Kv7.5

1

Mani BK et al. Kv7.5 Potassium Channel Subunits Are the Primary Targets for PKA-Dependent Enhancement of Vascular Smooth Muscle Kv7 Currents.
Mol. Pharmacol., 2016 Mar , 89 (323-34).

2

Provence A et al. The Novel KV7.2/KV7.3 Channel Opener ICA-069673 Reveals Subtype-Specific Functional Roles in Guinea Pig Detrusor Smooth Muscle Excitability and Contractility.
J. Pharmacol. Exp. Ther., 2015 Sep , 354 (290-301).

3

Kalappa BI et al. Potent KCNQ2/3-specific channel activator suppresses in vivo epileptic activity and prevents the development of tinnitus.
J. Neurosci., 2015 Jun 10 , 35 (8829-42).

4

Mills TA et al. Activation of KV7 channels stimulates vasodilatation of human placental chorionic plate arteries.
Placenta, 2015 Jun , 36 (638-44).

5

Sedivy V et al. Role of Kv7 channels in responses of the pulmonary circulation to hypoxia.
Am. J. Physiol. Lung Cell Mol. Physiol., 2015 Jan 1 , 308 (L48-57).

6

Caminos E et al. Relationship between rat retinal degeneration and potassium channel KCNQ5 expression.
Exp. Eye Res., 2015 Feb , 131 (1-11).

7

Li C et al. Activity-dependent downregulation of M-Type (Kv7) K⁺ channels surface expression requires the activation of iGluRs/Ca²⁺/PKC signaling pathway in hippocampal neuron.
Neuropharmacology, 2015 Aug , 95 (154-67).

8

Morales-Cano D et al. Kv7 channels critically determine coronary artery reactivity: left-right differences and down-regulation by hyperglycaemia.
Cardiovasc. Res., 2015 Apr 1 , 106 (98-108).

9

Shimizu S et al. A genome-wide association study of periodontitis in a Japanese population.
J. Dent. Res., 2015 Apr , 94 (555-61).

10

Caminos E et al. Loss of auditory activity modifies the location of potassium channel KCNQ5 in auditory brainstem neurons.
J. Neurosci. Res., 2015 Apr , 93 (604-14).

11

Svalø J et al. Functional and molecular evidence for Kv7 channel subtypes in human detrusor from patients with and without bladder outflow obstruction.
PLoS ONE, 2015 , 10 (e0117350).

12

Fidzinski P et al. KCNQ5 K(+) channels control hippocampal synaptic inhibition and fast network oscillations.
Nat Commun, 2015 , 6 (6254).

13

Wright GW et al. Cholinergic signalling-regulated KV7.5 currents are expressed in colonic ICC-IM but not ICC-MP.
Pflugers Arch., 2014 Sep , 466 (1805-18).

14

Grigorov A et al. Kv7 potassium channel subunits and M currents in cultured hippocampal interneurons.
Pflugers Arch., 2014 Sep , 466 (1747-58).

15

Grunnet M et al. Kv7 channels as targets for anti-epileptic and psychiatric drug-development.
Eur. J. Pharmacol., 2014 Mar 5 , 726 (133-7).

16

Brueggemann LI et al. KCNQ (Kv7) potassium channel activators as bronchodilators: combination with a β2-adrenergic agonist enhances relaxation of rat airways.
Am. J. Physiol. Lung Cell Mol. Physiol., 2014 Mar 15 , 306 (L476-86).

17

Jepps TA et al. Vasorelaxant effects of novel Kv7.4 channel enhancers ML213 and NS15370.
Br. J. Pharmacol., 2014 Jun 9 , ().

18

Brueggemann LI et al. Differential Activation of Vascular Smooth Muscle Kv7.4, Kv7.5, and Kv7.4/7.5 Channels by ML213 and ICA-069673.
Mol. Pharmacol., 2014 Jun 18 , ().

19

Li SS et al. MicroRNA-190 regulates hypoxic pulmonary vasoconstriction by targeting a voltage-gated K⁺ channel in arterial smooth muscle cells.
J. Cell. Biochem., 2014 Jun , 115 (1196-205).

20

Oliveras A et al. Functional assembly of kv7.1/kv7.5 channels with emerging properties on vascular muscle physiology.
Arterioscler. Thromb. Vasc. Biol., 2014 Jul , 34 (1522-30).

21

Brueggemann LI et al. Differential protein kinase C-dependent modulation of Kv7.4 and Kv7.5 subunits of vascular Kv7 channels.
J. Biol. Chem., 2014 Jan 24 , 289 (2099-111).

