition of kv7.2/kv7.3 channels.
PLoS ONE, 2013 , 8 (e76085).

442

332927

Hekkala AM et al. T-wave morphology after epinephrine bolus may reveal silent long QT syndrome mutation carriers.
J Electrocardiol, 2012 Jul-Aug , 45 (368-72).

444

334680

447

331167

Zumhagen S et al. Inherited long QT syndrome: clinical manifestation, genetic diagnostics, and therapy.
Herzschrittmacherther Elektrophysiol, 2012 Sep , 23 (211-9).

448

332697

450

332363

453

330832

Haugaa KH et al. Subclinical Cardiomyopathy and Long QT Syndrome: An Echocardiographic Observation.
Congenit Heart Dis, 2012 Oct 24 , ().

454

331438

Abderemane-Ali F et al. Dual effect of phosphatidyl (4,5)-bisphosphate PIP2 on Shaker K+ channels.
J. Biol. Chem., 2012 Oct 19 , 287 (36158-67).

459

338492

460

337992

Mannino GC et al. Individualized therapy for type 2 diabetes: clinical implications of pharmacogenetic data.
Mol Diagn Ther, 2012 Oct , 16 (285-302).

462

361144

463

330692

466

339349

Edelmann J et al. Long QT syndrome mutation detection by SNaPshot technique.
Int. J. Legal Med., 2012 Nov , 126 (969-73).

471

327276

Wilmes J et al. Regulation of KCNQ1/KCNE1 by β-catenin.
, 2012 May 14 , ().

472

328337

Osteen JD et al. Allosteric gating mechanism underlies the flexible gating of KCNQ1 potassium channels.
Proc. Natl. Acad. Sci. U.S.A., 2012 May 1 , 109 (7103-8).

474

330002

Birner C et al. Differential expression of potassium channels and abnormal conduction in experimental tachycardia-induced heart failure.
Naunyn Schmiedebergs Arch. Pharmacol., 2012 May , 385 (473-80).

478

334702

483

327036

Pattnaik BR et al. Effects of KCNQ channel modulators on the M-type potassium current in primate retinal pigment epithelium.
Am. J. Physiol., Cell Physiol., 2012 Mar , 302 (C821-33).

484

328937

Moreno JD et al. Pathophysiology of the cardiac late Na current and its potential as a drug target.
J. Mol. Cell. Cardiol., 2012 Mar , 52 (608-19).

485

329133

Besana A et al. Nadolol block of Nav1.5 does not explain its efficacy in the long QT syndrome.
J. Cardiovasc. Pharmacol., 2012 Mar , 59 (249-53).

486

329289

488

333927

489

334103

Kaddar N et al. Tizanidine (Zanaflex): a muscle relaxant that may prolong the QT interval by blocking IKr.
J. Cardiovasc. Pharmacol. Ther., 2012 Mar , 17 (102-9).

490

328011

Gönczi M et al. Age-dependent changes in ion channel mRNA expression in canine cardiac tissues.
Gen. Physiol. Biophys., 2012 Jun , 31 (153-62).

496

332116

Kulzer M et al. Inhibition of cardiac Kir2.1-2.3 channels by beta3 adrenoreceptor antagonist SR 59230A.
Biochem. Biophys. Res. Commun., 2012 Jul 27 , 424 (315-20).

497

328088

498

328077

499

332937

Hayashi M et al. An intermediate-conductance Ca2+-activated K+ channel is important for secretion in pancreatic duct cells.
Am. J. Physiol., Cell Physiol., 2012 Jul 15 , 303 (C151-9).

504

333192

505

331212

Vandenberg JI et al. hERG K(+) channels: structure, function, and clinical significance.
Physiol. Rev., 2012 Jul , 92 (1393-478).

508

325749

512

329194

Andersen MN et al. AMP-activated protein kinase downregulates Kv7.1 cell surface expression.
Traffic, 2012 Jan , 13 (143-56).

513

327739

Krishnan Y et al. Partially dominant mutant channel defect corresponding with intermediate LQT2 phenotype.
Pacing Clin Electrophysiol, 2012 Jan , 35 (3-16).

515

325131

519

327074

Dennis AT et al. Molecular determinants of pentamidine-induced hERG trafficking inhibition.
Mol. Pharmacol., 2012 Feb , 81 (198-209).

521

327482

524

330435

Abriel H et al. Cardiac channelopathies: Genetic and molecular mechanisms.
Gene, 2012 Dec 22 , ().

525

330668

Ishii K et al. Endocytic regulation of voltage-dependent potassium channels in the heart.
J. Pharmacol. Sci., 2012 Dec 18 , 120 (264-9).

