Channelpedia

PubMed 19636962


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Kir2.1 , Kir3.1



Title: Backbone resonance assignments for the cytoplasmic regions of G protein-activated inwardly rectifying potassium channel 1 (GIRK1).

Authors: Mariko Yokogawa, Takahiro Muramatsu, Koh Takeuchi, Masanori Osawa, Ichio Shimada

Journal, date & volume: Biomol NMR Assign, 2009 Jun , 3, 125-8

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/19636962


Abstract
G protein-activated inwardly rectifying potassium channel (GIRK) plays crucial roles in regulating heart rate and neuronal excitability in eukaryotic cells. A variety of ligands, including heterotrimeric G protein betagamma subunits (G betagamma), bind to the cytoplasmic regions of GIRK and modulate its activity. We established the backbone resonance assignments of (2)H/(13)C/(15)N-labeled cytoplasmic regions of mouse GIRK1, which form a tetramer with a molecular weight of 96 K.