22

Eckey K et al. Novel Kv7.1-phosphatidylinositol 4,5-bisphosphate interaction sites uncovered by charge neutralization scanning.
J. Biol. Chem., 2014 Aug 15 , 289 (22749-58).

23

Soh H et al. Conditional deletions of epilepsy-associated KCNQ2 and KCNQ3 channels from cerebral cortex cause differential effects on neuronal excitability.
J. Neurosci., 2014 Apr 9 , 34 (5311-21).

24

Chadha PS et al. Contribution of kv7.4/kv7.5 heteromers to intrinsic and calcitonin gene-related peptide-induced cerebral reactivity.
Arterioscler. Thromb. Vasc. Biol., 2014 Apr , 34 (887-93).

25

Purkey MT et al. Genetic variation in genes encoding airway epithelial potassium channels is associated with chronic rhinosinusitis in a pediatric population.
PLoS ONE, 2014 , 9 (e89329).

26

Wu C et al. Kcnq1-5 (Kv7.1-5) potassium channel expression in the adult zebrafish.
BMC Physiol., 2014 , 14 (1).

27

Lee BH et al. Serum starvation-induced voltage-gated potassium channel Kv7.5 expression and its regulation by Sp1 in canine osteosarcoma cells.
Int J Mol Sci, 2014 , 15 (977-93).

28

Takahashi H et al. Application of a combination of a knowledge-based algorithm and 2-stage screening to hypothesis-free genomic data on irinotecan-treated patients for identification of a candidate single nucleotide polymorphism related to an adverse effect.
PLoS ONE, 2014 , 9 (e105160).

29

Zhang X et al. KCNQ and KCNE potassium channel subunit expression in bovine retinal pigment epithelium.
Exp. Eye Res., 2013 Nov , 116 (424-32).

30

Zhou P et al. Phosphatidylinositol 4,5-bisphosphate alters pharmacological selectivity for epilepsy-causing KCNQ potassium channels.
Proc. Natl. Acad. Sci. U.S.A., 2013 May 21 , 110 (8726-31).

31

Spitzmaul G et al. Vestibular role of KCNQ4 and KCNQ5 K+ channels revealed by mouse models.
J. Biol. Chem., 2013 Mar 29 , 288 (9334-44).

32

Verhoeven VJ et al. Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia.
Nat. Genet., 2013 Mar , 45 (314-8).

33

Afeli SA et al. Molecular expression and pharmacological evidence for a functional role of kv7 channel subtypes in Guinea pig urinary bladder smooth muscle.
PLoS ONE, 2013 , 8 (e75875).

34

Robbins J et al. Effects of KCNQ2 gene truncation on M-type Kv7 potassium currents.
PLoS ONE, 2013 , 8 (e71809).

35

Ferrer T et al. Tamoxifen inhibition of kv7.2/kv7.3 channels.
PLoS ONE, 2013 , 8 (e76085).

36

Pattnaik BR et al. Effects of KCNQ channel modulators on the M-type potassium current in primate retinal pigment epithelium.
Am. J. Physiol., Cell Physiol., 2012 Mar , 302 (C821-33).

37

King CH et al. Kv7.5 is the primary Kv7 subunit expressed in C-fibers.
J. Comp. Neurol., 2012 Jun 15 , 520 (1940-50).

38

Roura-Ferrer M et al. Targeting of Kv7.5 (KCNQ5)/KCNE channels to surface microdomains of cell membranes.
Muscle Nerve, 2012 Jan , 45 (48-54).

39

Zhang J et al. Activity-dependent transcriptional regulation of M-Type (Kv7) K(+) channels by AKAP79/150-mediated NFAT actions.
Neuron, 2012 Dec 20 , 76 (1133-46).

40

Chadha PS et al. Reduced KCNQ4-encoded voltage-dependent potassium channel activity underlies impaired β-adrenoceptor-mediated relaxation of renal arteries in hypertension.
Hypertension, 2012 Apr , 59 (877-84).

41

Ren L et al. CTCF mediates the cell-type specific spatial organization of the Kcnq5 locus and the local gene regulation.
PLoS ONE, 2012 , 7 (e31416).

42

Kim JB et al. Expression patterns of two potassium channel genes in skeletal muscle cells of patients with familial hypokalemic periodic paralysis.
Neurol India, 2011 Jul-Aug , 59 (527-31).

43

Mistry HD et al. Novel expression and regulation of voltage-dependent potassium channels in placentas from women with preeclampsia.
Hypertension, 2011 Sep , 58 (497-504).

44

Zhang X et al. KCNQ5/K(v)7.5 potassium channel expression and subcellular localization in primate retinal pigment epithelium and neural retina.
Am. J. Physiol., Cell Physiol., 2011 Nov , 301 (C1017-26).