526

330439

527

330485

Organ-Darling LE et al. Interactions between hERG and KCNQ1 α-subunits are mediated by their C-termini and modulated by cAMP.
Am. J. Physiol. Heart Circ. Physiol., 2012 Dec 15 , ().

529

330728

530

337354

531

341007

Wang Y et al. Probing the structural basis for differential KCNQ1 modulation by KCNE1 and KCNE2.
J. Gen. Physiol., 2012 Dec , 140 (653-69).

532

337542

534

334510

535

336799

Fedoriw AM et al. Differentiation-driven nucleolar association of the mouse imprinted Kcnq1 locus.
G3 (Bethesda), 2012 Dec , 2 (1521-8).

537

339104

Song W et al. Cardiac sodium channel Nav1.5 mutations and cardiac arrhythmia.
Pediatr Cardiol, 2012 Aug , 33 (943-9).

538

339127

540

332259

541

332795

Ware JS et al. Paralogous annotation of disease-causing variants in long QT syndrome genes.
Hum. Mutat., 2012 Aug , 33 (1188-91).

542

332959

Purtell K et al. The KCNQ1-KCNE2 K⁺ channel is required for adequate thyroid I⁻ uptake.
FASEB J., 2012 Aug , 26 (3252-9).

543

334695

544

326400

Jiménez-Vargas JM et al. Toxin modulators and blockers of hERG K(+) channels.
, 2012 Apr 5 , ().

546

326668

552

330750

Couderc JP et al. Genotype- and Sex-Specific QT-RR Relationship in the Type-1 Long-QT Syndrome.
J Am Heart Assoc, 2012 Apr , 1 (e000570).

553

330271

Komarlu R et al. Fetal and neonatal presentation of long QT syndrome.
Pacing Clin Electrophysiol, 2012 Apr , 35 (e87-90).

554

337063

Lazarczyk MJ et al. Selective acquired long QT syndrome (saLQTS) upon risperidone treatment.
BMC Psychiatry, 2012 , 12 (220).

555

336819

556

330610

Knoche JW et al. Atrial Fibrillation and Long QT Syndrome Presenting in a 12-Year-Old Girl.
Case Rep Pediatr, 2012 , 2012 (124838).

558

331096

561

332675

562

333109

564

334554

571

328122

Morris LM et al. Mouse middle ear ion homeostasis channels and intercellular junctions.
PLoS ONE, 2012 , 7 (e39004).

574

338568

Ferro F et al. Long-chain acylcarnitines regulate the hERG channel.
PLoS ONE, 2012 , 7 (e41686).

575

339103

Moric-Janiszewska E et al. Molecular diagnostics of families with long-QT syndrome.
Cardiol J, 2012 , 19 (159-67).

578

337717

582

318054

583

323147

Dennis AT et al. Antidepressant-induced ubiquitination and degradation of the cardiac potassium channel hERG.
J. Biol. Chem., 2011 Sep 30 , 286 (34413-25).

585

317826

589

323983

Digby GC et al. Acquired long QT interval: a case series of multifactorial QT prolongation.
Clin Cardiol, 2011 Sep , 34 (577-82).

591

321047

598

324974

599

324877

600

324963

605

323960

Bonaldi A et al. Microduplication of the ICR2 domain at chromosome 11p15 and familial Silver-Russell syndrome.
Am. J. Med. Genet. A, 2011 Oct , 155A (2479-83).

606

322996

Tester DJ et al. Unexplained drownings and the cardiac channelopathies: a molecular autopsy series.
Mayo Clin. Proc., 2011 Oct , 86 (941-7).

607

320770

Calloe K et al. Multiple arrhythmic syndromes in a newborn, owing to a novel mutation in SCN5A.
Can. J. Physiol. Pharmacol., 2011 Oct , 89 (723-36).

613

324068

614

324891

Bai YL et al. HIV Tat protein inhibits hERG K+ channels: a potential mechanism of HIV infection induced LQTs.
J. Mol. Cell. Cardiol., 2011 Nov , 51 (876-80).

615

327001

Saif-Ali R et al. KCNQ1 variants associate with type 2 diabetes in Malaysian Malay subjects.
Ann. Acad. Med. Singap., 2011 Nov , 40 (488-92).

616

320676

Parvez B et al. The "missing" link in atrial fibrillation heritability.
J Electrocardiol, 2011 Nov , 44 (641-4).

617

320722

Kaufman ES Arrhythmic risk in congenital long QT syndrome.
J Electrocardiol, 2011 Nov , 44 (645-9).

619

320394

Nakajo K et al. KCNQ1 subdomains involved in KCNE modulation revealed by an invertebrate KCNQ1 orthologue.
J. Gen. Physiol., 2011 Nov , 138 (521-35).

624

322002

Ando F et al. Synergic effects of β-estradiol and erythromycin on hERG currents.
J. Membr. Biol., 2011 May , 241 (31-8).

