PubMed 25092467

Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Kir2.1 , Nav1 , Nav1.5

Title: Reduction in dynamin-2 is implicated in ischaemic cardiac arrhythmias.

Authors: Dan Shi, Duanyang Xie, Hong Zhang, Hong Zhao, Jian Huang, Changming Li, Yi Liu, Fei Lv, Erlinda The, Yuan Liu, Tianyou Yuan, Shiyi Wang, Jinjin Chen, Lei Pan, Zuoren Yu, Dandan Liang, Weidong Zhu, Yuzhen Zhang, Li Li, Luying Peng, Jun Li, Yi-Han Chen

Journal, date & volume: J. Cell. Mol. Med., 2014 Oct , 18, 1992-9

PubMed link:

Ischaemic cardiac arrhythmias cause a large proportion of sudden cardiac deaths worldwide. The ischaemic arrhythmogenesis is primarily because of the dysfunction and adverse remodelling of sarcolemma ion channels. However, the potential regulators of sarcolemma ion channel turnover and function in ischaemic cardiac arrhythmias remains unknown. Our previous studies indicate that dynamin-2 (DNM2), a cardiac membrane-remodelling GTPase, modulates ion channels membrane trafficking in the cardiomyocytes. Here, we have found that DNM2 plays an important role in acute ischaemic arrhythmias. In rat ventricular tissues and primary cardiomyocytes subjected to acute ischaemic stress, the DNM2 protein and transcription levels were markedly down-regulated. This DNM2 reduction was coupled with severe ventricular arrhythmias. Moreover, we identified that the down-regulation of DNM2 within cardiomyocytes increases the action potential amplitude and prolongs the re-polarization duration by depressing the retrograde trafficking of Nav1.5 and Kir2.1 channels. These effects are likely to account for the DNM2 defect-induced arrhythmogenic potentials. These results suggest that DNM2, with its multi-ion channel targeting properties, could be a promising target for novel antiarrhythmic therapies.