45

Lobarinas E et al. Effects of the potassium ion channel modulators BMS-204352 Maxipost and its R-enantiomer on salicylate-induced tinnitus in rats.
, 2011 May 27 , ().

46

Brueggemann LI et al. Diclofenac distinguishes among homomeric and heteromeric potassium channels composed of KCNQ4 and KCNQ5 subunits.
Mol. Pharmacol., 2011 Jan , 79 (10-23).

47

Jepps TA et al. Downregulation of Kv7.4 channel activity in primary and secondary hypertension.
Circulation, 2011 Aug 2 , 124 (602-11).

48

Roepke TA et al. Fasting and 17β-estradiol differentially modulate the M-current in neuropeptide Y neurons.
J. Neurosci., 2011 Aug 17 , 31 (11825-35).

49

Cooper EC Made for "anchorin": Kv7.2/7.3 (KCNQ2/KCNQ3) channels and the modulation of neuronal excitability in vertebrate axons.
Semin. Cell Dev. Biol., 2011 Apr , 22 (185-92).

50

Huang H et al. KCNQ5 channels control resting properties and release probability of a synapse.
Nat. Neurosci., 2011 , 14 (840-7).

51

Zhong XZ et al. Participation of KCNQ (Kv7) potassium channels in myogenic control of cerebral arterial diameter.
J. Physiol. (Lond.), 2010 Sep 1 , 588 (3277-93).

52

Tzingounis AV et al. The KCNQ5 potassium channel mediates a component of the afterhyperpolarization current in mouse hippocampus.
Proc. Natl. Acad. Sci. U.S.A., 2010 Jun 1 , 107 (10232-7).

53

Soh H et al. The specific slow afterhyperpolarization inhibitor UCL2077 is a subtype-selective blocker of the epilepsy associated KCNQ channels.
Mol. Pharmacol., 2010 Dec , 78 (1088-95).

54

Garcia-Pino E et al. KCNQ5 reaches synaptic endings in the auditory brainstem at hearing onset and targeting maintenance is activity-dependent.
J. Comp. Neurol., 2010 Apr 15 , 518 (1301-14).

55

McCallum LA et al. Expression and function of K(v)7 channels in murine myometrium throughout oestrous cycle.
Pflugers Arch., 2009 Mar , 457 (1111-20).

56

Namkung W et al. In situ measurement of airway surface liquid [K+] using a ratioable K+-sensitive fluorescent dye.
J. Biol. Chem., 2009 Jun 5 , 284 (15916-26).

57

Brueggemann LI et al. Differential Effects of Selective COX-2 Inhibitors on Vascular Smooth Muscle Ion Channels May Account for Differences in Cardiovascular Risk Profiles.
Mol. Pharmacol., 2009 Jul 15 , ().

58

Jepps TA et al. Molecular and functional characterization of Kv7 K+ channel in murine gastrointestinal smooth muscles.
Am. J. Physiol. Gastrointest. Liver Physiol., 2009 Jul , 297 (G107-15).

59

Greenwood IA et al. KCNQ-encoded channels regulate Na+ transport across H441 lung epithelial cells.
Pflugers Arch., 2009 Feb , 457 (785-94).

60

Shapiro MS An ion channel hypothesis to explain divergent cardiovascular safety of COX-2 inhibitors: the answer to a hotly-debated puzzle? (Relates to article by Brueggemann, et al., Fast Forward 15 July 2009).
Mol. Pharmacol., 2009 Aug 4 , ().

61

Mani BK et al. Opposite regulation of KCNQ5 and TRPC6 channels contributes to vasopressin-stimulated calcium spiking responses in A7r5 vascular smooth muscle cells.
Cell Calcium, 2009 Apr , 45 (400-11).

62

Brown DA et al. Neural KCNQ (Kv7) channels.
Br. J. Pharmacol., 2009 Apr , 156 (1185-95).

63

Wickenden AD et al. Kv7 channels as targets for the treatment of pain.
Curr. Pharm. Des., 2009 , 15 (1773-98).

64

Roura-Ferrer M et al. Functional implications of KCNE subunit expression for the Kv7.5 (KCNQ5) channel.
Cell. Physiol. Biochem., 2009 , 24 (325-34).

65

Yeung S et al. Bimodal effects of the Kv7 channel activator retigabine on vascular K+ currents.
Br. J. Pharmacol., 2008 Sep , 155 (62-72).

66

Buniel M et al. Distribution of voltage-gated potassium and hyperpolarization-activated channels in sensory afferent fibers in the rat carotid body.
J. Comp. Neurol., 2008 Oct 1 , 510 (367-77).