625

322231

627

322499

Soma K et al. Abundant expression of KCNE1 in the left ventricle of the miniature pig.
Heart Vessels, 2011 May , 26 (353-6).

629

318324

630

319546

632

319249

Jespersen T Regulation and physiological function of Na(v) 1.5 and KCNQ1 channels.
Acta Physiol (Oxf), 2011 May , 202 Suppl 683 (1-26).

641

316333

642

317456

Papatheodoropoulos C et al. α5GABAA receptors regulate hippocampal sharp wave-ripple activity in vitro.
Neuropharmacology, 2011 Mar , 60 (662-73).

645

319556

646

322174

654

322257

Kanduri C Kcnq1ot1: a chromatin regulatory RNA.
Semin. Cell Dev. Biol., 2011 Jun , 22 (343-50).

655

322176

Vigneault P et al. Prolongation of cardiac ventricular repolarization under paliperidone: how and how much?
J. Cardiovasc. Pharmacol., 2011 Jun , 57 (690-5).

658

321510

Zhou PZ et al. Activation of human ether-a-go-go related gene (hERG) potassium channels by small molecules.
Acta Pharmacol. Sin., 2011 Jun , 32 (781-8).

659

323615

Obata Y et al. Epigenetically immature oocytes lead to loss of imprinting during embryogenesis.
J. Reprod. Dev., 2011 Jun , 57 (327-34).

661

325891

Tveito A et al. Defining candidate drug characteristics for Long-QT (LQT3) syndrome.
Math Biosci Eng, 2011 Jul , 8 (861-73).

662

324232

Allegue C et al. Prevalence of HCM and long QT syndrome mutations in young sudden cardiac death-related cases.
Int. J. Legal Med., 2011 Jul , 125 (565-72).

663

321663

Jones MJ et al. An extended domain of Kcnq1ot1 silencing revealed by an imprinted fluorescent reporter.
Mol. Cell. Biol., 2011 Jul , 31 (2827-37).

664

321201

Schroner Z et al. Variation in KCNQ1 is associated with therapeutic response to sulphonylureas.
Med. Sci. Monit., 2011 Jul , 17 (CR392-6).

665

321920

667

323604

Couderc JP et al. T-wave morphology abnormalities in benign, potent, and arrhythmogenic I(kr) inhibition.
Heart Rhythm, 2011 Jul , 8 (1036-43).

670

314463

671

314345

672

316240

673

314307

675

315568

Thomas AM et al. Characterization of a binding site for anionic phospholipids on KCNQ1.
J. Biol. Chem., 2011 Jan 21 , 286 (2088-100).

676

317471

Kauferstein S et al. A novel mutation in the cardiac ryanodine receptor gene (RyR2) in a patient with an unequivocal LQTS.
Int. J. Cardiol., 2011 Jan 21 , 146 (249-50).

677

314092

678

314113

680

316058

681

316350

Han S et al. Fluconazole inhibits hERG K(+) channel by direct block and disruption of protein trafficking.
Eur. J. Pharmacol., 2011 Jan 10 , 650 (138-44).

682

314348

Stump MR et al. Multiple splicing defects caused by hERG splice site mutation 2592+1G>A associated with long QT syndrome.
Am. J. Physiol. Heart Circ. Physiol., 2011 Jan , 300 (H312-8).

684

314327

687

318709

688

318640

Fröhlich H et al. Hypothyroidism of gene-targeted mice lacking Kcnq1.
Pflugers Arch., 2011 Jan , 461 (45-52).

691

315495

693

315368

Ma LJ et al. Allosteric Features of KCNQ1 Gating Revealed by Alanine Scanning Mutagenesis.
Biophys. J., 2011 Feb 16 , 100 (885-94).

694

316339

696

317412

698

325518

Bentzen BH et al. Pharmacological activation of Kv11.1 in transgenic long QT-1 rabbits.
J. Cardiovasc. Pharmacol., 2011 Feb , 57 (223-30).

700

322125

Li JL et al. [Association of age-related hearing loss with ion transporter KCNQ1 and NKCC1 in cochlea of C57BL/6J mice].
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi, 2011 Feb , 46 (139-43).

706

327156

Sung RK et al. QTc prolongation and family history of sudden death in a patient with desmin cardiomyopathy.
Pacing Clin Electrophysiol, 2011 Dec , 34 (e105-8).

707

325844

Krause U et al. A rare association of long QT syndrome and syndactyly: Timothy syndrome (LQT 8).
Clin Res Cardiol, 2011 Dec , 100 (1123-7).

708

327117

Chen J et al. A dual mechanism for I(Ks) current reduction by the pathogenic mutation KCNQ1-S277L.
Pacing Clin Electrophysiol, 2011 Dec , 34 (1652-64).

