Channelpedia

PubMed 20809527


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Cav1.2 , KCNQ1 , Kir2.1 , Kv11.1 , Kv7.1 , Nav1.5



Title: LQTS gene LOVD database.

Authors: Tao Zhang, Arthur Moss, Peikuan Cong, Min Pan, Bingxi Chang, Liangrong Zheng, Quan Fang, Wojciech Zareba, Jennifer Robinson, Changsong Lin, Zhongxiang Li, Junfang Wei, Qiang Zeng, Ming Qi,

Journal, date & volume: , 2010 Aug 31 , ,

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/20809527


Abstract
The Long QT Syndrome (LQTS) is a group of genetically heterogeneous disorders that predisposes young individuals to ventricular arrhythmias and sudden death. LQTS is mainly caused by mutations in genes encoding subunits of cardiac ion channels (KCNQ1, KCNH2,SCN5A, KCNE1, and KCNE2). Many other genes involved in LQTS have been described recently(KCNJ2, AKAP9, ANK2, CACNA1C, SCNA4B, SNTA1, and CAV3). We created an online database(http://www.genomed.org/LOVD/introduction.html) that provides information on variants in LQTS-associated genes. As of February 2010, the database contains 1738 unique variants in 12 genes. A total of 950 variants are considered pathogenic, 265 are possible pathogenic, 131 are unknown/unclassified, and 292 have no known pathogenicity. In addition to these mutations collected from published literature, we also submitted information on gene variants, including one possible novel pathogenic mutation in the KCNH2 splice site found in ten Chinese families with documented arrhythmias. The remote user is able to search the data and is encouraged to submit new mutations into the database. The LQTS database will become a powerful tool for both researchers and clinicians.