67

Bal M et al. Homomeric and heteromeric assembly of KCNQ (Kv7) K+ channels assayed by total internal reflection fluorescence/fluorescence resonance energy transfer and patch clamp analysis.
J. Biol. Chem., 2008 Nov 7 , 283 (30668-76).

68

Mackie AR et al. Cardiovascular KCNQ (Kv7) potassium channels: physiological regulators and new targets for therapeutic intervention.
Mol. Pharmacol., 2008 Nov , 74 (1171-9).

69

Roura-Ferrer M et al. Skeletal muscle Kv7 (KCNQ) channels in myoblast differentiation and proliferation.
Biochem. Biophys. Res. Commun., 2008 May 16 , 369 (1094-7).

70

Mackie AR et al. Vascular KCNQ potassium channels as novel targets for the control of mesenteric artery constriction by vasopressin, based on studies in single cells, pressurized arteries, and in vivo measurements of mesenteric vascular resistance.
J. Pharmacol. Exp. Ther., 2008 May , 325 (475-83).

71

Shah MM et al. Functional significance of axonal Kv7 channels in hippocampal pyramidal neurons.
Proc. Natl. Acad. Sci. U.S.A., 2008 Jun 3 , 105 (7869-74).

72

Yeung SY et al. Expression profile and characterisation of a truncated KCNQ5 splice variant.
Biochem. Biophys. Res. Commun., 2008 Jul 11 , 371 (741-6).

73

Fedorenko O et al. A schizophrenia-linked mutation in PIP5K2A fails to activate neuronal M channels.
Psychopharmacology (Berl.), 2008 Jul , 199 (47-54).

74

Wladyka CL et al. The KCNQ/M-current modulates arterial baroreceptor function at the sensory terminal in rats.
J. Physiol. (Lond.), 2008 Feb 1 , 586 (795-802).

75

Miceli F et al. Molecular pharmacology and therapeutic potential of neuronal Kv7-modulating drugs.
, 2008 Feb , 8 (65-74).

76

Moser SL et al. Multiple KCNQ potassium channel subtypes mediate basal anion secretion from the human airway epithelial cell line Calu-3.
J. Membr. Biol., 2008 Feb , 221 (153-63).

77

Gao Z et al. Desensitization of chemical activation by auxiliary subunits: convergence of molecular determinants critical for augmenting KCNQ1 potassium channels.
J. Biol. Chem., 2008 Aug 15 , 283 (22649-58).

78

Hansen HH et al. Kv7 channels: interaction with dopaminergic and serotonergic neurotransmission in the CNS.
J. Physiol. (Lond.), 2008 Apr 1 , 586 (1823-32).

79

Maljevic S et al. Nervous system KV7 disorders: breakdown of a subthreshold brake.
J. Physiol. (Lond.), 2008 Apr 1 , 586 (1791-801).

80

Roepke TA et al. Estrogen regulation of genes important for K+ channel signaling in the arcuate nucleus.
Endocrinology, 2007 Oct , 148 (4937-51).

81

Brueggemann LI et al. Vasopressin stimulates action potential firing by protein kinase C-dependent inhibition of KCNQ5 in A7r5 rat aortic smooth muscle cells.
Am. J. Physiol. Heart Circ. Physiol., 2007 Mar , 292 (H1352-63).

82

Hu H et al. M-channels (Kv7/KCNQ channels) that regulate synaptic integration, excitability, and spike pattern of CA1 pyramidal cells are located in the perisomatic region.
J. Neurosci., 2007 Feb 21 , 27 (1853-67).

83

Caminos E et al. The potassium channel KCNQ5/Kv7.5 is localized in synaptic endings of auditory brainstem nuclei of the rat.
J. Comp. Neurol., 2007 Dec 1 , 505 (363-78).

84

Ekberg J et al. Regulation of the voltage-gated K(+) channels KCNQ2/3 and KCNQ3/5 by ubiquitination. Novel role for Nedd4-2.
J. Biol. Chem., 2007 Apr 20 , 282 (12135-42).

85

Jensen HS et al. Inactivation as a new regulatory mechanism for neuronal Kv7 channels.
Biophys. J., 2007 Apr 15 , 92 (2747-56).

86

Bentzen BH et al. The acrylamide (S)-1 differentially affects Kv7 (KCNQ) potassium channels.
Neuropharmacology, 2006 Nov , 51 (1068-77).

87

Schwake M et al. Structural determinants of M-type KCNQ (Kv7) K+ channel assembly.
J. Neurosci., 2006 Apr 5 , 26 (3757-66).