709

324784

Maillé E et al. Regulation of normal and cystic fibrosis airway epithelial repair processes by TNF-α after injury.
Am. J. Physiol. Lung Cell Mol. Physiol., 2011 Dec , 301 (L945-55).

710

324854

Mikuni I et al. Partial restoration of the long QT syndrome associated KCNQ1 A341V mutant by the KCNE1 β-subunit.
Biochim. Biophys. Acta, 2011 Dec , 1810 (1285-93).

713

325430

714

339269

Shao C et al. Electrophysiological study of V535M hERG mutation of LQT2.
J. Huazhong Univ. Sci. Technol. Med. Sci., 2011 Dec , 31 (741-8).

716

323131

718

321491

Lin S et al. Nonallelic transcriptional roles of CTCF and cohesins at imprinted loci.
Mol. Cell. Biol., 2011 Aug , 31 (3094-104).

723

319333

Yamagata K et al. Voltage-gated K+ channel KCNQ1 regulates insulin secretion in MIN6 β-cell line.
Biochem. Biophys. Res. Commun., 2011 Apr 15 , 407 (620-5).

726

319547

El Gebeily G et al. Upregulation of ventricular potassium channels by chronic tamoxifen treatment.
Cardiovasc. Res., 2011 Apr 1 , 90 (68-76).

727

321958

728

321957

Grilo LS et al. Patient with syncope and LQTS carrying a mutation in the PAS domain of the hERG1 channel.
Ann Noninvasive Electrocardiol, 2011 Apr , 16 (213-8).

729

319440

Van Horn WD et al. Working model for the structural basis for KCNE1 modulation of the KCNQ1 potassium channel.
Curr. Opin. Struct. Biol., 2011 Apr , 21 (283-91).

731

319891

Winbo A et al. Origin of the Swedish long QT syndrome Y111C/KCNQ1 founder mutation.
Heart Rhythm, 2011 Apr , 8 (541-7).

732

318410

Andersen MN et al. Kv7.1 surface expression is regulated by epithelial cell polarization.
Am. J. Physiol., Cell Physiol., 2011 Apr , 300 (C814-24).

734

317963

737

320405

Frolov RV et al. Inhibition of HERG potassium channels by celecoxib and its mechanism.
PLoS ONE, 2011 , 6 (e26344).

738

321272

Rotte A et al. Ca2+ activated K+ channel Kca3.1 as a determinant of gastric acid secretion.
Cell. Physiol. Biochem., 2011 , 27 (597-604).

739

321273

Strutz-Seebohm N et al. Structural basis of slow activation gating in the cardiac I Ks channel complex.
Cell. Physiol. Biochem., 2011 , 27 (443-52).

740

321616

Zareba W Counting mRNA in blood of LQTS - new direction?
Kardiol Pol, 2011 , 69 (430).

745

326212

Yun J et al. Hirsutenone directly blocks human ether-a-go-go related gene K+ channels.
Biol. Pharm. Bull., 2011 , 34 (1815-22).

746

326022

747

355328

Saif-Ali R et al. KCNQ1 haplotypes associate with type 2 diabetes in Malaysian Chinese Subjects.
Int J Mol Sci, 2011 , 12 (5705-18).

749

317640

Namekata I et al. Blocking effect of NIP-142 on the KCNQ1/KCNE1 channel current expressed in HEK293 cells.
Biol. Pharm. Bull., 2011 , 34 (153-5).

750

317896

751

314104

Lahtinen AM et al. KCNE1 D85N polymorphism - a sex-specific modifier in type 1 long QT syndrome?
BMC Med. Genet., 2011 , 12 (11).

752

314764

Couderc JP et al. Short and long QT syndromes: does QT length really matter?
J Electrocardiol, 2010 Sep-Oct , 43 (396-9).

753

314023

Lang F et al. SGK, renal function and hypertension.
J. Nephrol., 2010 Nov-Dec , 23 Suppl 16 (S124-9).

754

136291

Cirović S et al. Differential expression of KCNQ1 K+ channel in tubular cells of frog kidney.
Eur J Histochem, 2010 Jan-Mar , 54 (e7).

758

314882

761

139401

Zhong XZ et al. Participation of KCNQ (Kv7) potassium channels in myogenic control of cerebral arterial diameter.
J. Physiol. (Lond.), 2010 Sep 1 , 588 (3277-93).

762

139786

Nanda Kumar NS et al. Mucosal potassium efflux mediated via Kcnn4 channels provides the driving force for electrogenic anion secretion in colon.
Am. J. Physiol. Gastrointest. Liver Physiol., 2010 Sep , 299 (G707-14).

