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Kv12

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Gene

The Kv12, Elk subfamily of K+ channels, was first discovered in Drosophila on the basis of homology to the Drosophila Eag K+ channel [791]. Subsequently, three distinct mammalian Elk K+ channel genes have been identified [809], [810], [790]. Some level of confusion has been generated in the naming of these Elk genes, because the same names were given to distinct genes in two publications. Here we refer to the Elk gene presented by Shi et al. [[790] (#a790) as KCNH8. (From [808])

The Kv12, Elk subfamily forms part of the Eag family, which consists of three closely related subfamilies of genes defined by sequence homology: Eag, Erg (ether-a-go-go related gene), and Elk (ether-a-go-go-like K+ channel). Each of the three subfamilies is defined by the high degree of homology shared among members. A somewhat lower level of homology is shared between subfamilies (40% amino acid identity). All three subfamilies are conserved between Drosophila and mammals, suggesting an early origin in metazoan evolution.


References

791

Warmke JW et al. A family of potassium channel genes related to eag in Drosophila and mammals.
Proc. Natl. Acad. Sci. U.S.A., 1994 Apr 12 , 91 (3438-42).

808

Zou A et al. Distribution and functional properties of human KCNH8 (Elk1) potassium channels.
Am. J. Physiol., Cell Physiol., 2003 Dec , 285 (C1356-66).

809

Engeland B et al. Cloning and functional expression of rat ether-à-go-go-like K+ channel genes.
J. Physiol. (Lond.), 1998 Dec 15 , 513 ( Pt 3) (647-54).

810

Miyake A et al. New ether-à-go-go K(+) channel family members localized in human telencephalon.
J. Biol. Chem., 1999 Aug 27 , 274 (25018-25).


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To cite this page: [Contributors] Channelpedia https://channelpedia.epfl.ch/wikipages/203/ , accessed on 2024 Dec 02



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