88

Strutz-Seebohm N et al. Functional coassembly of KCNQ4 with KCNE-beta- subunits in Xenopus oocytes.
Cell. Physiol. Biochem., 2006 , 18 (57-66).

89

Jensen HS et al. The KCNQ5 potassium channel from mouse: a broadly expressed M-current like potassium channel modulated by zinc, pH, and volume changes.
Brain Res. Mol. Brain Res., 2005 Sep 13 , 139 (52-62).

90

Schenzer A et al. Molecular determinants of KCNQ (Kv7) K+ channel sensitivity to the anticonvulsant retigabine.
J. Neurosci., 2005 May 18 , 25 (5051-60).

91

Lan WZ et al. Electrophysiological and molecular identification of hepatocellular volume-activated K+ channels.
Biochim. Biophys. Acta, 2005 Mar 1 , 1668 (223-33).

92

Surti TS et al. A potassium channel, the M-channel, as a therapeutic target.
, 2005 Jul , 6 (704-11).

93

Shen W et al. Cholinergic suppression of KCNQ channel currents enhances excitability of striatal medium spiny neurons.
J. Neurosci., 2005 Aug 10 , 25 (7449-58).

94

Gamper N et al. Structural requirements for differential sensitivity of KCNQ K+ channels to modulation by Ca2+/calmodulin.
Mol. Biol. Cell, 2005 Aug , 16 (3538-51).

95

Wua YJ et al. Recent developments on KCNQ potassium channel openers.
Curr. Med. Chem., 2005 , 12 (453-60).

96

Seebohm G et al. Regulation of KCNQ4 potassium channel prepulse dependence and current amplitude by SGK1 in Xenopus oocytes.
Cell. Physiol. Biochem., 2005 , 16 (255-62).

97

Li Y et al. Single-channel analysis of KCNQ K+ channels reveals the mechanism of augmentation by a cysteine-modifying reagent.
J. Neurosci., 2004 Jun 2 , 24 (5079-90).

98

Hadley JK et al. Stoichiometry of expressed KCNQ2/KCNQ3 potassium channels and subunit composition of native ganglionic M channels deduced from block by tetraethylammonium.
J. Neurosci., 2003 Jun 15 , 23 (5012-9).

99

Gamper N et al. Subunit-specific modulation of KCNQ potassium channels by Src tyrosine kinase.
J. Neurosci., 2003 Jan 1 , 23 (84-95).

100

Schwake M et al. A carboxy-terminal domain determines the subunit specificity of KCNQ K+ channel assembly.
EMBO Rep., 2003 Jan , 4 (76-81).

101

Cooper EC et al. M-channels: neurological diseases, neuromodulation, and drug development.
Arch. Neurol., 2003 Apr , 60 (496-500).

102

Yus-Nájera E et al. Localization of KCNQ5 in the normal and epileptic human temporal neocortex and hippocampal formation.
Neuroscience, 2003 , 120 (353-64).

103

Shah MM et al. Molecular correlates of the M-current in cultured rat hippocampal neurons.
J. Physiol. (Lond.), 2002 Oct 1 , 544 (29-37).

104

Dupuis DS et al. Activation of KCNQ5 channels stably expressed in HEK293 cells by BMS-204352.
Eur. J. Pharmacol., 2002 Feb 22 , 437 (129-37).

105

Yus-Najera E et al. The identification and characterization of a noncontinuous calmodulin-binding site in noninactivating voltage-dependent KCNQ potassium channels.
J. Biol. Chem., 2002 Aug 9 , 277 (28545-53).

106

Wickenden AD et al. Characterization of KCNQ5/Q3 potassium channels expressed in mammalian cells.
Br. J. Pharmacol., 2001 Jan , 132 (381-4).

107

Robbins J KCNQ potassium channels: physiology, pathophysiology, and pharmacology.
Pharmacol. Ther., 2001 Apr , 90 (1-19).

108

Cooper EC Potassium channels: how genetic studies of epileptic syndromes open paths to new therapeutic targets and drugs.
Epilepsia, 2001 , 42 Suppl 5 (49-54).

109

Kananura C et al. The new voltage gated potassium channel KCNQ5 and neonatal convulsions.
Neuroreport, 2000 Jun 26 , 11 (2063-7).

110

Lerche C et al. Molecular cloning and functional expression of KCNQ5, a potassium channel subunit that may contribute to neuronal M-current diversity.
J. Biol. Chem., 2000 Jul 21 , 275 (22395-400).

111

Schroeder BC et al. KCNQ5, a novel potassium channel broadly expressed in brain, mediates M-type currents.
J. Biol. Chem., 2000 Aug 4 , 275 (24089-95).