763

314963

Bokil NJ et al. Molecular genetics of long QT syndrome.
Mol. Genet. Metab., 2010 Sep , 101 (1-8).

764

140250

Moretti A et al. Patient-specific induced pluripotent stem-cell models for long-QT syndrome.
N. Engl. J. Med., 2010 Oct 7 , 363 (1397-409).

765

140296

Nakajo K et al. Stoichiometry of the KCNQ1 - KCNE1 ion channel complex.
, 2010 Oct 20 , ().

769

316111

770

314924

Dautova Y et al. Atrial arrhythmogenic properties in wild-type and Scn5a+/- murine hearts.
Exp. Physiol., 2010 Oct , 95 (994-1007).

771

315385

772

140665

775

316112

Sy RW et al. Repolarization dynamics during exercise discriminate between LQT1 and LQT2 genotypes.
J. Cardiovasc. Electrophysiol., 2010 Nov , 21 (1242-6).

776

314827

Purtell K et al. Cardiac arrhythmia and thyroid dysfunction: a novel genetic link.
Int. J. Biochem. Cell Biol., 2010 Nov , 42 (1767-70).

777

141041

Garweg C et al. [The long QT syndrome].
Rev Med Liege, 2010 Nov , 65 (628-33).

778

314636

Schubert ML Gastric secretion.
Curr. Opin. Gastroenterol., 2010 Nov , 26 (598-603).

779

140191

Roura-Ferrer M et al. Impact of KCNE subunits on KCNQ1 (Kv7.1) channel membrane surface targeting.
J. Cell. Physiol., 2010 Nov , 225 (692-700).

783

138565

Eldstrom J et al. Mechanistic basis for LQT1 caused by S3 mutations in the KCNQ1 subunit of IKs.
J. Gen. Physiol., 2010 May , 135 (433-48).

784

139337

Allegue C et al. A new approach to long QT syndrome mutation detection by Sequenom MassARRAY system.
Electrophoresis, 2010 May , 31 (1648-55).

785

137203

Dong MQ et al. Regulation of human cardiac KCNQ1/KCNE1 channel by epidermal growth factor receptor kinase.
Biochim. Biophys. Acta, 2010 May , 1798 (995-1001).

787

136137

791

125135

Lu JT et al. Recent progress in congenital long QT syndrome.
, 2010 Mar 10 , ().

792

137331

Pan Q et al. KCNQ1 loss-of-function mutation impairs gastric acid secretion in mice.
Mol. Biol. Rep., 2010 Mar , 37 (1329-33).

794

139894

795

136555

796

136957

Fink M et al. Pharmacodynamic effects in the cardiovascular system: the modeller's view.
Basic Clin. Pharmacol. Toxicol., 2010 Mar , 106 (243-9).

797

140766

Vanoye CG et al. KCNQ1/KCNE1 assembly, co-translation not required.
Channels (Austin), 2010 Mar , 4 (108-14).

799

137399

800

138406

Yang Y et al. Identification of a Kir3.4 mutation in congenital long QT syndrome.
Am. J. Hum. Genet., 2010 Jun 11 , 86 (872-80).

802

139440

804

137961

Lin EC et al. Properties of WT and mutant hERG K(+) channels expressed in neonatal mouse cardiomyocytes.
Am. J. Physiol. Heart Circ. Physiol., 2010 Jun , 298 (H1842-9).

805

139438

811

139883

Fabritz L et al. Autonomic modulation and antiarrhythmic therapy in a model of long QT syndrome type 3.
Cardiovasc. Res., 2010 Jul 1 , 87 (60-72).

812

139592

Sanguinetti MC HERG1 channelopathies.
Pflugers Arch., 2010 Jul , 460 (265-76).

813

139068

815

142445

817

125471

818

125019

Ponte ML et al. Mechanisms of Drug Induced QT Interval Prolongation.
Curr Drug Saf, 2010 Jan 1 , 5 (44-53).

822

123391

Shin HD et al. Association of KCNQ1 polymorphisms with the gestational diabetes mellitus in Korean women.
J. Clin. Endocrinol. Metab., 2010 Jan , 95 (445-9).

823

124092

Lang F et al. Heterocyclic indazole derivatives as SGK1 inhibitors, WO2008138448.
Expert Opin Ther Pat, 2010 Jan , 20 (129-35).

824

138910

825

137627

Alvarez PA et al. QT alterations in psychopharmacology: proven candidates and suspects.
Curr Drug Saf, 2010 Jan , 5 (97-104).

826

136808

Thomas D et al. Biophysical characterization of KCNQ1 P320 mutations linked to long QT syndrome 1.
J. Mol. Cell. Cardiol., 2010 Jan , 48 (230-7).

