Channelpedia

PubMed 11821532


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Kir2.1



Title: Human myoblast differentiation: Ca(2+) channels are activated by K(+) channels.

Authors: Laurent Bernheim, Charles R Bader

Journal, date & volume: News Physiol. Sci., 2002 Feb , 17, 22-6

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/11821532


Abstract
In a paradigm of cellular differentiation, human myoblast fusion, we investigated how a Ca(2+) influx, indispensable for fusion, is triggered. We show how newly expressed Kir2.1 K(+) channels, via their hyperpolarizing effect on the membrane potential, generate a window Ca(2+) current (mediated by alpha 1H T-type Ca(2+) channels), which causes intracellular Ca(2+) to rise.