Referenced in: none

Automatically associated channels: Kir2.1 , Kv1.1

Title: Do voltage-gated Kv1.1 and inward rectifier Kir2.1 potassium channels form heteromultimers?

Authors: J Tytgat, G Buyse, J Eggermont, G Droogmans, B Nilius, P Daenens

Journal, date & volume: FEBS Lett., 1996 Jul 29 , 390, 280-4

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/8706877

Abstract
Possible heteromultimer formation between Kv- and Kir-type K+ channels was investigated, in connection with the known functional diversity of K+ channels in vivo. Voltage-clamp experiments were performed on Xenopus oocytes, either injected with concatenated Kir2.1-Kv1.1 mRNA, or co-injected with Kv1.1 and Kir2.1 mRNA. K+ currents could be approximated by the algebraic sum of the 2 K+ current types alone. The tandem construct did not show functional expression, although it could be detected by Western blotting. We conclude that Kv1.1 and Kir2.1 alpha-subunit proteins fail to assemble and do not contribute functional diversity to K+ channels.