828

136794

Charpentier F et al. Delayed rectifier K(+) currents and cardiac repolarization.
J. Mol. Cell. Cardiol., 2010 Jan , 48 (37-44).

829

138857

Banderali U et al. Impaired stretch modulation in potentially lethal cardiac sodium channel mutants.
Channels (Austin), 2010 Jan , 4 (12-21).

830

124389

832

125309

Kang C et al. Functional delivery of a membrane protein into oocyte membranes using bicelles.
Biochemistry, 2010 Feb 2 , 49 (653-5).

833

124945

Bal M et al. Ca2+/calmodulin disrupts AKAP79/150 interactions with KCNQ (M-Type) K+ channels.
J. Neurosci., 2010 Feb 10 , 30 (2311-23).

834

125052

Saba S et al. Effect of right ventricular versus biventricular pacing on electrical remodeling in the normal heart.
Circ Arrhythm Electrophysiol, 2010 Feb 1 , 3 (79-87).

836

121049

Harmer SC et al. Mechanisms of disease pathogenesis in long QT syndrome type 5.
Am. J. Physiol., Cell Physiol., 2010 Feb , 298 (C263-73).

838

140196

Jing H et al. Ephedrine controls heart rhythms by activating cardiac I(ks) currents.
J. Cardiovasc. Pharmacol., 2010 Feb , 55 (145-52).

839

137143

Lian J et al. [A novel mutation of the KCNH2 gene in a family with congenital long QT syndrome]
Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2010 Feb , 27 (77-80).

840

136776

Grallert H et al. Association of genetic variation in KCNQ1 with type 2 diabetes in the KORA surveys.
Horm. Metab. Res., 2010 Feb , 42 (149-51).

842

315375

Serratrice G et al. [Potassium channelopathies and Morvan's syndromes].
Bull. Acad. Natl. Med., 2010 Feb , 194 (391-406; discussion 406-7).

843

141128

Osteen JD et al. KCNE1 alters the voltage sensor movements necessary to open the KCNQ1 channel gate.
Proc. Natl. Acad. Sci. U.S.A., 2010 Dec 28 , 107 (22710-5).

844

315967

Wu D et al. KCNE1 remodels the voltage sensor of Kv7.1 to modulate channel function.
Biophys. J., 2010 Dec 1 , 99 (3599-608).

845

141169

Cao X et al. Cardiac ion channel safety profiling on the IonWorks Quattro automated patch clamp system.
Assay Drug Dev Technol, 2010 Dec , 8 (766-80).

846

141161

848

314017

Kim HT et al. Long QT syndrome provoked by induction of general anesthesia -A case report-.
Korean J Anesthesiol, 2010 Dec , 59 Suppl (S114-8).

851

317006

Kim JA et al. Trigger-specific risk factors and response to therapy in long QT syndrome type 2.
Heart Rhythm, 2010 Dec , 7 (1797-805).

853

314593

857

139379

Zhang T et al. LQTS gene LOVD database.
, 2010 Aug 31 , ().

860

140608

Choufani S et al. Beckwith-Wiedemann syndrome.
Am J Med Genet C Semin Med Genet, 2010 Aug 15 , 154C (343-54).

861

139073

Weaver JR et al. Domain-specific response of imprinted genes to reduced DNMT1.
Mol. Cell. Biol., 2010 Aug , 30 (3916-28).

862

140381

Stead LF et al. KvDB; mining and mapping sequence variants in voltage-gated potassium channels.
Hum. Mutat., 2010 Aug , 31 (908-17).

865

137212

Wong JA et al. Utility of treadmill testing in identification and genotype prediction in long-QT syndrome.
Circ Arrhythm Electrophysiol, 2010 Apr 1 , 3 (120-5).

868

138529

870

137674

Gladding PA et al. Posthumous diagnosis of long QT syndrome from neonatal screening cards.
Heart Rhythm, 2010 Apr , 7 (481-6).

872

138497

873

137970

Duranton C et al. KCNQ1 K+ channels are involved in lipopolysaccharide-induced apoptosis of distal kidney cells.
Cell. Physiol. Biochem., 2010 , 25 (367-78).

875

136665

Berger SI et al. Systems pharmacology of arrhythmias.
Sci Signal, 2010 , 3 (ra30).

877

140558

878

314939

879

140897

Kotta CM et al. Cardiac ion channel gene mutations in Greek long QT syndrome patients.
J. Appl. Genet., 2010 , 51 (515-8).

880

314669

881

316605

Cardona K et al. Effects of late sodium current enhancement during LQT-related arrhythmias. A simulation study.
Conf Proc IEEE Eng Med Biol Soc, 2010 , 2010 (3237-40).

882

141593

884

6832

Lee HA et al. Cellular mechanism of the QT prolongation induced by sulpiride.
Int. J. Toxicol., 2009 May-Jun , 28 (207-12).

885

123950

Strutz-Seebohm N et al. Serum- and glucocorticoid-inducible kinases (SGK) regulate KCNQ1/KCNE potassium channels.
Channels (Austin), 2009 Mar-Apr , 3 (88-90).

886

122998

Towart R et al. Blockade of the I(Ks) potassium channel: an overlooked cardiovascular liability in drug safety screening?
J Pharmacol Toxicol Methods, 2009 Jul-Aug , 60 (1-10).

889

131411

Rieg T et al. Unravelling a role for KCNQ1 in K+ recycling and gastric acid secretion.
J. Physiol. (Lond.), 2009 Sep 1 , 587 (4149-50).

891

124416

894

122861

Ponte ML et al. Mechanisms of Drug Induced QT Interval Prolongation.
, 2009 Oct 7 , ().

895

121425

896

136385

Goldman AM et al. Arrhythmia in heart and brain: KCNQ1 mutations link epilepsy and sudden unexplained death.
Sci Transl Med, 2009 Oct 14 , 1 (2ra6).

898

123533

Roepke TK et al. Kcne2 deletion uncovers its crucial role in thyroid hormone biosynthesis.
Nat. Med., 2009 Oct , 15 (1186-94).

900

121297

Itoh H et al. Latent genetic backgrounds and molecular pathogenesis in drug-induced long-QT syndrome.
Circ Arrhythm Electrophysiol, 2009 Oct , 2 (511-23).

902

131322

903

131296

Shimizu W et al. Genotype-phenotype aspects of type 2 long QT syndrome.
J. Am. Coll. Cardiol., 2009 Nov 24 , 54 (2052-62).

904

122559

Padilla K et al. The KCNQ2/3 selective channel opener ICA-27243 binds to a novel voltage-sensor domain site.
Neurosci. Lett., 2009 Nov 13 , 465 (138-42).

905

122305

O'Mahony F et al. Novel female sex-dependent actions of oestrogen in the intestine.
J. Physiol. (Lond.), 2009 Nov 1 , 587 (5039-44).

906

122844

Brink PA et al. Of founder populations, long QT syndrome, and destiny.
Heart Rhythm, 2009 Nov , 6 (S25-33).

907

123355

Lang F et al. Targeting SGK1 in diabetes.
Expert Opin. Ther. Targets, 2009 Nov , 13 (1303-11).

908

124846

Hedley PL et al. The genetic basis of long QT and short QT syndromes: a mutation update.
Hum. Mutat., 2009 Nov , 30 (1486-511).

912

1144

Li W et al. The G314S KCNQ1 mutation exerts a dominant-negative effect on expression of KCNQ1 channels in oocytes.
Biochem. Biophys. Res. Commun., 2009 May 29 , 383 (206-9).

914

124366

Hammami S et al. Cell volume and membrane stretch independently control K+ channel activity.
J. Physiol. (Lond.), 2009 May 15 , 587 (2225-31).

917

2755

Matavel A et al. PKC activation and PIP(2) depletion underlie biphasic regulation of IKs by Gq-coupled receptors.
J. Mol. Cell. Cardiol., 2009 May , 46 (704-12).

918

131768

Chen J et al. PKA phosphorylation of HERG protein regulates the rate of channel synthesis.
Am. J. Physiol. Heart Circ. Physiol., 2009 May , 296 (H1244-54).

921

4123

922

7757

McCrossan ZA et al. Regulation of the Kv2.1 potassium channel by MinK and MiRP1.
J. Membr. Biol., 2009 Mar , 228 (1-14).

923

1321

Salama G et al. Arrhythmia phenotype in mouse models of human long QT.
, 2009 Mar , 24 (77-87).

924

1573

Aurlien D et al. New SCN5A mutation in a SUDEP victim with idiopathic epilepsy.
, 2009 Mar , 18 (158-60).

925

120519

McCallum LA et al. Expression and function of K(v)7 channels in murine myometrium throughout oestrous cycle.
Pflugers Arch., 2009 Mar , 457 (1111-20).

926

678

927

2254

Ureche ON et al. Differential modulation of cardiac potassium channels by Grb adaptor proteins.
Biochem. Biophys. Res. Commun., 2009 Jun 19 , 384 (28-31).

928

124191

930

131684

931

131784

Xu X et al. MinK-dependent internalization of the IKs potassium channel.
Cardiovasc. Res., 2009 Jun 1 , 82 (430-8).

933

122709

Zienciuk A et al. [Atrial fibrillation in the long QT syndrome]
Kardiol Pol, 2009 Jun , 67 (681-4, discussion 685-6).

936

3527

Boini KM et al. Enhanced insulin sensitivity of gene-targeted mice lacking functional KCNQ1.
Am. J. Physiol. Regul. Integr. Comp. Physiol., 2009 Jun , 296 (R1695-701).

938

758

Silva JR et al. A multiscale model linking ion-channel molecular dynamics and electrostatics to the cardiac action potential.
Proc. Natl. Acad. Sci. U.S.A., 2009 Jul 7 , 106 (11102-6).

939

120752

940

120581

Bajwa PJ et al. Activation of PPARgamma by rosiglitazone attenuates intestinal Cl- secretion.
Am. J. Physiol. Gastrointest. Liver Physiol., 2009 Jul , 297 (G82-9).

946

123563

Missan S et al. Regulation of wild-type and mutant KCNQ1/KCNE1 channels by tyrosine kinase.
Pflugers Arch., 2009 Jul , 458 (471-80).

947

1105

El-Sherif N et al. Role of pharmacotherapy in cardiac ion channelopathies.
, 2009 Jul , 7 (358-66).

948

131791

954

2396

956

131877

957

4528

Ikrar T et al. Evaluation of channel function after alteration of amino acid residues at the pore center of KCNQ1 channel.
Biochem. Biophys. Res. Commun., 2009 Jan 16 , 378 (589-94).

958

5546

Manderfield LJ et al. KCNE4 domains required for inhibition of KCNQ1.
J. Physiol. (Lond.), 2009 Jan 15 , 587 (303-14).

959

9904

960

7506

Shin JM et al. The gastric HK-ATPase: structure, function, and inhibition.
Pflugers Arch., 2009 Jan , 457 (609-22).

962

8051

Markiewicz-Łoskot G et al. The risk of cardiac events and genotype-based management of LQTS patients.
Ann Noninvasive Electrocardiol, 2009 Jan , 14 (86-92).

963

9157

Eckardt L LQT3: who is at risk for sudden cardiac death?
, 2009 Jan , 6 (121-2).

964

1837

Schwartz PJ et al. All LQT3 patients need an ICD: true or false?
, 2009 Jan , 6 (113-20).

965

131835

George AL Restoring repolarization in LQT3.
Heart Rhythm, 2009 Jan , 6 (107-8).

966

131836

Diness JG et al. Antiarrhythmic effect of IKr activation in a cellular model of LQT3.
Heart Rhythm, 2009 Jan , 6 (100-6).

967

5871

Kauferstein S et al. Cardiac gene defects can cause sudden cardiac death in young people.
Dtsch Arztebl Int, 2009 Jan , 106 (41-7).

968

131925

Kanber D et al. Low frequency of imprinting defects in ICSI children born small for gestational age.
Eur. J. Hum. Genet., 2009 Jan , 17 (22-9).

969

9816

Asada K et al. Redox- and calmodulin-dependent S-nitrosylation of the KCNQ1 channel.
J. Biol. Chem., 2009 Feb 27 , 284 (6014-20).

970

832

Li W et al. Congenital long QT syndrome caused by the F275S KCNQ1 mutation: mechanism of impaired channel function.
Biochem. Biophys. Res. Commun., 2009 Feb 27 , 380 (127-31).

971

3388

Peroz D et al. LQT1-associated mutations increase KCNQ1 proteasomal degradation independently of Derlin-1.
J. Biol. Chem., 2009 Feb 20 , 284 (5250-6).

972

1338

973

7722

Bardou O et al. Molecular diversity and function of K+ channels in airway and alveolar epithelial cells.
Am. J. Physiol. Lung Cell Mol. Physiol., 2009 Feb , 296 (L145-55).

975

122924

Ma L et al. [The effects of hypokalemia on the Na+ channel in cardiac tissue--a computer simulation study]
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi, 2009 Feb , 26 (1-5).

976

8715

978

5583

Greenwood IA et al. KCNQ-encoded channels regulate Na+ transport across H441 lung epithelial cells.
Pflugers Arch., 2009 Feb , 457 (785-94).

981

124983

982

121074

Sato A et al. Novel mechanisms of trafficking defect caused by KCNQ1 mutations found in long QT syndrome.
J. Biol. Chem., 2009 Dec 11 , 284 (35122-33).

984

131273

Winbo A et al. Low incidence of sudden cardiac death in a Swedish Y111C type 1 long-QT syndrome population.
Circ Cardiovasc Genet, 2009 Dec , 2 (558-64).

985

124628

Shi RM et al. [Gene mutation analysis of a Chinese family of congenital long Q-T syndrome type three.]
Zhonghua Er Ke Za Zhi, 2009 Dec , 47 (926-30).

986

136403

Iturralde-Torres P et al. [Genetic in long QT syndromes]
Arch Cardiol Mex, 2009 Dec , 79 Suppl 2 (26-30).